Journal
TOXICON
Volume 83, Issue -, Pages 69-74Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2014.02.022
Keywords
Ribotoxins; alpha-Sarcin; Hirsutelllin A; Entomopathogen; Insecticide
Categories
Funding
- Spanish Ministerio de Economia y Competitividad [BFU2009-10185, BFU2012-32404, AGL2010-22196-C02-02]
- ESFUNPROT-UCM from Universidad Complutense de Madrid
- Spanish Ministerio de Educacion
- postdoctoral researcher of the PICATA program Campus de Excelencia Internacional Moncloa
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Ribotoxins are fungal extracellular ribonucleases highly toxic due to their ability to enter host cells and their effective ribonucleolytic activity against the ribosome. The natural role of these proteins in the producing fungi is still unsolved. Nevertheless, recent studies showing the insecticidal properties of two ribotoxins from different origin support their involvement in defense mechanisms. Thus, it seems that not just the entomopathogen Hirsutella thompsonii expresses the ribotoxin hirsutellin A as a virulence factor but also Aspergillus, the main ribotoxin producer, does so. In this review we focus on this little known aspect of this family of proteins, their toxicity against insects, from the point of view of its biological relevance and its potential biotechnological applications. (C) 2014 Elsevier Ltd. All rights reserved.
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