Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 43, Issue -, Pages 146-160Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.10.007
Keywords
Environmental sample; Food sample; LC-GC; LCxGC; Liquid chromatography-gas chromatography; Multi-dimensional technique; Normal-phase liquid chromatography (NPLC); Reversed-phase liquid chromatography (RPLC); Sample fractionation; Sample preparation
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Multidimensional techniques are very powerful tools for unraveling naturally-occurring complex samples. The potential of multidimensional techniques is reviewed, also, as a substitute for the preparation step, with special attention to the hyphenation of liquid chromatography (LC) with gas chromatography (GC). An excursus on the evolution of hyphenated GC-based techniques and the main features of the LC-GC instruments is presented, before focusing on the more recent applications, discussing the performance of the LC separation as a preparation step. An overview of the potential of both comprehensive LCxGC and LC-GCxGC is reported. (C) 2012 Elsevier Ltd. All rights reserved.
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