Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

Gossypol Increases Expression of the Pro-apoptotic BH3-only Protein NOXA through a Novel Mechanism Involving Phospholipase A2, Cytoplasmic Calcium, and Endoplasmic Reticulum Stress

(2014) Ryan S. Soderquist et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo

(2013) R Soderquist et al.   LEUKEMIA

Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks

(2012) Muge Senarisoy et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Involvement of Host Cell Integrin α2 in Cryptosporidium parvum Infection

(2012) Haili Zhang et al.   INFECTION AND IMMUNITY

Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP)

(2011) J. M. Fritzler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Treatment and prevention of cryptosporidiosis: what options are there for a country like Zambia?

(2011) PAUL KELLY   PARASITOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT

(2008) Dong-Oh Moon et al.   FEBS LETTERS