Journal
TOXIN REVIEWS
Volume 33, Issue 1-2, Pages 7-15Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/15569543.2013.855789
Keywords
Antivenomics; coagulopathy; geographical variation; Indian Russell's viper; in vitro neutralization
Categories
Funding
- DBT, Governmet of India
- DST
- DBT
- UGC
- DST, New Delhi
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Indian Russell's viper venoms of four different geographical locations were found to vary in composition, coagulopathy and phospholipase A(2) (PLA(2)) activity. Venom from Kerala showed highest procoagulant activity followed by Tamil Nadu, West Bengal and Karnataka whereas PLA(2) activity was highest in venom from West Bengal. The commercial polyvalent antivenom differentially neutralized the aforesaid activities of the crude venoms. Antivenomics study showed the presence of non-immunodepleted and partially immunodepleted proteins in the crude venoms. Thus, Indian Russell's viper venom from different region varies in composition and accentuates the need to design regiospecific antivenoms to confront the problem of envenomation more effectively.
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