Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 103, Issue 10, Pages 1062-1064Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.trstmh.2009.01.026
Keywords
Schistosomiasis; Artesunate; Sulfadoxine/pyrimethamine; Praziquantel; Treatment outcome; Sudan
Funding
- Kenana Engineering and Technical Services, Khartoum, Sudan
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The efficacy and safety of oral artesunate+sulfadoxine/pyrimethamine (AS+SP) (4 mg/kg AS for 3 consecutive days + 25 mg sulfadoxine on Day 0) in the treatment of Schistosoma mansoni infections were compared with those of praziquantel (PZQ) (40 mg/kg) among infected schoolchildren (46 in each study arm) in eastern Sudan. The cure rate at 28 days was 58.6% in the AS+SP group and 100% in the PZQ group (P < 0.001). While drug-related adverse effects (headache, dizziness, nausea and diarrhoea) were not significantly different between the two groups, significantly more children suffered abdominal pain in the PZQ group than in the AS+SP group (P = 0.001). Thus, AS+SP has poor efficacy in the treatment of S. mansoni compared with PZQ. (c) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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