Article
Pediatrics
Carlo Dani, Caterina Coviello, Simona Montano, Giulia Remaschi, Chiara Petrolini, Maria Chiara Strozzi, Elena Maggiora, Miriam Sabatini, Diego Gazzolo
Summary: Using near-infrared spectroscopy, the study found that mother's own milk feeding had minimal impact on splanchnic oxygenation, while preterm formula feeding led to a persistent decrease in splanchnic oxygenation. Fortified human milk feeding transiently increased splanchnic energy expenditure.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Carlo Dani, Simone Pratesi, Michele Luzzati, Chiara Petrolini, Simona Montano, Giulia Remaschi, Caterina Coviello
Summary: The study aimed to evaluate the impact of the PRICO(R) system on oxygenation in preterm infants with frequent desaturations. Results showed that while automated FiO(2) control did not improve cerebral and splanchnic oxygenation, it did decrease SpO(2) fluctuations and duration of hypoxemia and hyperoxemia.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Willemien S. Kalteren, Arend F. Bos, Klasien A. Bergman, Willem van Oeveren, Jan B. F. Hulscher, Elisabeth M. W. Kooi
Summary: Transfusions of red blood cells (RBC) in preterm infants are associated with oxidative stress and intestinal injury, along with decreased variability in splanchnic oxygenation. This may represent the early pathogenesis of transfusion-associated necrotizing enterocolitis (NEC).
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Willemien S. Kalteren, Elise A. Verhagen, Jonathan P. Mintzer, Arend F. Bos, Elisabeth M. W. Kooi
Summary: Anemia and RBC transfusions in preterm infants in the NICU are associated with cerebral oxygenation, brain injury and development, and NDO. Avoiding cerebral hypoxia may support improved brain development, although restrictive RBC transfusion strategies are linked to better long-term neurodevelopmental outcomes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Silvia Martini, Marek Czosnyka, Peter Smielewski, Marica Iommi, Silvia Galletti, Francesca Vitali, Vittoria Paoletti, Federica Camela, Topun Austin, Luigi Corvaglia
Summary: This study found that dopamine treatment, low blood pressure, haemodynamically significant patent ductus arteriosus (hsPDA), and high CRIB-II score are associated with impaired cerebrovascular reactivity in preterm infants during the transitional period. This has potential implications for the development of intraventricular haemorrhage (IVH).
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Gisela Laura Sirota, Ita Litmanovitz, Carmel Vider, Shmuel Arnon, Shiran Sara Moore, Eynit Grinblatt, Orly Levkovitz, Sofia Bauer Rusek
Summary: This study aimed to compare regional splanchnic oxygenation in stable preterm infants during continuous and bolus feeding. The results showed that continuous feeding decreased regional splanchnic oxygen saturation, while bolus feeding led to a trend of decreased systemic saturation. However, the intestinal oxygen extraction was not affected by the feeding mode.
Article
Obstetrics & Gynecology
Carlo Dani, Martina Ciarcia, Francesca Miselli, Michele Luzzati, Chiara Petrolini, Iuri Corsini, Simone Pratesi
Summary: During phototherapy, regional mesenteric oxygenation and cerebrosplanchnic oxygenation ratio significantly decrease in preterm infants, while oxygen extraction fraction increases. These effects may last for several hours and are likely due to peripheral vasodilation triggering blood flow redistribution.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the amount of time spent in periodic breathing and its consequences in infants born preterm before and after hospital discharge. The results showed no significant changes in the percentage of sleep time spent in periodic breathing between different time points. Infants who had a high percentage of periodic breathing at 32-36 weeks of gestational age also had a high percentage at 36-40 weeks and 6 months of corrected age.
JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Yvonne A. Eiby, Barbara E. Lingwood, Ian M. R. Wrightt
Summary: Preterm infants are at high risk of death and disability due to brain injury caused by impaired cardiovascular function. Research indicates that loss of plasma from circulation leading to hypovolemia is a major driver of cardiovascular instability and poor cerebral oxygenation in preterm infants. Changes in capillary permeability, pressure gradients, and lymphatic return contribute to increased plasma loss at the capillary level.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Jarinda A. Poppe, Tanja van Essen, Willem van Weteringen, Sten P. Willemsen, Irwin K. M. Reiss, Sinno H. P. Simons, Rogier C. J. de Jonge
Summary: Red blood cell transfusions can decrease the incidence of desaturations and hypoxia in preterm infants, especially if more desaturations have occurred before transfusion. Monitoring cardiorespiratory data may help identify infants who will benefit most from these transfusions.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Martin van der Heide, Baukje M. Dotinga, Roy E. Stewart, Willemien S. Kalteren, Jan B. F. Hulscher, Sijmen A. Reijneveld, Arend F. Bos, Elisabeth M. W. Kooi
Summary: This study aimed to establish reference values of regional splanchnic oxygen saturation (r(s)SO(2)) for preterm infants during the first week after birth, and found that gestational age (GA), postnatal age (PNA), and small-for-gestational age (SGA) status affect these values. By using a polynomial model, accurate predictions of r(s)SO(2) values can be made based on these variables.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Jurate Navikiene, Ernestas Virsilas, Ramune Vankeviciene, Arunas Liubsys, Augustina Jankauskiene
Summary: The study found that renal oxygenation in preterm infants is affected by ductus patency, with significant differences in cerebral oxygenation observed between the hsPDA group and the PDA and noPDA groups.
Article
Obstetrics & Gynecology
Ozkan Ilhan, Meltem Bor
Summary: This study aimed to assess the effects of administering a loading dose of caffeine citrate intravenously on splanchnic oxygenation in preterm infants. The results showed a significant reduction in splanchnic oxygen saturation and an increase in oxygen extraction rate after caffeine infusion, with partial recovery to baseline levels observed at 3 hours postdose.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Pediatrics
Anna Elisabet Lewis, Susanne S. S. Kappel, Samya Hussain, Per T. T. Sangild, Gitte Zachariassen, Lise Aunsholt
Summary: The aim of this study was to investigate whether trial-related blood sampling increases the risk of later red blood cell (RBC) transfusion in very preterm infants. The results showed that trial-related blood sampling had no impact on the need for RBC transfusion.
Article
Hematology
Kiran Kumar Balegar, Madhuka Jayawardhana, Philip de Chazal, Ralph Kay Heinrich Nanan
Summary: This study examines the changes in splanchnic-cerebral oxygenation ratio (SCOR) in preterm infants after packed red blood cell transfusion (PRBCT). The results show that a decrease in SCOR after PRBCT does not indicate worsened splanchnic oxygenation, but rather suggests improved cerebral oxygenation. Therefore, it is necessary to determine the individual components of SCOR, namely cerebral and splanchnic tissue oxygenation, to understand changes in SCOR in the context of PRBCT.
TRANSFUSION MEDICINE
(2022)
Article
Obstetrics & Gynecology
S. Lori, G. Bertini, S. Gabbanini, M. Bastianelli, C. Cossu, F. Lolli, C. Dani
EARLY HUMAN DEVELOPMENT
(2020)
Editorial Material
Pediatrics
Simone Pratesi, Carlo Dani
FRONTIERS IN PEDIATRICS
(2020)
Review
Pediatrics
Carlo Dani, Simone Pratesi
TRANSLATIONAL PEDIATRICS
(2020)
Article
Pediatrics
Francesco Cavallin, Nicoletta Doglioni, Alessandra Allodi, Nadia Battajon, Stefania Vedovato, Letizia Capasso, Eloisa Gitto, Nicola Laforgia, Giulia Paviotti, Maria Grazia Capretti, Camilla Gizzi, Paolo Ernesto Villani, Paolo Biban, Simone Pratesi, Gianluca Lista, Fabrizio Ciralli, Massimo Soffiati, Alex Staffler, Eugenio Baraldi, Daniele Trevisanuto
Summary: This study compared two modalities of thermal management immediately after birth in preterm infants, and found that using a thermal servo-controlled system did not show significant advantage in maintaining normothermia at NICU admission, while it was associated with increased mild hypothermia. Thermal management of preterm infants remains a challenge in the immediate postnatal phase.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Obstetrics & Gynecology
Carlo Dani, Martina Ciarcia, Michele Luzzati, Silvia Nardecchia, Chiara Petrolini, Walter Maria Sarli, Marco Tellini, Simone Pratesi
Summary: This study found that approximately half of the preterm infants developed transient feeding intolerance during phototherapy, with the majority of them recovering after the therapy was terminated. There was a trend towards a slightly decreased risk of feeding intolerance in infants with higher birth weight and older age at the start of phototherapy, although it was not significant. Further research is needed to confirm the relationship between phototherapy and feeding intolerance.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Carlo Dani, Simone Pratesi, Michele Luzzati, Chiara Petrolini, Simona Montano, Giulia Remaschi, Caterina Coviello
Summary: The study aimed to evaluate the impact of the PRICO(R) system on oxygenation in preterm infants with frequent desaturations. Results showed that while automated FiO(2) control did not improve cerebral and splanchnic oxygenation, it did decrease SpO(2) fluctuations and duration of hypoxemia and hyperoxemia.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Carlo Dani, Simone Pratesi, Guido Mannaioni, Elisabetta Gerace
Summary: The study found that UCB enhances neurotoxicity and oxidative stress induced by OGD in mature and immature hippocampal slices. HSA and allopurinol have protective effects on UCB-induced neurotoxicity, while pioglitazone has slight impact on ROS production.
FRONTIERS IN PEDIATRICS
(2021)
Editorial Material
Pediatrics
David Hutchon, Simone Pratesi, Anup Katheria
Editorial Material
Pediatrics
Carlo Dani, Fabrizio Sandri, Simone Pratesi
Review
Biochemistry & Molecular Biology
Alessio Nocentini, Alessandro Bonardi, Simone Pratesi, Paola Gratteri, Carlo Dani, Claudiu T. Supuran
Summary: Bilirubin is the final product of haem catabolism, and disruptions in its metabolic pathways can lead to increased plasma concentration, which may cause brain damage. However, bilirubin also has antioxidant and anti-inflammatory properties, making it a potential treatment for various diseases. This review discusses pharmaceutical strategies to reduce plasma bilirubin concentration and the therapeutic effects of bilirubin in different disorders.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Letter
Pediatrics
Martina Ciarcia, Iuri Corsini, Francesca Miselli, Michele Luzzati, Caterina Coviello, Valentina Leonardi, Simone Pratesi, Carlo Dani
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Pediatrics
Carlo Dani, Martina Ciarcia, Vittoria Barone, Mariarosaria Di Tommaso, Federico Mecacci, Lucia Pasquini, Simone Pratesi
Summary: The severity of meconium-stained amniotic fluid during labor is independently correlated with adverse neonatal outcomes. Evaluating and grading meconium-stained amniotic fluid can help predict the condition of term infants and ensure immediate and proper neonatal care.
Article
Pediatrics
Lorenzo Zanetto, Francesco Cavallin, Nicoletta Doglioni, Benedetta Bua, Sandro Savino, Giuseppe De Bernardo, Simone Pratesi, Paolo Ernesto Villani, Gary M. Weiner, Daniele Trevisanuto
Summary: Participants in a simulation competition on neonatal resuscitation expressed satisfaction with the educational experience and believed that it improved their knowledge and self-confidence. Suggestions for improvement include more time for familiarization and better communication between judges and participants.
Article
Medicine, General & Internal
Gabriele Morucci, Larisa Ryskalin, Simone Pratesi, Jacopo J. Branca, Alessandra Modesti, Pietro Amedeo Modesti, Massimo Gulisano, Marco Gesi
Summary: This study evaluated the effects of a 24-week regular multimodal exercise program on functional fitness, oxidative stress, salivary cortisol level, and self-perceived quality of life in physically active elderly subjects. The results showed that the exercise program improved flexibility, muscle strength, and dynamic balance, while also regulating antioxidant activity and cortisol levels. This confirms the benefits of regular physical activity in older adults.
MEDICINA-LITHUANIA
(2022)
Article
Pediatrics
Sara Cavaliere, Silvia Lori, Maria Bastianelli, Cesarina Cossu, Simonetta Gabbanini, Carlo Dani, Giovanna Bertini
Summary: During Integrated Multiparametric Neurophysiological Monitoring (IMNA), specific EEG patterns characterized by rolandic and temporal spikes and the appearance of a unilateral enhanced Somatosensory Evoked Potential (SEP) were observed in a newborn with suspected hypoxia at birth and microhaemorrhagic and ischaemic lesions. This case report discusses the hypotheses underlying these findings, suggesting that the ischaemic and haemorrhagic lesions in the newborn may have resulted from a neurotransmitter balance failure, which could have triggered the high amplitude potential observed in the EEG.
