Article
Biochemistry & Molecular Biology
Tassia R. Costa, Aleff F. Francisco, Fabio F. Cardoso, Leandro S. Moreira-Dill, Carlos A. H. Fernandes, Antoniel A. S. Gomes, Cesar L. S. Guimaraes, Silvana Marcussi, Paulo S. Pereira, Hamine C. Oliveira, Marcos R. M. Fontes, Saulo L. Silva, Juliana P. Zuliani, Andreimar M. Soares
Summary: Snakebite envenoming is a major health crisis in many tropical regions, prompting the need for new solutions. This study highlights gallic acid as an effective inhibitor of snake venom myotoxicity, proposing a new mechanism of action and potential as an antivenom compound.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Weijun Leng, Xiaoyun Wu, Tong Shi, Zhiyu Xiong, Li Yuan, Wengang Jin, Ruichang Gao
Summary: The skin mucus extract of Channa argus possesses strong inhibitory action against Staphylococcus aureus, disrupting cell membrane functions to induce intracellular metabolic imbalance and affecting the normal physiological functions and growth of the bacteria. The antimicrobial mechanism involves inhibiting primary metabolic pathways of the bacteria such as the tricarboxylic acid cycle and amino acid biosynthesis.
Article
Immunology
Insaf-Meriem Boutemine, Manel Amri, Karim Dorgham, Zine-Charaf Amir, Sara Benazzouz, Fahima Ameur, Karim Layaida, Hans Yssel, Chafia Touil-Boukoffa
Summary: The aqueous extract of Pistacia lentiscus leaves showed significant anti-inflammatory effects in treating Dextran Sulfate Sodium-induced acute colitis, reducing clinical symptoms and inflammatory mediator levels. The extract improved mucosal lesions, maintained tissue integrity, and reduced inflammatory cell infiltration, suggesting its potential therapeutic use in ulcerative colitis.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Xinyue Hu, Songjia Ni, Kai Zhao, Jing Qian, Yang Duan
Summary: This study used bioinformatic methods to identify key biomarkers and immune infiltration in osteoarthritis. It discovered differentially expressed genes enriched in immunological response and inflammatory pathways. Two distinct immune patterns were identified and important genes in cartilage cells were investigated. Understanding the differences in immune infiltration between osteoarthritic tissues and normal tissues contributes to the understanding of osteoarthritis development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Mahboubeh Eslami, Amine Zaretabar, Mahmoud A. O. Dawood, Sedigheh Mohammadzadeh, Youcef Shahali, Ehsan Ahmadifar, Najmeh Sheikhzadeh, Mohsen Shahriari Moghadam, Seyed Hossein Hoseinifar, Hien Van Doan
Summary: Supplementation of ethanolic extract of propolis can improve digestive enzyme activities, liver antioxidant capacity, and skin mucus immunity in juvenile beluga sturgeon.
Article
Plant Sciences
Leandro Ferrini, Juan Pablo Rodriguez, Juan Pablo Melana Colavita, Gabriela Olea, Gonzalo Adrian Ojeda, Gabriela Ricciardi, Ana Maria Torres, Maria Victoria Aguirre
Summary: The ethanolic extract of Nectandra angustifolia has a high content of flavonoids and possesses antioxidant and anti-inflammatory properties as demonstrated by multiparametric analyses from in vitro assays and an in vivo model of inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virginia Claudia Carneiro Girao-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett, Francisco Airton Castro Rocha
Summary: TNF inhibitors are commonly used for the treatment of arthropathies like rheumatoid arthritis (RA), but not all patients achieve remission and there is a risk of infection. This study found that the lectin-like domain of TNF has anti-inflammatory effects and can mitigate the development of immune-mediated arthritis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Arun Sridhar, Rajkumar Krishnasamy Sekar, Dinesh Babu Manikandan, Manikandan Arumugam, Srinivasan Veeran, Thirumurugan Ramasamy
Summary: The study extracted skin mucus proteins from three freshwater fish species and found that pH had an impact on protein solubility and enzyme activity. Mrigal fish showed better innate immune enzymes and bactericidal activity at pH 8.0.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Sanga Kim, Hee-Won Kim, Seok-Hwan Chang, Kang-Hyun Leem, Hae-Jeong Park
Summary: IL-13 induces mucus metaplasia in asthma, and bee venom (BV) has shown anti-inflammatory effects in allergic diseases. BV inhibits MUC5AC production through the regulation of SPDEF and FOXA2, mediated via the suppression of PI3K/AKT activation. BV may be beneficial in preventing mucus metaplasia in asthma.
Article
Biochemistry & Molecular Biology
Hyo-Sung Lee, Yong Soo Kim, Kyeong-Seob Lee, Hyoung-Suk Seo, Chan-Yong Lee, Kee K. Kim
Summary: The study effectively removed the cytotoxicity of bee venom by hydrolyzing melittin and eliminating other components, demonstrating the detoxified bee venom's antioxidant and anti-inflammatory efficacy, as well as its reduced cytotoxicity and allergenicity.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Lin Zhang, Emilie Steinbakk Ulriksen, Havard Hoel, Lene Sandvik, Karl Egil Malterud, Kari Tvete Inngjerdingen, Marit Inngjerdingen, Helle Wangensteen
Summary: This study aimed to explore the content of bioactive compounds in the water extract of Gentiana purpurea roots, commonly used in traditional medicine in Norway, and assess its anti-inflammatory potential. The major bitter compounds in both roots and leaves were also quantified.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Chien-Chun Liu, Cho-Ju Wu, Tsai-Ying Chou, Geng-Wang Liaw, Yung-Chin Hsiao, Lichieh-Julie Chu, Chi-Hsin Lee, Po-Jung Wang, Cheng-Hsien Hsieh, Chun-Kuei Chen, Jau-Song Yu
Summary: The study found that cytotoxin (CTX) is a key component of Taiwanese cobra venom responsible for cytotoxicity against myoblast cells. Monoclonal scFv S1 was developed using phage display technology and showed higher neutralization potency against CTX-induced cytotoxicity compared to conventional antivenom. This findings suggest that scFv S1, when combined with currently available antivenom, can improve the potency of the latter, thereby preventing tissue damage induced by cobra envenoming.
Article
Microbiology
Jianzhen Zhuo, Ke Wang, Zijun Shi, Chunlei Yuan
Summary: By acquiring COVID-19-related information from the GEO database, 14 differentially expressed genes (DEGs) related to immunogenic cell death (ICD) were identified, which were closely associated with inflammation and immune activity. Functional enrichment analysis indicated that these feature genes may have a potential role in COVID-19 by being involved in the regulation of immune response and metabolism. CIBERSORT analysis demonstrated that the variations in the immune microenvironment of COVID-19 patients may be correlated with CASP1, CD4, and EIF2AK3. Additionally, 33 drugs targeting these feature genes were identified, and the ceRNA network demonstrated a complicated regulative association based on these feature genes.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
L. Moine, M. M. Canali, C. Porporatto, S. G. Correa
Summary: Chitosan is a versatile polymer with various biomedical applications, and its chemical modification can give rise to numerous derivatives that are suitable for different types of drug formulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Minda Asefa, Nathnael Teshome, Abel Degu
Summary: The 80% methanol root extract of Verbasicum sinaiticum was found to possess peripheral and central analgesic as well as anti-inflammatory activity, possibly due to the presence of phytochemicals.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Toxicology
Juliana Luiza Varjao Lameiras, Oscar Tadeu Ferreira da Costa, Maria Cristina Dos-Santos
Article
Fisheries
Eike N. de Oliveira, Wallice P. Duncan, Thais B. Carvalho
AQUACULTURE RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Juliana Luiza Varjao Lameiras, Valeria Mourao de Moura, Lucas Castanhola Dias, Evandro Rezende Pessoa Junior, Cacilda Satomi Yano Mallmann, Allyson Guimaraes Costa, Michella Lima Lasmar, Cecilia Veronica Nunez, Oscar Tadeu Ferreira da Costa, Maria Cristina Dos-Santos
Article
Multidisciplinary Sciences
Yasmin Cabral Moreira, Maele Jordao, Oscar Tadeu Ferreira da Costa, Elizangela Farias, Alysson Guimaraes Costa, Viviane de Farias, Dorval Antonio Mafra Coimbra, Tatiana Bacry Cardoza, Yury Oliveira Chaves, Patricia Puccinelli Orlandi, Fabio Trindade Maranhao Costa, Paulo Afonso Nogueira
Summary: Our study found that malaria disrupts intestinal homeostasis, exacerbates proinflammatory cytokines, and impairs neutrophil function, making the host more susceptible to bacteremia by Salmonella spp.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Wallice P. Duncan, Rubia N. Machado, Marisa N. Fernandes
Summary: The study discovered that freshwater stingrays from blackwater and clearwater rivers showed lower levels of osmolytes and plasma osmolality but higher gill and kidney Na+/K+-ATPase activities, likely due to their ability to achieve high ion uptake from ion-poor waters. These physiological traits exhibited a weak phylogenetic signal, indicating strong evolutionary convergence. The variations in physiological traits were significantly associated with the type of water and its physical and chemical characteristics such as electric conductivity and pH.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Iurych Nicolau Barros Bussons, Elcimar da Silva Sousa, Paulo Henrique Rocha Aride, Wallice Luiz Paxiuba Duncan, Jackson Pantoja-Lima, Wilson Massamitu Furuya, Adriano Teixeira de Oliveira, Marcia Regina Fragoso Machado Bussons, Caterina Faggio
Summary: The study results indicate that juvenile tambaqui diets can contain up to 50% replacement of corn by glycerol without compromising the fishes' development under the conditions studied.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Parasitology
Mayra da Silva Goncalves, Oscar Tadeu Ferreira da Costa, German Augusto Murrieta Morey, Lucas Castanhola Dias, Edsandra Campos Chagas, Sanny Maria de Andrade Porto
Summary: The study provides a detailed description of the embryonic development stages of N. buttnerae eggs and a stereological evaluation of the body of adult females of the parasite. These results are crucial for supporting future research aiming to interrupt the life cycle of this parasite.
Review
Veterinary Sciences
Ariany Rabello da Silva Liebl, Mirleide Araujo Cao, Marcelo dos Santos Nascimento, Philp Dalbert da Silva Castro, Wallice Luiz Paxiuba Duncan, Jackson Pantoja-Lima, Paulo Henrique Rocha Aride, Marcia Regina Fragoso Machado Bussons, Wilson Massamitu Furuya, Caterina Faggio, Adriano Teixeira de Oliveira
Summary: This study aimed to determine the dietary lysine requirements of juvenile Colossoma macropomum tambaqui based on growth performance, hepatic and intestinal morphohistology, and hematology. The results showed that the dietary lysine level of 15.96 g/kg resulted in higher final weight and improved feed conversion ratio. The morphohistological analysis revealed changes in liver and intestinal tissues due to low levels of lysine. The study concluded that the dietary requirement for lysine for tambaqui juveniles is estimated to be 15.4 - 15.6 g/kg of diet.
VETERINARY RESEARCH COMMUNICATIONS
(2022)
Article
Zoology
Wallice P. Duncan, Janes N. A. Junior, Washington C. S. Mendonca, Idamara F. Santa Cruz, Jean F. Samonek, Ester J. F. Morais, Jaydione L. Marcon, Ronis Da Silveira
Summary: The study found that stressed caimans exhibit increased plasma corticosterone levels, as well as elevated lactate and glucose levels. There are differences in recovery time and lactate clearance between the two caiman species, indicating potential variations in sensitivity to acute stress. These findings have implications for management and conservation programs, as well as assessing the impact of tourism and recreational capture on caimans in the Amazon.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2022)
Article
Ecology
Paulo Cesar Machado Andrade, Paulo Henrique Guimaraes de Oliveira, Aldeniza Cardoso de Lima, Joao Alfredo da Mota Duarte, Sandra Helena da Silva Azevedo, Anndson Brelaz de Oliveira, Carlos Dias Junior de Almeida, Eleyson Barboza da Silva, Janderson Rocha Garcez, Jose Ribamar da Silva Pinto, Liriann Chrisley Nascimento da Silva, Midian Salgado Monteiro, Wander da Silva Rodrigues, Thiago Luiz Ferreira Anizio, Alfredo Luiz Belem Pontes, Ruth Lima Teixeira, Jefferson Moreira da Silva, Wallice Luiz Paxiuba Duncan, Richard Carl Vogt
Summary: Chelonians play an important role in the Amazon as a source of protein and in the dispersion of plant seeds. The consumption and predatory exploitation of chelonians by local populations pose a major threat to these animals. Community-based conservation projects, in collaboration with official protection programs, have been successful in restoring chelonian populations in the Amazon. Community protection schemes have been particularly effective in protecting nests and hatchlings, while government-controlled areas have higher support capacity for nest production.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Fisheries
Franmir Rodrigues Brandao, Wallice Paxiuba Duncan, Caio Francisco Santana Farias, Damy Caroline de Melo Souza, Maria Ines Braga de Oliveria, Maria Juliete Souza Rocha, Patricia Castro Monteiro, Claudia Majolo, Francisco Celio Maia Chaves, Fernanda Loureiro de Almeida O'Sullivan, Edsandra Campos Chagas
Summary: This study evaluated the use of Lippia sidoides and Mentha piperita essential oils as a stress reducer in the transport of Colossoma macropomum. The results showed that Lippia sidoides essential oil reduced cortisol levels, while Mentha piperita essential oil stimulated the glycolytic pathway. Furthermore, the essential oils did not affect the fish's neurological and enzymatic activity. Therefore, it is recommended to use 20 mg L-1 Lippia sidoides essential oil in the transport of Colossoma macropomum.
Article
Biochemistry & Molecular Biology
Eduardo Freitas de Farias, Hallana Cristina Menezes da Silva, Ana Paula Costa de Carvalho, Rodrigo de Melo Martins, Andrea Belem-Costa, Wallice Paxiuba Duncan, Ana Lucia Silva Gomes, Daniele Aparecida Matoso
Summary: Austrodiplostomum Szidat & Nani, 1951 is a widely distributed genus of parasitic digenetic trematodes in the Neotropical region. In this study, we identified Austrodiplostomum sp. based on metacercariae isolates from tambaqui fish. The obtained sequences clustered with A. compactum, indicating the first report of diplostomids occurrence in farmed tambaqui in the Amazonia region.
GENETICS AND MOLECULAR BIOLOGY
(2023)
Editorial Material
Fisheries
Akemi Shibuya, Wallice P. Duncan, Jansen Zuanon
ICHTHYOLOGICAL RESEARCH
(2023)
Article
Ecology
Washington C. S. Mendonca, Wallice P. Duncan, Marcelo D. Vidal, William E. Magnusson, Ronis Da Silveira
Summary: Ecotourism, while important for biodiversity conservation, may have negative effects on animal health and welfare. A study in Anavilhanas National Park, Brazil revealed that interactions between tourists and Amazonian crocodilians led to increased levels of corticosterone and lactate in black caimans, but not in spectacled caimans. These findings have implications for the management and conservation of Amazonian crocodilians, especially in tourism programs.
JOURNAL OF WILDLIFE MANAGEMENT
(2023)
Article
Agronomy
Akemi Shibuya, Wallice P. Duncan
Summary: In this study, we examined bite wounds in Potamotrygon motoro of Catalao Lake in the Amazonas state of Brazil to assess reproductive activity prior to copulation. Both male and female individuals showed wounds on their pectoral fins. Males had a higher number of bite wounds distributed randomly throughout the body, while females had more bite wounds on the posterior region. This suggests aggressive interactions among males in competition for females.
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
