Journal
TRAFFIC
Volume 14, Issue 12, Pages 1242-1254Publisher
WILEY
DOI: 10.1111/tra.12121
Keywords
Endosome; PDGF receptor; Rho GTPases; RhoD; Rab5; Rabankyrin-5
Categories
Funding
- Karolinska Institutet
- Ludwig Institute
- Swedish Cancer Society
- Swedish Research Council
Ask authors/readers for more resources
RhoD is a member of the classical Rho GTPases and it has essential roles in the regulation of actin dynamics. RhoD localizes to early endosomes and recycling endosomes, which indicates its important role in the regulation of endosome trafficking. Here, we show that RhoD binds to the Rab5 effector Rabankyrin-5, and RhoD and Rabankyrin-5 colocalize to Rab5-positive endosomes, which suggests a role for Rabankyrin-5 in the coordination of RhoD and Rab5 in endosomal trafficking. Interestingly, depletion of RhoD using siRNA techniques interfered with the internalization of the PDGF beta receptor and the subsequent activation of the downstream signaling cascades. Our data suggest that RhoD and Rabankyrin-5 have important roles in coordinating RhoD and Rab activities during internalization and trafficking of activated tyrosine kinase receptors
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available