Review
Cell Biology
Jerry Edward Chipuk, Jarvier N. Mohammed, Jesse D. Gelles, Yiyang Chen
Summary: Mitochondria play crucial roles not only in maintaining organismal homeostasis and contributing to human diseases, but also in regulating regulated cell death processes. They serve as essential compartments for the production and presentation of key molecules, as well as platforms for enabling, initiating, and executing regulated cell death.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Hector Flores-Romero, Shashank Dadsena, Ana J. Garcia-Saez
Summary: Mitochondria play a crucial role in cellular processes, including energy production, metabolism, and immune response. Their bacterial origin allows them to release potent immune triggers, which are normally hidden within mitochondrial membranes. Alteration of mitochondrial permeability through pores is not only a way to communicate stress to the cell, but also a key event in cellular responses. Understanding the structure and mechanisms of mitochondrial pores can provide insights into regulating cell death and inflammatory pathways, offering new therapeutic opportunities.
Article
Biology
Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou Ks Camara, Wai-Meng Kwok, Emad Tajkhorshid
Summary: The study elucidates the process of complex formation between HKII and VDAC1, confirming a partial blockade of the VDAC1 channel in the complex and the disruptive effect of VDAC1 phosphorylation on HKII binding.
COMMUNICATIONS BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Bo Zou, Qianqian Yu, Lele Shao, Yingying Sun, Xingmin Li, Ruitong Dai
Summary: Lipid molecules play a crucial role in mitochondria-mediated apoptosis. This study reveals that the levels of mitochondrial lipids increase during early postmortem, accelerating apoptosis in beef muscle. The psoas major muscle has a higher degree of apoptosis and more severe muscle oxidation and antioxidant system damage compared to the longissimus lumborum muscle.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Xue Li, Pingping Liu, Yunfeng Zhao, Lianfu Zhang, Jian Zhang
Summary: The study found that oxidative stress can activate the mitochondrial apoptotic pathway in fish, promoting protein degradation, and ultimately leading to the deterioration of fish muscle.
Review
Biochemistry & Molecular Biology
Hagai Rottenberg
Summary: It is widely reported that the mitochondrial membrane potential, increment ψm, is reduced in aging animals. It was recently suggested that the lower increment ψm in aged animals modulates mitochondrial bioenergetics and that this effect is a major cause of aging since artificially increased increment ψm in C. elegans increased lifespan. The activation of the voltage-gated mitochondrial permeability transition pore (mPTP) is the main cause of the increase in depolarized mitochondria in aged cells, inhibiting oxidative phosphorylation, releasing calcium and mROS, and depleting NAD(+), thereby accelerating degenerative diseases and aging. The reported lifespan extension by artificially generated increment ψm in C. elegans is best explained by inhibition of the voltage-gated mPTP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hongji Wang, Chaowen Zhang, Mengnan Li, Chaoran Liu, Jingyi Wang, Xuan Ou, Yuzhu Han
Summary: This paper reviews the molecular mechanisms of antimicrobial peptides (AMPs)-mediated apoptosis by changing the permeability of the mitochondrial membrane, and discusses the roles of AMPs in inducing apoptosis and their potential application prospects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sergey M. Korotkov, Artemy Novozhilov
Summary: This study found that the effects of thiol-modifying agents and MPTP inhibitors on MPTP opening were diverse and concentration-dependent. The research suggests that Tl+-induced MPTP opening in calcium-loaded mitochondrial inner membrane may be caused by the interaction of active groups. This study provides further insight into the causes of thallium toxicity and may be useful in developing new treatments for thallium poisoning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aikaterini Poulaki, Stavroula Giannouli
Summary: Mitochondrial double membrane lipids play a crucial role in maintaining mitochondrial health and apoptosis process. Understanding the physiological properties of mitochondrial membrane lipids is essential for cancer research and maintaining overall health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Malaysha Rice, Bokey Wong, Mare Oja, Kelley Samuels, Alicia K. Williams, Jenny Fong, Anne-Marie Sapse, Uko Maran, Ekaterina A. Korobkova
Summary: The study investigated the impact of 17 dietary flavonoids on the peroxidase activity of cyt c bound to liposomes, revealing that flavones, flavonols, and flavanols were the strongest inhibitors while isoflavones were the weakest. The research also highlighted the correlation between flavonoids' peroxidase inhibition activity and their ability to suppress Trp-59 fluorescence in cyt c as well as the number of OH groups.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yisang Yoon, Hakjoo Lee, Marilen Federico, Shey-Shing Sheu
Summary: Mitochondrial permeability transition (MPT) is a phenomenon that leads to mitochondrial dysfunction and cell injury. The opening of a mega-channel called the permeability transition pore (PTP) is responsible for MPT. Mitochondrial fission and fusion play a role in regulating MPT. There may also exist a non-conventional form of MPT that is insensitive to certain inhibitors.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Review
Medicine, Research & Experimental
Rajalaxmi Behera, Veerta Sharma, Amarjot Kaur Grewal, Amit Kumar, Bhaskar Arora, Agnieszka Najda, Ghadeer M. Albadrani, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Thakur Gurjeet Singh
Summary: Mitochondrial dysfunction is a fundamental cause of ischemia reperfusion (I/R) damage, which refers to the paradoxical progression of cellular dysfunction and death when blood flow is restored to previously ischemic tissues. The opening of mitochondrial permeability transition pores (MPTP) due to increased mitochondrial permeability is a key factor in I/R injury. The interaction between MPTP and mitoKATP and their roles in I/R injury are the focus of this review.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xiaomin Zhao, Jianxiong Guo, Xinyue Wang, Jiadi Lin, Zhihao Liu, Chunmei Xu, Di Zhang, Dewen Tong
Summary: TGEV infection reduces circBIRC6-2 levels, leading to a decrease in mitochondrial calcium, membrane potential, and mPTP opening. Furthermore, we identified an interaction between the novel protein BIRC6-236aa encoded by circBIRC6-2 and VDAC1, suggesting that BIRC6-236aa destabilizes the VDAC1-CypD complex and inhibits mPTP opening.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Christiane Ott, Florencia Tomasina, Nicolas Campolo, Silvina Bartesaghi, Mauricio Mastrogiovanni, Alejandro Leyva, Carlos Batthy, Walter Meinl, Tilman Grune, Rafael Radi
Summary: The proteasome has a decreased capability to cleave at C-terminal of NO2Y residues in proteins, leading to a possible factor that decreases the turnover of oxidized proteins and facilitates the accumulation of nitrated proteins.
Article
Biochemistry & Molecular Biology
Chang Ying, Chengmeng Jin, Siying Zeng, Ming Chao, Xun Hu
Summary: This study reveals that interfering cellular pH may provide a valuable approach to treat cancer.
Article
Biochemistry & Molecular Biology
C. A. Mini, D. J. Dorta, S. S. Maria-Engler, D. P. Oliveira
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Environmental Sciences
Flavia Renata Abe, Andreia Avila Soares de Oliveira, Renan Vieira Marino, Taisa Carla Rizzi Rialto, Danielle Palma Oliveira, Daniel Junqueira Dorta
Summary: This study evaluated the toxicity of BDEs and HFFR on zebrafish early development. Results showed that at the highest concentration, BDE-47 induced edemas while HFFR ALPI had a lesser impact on development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Carlos E. Matos dos Santos, Raul Ghiraldelli Miranda, Danielle Palma de Oliveira, Daniel Junqueira Dorta
Article
Chemistry, Analytical
Eduardo Geraldo de Campos, Daniel Junqueira Dorta, Bruno Spinosa De Martinis
Summary: The COVID-19 pandemic has led to changes in scientific meetings, with many being cancelled, postponed, or converted to virtual format. Virtual conferences have shown numerous benefits in Forensic Sciences, including promoting scientific communication, accessibility, diversity, and continuing education. While virtual meetings cannot replace in-person meetings, a combination of both can be a valuable strategy.
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Carlos E. Matos dos Santos, Fernanda C. R. de Paiva, Daniel Junqueira Dorta, Danielle Palma de Oliveira
Summary: This article presents a preliminary assessment of the toxicity of pregabalin lactam (prega-L) using computational methods, following the principles outlined in the ICH guidance M7. Mutagenicity potential is considered as the endpoint, and implications for qualifying this impurity in drug substances and/or drug products are discussed.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Toxicology
Anilda Rufino de Jesus Santos Guimaraes, Paulo Francisco Veiga Bizerra, Camila Araujo Miranda, Fabio Erminio Mingatto
Summary: Imidacloprid induces cytotoxicity in HepG2 cells, with higher doses and longer exposure times resulting in more pronounced effects. This toxicity may be associated with an increase in the generation of reactive oxygen and nitrogen species (ROS/RNS).
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Saad U. Khan, Hammad Khan, Sajjad Hussain, Lilian D. M. Torquato, Sabir Khan, Raul G. Miranda, Danielle P. Oliveira, Daniel J. Dorta, Joao A. Lima Perini, Hyeok Choi, Maria Boldrin Zanoni
Summary: Photocatalytic activation of persulfate (PS) using Fe2O3 nanoparticles has shown to efficiently degrade reactive red 120 (RR120) dye. Among the different facets of Fe2O3, beta-Fe2O3 exhibited the highest photocatalytic activity due to enhanced charge carrier separation and greater active sites for PS activation. Optimization experiments achieved nearly 100% color removal and 82% organic removal. Scavenger test suggested the involvement of sulfate and hydroxyl radicals in the degradation process. However, the treatment did not significantly reduce the cytotoxicity of the wastewater. Overall, beta-Fe2O3/PS at low doses showed great potential for decomposing and mineralizing recalcitrant dyes in wastewater under visible light.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Meeting Abstract
Toxicology
D. P. De Oliveira, F. G. Leite, D. B. Carrao, A. R. Moraes De Oliveira, D. J. Dorta
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
T. C. R. Rialto, A. F. D. Micas, E. A. Savazzi, D. J. Dorta, D. P. Oliveira
TOXICOLOGY LETTERS
(2022)
Article
Medicine, Legal
Carlos E. Matos dos Santos, Daniel Junqueira Dorta, Danielle Palma de Oliveira
Summary: This paper introduces DARAN (Defined Approach for Risk Assessment of New Nitrosamines), a new approach that uses structure-activity relationship (SAR) patterns and Read-Across (RAx) to set transparent and acceptable limits for new N-nitrosamines. The authors applied this approach to calculate an acceptable limit for 1-methyl-4-nitrosopiperazine (MeNP) based on a scientifically reasoned RAx. By analyzing publicly available data, they identified patterns in the carcinogenic potency of N-nitrosopiperazine compounds and compared them with potent nitrosamines NDMA and NDEA. Using this information, they proposed a robust RAx to estimate the acceptable limit for MeNP.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Toxicology
Tais S. Viana, Diana Campos, Mariana Bartilotti, Fernanda G. Leite, Maria Valnice Zanoni, Daniel J. Dorta, Danielle P. Oliveira, Joao L. T. Pestana
Summary: Produced water (PW) generated by oil companies is a highly impacting waste that contains chemicals such as metals and organic and inorganic compounds. Conventional treatments have limited efficiency in removing PW toxicity, so alternative approaches must be developed and standardized. Treatment with magnetized vermiculite (VMT-mag) shows potential in reducing PW toxicity to aquatic biota.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ivo F. Machado, Raul G. Miranda, Daniel J. Dorta, Anabela P. Rolo, Carlos M. Palmeira
Summary: Reactive oxygen species (ROS) are important second messengers in metabolic processes and signaling pathways. Imbalance between ROS generation and antioxidant defenses leads to overproduction of ROS and subsequent oxidative damage, which disrupt cellular function. Oxidative stress plays a role in liver pathologies such as ischemia-reperfusion injury (LIRI), non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC). Polyphenols like quercetin, resveratrol, and curcumin have shown therapeutic effects by regulating ROS levels in liver injury conditions. This review summarizes the effects of polyphenols on oxidative damage in LIRI, NAFLD, and HCC.
Article
Toxicology
Caroline Scaramboni, Maria Lucia Arruda Moura Campos, Daniel Junqueira Dorta, Danielle Palma de Oliveira, Silvia Regina Batistuzzo de Medeiros, Marcos Felipe de Oliveira Galva, Kristian Dreij
Summary: This study investigated the cytotoxicity and genotoxicity of Retene in human HepG2 liver cells. Results showed that Retene induced DNA strand breaks, micronuclei formation, and reactive oxygen species (ROS) formation in a dose-and time-dependent manner. The study suggested that oxidative stress may be a key mechanism of the genotoxic effects of Retene.
TOXICOLOGY IN VITRO
(2023)
Article
Environmental Sciences
Taisa Carla Rizzi Rialto, Renan Vieira Marino, Flavia Renata Abe, Daniel Junqueira Dorta, Danielle Palma Oliveira
Summary: This study assessed and compared the toxicity of BDE-47 and ALPI to zebrafish by analyzing various parameters. The results showed that BDE-47 was more toxic than ALPI.
Review
Toxicology
Enzo Zini Moreira Silva, Daniel Junqueira Dorta, Danielle Palma de Oliveira, Daniela Morais Leme
Summary: While the effects of oral and inhaled flame retardants have been well studied, dermal exposure to them has been relatively less explored. Future research should focus on filling the gaps in understanding the impact of dermal exposure on human health for a more comprehensive picture.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
