Article
Medical Laboratory Technology
You Keun Ko, Jong Kwon Lee, Hye Kyung Park, Ae Kyung Han, Sun Kyoung Mun, Hye Jeong Park, Hae Kyoung Choung, Se Mi Kim, Kwang Mo Choi, Nam Yong Lee, Duck Cho, Dae Won Kim, Eun-Suk Kang
Summary: In order to ensure the sterility and safety of hematopoietic stem cell (HSC) products, it is important for each hospital to implement and maintain good practice guidelines and regulations for the HSC collection and processing unit. Retrospective analysis of microbial culture results of 11,743 HSC products over a 25-year period revealed a decrease in contamination rate from 0.5% in the first period to 0.2% in the second period. The study suggests that handling HSC products by trained personnel and adopting established protocols, including quality assurance programs, can help decrease the risk of contamination.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
L. Damonti, N. Buetti, S. Droz, U. Bacher, T. Pabst, B. M. Taleghani, G. M. Baerlocher, J. Marschall
Summary: Limited and conflicting information exists on the prevalence of contamination of haematopoietic stem and progenitor cell products (HPCPs), but data suggest that microbial contamination of autologous HPCPs and associated adverse outcomes are rare.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Cell & Tissue Engineering
Mei San Tang, Diane S. Sempek, Karlyn J. Rensing, Suzanne R. Thibodeaux
Summary: The study found that volumes and CD34+ cell/kg doses calculated based on specific gravity and apheresis instruments were similar. Different calculation methods did not affect patients requiring multiple collections.
Review
Cell & Tissue Engineering
Pijus K. Barman, Helen S. Goodridge
Summary: Balanced production of immune cells is important for immune surveillance, and commensal microbes can influence hematopoietic stem and progenitor cell (HSPC) activity. HSPCs sense microbes through pattern recognition receptors and cytokine receptors, and the long-term effects of microbial stimuli on HSPCs are significant. There may be a connection between myeloid-biased hematopoiesis and elevated levels of microbiome-derived components in aging and metabolic stress. Trained immunity-based vaccines that exploit microbial stimulation of HSPCs show promise.
Article
Cell & Tissue Engineering
Thomas Z. Thompson, Ashley A. Krull, Dustin J. Strasburg, Jill Adamski, Eapen K. Jacob, Margaret A. DiGuardo
Summary: This article describes the phenomenon of cold agglutinins and cryoglobulins causing erythrocyte agglutination in an extracorporeal circuit, and shares the experience in preventing and responding to this situation.
Article
Cell & Tissue Engineering
Zenghua Lin, Maile K. Hollinger, Zhijie Wu, Wanling Sun, Kaylind Batey, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: It was found that sirolimus enhanced the regeneration of hematopoietic stem and progenitor cells in mice exposed to sublethal total body irradiation and other regenerative stressors. The effects were associated with increased expression of hematopoietic genes, reduced DNA damage and clearance of cellular reactive oxygen species. Sirolimus also showed potential clinical applications for the treatment and prevention of hematopoietic injury.
Article
Immunology
Yingying Huo, Linjie Wu, Aiming Pang, Qing Li, Fang Hong, Caiying Zhu, Zining Yang, Weiqian Dai, Yawei Zheng, Qianqian Meng, Jiali Sun, Shihui Ma, Linping Hu, Ping Zhu, Fang Dong, Xin Gao, Erlie Jiang, Sha Hao, Tao Cheng
Summary: Hematopoietic stem cell transplantation is an effective regenerative therapy for various diseases, but our understanding of the reconstitution process is limited. This study reveals the dynamics of transplanted hematopoietic stem and progenitor cells (HSPCs) in humans. Transcriptomic analysis shows that immunoregulatory neutrophil progenitors expressing high levels of the S100A gene family are enriched in peripheral blood stem cells. Patients with acute graft-versus-host disease (aGVHD) have fewer S100Ahigh immunoregulatory neutrophil progenitors, suggesting a potential criterion for identifying high-risk patients.
SCIENCE IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Franziska Olm, Lena Panse, Josefina H. Dykes, Daniel Bexell, Thomas Laurell, Stefan Scheding
Summary: The study established a label-free acoustophoresis-based microfluidic technology for neuroblastoma enrichment and removal, demonstrating the effective separation of PDX cells and retention of patient's stem and progenitor cells. This technology has the potential for label-free, non-contact tumor cell purification in future clinical applications.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Le Qi, Misty S. Martin-Sandoval, Salma Merchant, Wen Gu, Matthias Eckhardt, Thomas P. Mathews, Zhiyu Zhao, Michalis Agathocleous, Sean J. Morrison
Summary: The study found that mouse hematopoietic stem cells depend entirely on cell-autonomous aspartate synthesis, which increases upon HSC activation. Aspartate, purine, and asparagine availability limits the function of HSCs during hematopoietic regeneration.
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maiko Sezaki, Yoshikazu Hayashi, Gaku Nakato, Yuxin Wang, Sayuri Nakata, Subinoy Biswas, Tatsuya Morishima, Md Fakruddin, Jieun Moon, Soyeon Ahn, Pilhan Kim, Yuji Miyamoto, Hideo Baba, Shinji Fukuda, Hitoshi Takizawa
Summary: The study reveals the communication between bone marrow and inflamed sites during gut inflammation, where hematopoietic stem and progenitor cells are activated and directed towards inflamed lymph nodes for expansion and differentiation. This process is mediated by the commensal bacteria Bacteroides and highlights the importance of maintaining immune balance.
Review
Food Science & Technology
Boguslaw Buszewski, Olga Wrona, Razgonova P. Mayya, Alexander Mikhailovich Zakharenko, Tatyana Kuzminichna Kalenik, Kirill Sergeevich Golokhvast, Wojciech Piekoszewski, Katarzyna Rafinska
Summary: This study reviews the potential use of supercritical CO2 for microbial inactivation of raw materials in the food industry. It discusses the history, bactericidal mechanism, and enzyme inactivation related to supercritical CO2. In conclusion, the study provides an overview of the latest research in this field.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Multidisciplinary Sciences
Irene Mariam Roy, P. V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar, Sarah Schouteden, Joerg Huelsken, Catherine M. Verfaillie, Satish Khurana
Summary: Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell function. In this study, it was found that integrin signaling regulates the expression of SDF-1 alpha through transcriptional regulation. Inhibition of SRC gene or pharmacological inhibition resulted in increased expression of the chemokine SDF-1 alpha. Systemic inhibition of SRC led to increased SDF-1 alpha levels in BM plasma, which improved the homing efficiency of transplanted HSCs and enhanced hematopoietic function.
Review
Immunology
Marco De Zuani, Jan Fric
Summary: Recent evidence shows that innate immune cells, in addition to B and T cells, can retain immunological memory of their encounters and provide long-term resistance against infections. Hematopoietic stem cells play a crucial role in trained immunity and are influenced by specific cytokines and Toll-like receptor ligands in terms of their memory phenotype and molecular mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ni Zeng, Yichao Wu, Wenli Chen, Qiaoyun Huang, Peng Cai
Summary: Microbial cell-based bioreporters provide a flexible, rapid, and cost-effective strategy for assessing environmental risks posed by contaminants in soil. This review outlines the recent progress in utilizing bioreporters for soil contamination detection, covering biosensing principles, genetic circuit engineering, and developments in detecting heavy metal and organic contaminants. Future opportunities for using whole-cell bioreporters in soil contamination monitoring are also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Hematology
Sinem Civriz Bozdag, Guldane Cengiz Seval, Ipek Yonal Hindilerden, Fehmi Hindilerden, Neslihan Andic, Mustafa Baydar, Lale Aydin Kaynar, Selami Kocak Toprak, Hasan Sami Goksoy, Berrin Balik Aydin, Ufuk Demirci, Ferda Can, Vildan Ozkocaman, Eren Gunduz, Zeynep Tugba Guven, Zubeyde Nur Ozkurt, Sinan Demircioglu, Meral Beksac, Idris Ince, Umut Yilmaz, Hilal Eroglu Kucukdiler, Elgun Abishov, Boran Yavuz, Unal Atas, Yasa Gul Mutlu, Volkan Bas, Fahir Ozkalemkas, Hava Uskudar Teke, Vildan Gursoy, Serhat Celik, Rafiye Ciftciler, Munci Yagci, Pervin Topcuoglu, Ozcan Ceneli, Hamza Abbasov, Cem Selim, Muhlis Cem Ar, Orhan Kemal Yucel, Sevil Sadri, Canan Albayrak, Ahmet Muzaffer Demir, Nil Guler, Muzaffer Keklik, Hatice Terzi, Ali Dogan, Zeynep Arzu Yegin, Meltem Kurt Yuksel, Sogol Sadri, Irfan Yavasoglu, Huseyin Saffet Bekoz, Tekin Aksu, Senem Maral, Veysel Erol, Leylagul Kaynar, Osman Ilhan, Ali Zahit Bolaman, Omur Gokmen Sevindik, Arzu Akyay, Muhit Ozcan, Gunhan Gurman, Sule Unal Cangul, Yasemin Yavuz, Reyhan Diz Kucukkaya, Guner Hayri Ozsan
Summary: Patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality. Active hematological disease, lower life expectancy related to primary hematological disease, neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line therapy used for coronavirus disease-2019 treatment were found to be related to higher mortality rates.
TURKISH JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Derya Koyun, Guldane Cengiz Seval, Ekin Kircali, Sinem Civriz Bozdag, Selami Kocak Toprak, Pervin Topcuoglu, Muhit Ozcan, Onder Arslan, Taner Demirer, Osman Ilhan, Meral Beksac, Gunhan Gurman, Meltem Kurt Yuksel
Summary: This study evaluated the effectiveness and safety of alpha-1-antitrypsin (AAT) in the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD). Results showed that AAT was an effective and safe treatment option for SR-aGVHD.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2022)
Article
Clinical Neurology
Gokmen Kahilogullari, Eyup Bayatli, Murat Geyik, Burak Cabuk, Suha Beton, Omur Gunaldi, Osman Tanriverdi, Nuri Eralp Cetinalp, Ozgur Tarkan, Ali Erdem Yildirim, Yahya Efe Guner, Ali Nehir, Ethem Goksu, Mahmut Akyuz, Ilkay Isikay, Bulent Duz, Emrah Celtikci, Hayri Kertmen, Ender Koktekir, Mahmut Camlar, Adile Begum Bahcecioglu Mutlu, Cevriye Cansiz Ersoz, Sinem Civriz Bozdag, Mustafa Berker, Savas Ceylan
Summary: This study focuses on sellar metastases, rare lesions that are difficult to diagnose. By retrospectively analyzing clinical and radiographic features, treatment methods, and patient outcomes, the study aims to evaluate and emphasize the key factors in the diagnosis and endonasal endoscopic management of sellar metastases.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Zehra Narli Ozdemir, Ekin Kircali, Ugur Sahin, Guldane Cengiz Seval, Sinem Civriz Bozdag, Selami Kocak Toprak, Meltem Kurt Yuksel, Pervin Topcuoglu, Onder Arslan, Taner Demirer, Osman Ilhan, Meral Beksac, Gunhan Gurman, Muhit Ozcan
Summary: The benefit of pre-transplant consolidation treatments remains unclear in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, receiving >= 2 consolidation treatments was associated with better overall survival. Consolidation treatments reduced non-relapse mortality and improved survival.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Dermatology
Guldane Cengiz Seval, Ugur Sahin, Sinem Civriz Bozdag, Meltem Kurt Yuksel, Pervin Topcuoglu, Bengu Nisa Akay, Hatice Erdi Sanli, Gunhan Gurman, Selami Kocak Toprak, Muhit Ozcan
Summary: This study retrospectively evaluated the outcomes of AHSCT in heavily pretreated patients with MF/SS. The results showed that AHSCT could effectively rescue a portion of these patients and improve progression-free survival.
DERMATOLOGIC THERAPY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Cemre Gul Tekin Cebeci, Demet Menekse Gerede Uludag, Turkan Seda Tan, Irem Muge Akbulut Koyuncu, Sinem Civriz Bozdag, Irem Dincer, Eralp Tutar
KARDIOLOGIA POLSKA
(2022)
Meeting Abstract
Hematology
Derya Koyun, Guldane Cengiz, Sinem Civriz Bozdag, Selami Kocak Toprak, Pervin Topcuoglu, Muhit Ozcan, Onder Arslan, Taner Demirer, Osman Ilhan, Gunhan Gurman, Meral Beksac, Meltem Kurt Yuksel
Meeting Abstract
Hematology
Hulya Yilmaz, Guldane Cengiz, Bulent Karakaya, Gul Yavuz, Merve Aydogan, Sinem Civriz Bozdag, Selami Kocak Toprak, Meltem Kurt Yuksel, Pervin Topcuoglu, Onder Arslan, Muhit Ozcan, Osman Ilhan, Meral Beksac
Article
Medicine, General & Internal
Ekin Kircali, Gueldane Cengiz Seval, Cemaleddin Ozturk, Huelya Yilmaz, Derya Koyun, Sinem Civriz Bozdag, Selami Kocak Toprak, Pervin Topcuoglu, Onder Arslan, Muhit Ozcan, Taner Demirer, Osman Ilhan, Guenhan Gurman, Meral Beksac, Meltem Kurt Yuksel
Summary: This retrospective cross-sectional study presented the experience of using eltrombopag in patients with delayed thrombocyte recovery and poor graft functioning following haematopoietic cell transplantation. The results showed that eltrombopag could provide a rapid and sustained response, which is crucial for reducing non-relapse mortality after transplantation.
BALKAN MEDICAL JOURNAL
(2023)
Article
Oncology
Sumeyye Noyan, Fatma Gundogdu, Sinem Civriz Bozdag
Summary: This study examined the occurrence of fatigue, insomnia, depression, anxiety, and stress symptoms in patients after allogeneic hematopoietic stem cell transplantation (AHSCT) and explored potential relationships among these symptoms. The results showed that fatigue was the most common symptom, followed by insomnia, depression, anxiety, and stress. There were moderate relationships between these symptoms, with insomnia being strongly associated with fatigue.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Guldane Cengiz Seval, Sinem Civriz Bozdag, Selami Kocak Toprak, Meltem Kurt Yuksel, Pervin Topcuoglu, Onder Arslan, Taner Demirer, Gunhan Gurman, Meral Beksac, Osman Ilhan, Muhit Ozcan
Summary: This study retrospectively analyzed the overall outcome of 26 patients with primary myelofibrosis who underwent allogeneic hematopoietic stem cell transplantation. The results showed that allogeneic hematopoietic stem cell transplantation has a favorable therapeutic effect for patients with primary myelofibrosis.
BALKAN MEDICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
O. Ilhan, G. Yavuz, G. Cengiz Seval, S. Civriz Bozdag, M. Kurt Yuksel, P. Topcuoglu, O. Arslan, M. Ozcan, T. Demirer, G. Gurman, M. Beksac
BONE MARROW TRANSPLANTATION
(2022)
Meeting Abstract
Biophysics
E. Kircali, G. Cengiz Seval, S. Civriz Bozdag, M. Kurt Yuksel, P. Topcuoglu, O. Arslan, M. Ozcan, T. Demirer, G. Gurman, M. Beksac, O. Ilhan, S. K. Toprak
BONE MARROW TRANSPLANTATION
(2022)
Meeting Abstract
Biophysics
C. Ozturk, U. Sahin, G. C. Seval, S. C. Bozdag, S. K. Toprak, M. K. Yuksel, P. Topcuoglu, M. Ozcan, G. Gurman, O. Ilhan, O. Arslan
BONE MARROW TRANSPLANTATION
(2022)
Meeting Abstract
Oncology
Selami Kocak Toprak, Ekin Korcalo, Guldane Cengiz Seval, Sinem Civriz Bozdag, Meltem Kurt Yuksel, Pervin Topcuoglu, Onder Arslan, Muhit Ozcan, Taner Demirer, Gunhan Gurman, Meral Beksac, Osman Ilhan
JOURNAL OF CLINICAL ONCOLOGY
(2022)
