Article
Hematology
Ian Kracalik, Sanjida Mowla, Sridhar V. Basavaraju, Mathew R. P. Sapiano
Summary: Despite current blood safety measures, transfusion recipients can still experience adverse reactions. Monitoring these reactions is important to evaluate the effectiveness of safety measures. Data from a national healthcare safety network show that the rate of adverse reactions is relatively low, but some serious reactions may be preventable. Further study is needed on higher reaction rates among pathogen-reduced platelets.
Review
Hematology
Sanjida J. Mowla, Ian T. Kracalik, Mathew R. P. Sapiano, Lynne O'Hearn, Chester Andrzejewski, Sridhar Basavaraju
Summary: Despite advances in transfusion safety, concerns with safety of platelet transfusions remain. Adverse reaction rates were higher and more often serious for apheresis platelets (APLTs) compared with whole blood-derived platelets (WBD-PLTs). Platelet additive solution (PAS) and pathogen reduction technology (PRT) may impact adverse reaction rates.
TRANSFUSION MEDICINE REVIEWS
(2021)
Article
Medical Laboratory Technology
Sooin Choi, Jungwon Hyun, HongBi Yu, Duck Cho
Summary: Fatal ABO-incompatible (ABOi) transfusion is a common cause of transfusion-related death in Korea, with 32 cases identified through comprehensive review. Errors mainly occurred at the administration stage, leading to four deaths out of the 32 cases.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Pediatrics
Kai Guo, Xiaohuan Wang, Huimin Zhang, Mengjian Wang, Shanshan Song, Shuxuan Ma
Summary: Transfusion reactions are relatively common in pediatric patients, particularly allergic reactions caused by platelets. Further studies are needed to address differences, especially in allergic and FNHTRs, with robust hemovigilance systems dedicated to children to improve understanding and potential need for prospective trials to implement preventive measures.
FRONTIERS IN PEDIATRICS
(2021)
Review
Hematology
Charles Tacquard, Georges Andreu, Nicolas Meyer, Monique Carlier, Jean-Yves Py, Christian Drouet, Jacques Bienvenu, Paul Michel Mertes, Karim Boudjedir
Summary: The incidence of hypersensitivity transfusion reactions (HTRs) after fresh frozen plasma (FFP) transfusion has increased over the years in France, while the incidence of other adverse transfusion reactions (ATRs) has decreased. The study also found that solvent-detergent-treated apheresis FFP (SD-APH) had a lower risk of HTRs.
TRANSFUSION MEDICINE REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Manish J. J. Barvaliya, A. C. Chetan, N. Chandan, Suman Kumar Ray, Harsha V. V. Hegde, Banappa S. S. Unger, Tejas K. K. Patel, Subarna Roy
Summary: Data analysis of WHO database shows that traditional medicines can cause cutaneous adverse drug reactions, including pruritus, rash, urticaria, and hyperhidrosis. Some commonly suspected traditional medicines for cutaneous ADRs include Artemisia argyi H.Lev., Ginkgo biloba L., Vitis vinifera L., Vitex agnus-castus L., Silybum marianum, and Viscus album L. There were reported cases of Stevens-Johnson syndrome, toxic epidermal necrolysis, and death related to traditional medicines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Anne-Claire Duchez, Sebastien Fauteux-Daniel, Caroline Sut, Theo Ebermeyer, Marco Heestermans, Charles-Antoine Arthaud, Marie-Ange Eyraud, Amelie Prier, Estelle Audoux, Justine Bertrand-Michel, Bernard Payrastre, Olivier Garraud, Eric Boilard, Hind Hamzeh-Cognasse, Fabrice Cognasse
Summary: Platelet concentrate transfusion aims to provide hemostasis in patients with severe central thrombocytopenia or severe bleeding. The processing and storage of platelet concentrates can lead to the accumulation of structural and biochemical storage lesions. We investigated lipid mediators as bioactive molecules of interest during storage and their associations with adverse reactions post-transfusion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Niti M. Patel, Britney A. Stottlemyer, Matthew P. Gray, Richard D. Boyce, Sandra L. Kane-Gill
Summary: This study looked into the safety outcomes of 29 FDA-approved cardiovascular disease (CVD) therapies between 2012 and 2017, by analyzing adverse drug reports (ADRs) in the FDA Adverse Event Reporting System (FAERS). Additional research is needed to evaluate the safety concerns for recently approved CVD medications.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Pepijn W. A. Thomas, Tessa E. H. Romkens, Rachel L. West, Maurice G. V. M. Russel, Jeroen M. Jansen, Jette A. van Lint, Naomi T. Jessurun, Frank Hoentjen
Summary: This study found that IBD patients frequently report ADRs during biological therapy, with a significant difference between the types and frequencies of patient-reported ADRs compared to HCP-reported ADRs, leading to an underestimation of more subjective ADRs and patients' ADR-related burden.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Diego Montano
Summary: This study provides a risk assessment of adverse reactions related to COVID-19 vaccines manufactured by AstraZeneca, Janssen, Moderna, and Pfizer-BioNTech. The results show a higher risk of serious adverse reactions for COVID-19 vaccines compared to influenza vaccines, particularly among individuals aged 65 and older.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Hematology
Mark J. McVey, Robert Cohen, Valerie Arsenault, Alioska Escorcia, Farzana Tasmin, Jacob Pendergrast, Lani Lieberman, Yulia Lin, Jeannie Callum, Christine Cserti-Gazdewich
Summary: The study demonstrates that cardiopulmonary transfusion reactions may significantly impact mortality, especially in patients with highly certain diagnoses. Patients with short time-to-death (<1 week) may face treatment refractoriness or increased susceptibility to transfusion reactions.
Article
Biotechnology & Applied Microbiology
Dorcas Serwaa, Felix Osei-Boakye, Charles Nkansah, Selasie Ahiatrogah, Emmanuel Lamptey, Ratif Abdulai, Maxwell Hubert Antwi, Eric Yaw Wirekoh, Ernest Owusu, Tonnies Abeku Buckman, Mark Danquah
Summary: The study found that 80.7% of healthcare workers experienced adverse reactions after receiving the COVID-19 vaccine, lasting between 0 and 2 days. The most common adverse reactions were general body weakness, headache, and fever. Healthcare workers aged 35-39 and 40-44 had lower odds of adverse reactions compared with those aged 25-29.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Mansour Tobaiqy, Hajer Elkout, Katie MacLure
Summary: The development of safe and effective vaccines against COVID-19 is crucial in the fight against the pandemic. Although some thrombotic adverse reactions were associated with the Oxford-AstraZeneca vaccine, the European Medicines Agency affirmed the vaccine's safety and effectiveness, with the benefits outweighing the risks. Conducting further analyses based on more detailed thrombotic adverse event reports may help evaluate causality with higher specificity.
Article
Allergy
Sha Wang, Yang Jiang, Jing Lyu, Jiajia Li, Qingchun Diao
Summary: Cosmetic adverse reactions are becoming increasingly common in China, with contact dermatitis being the most prevalent. Most adverse reactions are caused by ordinary cosmetics, but there is also a significant percentage attributed to cosmetics with special functions, particularly whitening and sunscreen products.
CONTACT DERMATITIS
(2022)
Article
Pharmacology & Pharmacy
Bogireddy Sahithi, Polamada Prathyusha, Kandibedala Chandana Sree, Ramagoni Alekya, Goruntla Narayana, N. Hariharanadha Sarma
Summary: This study aimed to assess adverse transfusion reactions in patients transfused with blood or blood components at a secondary care referral hospital. The findings showed that most reported reactions were febrile non-hemolytic transfusion reactions, with females experiencing more reactions than males. The study pointed out a low incidence of adverse transfusion reactions, likely due to underreporting in the healthcare system.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)