Article
Biochemistry & Molecular Biology
Silvia D'Ambrosi, Stavros Giannoukakos, Mafalda Antunes-Ferreira, Carlos Pedraz-Valdunciel, Jillian W. P. Bracht, Nicolas Potie, Ana Gimenez-Capitan, Michael Hackenberg, Alberto Fernandez Hilario, Miguel A. Molina-Vila, Rafael Rosell, Thomas Wurdinger, Danijela Koppers-Lalic
Summary: This study investigates the synergistic contribution of circRNA and mRNA derived from blood platelets as biomarkers for lung cancer detection. Using a comprehensive bioinformatics pipeline, platelet-derived circRNA and mRNA from non-cancer individuals and lung cancer patients were analyzed. Machine learning algorithms were used to generate predictive classification models based on an optimal selected signature. The study demonstrates the potential of a multi-analyte-based approach using platelet-derived biomarkers for lung cancer detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yumin Zhu, Siqi Wang, Xiaochen Xi, Minfeng Zhang, Xiaofan Liu, Weina Tang, Peng Cai, Shaozhen Xing, Pengfei Bao, Yunfan Jin, Weihao Zhao, Yinghui Chen, Huanan Zhao, Xiaodong Jia, Shanshan Lu, Yinying Lu, Lei Chen, Jianhua Yin, Zhi John Lu
Summary: The study utilized sequencing technologies to detect different types of cancer-related RNA variations in plasma, revealing pathways associated with tumorigenesis and metastasis, immune responses, and metabolism. A 3-RNA detection panel for liver cancer was identified, showing promise for detecting AFP-negative and early-stage patients.
Article
Cell Biology
Xiufang Wang, Chenyang Dai, Minqing Ye, Jingyun Wang, Weizhao Lin, Ruiman Li
Summary: This study identified 1297 lncRNAs related to autophagy genes and established a prognostic signature consisting of five autophagy-related lncRNAs for endometrial cancer. The signature showed potential as an independent prognostic indicator and may play a key role in the development of the disease.
Article
Cell Biology
Linli Zhao, Qiong Teng, Yuan Liu, Hao Chen, Wei Chong, Fengying Du, Kun Xiao, Yaodong Sang, Chenghao Ma, Jian Cui, Liang Shang, Ronghua Zhang
Summary: In this study, we developed an integrative analysis to construct a 9-lncRNA signature for predicting the prognosis of gastric cancer patients. The model showed promise in predicting prognostic outcomes and immunotherapeutic responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biophysics
Raquel Sanchez-Salcedo, Rebeca Miranda-Castro, Noemi de-los-Santos-Alvarez, Maria Jesus Lobo-Castanon
Summary: A sandwich-type hybridization assay has been developed for detecting prostate cancer by simultaneously measuring prostate cancer antigen 3 and PSA mRNA. This method improves the sensitivity of long noncoding RNA detection and shows good performance in PCa diagnosis without significant cross-talk in the dual configuration.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai, Ping Han
Summary: The study developed a hypoxia-related lncRNA signature to predict survival outcomes in bladder cancer patients, accurately predicting survival outcomes and showing associations with immune cell infiltration, tumor mutation burden, and gene set enrichment.
Article
Oncology
Johannes F. Fahrmann, Ehsan Irajizad, Makoto Kobayashi, Jody Vykoukal, Jennifer B. Dennison, Eunice Murage, Ranran Wu, James P. Long, Kim-Anh Do, Joseph Celestino, Karen H. Lu, Zhen Lu, Robert C. Bast, Samir Hanash
Summary: The study identified a plasma polyamine signature associated with ovarian cancer that complemented CA125 in detecting early-stage ovarian cancer, providing potential markers for improving sensitivity in ovarian cancer detection. Mass spectrometry quantified four polyamines in plasma samples from ovarian cancer cases and controls, with a polyamine signature showing improved sensitivity and capturing cases missed by CA125 alone. This MYC-driven plasma polyamine signature offers promise for enhancing early ovarian cancer detection.
Article
Immunology
Mingxuan Zhou, Silin Lv, Yufang Hou, Rixin Zhang, Weiqi Wang, Zheng Yan, Tiegang Li, Wenqiang Gan, Zifan Zeng, Fang Zhang, Min Yang
Summary: This study identified the importance of sialylation-related lncRNAs in the prognosis of colorectal cancer patients and proposed a novel lncRNA signature for accurately evaluating prognosis and exploring potential molecular mechanisms related to sialylation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Bashdar Mahmud Hussen, Snur Rasool Abdullah, Goran Sedeeq Hama Faraj, Mohammed Fatih Rasul, Abbas Salihi, Soudeh Ghafouri-Fard, Mohammad Taheri, Majid Mokhtari
Summary: Exosomes are membrane vesicles with a diameter of 30-150 nm, secreted by various cancer types and containing circRNAs among other substances. Exo-circRNAs play a crucial role in lung cancer progression, but the specific activities and regulatory mechanisms are still unclear. A better understanding of exo-circRNA regulation and network connections can lead to improved treatment for lung cancer, including potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Genetics & Heredity
Shaoqin Jiang, Zhihao Li, Ruiling Dou, Zequn Lin, Jili Zhang, Wenhui Zhang, Zeyu Chen, Xianqi Shen, Jin Ji, Min Qu, Yan Wang, Mengqiang Li, Xu Gao
Summary: This study identified seven CRLs closely related to the prognosis of PCa patients. A risk score model based on these CRLs accurately predicted the prognosis of PCa patients. GO and KEGG analyses showed that CRLs were mainly enriched in metabolism-related biological pathways in PCa.
FRONTIERS IN GENETICS
(2022)
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Mei Jiang, Yihang Cheng, Dan Wang, Yali Lu, Shaohua Gu, Chenji Wang, Yan Huang, Yao Li
Summary: By integrative analysis and experimental validation, a prognostic signature of 16 transcription factors in prostate cancer and their interactions with long noncoding RNAs have been identified, providing new insights into potential biomarkers and therapeutic targets for prostate cancer.
Article
Genetics & Heredity
Jichang Liu, Qiang Liu, Hongchang Shen, Yong Liu, Yadong Wang, Guanghui Wang, Jiajun Du
Summary: In this study, a novel pyroptosis-related lncRNA signature was constructed, which showed excellent performance in predicting prognosis and immune value in lung adenocarcinoma patients. The low-risk group demonstrated better overall survival, tumor microenvironment, and response to immunotherapy compared to the high-risk group.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Tobias Sikosek, Rastislav Horos, Franziska Trudzinski, Julia Jehn, Maurice Frank, Timothy Rajakumar, Laura V. Klotz, Nathaniel Mercaldo, Mustafa Kahraman, Marco Heuvelman, Yasser Taha, Jennifer Gerwing, Jasmin Skottke, Alberto Daniel-Moreno, Marta Sanchez-Delgado, Sophie Bender, Christina Rudolf, Franziska Hinkfoth, Kaja Tikk, Judith Schenz, Markus A. Weigand, Peter Feindt, Christian Schumann, Petros Christopoulos, Hauke Winter, Michael Kreuter, Marc A. Schneider, Thomas Muley, Stephan Walterspacher, Martin Schuler, Kaid Darwiche, Christian Taube, Balazs Hegedus, Klaus F. Rabe, Kimberly Rieger-Christ, Francine L. Jacobsen, Clemens Aigner, Martin Reck, Alexander A. Bankier, Amita Sharma, Bruno R. Steinkraus
Summary: Lung cancer is the deadliest cancer and its survival is influenced by tumor stage. Low-dose computed tomography screening can reduce mortality but has low adherence in the US and limited implementation in Europe. Therefore, additional screening tests, such as blood tests, are needed for early detection in primary care settings.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Microbiology
Huifen Zhou, Jipei Liao, Qixin Leng, Molangur Chinthalapally, Pushpa Dhilipkannah, Feng Jiang
Summary: Pathogenic bacteria related to lung cancer were analyzed in lung tumors, normal lung tissues, and plasma samples. Three bacteria (Selenomonas, Streptococcus, and Veillonella) showed consistent changes in plasma and higher DNA abundances in cancer patients. Using these bacteria as a biomarker panel could identify lung cancer, regardless of stage or histology. The potential of circulating bacterial DNA as plasma biomarkers for early lung cancer detection was confirmed.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)