Article
Immunology
Mathieu Nacher, Kinan Drak Alsibai, Audrey Valdes, Philippe Abboud, Antoine Adenis, Romain Blaizot, Denis Blanchet, Magalie Demar, Felix Djossou, Loic Epelboin, Caroline Misslin, Balthazar Ntab, Nadia Sabbah, Pierre Couppie
Summary: Adrenal histoplasmosis and primary adrenal insufficiency are more rare in HIV patients than previously reported, suggesting potentially undiagnosed less severe functional deficiencies. Immunosuppression might lead to different tissue responses, reducing the likelihood of adrenal function impairment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Andrew J. Stefan, Erica S. Herc, Smitha Gudipati, Indira Brar, Alyssa Vitale, Zain Tariq
Summary: Opportunistic infections such as progressive disseminated histoplasmosis (PDH) can have varying and unexpected presentations in AIDS patients. It can be either a primary infection or a reactivation of latent infection. PDH can be challenging to diagnose due to its variable presentation and overlapping symptoms with other opportunistic infections. Serum and urine antigen testing are highly sensitive and commonly used as initial diagnostic tests for suspected PDH. However, a negative test does not rule out Histoplasmosis capsulatum infection, and a high suspicion for PDH should be maintained in the appropriate clinical context. A definitive diagnosis may require biopsy-proven narrow-based budding yeast. We present a case of an AIDS patient who presented with worsening cognitive decline and was ultimately diagnosed with PDH based on biopsy histopathology, despite negative antigen and antibody testing results. (c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Kalyani Avva, Brandon Wu, Leslie Cler
Summary: Histoplasma capsulatum is an endemic fungus in the Americas, and it can cause systemic inflammatory disease. Progressive disseminated histoplasmosis mainly affects immunocompromised individuals and presents with non-specific symptoms. Accurate diagnosis is crucial and can be achieved through antigen detection or tissue diagnosis. Treatment involves antifungal medication, with more severe cases requiring additional induction therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pediatrics
Miguel Garcia-Boyano, William Vega, Luis Prieto, Nelly Chavez-Solorzano, Dalton Solis Montiel, Greta Mino-Leon
Summary: Progressive disseminated histoplasmosis is considered a top AIDS-defining illness in South America, with limited reported experience in children. This study in Ecuador found that clinical manifestations and laboratory findings in children living with HIV and PDH are similar to those in adults, with low CD4 cell count being a significant risk factor.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Maha Alamri, Ahmed M. Albarrag, Haitham Khogeer, Jehad Alburaiki, Magid Halim, Reem S. Almaghrabi
Summary: A case of disseminated histoplasmosis in a heart transplant recipient outside known endemic areas was successfully treated with Liposomal Amphotericin and Itraconazole, showing significant improvement in symptoms, possibly due to reactivation of latent infection.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Taksaon Angsutararux, Piriyaporn Chongtrakool, Sanya Sukpanichnant, Kornpawee Wongwaipijarn, Walaiporn Wangchinda
Summary: This case report describes a kidney transplant recipient in Thailand who developed disseminated histoplasmosis and was diagnosed and treated with antifungal medication. Although cases of histoplasmosis after solid organ transplantation are rare in non-endemic areas, early diagnosis and prompt management should still be prioritized to reduce morbidity and mortality, especially in patients with impaired cell-mediated immunity.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Review
Infectious Diseases
Neng Wang, Conglin Zhao, Congchen Tang, Lichun Wang
Summary: This case report demonstrates that disseminated histoplasmosis infection can present with unexplained fever and that mNGS can be an important complement to bone marrow aspiration for the diagnosis of this disease.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, General & Internal
Marko Kozyk, Kateryna Strubchevska, John Szela
Summary: This paper presents a case study of an adult patient with decompensated liver cirrhosis who tested positive for Histoplasma capsulatum and Blastomyces dermatitidis antigens. Disseminated histoplasmosis was confirmed by additional antibody testing in a patient with septic shock and duodenal perforation. A high level of suspicion is necessary for detecting disseminated histoplasmosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pediatrics
Brian Chang, Tawny Saleh, Cameron Wales, Lawrence Kuklinski, Prerana Malla, Shangxin Yang, David Fuller, Karin Nielsen-Saines
Summary: This case report discusses an immunocompromised adolescent patient presenting with systemic symptoms, ultimately diagnosed with disseminated histoplasmosis. The importance of this case lies in reminding physicians to maintain a high index of suspicion for fungal infections when evaluating immunocompromised patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Rachel Ann Pellegrino, Roopa Naik, Atul Bali
Summary: Histoplasmosis is a common fungal infection that is usually asymptomatic but can lead to severe illness in immunocompromised patients. We report a case of disseminated histoplasmosis that was incidentally found during a bone marrow biopsy and successfully treated with antifungal therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Mingjing Zhou, Ke Wang, Haoyuan Liu, Ran Ran, Xuan Wang, Yuqian Yang, Qunying Han, Yi Zhou, Xiaojing Liu
Summary: This report presents the first case of Brucellosis in China with multiple pulmonary nodules and depression. The study expands the evidence of respiratory involvement caused by Brucellosis and emphasizes the importance of collecting comprehensive medical history in epidemic areas. Brucellosis should be considered for febrile patients with pulmonary nodules and depression, especially in endemic areas.
FRONTIERS IN MEDICINE
(2023)
Review
Immunology
Hongchao Chen, Qing Yuan, Hangbin Hu, Jie Wang, Meihong Yu, Qing Yang, Tingting Qu
Summary: This study reported a case of HLH secondary to histoplasmosis in an immunocompetent patient in China and reviewed all cases on this situation. The study found that disseminated Histoplasma capsulatum infection with HLH becomes increasingly common in emerging endemic areas and has a high mortality rate. Timely diagnosis and early use of antifungal agents can lead to better prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Henrik Ghantarchyan, Yousuf Bholat, Amir Patel, Katherine Bourbeau, Dan Vo
Summary: This case report describes the clinical findings of disseminated histoplasmosis in an immunocompromised patient with AIDS, initially presenting with sepsis of unclear source. The importance of detailed history-taking for appropriate investigation and recognition of the infectious source is highlighted, along with insights into the management of disseminated histoplasmosis in outpatient and inpatient settings.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Raed Atiyat, Riyashat Kazmi, Krunal Trivedi, Hamid S. Shaaban
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome that is often underdiagnosed in adults, especially in immunocompromised populations. Limited treatments and clinical outcomes are documented in this group of patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Rheumatology
Peinado-Acevedo Juan Sebastian, Varela Diana-Cristina, Hidron Alicia
Summary: Concomitant infections during systemic lupus erythematosus debut or relapse, especially invasive fungal infections, are rare but can be associated with fatal outcomes in patients receiving immunosuppressive therapy. Disseminated histoplasmosis is the most common presentation in lupus patients, often in those with prior immunosuppressant use, and early clinical recognition is crucial for timely intervention and management.
RHEUMATOLOGY INTERNATIONAL
(2021)
