Article
Immunology
Yasmin Maor, Eilat Shinar, Marina Izak, Galia Rahav, Tal Brosh-Nissimov, Asa Kessler, Naomi Rahimi-Levene, Odeda Benin-Goren, Dani Cohen, Iris Zohar, Noga Alagem, Sharon Castro, Oren Zimhony
Summary: In this study, convalescent immunoglobulins (cIgGs) were compared with convalescent plasma (CP) for treating COVID-19 patients. The study found that cIgGs did not meet the noninferiority endpoint on day 14 but showed superior performance to CP on day 28. Unvaccinated patients treated with cIgGs had better survival and improvement by day 28.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Jonathan M. Ciencewicki, Andrew S. Herbert, Nadia Storm, Nicole M. Josleyn, Kathleen E. Huie, Lindsay G. A. McKay, Anthony Griffiths, John M. Dye, Todd Willis, Vikram Arora
Summary: This paper describes the manufacturing process of a purified anti-Ebola virus immunoglobulin from pooled convalescent plasma and evaluates its efficacy in antibody potency and an animal model. The results show that the anti-Ebola virus immunoglobulin exhibits significantly enhanced neutralizing activity in both in vitro and in vivo experiments. These findings provide important support for the treatment and prophylaxis of Ebola virus disease.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Environmental Sciences
Jile Fu, Yiyi Xu, Eric J. Arts, Zhengyu Bai, Zhongwei Chen, Ying Zheng
Summary: The transmission of viral infections via aerosol is a serious threat to public health, and non-thermal plasma technology has gained interest for its highly effective disinfection and flexible operation.
Article
Hematology
Aarthi G. Shenoy, Aaron Z. Hettinger, Stephen J. Fernandez, Joseph Blumenthal, Valentina Baez
Summary: The study demonstrated that patients with COVID-19 who received CCP had a decreased risk of death at 7 and 14 days, but not 28 days after transfusion, compared to matched controls.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, General & Internal
Lise J. Estcourt, Claudia S. Cohn, Monica B. Pagano, Claire Iannizzi, Nina Kreuzberger, Nicole Skoetz, Elizabeth S. Allen, Evan M. Bloch, Gregory Beaudoin, Arturo Casadevall, Dana V. Devine, Farid Foroutan, Thomas J. Gniadek, Ruchika Goel, Jed Gorlin, Brenda J. Grossman, Michael J. Joyner, Ryan A. Metcalf, Jay S. Raval, Todd W. Rice, Beth H. Shaz, Ralph R. Vassallo, Jeffrey L. Winters, Aaron A. R. Tobian
Summary: This article introduces the therapeutic application of convalescent plasma for COVID-19 patients and provides corresponding clinical practice guidelines. The guidelines include recommendations for the use of convalescent plasma for outpatients and inpatients, as well as for prophylactic application. For high-risk patients, it is recommended to transfuse convalescent plasma in addition to standard care, while for hospitalized patients without detectable SARS-CoV-2 antibodies, it is suggested to transfuse convalescent plasma in addition to standard care.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Hematology
Henry E. Wang, Luis Ostrosky-Zeichner, Jeffrey Katz, Audrey Wanger, Yu Bai, Sujatha Sridhar, Bela Patel
Summary: The recruitment of convalescent plasma donors for COVID-19 treatment in a health system in Houston, Texas resulted in a limited number of donations despite screening a high number of candidates. This highlights important implications for CCP donor recruitment and community pandemic planning.
Article
Medicine, General & Internal
Anna Moniuszko-Malinowska, Piotr Czupryna, Dorota Zarebska-Michaluk, Krzysztof Tomasiewicz, Slawomir Pancewicz, Marta Rorat, Anna Dworzanska, Katarzyna Sikorska, Beata Bolewska, Beata Lorenc, Andrzej Chcialowski, Dorota Kozielewicz, Barbara Oczko-Grzesik, Anna Szymanek-Pasternak, Bartosz Szetela, Magdalena Figlerowicz, Magdalena Rogalska, Izabela Zaleska, Robert Flisiak
Summary: This study analyzed the effectiveness of convalescent plasma on COVID-19 patients and found that early administration of convalescent plasma can shorten hospitalization time. The efficacy of convalescent plasma is inferior to remdesivir, but comparable to other treatment options in most endpoints.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Vladimir Scholtz, Eva Vankova, Petra Kasparova, Ramya Premanath, Iddya Karunasagar, Jaroslav Julak
Summary: ESKAPE bacteria are a group of pathogens resistant to commonly used antibiotics, and non-thermal plasma shows promising potential as a bactericidal agent. Studies have shown that NTP can be widely applied for sterilization and disinfection in different fields, with significant application prospects.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Geriatrics & Gerontology
Inigo Romon, Juan J. Dominguez-Garcia, Jose L. Arroyo, Borja Suberviola, Itxasne Cabezon, Beatriz Abascal, Cristina Baldeon, Amalia Cuesta, Raquel Portilla, Elena Casuso, Enrique Ocio, Montserrat Briz
Summary: The study found that convalescent plasma treatment in COVID-19 patients over 80 years old was well tolerated but did not show statistically significant differences in hospital mortality, ICU admission, or length of hospitalization. Results should be interpreted with caution due to the limited number of patients and only half receiving high-titer CP.
Article
Mathematics
Hennie Husniah, Ruhanda Ruhanda, Asep K. Supriatna, Md H. A. Biswas
Summary: A mathematical model considering convalescent plasma transfusion (CPT) was developed to analyze the effects of different application rates on lowering the number of infectious individuals. Standard procedures in mathematical epidemiology were used to analyze the model, showing that the use of CPT resulted in a lower peak of infection cases and other epidemiological measures.
Article
Microbiology
Armando M. Perichon, Andrea Acosta, Liliana Di Tulio, Maria Jose Munuce, Stella Pezzotto, Oscar Bottasso, Esteban C. Nannini
Summary: Early treatment with convalescent plasma (CP) within 3 days of hospitalization is associated with reduced 28-day mortality in hospitalized COVID-19 patients. This suggests that CP may be a relatively safe, cheap, and potentially effective therapeutic option.
Article
Medicine, General & Internal
Fabrice Cognasse, Hind Hamzeh-Cognasse, Mickael Rosa, Delphine Corseaux, Brigitte Bonneaudeau, Chloe Pierre, Julie Huet, Charles Antoine Arthaud, Marie Ange Eyraud, Amelie Prier, Anne Claire Duchez, Theo Ebermeyer, Marco Heestermans, Estelle Audoux-Caire, Quentin Philippot, Tom Le Voyer, Olivier Hequet, Anne-Marie Fillet, Patricia Chavarin, Dominique Legrand, Pascale Richard, France Pirenne, Pierre Gallian, Jean Laurent Casanova, Sophie Susen, Pascal Morel, Karine Lacombe, Paul Bastard, Pierre Tiberghien
Summary: COVID-19 convalescent plasma (CCP) contains neutralising antibodies that may be useful as passive immunotherapy. CCP showed increased levels of IL-6 and TNF-alpha and lower levels of IL-10 compared to control plasma. Auto-Antibodies against type I IFNs in CCP were not associated with reported adverse events. Further studies are needed to define the clinical relevance of these findings.
Review
Virology
Saly Kanj, Basem Al-Omari
Summary: After over a year of the COVID-19 pandemic, healthcare systems worldwide are still struggling with rising cases. The use of convalescent plasma transfusion (CPT) shows potential in reducing the severity and duration of COVID-19 symptoms, but early intervention, donor recruitment, and plasma potency present challenges for scaled-up implementation. More randomized clinical trials are needed to fully assess the risks and benefits of CPT.
Review
Medicine, General & Internal
Claire Iannizzi, Khai Li Chai, Vanessa Piechotta, Sarah J. Valk, Catherine Kimber, Ina Monsef, Erica M. Wood, Abigail A. Lamikanra, David J. Roberts, Zoe McQuilten, Cynthia So-Osman, Aikaj Jindal, Nora Cryns, Lise J. Estcourt, Nina Kreuzberger, Nicole Skoetz
Summary: This study investigated the effectiveness and safety of convalescent plasma transfusion for COVID-19 patients. The results showed that convalescent plasma had limited impact on reducing mortality, improving clinical status, reducing the need for mechanical ventilation, and increasing discharge rates. Compared to placebo or standard care, convalescent plasma did not show significant advantages in patient outcomes.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Hematology
Cyril Jacquot, Oren Gordon, Daniel Noland, Jeffrey R. Donowitz, Emily Levy, Sanjay Jain, Zachary Willis, Casey Rimland, Michele Loi, Antonio Arrieta, Kyle Annen, Noelle Drapeau, Stephanie Osborne, Monica I. Ardura, Satyam Arora, Elise Zivick, Meghan Delaney
Summary: A multi-institutional registry was created to study the use of convalescent COVID-19 plasma (CCP) in pediatric patients. The results showed that CCP was safe and well-tolerated in children, with no serious adverse events reported.
Article
Engineering, Biomedical
Flore Gouel, Kelly Timmerman, Philippe Gosset, Cedric Raoul, Mary Dutheil, Aurelie Jonneaux, Guillaume Garcon, Caroline Moreau, Veronique Danel-Brunaud, James Duce, Thierry Burnouf, Jean-Christophe Devedjian, David Devos
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no cure. This study shows that heat-treated human platelet lysate may have neuroprotective effects in ALS models, suggesting it as a potential therapeutic approach.
Review
Hematology
Thierry Burnouf, Birgit Gathof, Evan M. Bloch, Renee Bazin, Vincenzo de Angelis, Gopal Kumar Patidar, Rada M. Grubovic Rastvorceva, Adaeze Oreh, Ruchika Goel, Naomi Rahimi-Levene, Salwa Hindawi, Arwa Z. Al-Riyami, Cynthia So-Osman
Summary: The COVID-19 pandemic has highlighted the potential therapeutic value of early passive polyclonal immunotherapy using high-titer convalescent plasma (CCP). Human polyclonal hyperimmune immunoglobulin (HIG) has several advantages over CCP, such as standardized antibody content, viral safety, and preserved immunoglobulin neutralization capacity. This document provides an overview of current practices and guidance for the collection and testing of plasma rich in antibodies against SARS-CoV-2 and its fractionation for the manufacture of quality-assured and safe HIG. Considerations are also given to the production of HIG preparations in low- and middle-income countries.
TRANSFUSION MEDICINE REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Lassina Barro, Ming-Li Chou, Yu-Wen Wu, Naoto Watanabe, Masayasu Takahara, Luc Buee, David Blum, David Devos, Thierry Burnouf
Summary: This study evaluated the virus removal properties of a nanofiltration process on human platelet lysates (HPL) and found that it effectively reduced viral and procoagulant risks while preserving the neuroprotective and anti-inflammatory properties of HPL.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemical Research Methods
Thierry Burnouf, Jay Epstein, Jean-Claude Faber, Claude Tayou Tagny, Daniel Somuah, W. Martin Smid
Summary: This document provides a commentary on the conclusions of an international workshop on plasma protein therapies and highlights the importance of improving access to these therapies in low- and middle-income countries. It suggests that locally producing small-scale virus-inactivated concentrates of clotting factors and immune globulins from domestic recovered plasma through validated technologies is a pragmatic approach. The active involvement of international blood donor and blood transfusion organizations, patient organizations, governments, and industry is emphasized.
Editorial Material
Hematology
Jerry A. Holmberg, Stephen M. Henry, Thierry Burnouf, Dana Devine, Susanne Marschner, Thomas C. Boothby, Scott R. Burger, Stella T. Chou, Brian Custer, Neil Blumberg, Donald L. Siegel, Steven L. Spitalnik
Article
Hematology
Hadi Goubran, Gaafar Ragab, Jerard Seghatchian, Thierry Burnouf
Summary: Autoimmune rheumatic disorders (ARD) are a group of diseases that primarily affect joints, bones, muscles, and connective tissues. Patients with ARD often require blood transfusion, but the autoimmune background and use of immunosuppressive medications increase their vulnerability to the potential risks associated with transfusion. Therefore, strategies should be implemented to reduce the impact and risks of transfusion on these patients.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Hematology
Mohamed Shouman, Hadi Goubran, Jerard Seghatchian, Thierry Burnouf
Summary: Patients with solid and hematologic malignancies have traditionally been treated with chemotherapy or a holistic targeted strategy. The use of immunomodulatory drugs and immune checkpoint inhibitors has significantly changed the treatment paradigm and improved patient survival. However, the widespread use of immune checkpoint inhibitors has also led to an increase in immune-related hematological adverse events. Studies suggest that transfusion may have a negative impact on the effectiveness of immunotherapy.
TRANSFUSION AND APHERESIS SCIENCE
(2023)
Article
Hematology
Christian Gabriel, Denese C. Marks, Reinhard Henschler, Katharina Schallmoser, Thierry Burnouf, Mickey B. C. Koh
Summary: Serum eye drops are commonly used to treat ocular surface disease, but their use and production lack standardization. A workshop was held to review the current status of human eye drops and identify the need for standardization. The workshop highlighted the variability in manufacturing, lack of quality standards, distribution issues, and the need for guidelines.
Article
Nanoscience & Nanotechnology
Yan-Ting Chen, Chia-Hung Liu, Wen-Yu Pan, Pei-Ru Jheng, Yves S. Y. Hsieh, Thierry Burnouf, Yu-Jui Fan, Chia-Che Chiang, Tzu-Yin Chen, Er-Yuan Chuang
Summary: Due to the risk associated with thrombosis, alternative techniques for antithrombotic therapy are needed. A new technique using a cotton-ball-shaped platelet-mimetic self-assembly framework has been developed. This technique enables noninvasive site-specific thrombolysis and vascular restoration. The biomimetic nanomotors show promising results in improving the efficacy of antithrombotic therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Physical
Pradeep Kumar, Anup Pandith, Ching-Li Tseng, Thierry Burnouf
Summary: Mitochondria regulate cell metabolism through the replication and transcription of their genes. Guanine-rich nucleotides, known as G-quadruplexes (G4s), are involved in these processes. The study of G4s is important due to their association with fatal diseases. This article documents the use of small fluorescent probes to recognize G4s in mitochondria, providing valuable information for understanding their function and potential applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2023)
Article
Cell Biology
Yu-Wen Wu, Deng-Yao Lee, Yeh-Lin Lu, Liling Delila, Ouada Nebie, Lassina Barro, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran, Thierry Burnouf
Summary: This study compared different methods to produce platelet extracellular vesicles (PEVs) and found that sonication and extrusion were the most effective ones. The PEVs loaded with the drug doxorubicin (DOX) showed significant anticancer activity against breast cancer cells. These findings suggest that PEVs could be a promising strategy for delivering cancer drugs and further evaluation in preclinical animal models is needed.
Review
Neurosciences
Ming-Li Chou, Abdulkareem Olarewaju Babamale, Tara L. Walker, Fabrice Cognasse, David Blum, Thierry Burnouf
Summary: This review summarizes the roles of platelet-neutrophil interactions in neuroinflammatory diseases, emphasizing their importance and impact on pathological events in the brain. The study also highlights the activation of inflammasomes by damage-associated molecular patterns derived from platelets and neutrophils, and suggests the potential of interventions targeting platelets and neutrophils for treating neuroinflammatory diseases.
TRENDS IN NEUROSCIENCES
(2023)
Review
Hematology
Thierry Burnouf, Jay Epstein, Jean-Claude Faber, W. Martin Smid
Summary: Industrial plasma fractionation is difficult to access for many low- and middle-income countries, resulting in inadequate treatment options for patients in these countries. However, these countries produce surplus plasma that is currently discarded. This article reviews options for processing plasma from low- and middle-income countries and proposes a stepwise approach to improve plasma utilization.
Article
Oncology
Yuan-Hung Wu, Heng-sheng Chao, Chi-Lu Chiang, Yung-Hung Luo, Chao-Hua Chiu, Sang-Hue Yen, Chun-Yu Liu, Jeng-Fong Chiou, Thierry Burnouf, Yin-Ju Chen, Peng-Yuan Wang, Tsu-Yi Chao, Shih-Ming Hsu, Long-Sheng Lu
Summary: This study demonstrates the potential of drug sensitivity tests on circulating tumor cell-derived organoids to inform personalized treatment for advanced thymic malignancies.
Review
Chemistry, Physical
Asmaa Khalil, Alexandre Barras, Rabah Boukherroub, Ching-Li Tseng, David Devos, Thierry Burnouf, Winfried Neuhaus, Sabine Szunerits
Summary: Paracellular permeability is regulated by tight junctions, which not only restrict the diffusion of ions and hydrophilic molecules, but also play important roles in cell polarization and protein localization. New understanding of tight junction components has challenged the traditional concept of diffusion barriers. Nanotechnological approaches and nanomaterials offer potential solutions for enhancing drug delivery across tight junctions.
NANOSCALE HORIZONS
(2023)
