Interaction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway

Intracellular Vibrio parahaemolyticus Escapes the Vacuole and Establishes a Replicative Niche in the Cytosol of Epithelial Cells

(2014) M. de Souza Santos et al.   mBio

TheVibrio parahaemolyticuseffector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection

(2013) Ryu Okada et al.   CELLULAR MICROBIOLOGY

Tight junction-related human diseases

(2013) Norimasa Sawada   PATHOLOGY INTERNATIONAL

A Vibrio parahaemolyticus T3SS Effector Mediates Pathogenesis by Independently Enabling Intestinal Colonization and Inhibiting TAK1 Activation

(2013) Xiaohui Zhou et al.   Cell Reports

RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension

(2012) Chrystelle Cario-Toumaniantz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis

(2012) Manirath Khounlotham et al.   IMMUNITY

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

(2012) David Meiri et al.   MOLECULAR CELL

Type III Effector VopC Mediates Invasion for Vibrio Species

(2012) Lingling Zhang et al.   Cell Reports

Inflammation and Disintegration of Intestinal Villi in an Experimental Model for Vibrio parahaemolyticus-Induced Diarrhea

(2012) Jennifer M. Ritchie et al.   PLoS Pathogens

Dynamic regulation of GEF-H1 localization at microtubules by Par1b/MARK2

(2011) Yuta Yoshimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VopV, an F-Actin-Binding Type III Secretion Effector, Is Required for Vibrio parahaemolyticus-Induced Enterotoxicity

(2011) Hirotaka Hiyoshi et al.   Cell Host & Microbe

Mimicking GEFs: a common theme for bacterial pathogens

(2011) Robert C. Orchard et al.   CELLULAR MICROBIOLOGY

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Recent insights intoPasteurella multocidatoxin and other G-protein-modulating bacterial toxins

(2010) Brenda A Wilson et al.   Future Microbiology

Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors

(2010) R. Bulgin et al.   INFECTION AND IMMUNITY

Contribution of Vibrio parahaemolyticus Virulence Factors to Cytotoxicity, Enterotoxicity, and Lethality in Mice

(2010) H. Hiyoshi et al.   INFECTION AND IMMUNITY

Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro

(2010) Nicolas Schlegel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bile Acid-Induced Virulence Gene Expression of Vibrio parahaemolyticus Reveals a Novel Therapeutic Potential for Bile Acid Sequestrants

(2010) Kazuyoshi Gotoh et al.   PLoS One

Common Themes in the Design and Function of Bacterial Effectors

(2009) Jorge E. Galán   Cell Host & Microbe

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Percutaneous interventions for treating ischemic complications of aortic dissection

(2008) Ajay Chavan et al.   EUROPEAN RADIOLOGY

Comparative Genomic Analysis Using Microarray Demonstrates a Strong Correlation between the Presence of the 80-Kilobase Pathogenicity Island and Pathogenicity in Kanagawa Phenomenon-Positive Vibrio parahaemolyticus Strains

(2008) K. Izutsu et al.   INFECTION AND IMMUNITY

Identification of Two Translocon Proteins of Vibrio parahaemolyticus Type III Secretion System 2

(2008) T. Kodama et al.   INFECTION AND IMMUNITY

Identification and Characterization of a Novel Type III Secretion System in trh-Positive Vibrio parahaemolyticus Strain TH3996 Reveal Genetic Lineage and Diversity of Pathogenic Machinery beyond the Species Level

(2008) N. Okada et al.   INFECTION AND IMMUNITY

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

(2008) Jörg Birkenfeld et al.   TRENDS IN CELL BIOLOGY