Article
Chemistry, Multidisciplinary
Tuhui Wang, Lening Zhang, Hua Xin
Summary: In this study, a test kit based on gold nanoclusters and hydrogel was fabricated for the precise quantification of chlorpyrifos. Using a homemade subsidiary device and smartphone, the fluorescence color was transformed into digital information, enabling on-site quantitative detection of chlorpyrifos.
FRONTIERS IN CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Guojun Chen, Zhitong Chen, Zejun Wang, Richard Obenchain, Di Wen, Hongjun Li, Richard E. Wirz, Zhen Gu
Summary: The cold atmospheric plasma (CAP) post-surgical treatment effectively induces immunogenic cell death in residual tumor cells and evokes T cell-mediated immune responses to combat them, contributing to tumor growth inhibition and prolonged survival in cancer models.
Article
Biochemical Research Methods
Arash Khorrami Jahromi, Roozbeh Siavash Moakhar, Sripadh Guptha Yedire, Hamed Shieh, Katerina Rosenflanz, Amber Birks, Justin de Vries, Yao Lu, Houda Shafique, Julia Strauss, Sara Mahshid
Summary: This study presents a portable sample-to-answer device for the detection of biomarkers in blood and saliva. The device, called AMMED, consists of a smartphone-operated portable potentiostat, a 3D-printed sample collection cartridge, a smartphone application for remote control, and a 3D-printed multiplexed microfluidic electrochemical biosensor. The device offers rapid, accurate, and selective biosensing capabilities, and has been successfully tested with saliva patient samples.
Article
Environmental Sciences
Tamara Bardina, Marina Chugunova, Lyudmila P. Kapelkina, Victoria Bardina, Alexander O. Gerasimov
Summary: The aim of this study was to assess the ecological state of the soil in a megalopolis using bioassay and develop a set of sensitive biotests for comprehensive ecotoxicological assessment. The results showed that the combined use of eluate and contact bioassays allows for accurate evaluation of the ecological state of urban soils, and biotests are valuable for monitoring negative phenomena in urban soils.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Chemistry, Analytical
Fan-En Chen, Alexander Y. Trick, Alexander C. Hasnain, Kuangwen Hsieh, Liben Chen, Dong Jin Shin, Tza-Huei Wang
Summary: In this study, a new PCR method called ratiometric PCR is developed to enable multiplexed identification of pathogens while minimizing the use of optical components. The ratiometric PCR is combined with automated magnetic bead-based sample preparation in a thermoplastic cartridge and a portable droplet magnetofluidic platform, presenting a simple and effective approach for pathogen identification.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Fan -En Chen, Alexander Y. Trick, Alexander C. Hasnain, Kuangwen Hsieh, Liben Chen, Dong Jin Shin, Tza-Huei Wang
Summary: In this study, a ratiometric PCR method called POC-ratioPCR was developed for fast and efficient identification of pathogens. The method amplifies targeted pathogens using fluorescently labeled hydrolysis probes with a specific ratio of red-to-green fluorophores, and combines ratiometric PCR with automated sample preparation. This method holds promise for practical applications due to its simplicity and effectiveness in identifying pathogens directly from crude biosamples with minimal optical instrumentation complexity.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Yong Li, Zhiyang Huang, Baoxia Liu, Zhen-Zhong Huang, Huilin Yang, Hongliang Tan
Summary: We developed a portable hydrogel test kit for on-site detection of organophosphate pesticides (OPs), based on the integration of agarose hydrogel with dual-emission coordination polymers (CPs) nanocomposite. The hydrogel test kit exhibited ratiometric fluorescence responses to acetylcholinesterase (AChE), enabling the detection of OPs. By employing a smartphone as a signal readout, the on-site quantitation of OPs was achieved with the features of easy to use, portability, and low cost, showing great promise for point-of-care testing in food safety monitoring.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Environmental Sciences
Meike Mevissen, Jerrold M. Ward, Annette Kopp-Schneider, James P. McNamee, Andrew W. Wood, Tania M. Rivero, Kristina Thayer, Kurt Straif
Summary: This study presents the protocol for a systematic review of laboratory animal studies on the effect of exposure to RF fields on cancer outcomes. The aim is to evaluate the effects of RF EMF exposure on cancer in laboratory animals and provide a comprehensive assessment of the evidence.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Neurosciences
Giulia Paparella, Alessandro De Biase, Antonio Cannavacciuolo, Donato Colella, Massimiliano Passaretti, Luca Angelini, Andrea Guerra, Alfredo Berardelli, Matteo Bologna
Summary: Blinking analysis contributes to understanding the physiological and pathophysiological mechanisms of healthy subjects and neurological diseases. Comparing blinking data recorded by a new portable device, EyeStat, with traditional laboratory-based techniques, we found high accuracy and reliability in the analysis, suggesting its potential for large-scale studies in both research and clinical practice.
Article
Environmental Sciences
Olivier Simon, Frederic Coppin, Nadine Micozzi, Karine Beaugelin-Seiller, Laureline Fevrier, Pascale Henner, Claire Della-Vedova, Virginie Camilleri, Rodolphe Gilbin
Summary: This study aimed to contribute to the determination of a Quality Standard for sediment (QS(sediment)) according to European recommendations by enriching existing toxicity data for uranium. Results showed high toxicity of uranium to benthic organisms and lower toxicity to plants, suggesting a conservative preliminary QS(sediment) value of 4 mgU kg(-1), dry mass.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2022)
Article
Environmental Sciences
Miao Liu, Hai-Jun Wang, Hong-Zhu Wang, Shuo-Nan Ma, Qing Yu, Kazi Belal Uddin, Yan Li, Johan Hollander, Erik Jeppesen
Summary: The study found that B. aeruginosa showed higher tolerance to ammonia exposure in the field than under laboratory conditions. Additionally, the body size of the gastropods may increase with increasing ammonia concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Worawit Wongniramaikul, Bussakorn Kleangklao, Chanita Boonkanon, Tarawee Taweekarn, Kharittha Phatthanawiwat, Wilasinee Sriprom, Wadcharawadee Limsakul, Wanchitra Towanlong, Danai Tipmanee, Aree Choodum
Summary: Portable colorimetric hydrogel test kits have been developed for on-site detection of nitrite, nitrate, and phosphate in water, with good analytical performance. These kits, when used with on-mobile digital image colorimetry, showed detection limits of 0.02, 0.04, and 0.14 mg L-1 for nitrite, nitrate, and phosphate, respectively, and were successfully used for on-site determination of these nutrients in canals in Phuket, Thailand.
Article
Infectious Diseases
Alison J. Basile, Matthias Niedrig, Amy J. Lambert, Robyn Meurant, Aaron C. Brault, Cristina Domingo, Christin H. Goodman, Barbara W. Johnson, Eric C. Mossel, Mick N. Mulders, Jason O. Velez, Holly R. Hughes
Summary: This study evaluated the performance and feasibility of a YF molecular assay in YF-endemic regions. The results showed that the assay had high accuracy and sensitivity, and it is suitable for use in YF-endemic regions. It is expected to reduce YF outbreak detection time and save lives.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Engineering, Biomedical
Ali Moradkhani, Ali Broumandnia, Seyed Javad Mirabedini
Summary: Early diagnosis of diseases such as lung and breast cancer, as well as heart diseases, is crucial but challenging due to the busy everyday life of patients.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Biotechnology & Applied Microbiology
Shang Wei Song, Rashi Gupta, Niharika Jothilingam, Xinlei Qian, Yue Gu, V. Vien Lee, Yoann Sapanel, David Michael Allen, John Eu Li Wong, Paul MacAry, Dean Ho, Agata Blasiak
Summary: Despite the potential of saliva as a convenient clinical substrate for biomonitoring, its widespread utilization has not been fully achieved due to challenges in handling its non-Newtonian, heterogenous, and highly viscous nature. Conventional saliva processing methods are time and resource intensive, limiting testing capabilities especially during a pandemic. To address these challenges, the SHEAR saliva collection device is introduced, which mechanically processes saliva in a rapid and resource-efficient manner. The device has shown improvements in reducing saliva viscosity, enhancing sample uniformity, and increasing diagnostic performance for COVID-19 rapid antigen tests.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Analytical
Claudia Campanale, Silvia Galafassi, Francesca Di Pippo, Iulian Pojar, Carmine Massarelli, Vito Felice Uricchio
Summary: Biodegradable plastic mulches (BDMs) have the potential to be an eco-friendly alternative to conventional plastic mulches in agriculture. However, their long-term impacts on soil ecosystems are still uncertain, and further research is needed. Incorporating BDMs into the soil may stimulate microbial activity, but there is also a risk of incomplete degradation and release of residual microplastics and additives.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim
Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Yaxin Cao, Longyi Shao, Timothy P. Jones, Wenjing Deng, M. Santosh, Pengju Liu, Cheng-Xue Yang, Yaowei Li, Daizhou Zhang, Kelly Berube
Summary: The toxicity of fibrous particles in ambient air can be higher than other types of particles. Microfibers can be organic or inorganic and their presence in the atmosphere as a result of human activity raises concerns for environmental and public health. Accurate collection, identification, and understanding of the health hazards associated with these fibers are crucial for mitigation strategies and protection of public health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Chenchen Xie, Chen Meng, Huilin Liu, Baoguo Sun
Summary: The development of food hazard factor (FHF) detection has been moving towards on-site inspection and mobile law enforcement, calling for simple, fast, and affordable analysis technology to ensure food safety and quality. This review comprehensively summarizes the progress in research on smartphone-assisted MIP optosensors, focusing on the key issues of accuracy and sensitivity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Guillem Peris-Pastor, Cristian Azorin, Jose Grau, Juan L. Benede, Alberto Chisvert
Summary: Green Analytical Chemistry plays an important role in every stage of method development, including sample preparation. Extraction techniques have evolved from conventional ones to a variety of miniaturized techniques in order to enhance analytical performance and ensure safety for operators and the environment. Green metric tools are used to evaluate the impact and sustainability of methods, with AGREEprep selected as the most suitable tool for evaluating published methods in various applications. The miniaturization of sample preparation strategies has led to the use of less and safer solvents, reduced waste generation and energy consumption, and improved portability and throughput.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Helena Hruskova, Roman Reminek, Frantisek Foret
Summary: This review article summarizes the progress and recent studies in offline electromigration preparative techniques between 2018 and 2023. It covers various techniques including electrophoresis, free-flow electrophoresis, isoelectric focusing, and isotachophoresis, providing theoretical aspects, trends, and solutions to existing limitations in each technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Ivneet Banga, Anirban Paul, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar, Sriram Muthukumar, Shalini Prasad
Summary: Breathomics is an emerging field that focuses on analyzing exhaled breath to diagnose and monitor respiratory diseases. Electrochemical sensors, with their high sensitivity, selectivity, and low cost, play a significant role in breathomics and can be integrated into portable devices for point-of-care diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Fabjola Bilo, Paola Cirelli, Laura Borgese
Summary: This review explores the application of X-ray fluorescence (XRF) spectrometry for elemental analysis of particulate matter (PM) in air quality monitoring. It discusses the fundamentals of XRF, experimental configurations, PM sampling devices and substrate, sample preparation strategies, qualitative and quantitative analysis, as well as the challenges faced by XRF in becoming a reliable analytical technique for PM analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hakim Faraji
Summary: The dispersive liquid-liquid microextraction (DLLME) technique is widely popular in analytical chemistry due to its high efficiency, cost-effectiveness, and simplicity. Recent advancements have addressed the limitations of DLLME, incorporating greener solvents, innovative dispersion strategies, and simplified procedures. These changes have made DLLME a more sustainable and efficient technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Sherin F. Hammad, Inas A. Abdallah, Alaa Bedair, Reda M. Abdelhameed, Marcello Locatelli, Fotouh R. Mansour
Summary: Carbon nanomaterials (CNMs) have excellent capabilities in terms of adsorption, enhanced oxidation, and photocatalysis, attracting widespread attention in different fields. Metal-organic frameworks (MOFs) have been widely used due to their regular network structure, porous nature, and large specific surface area. However, the instability of MOFs in aqueous solutions limits their applications in chemical sensing. Recent studies have focused on increasing the stability of MOFs in water-based matrices through chemical modifications using CNMs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Alexandra Pape, Oliver J. Schmitz
Summary: Low temperature plasmas based on dielectric barrier discharges have emerged as a recent development in ion source research. These ion sources are applicable to heat-sensitive analytes and can ionize a wide range of compounds. Despite intensive research on important parameters such as configuration, shape, size, and materials in the past two decades, the actual ionization mechanism for all plasma gases has not been fully elucidated. This review provides an overview of atmospheric pressure ion sources, with a focus on plasma and dielectric barrier discharge based ion sources, summarizing the reactions occurring in the plasma and discussing the applications developed by different research groups.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hai Xiong, Fengli Li, Linyu Zeng, Qiyu Lei
Summary: This review provides an overview of the emerging trends in the use of functional COF nanomaterials as biosensors for DNA/RNA detection. It summarizes the construction of DNA/RNA hybridized COF nanoprobes and their potential applications in bioanalyte detection, biosensing, biomarker imaging, and clinical biomedicine.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Bing Yan
Summary: This article summarizes the recent progress in logic gate computing and operation based on multiple luminescence response and chemical sensing for lanthanide functionalized MOF hybrid systems. The article first describes multi-color luminescence and the subsequent multiple luminescence response. The basic concept of logic gate operation and the advantages of lanthanide-based hybrid materials are then introduced. Reports on logic gate operation using pure lanthanide MOFs are provided, followed by a detailed summary of logic gate operations using lanthanide functionalized MOF hybrid materials. Additionally, the article discusses the practical luminescent detection of analytes by correlating the luminescence responsive signals and the concentration of different analytes. Finally, the article concludes with a prospect for this topic.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Brij Mohan, Gurjaspreet Singh, Rakesh Kumar Gupta, Pawan Kumar Sharma, Alexander A. Solovev, Armando J. L. Pombeiro, Peng Ren
Summary: Porous materials, particularly hydrogen-bonded organic frameworks (HOFs), have gained significant attention due to their versatile applications and unique properties such as well-defined crystalline structure and easy regeneration processes. This article provides a comprehensive overview of HOFs, including synthesis methods, hydrogen bonding motifs, recent advancements, and potential applications, offering valuable guidance for further exploration in this dynamic field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)