Article
Environmental Sciences
Michal Adamski, Eliza Zimolag, Ariel Kaminski, Justyna Drukala, Jan Bialczyk
Summary: Cyanotoxins produced by cyanobacteria pose significant threats to human keratinocytes, inhibiting proliferation and migration, and causing cytotoxic effects. Among them, CYN and its decomposition products exhibit strong inhibitory effects on keratinocytes, while ANTX-a shows lower toxicity, requiring higher concentrations and longer exposure. Further research on cyanotoxins should focus on their decomposition products and ecotoxicology in natural aquatic environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Organic
Kaivin Hadidi, Maria Cristina Bellucci, Sergio Dall'Angelo, Alasdair Leeson-Payne, Justin J. Rochford, Jeffery D. Esko, Yitzhak Tor, Alessandro Volonterio
Summary: Guanidinoglycosides are non-cytotoxic molecular transporters capable of delivering high molecular weight bioactive cargos into cells at low nanomolar concentrations. The use of a stable guanidinoneomycin derivative armed with a highly specific maleimide moiety allows for efficient bioconjugation through thiol-maleimide click chemistry, expanding the field of application for these delivery vehicles.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Review
Environmental Sciences
Shulian Wang, Yiying Jiao, Zhi Rao
Summary: This paper reviews recent advancements in research on the selective oxidation and adsorption of cyanotoxins in water bodies, discussing the potential and challenges of selective removal methods in addressing cyanotoxins, while also examining the prospects of cyanotoxin control and in situ selective elimination approaches. It is aimed to provide useful reference and direction for future pilot-scale applications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Michal Adamski, Ariel Kaminski
Summary: The study found that both Cylindrospermopsin (CYN) and its decomposition products did not affect the antioxidant properties of glutathione (GSH), providing new insights into understanding the cytotoxic mechanism of CYN.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Environmental Sciences
Encarnacion Romera-Garcia, Rick Helmus, Ana Ballesteros-Gomez, Petra M. Visser
Summary: The increase in cyanobacterial blooms is linked to anthropogenic factors, causing concerns for drinking water companies and water managers due to the toxins produced. Simple, sensitive, and cost-effective analytical approaches are essential for risk assessment and large-scale studies. The development of a method for the multi-class determination of cyanotoxins in fresh water, which can separately report intra- and extracellular toxins, meets validation criteria and helps in risk management.
Article
Engineering, Environmental
Grace T. Crowe, Husein Almuhtaram, Robert C. Andrews, Michael J. McKie
Summary: Incorporating GAC caps into the filtration process can effectively reduce cyanotoxin exposure, but complete replacement of filter media with GAC is costly. A pilot study conducted in Oregon showed that replacing the top 15 cm of anthracite media with GAC caps can improve cyanotoxin removal, but the effectiveness decreases over time. However, this study suggests that using GAC caps can provide a cost-efficient and effective barrier for reducing cyanotoxin exposure after several months of continuous operation.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Kevin Lou, Douglas R. Wassarman, Tangpo Yang, YiTing Paung, Ziyang Zhang, Thomas A. O'Loughlin, Megan K. Moore, Regina K. Egan, Patricia Greninger, Cyril H. Benes, Markus A. Seeliger, Jack Taunton, Luke A. Gilbert, Kevan M. Shokat
Summary: The traditional search for cell-permeable drugs has focused on small, nonpolar, rigid chemical structures. However, emerging therapeutic strategies have introduced flexible chemical entities composed of multiple ligands. This study identified an endogenous chemical uptake pathway involving interferon-induced transmembrane proteins (IFITMs) that modulate the cell permeability of specific inhibitors. The study also found that IFITMs moderately assist certain proteolysis-targeting chimeras and investigated the physicochemical requirements for involvement in this uptake pathway.
Article
Microbiology
Brenda Y. Hernandez, Jason Biggs, Xuemei Zhu, Patrick Sotto, Michelle Nagata, Ana Joy Pacilan Mendez, Yvette Paulino
Summary: A study conducted in Guam found higher levels of cyanobacterial hepatotoxins in individuals who primarily used municipal tap water as their drinking water source and did not use store-bought water. Urine levels of cyanotoxins were also higher in individuals who consumed fruits and vegetables exclusively from local sources.
Article
Biochemistry & Molecular Biology
Yixiang Jiang, Sha Liu, Gaofei Tian, Hayden Jit Hei Cheung, Xin Li, Xiang David Li
Summary: The new synthesis method significantly reduced the time required for the preparation of YEATS domain-selective cyclopeptide inhibitors and led to a higher overall yield. Furthermore, the new synthetic route allowed further derivatisation of the cyclopeptides with various functional modules, including conjugation with cell-penetrating peptide.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Michal Saladyga, Malgorzata Kucala, Michal Adamski, Saravana Selvaraj, Ariel Kaminski
Summary: Phytoremediation is a useful method for removing cyanotoxins from water, but its efficacy is influenced by the composition of cyanobacterial mixtures. This study found that while some plants can effectively reduce intracellular toxins and cyanobacterial biomass, they can also cause an increase in toxin concentration in the medium.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Weihua Jin, Chenghui Lu, Yanan Zhu, Jing Zhao, Wenjing Zhang, Lianchun Wang, Robert J. Linhardt, Chunyu Wang, Fuming Zhang
Summary: Tau spreading in Alzheimer's disease is mediated by cell surface heparan sulfate (HS). Fucoidans, a class of sulfated polysaccharides, can compete with HS to bind tau and inhibit tau spreading. Two fractions of fucoidans, sulfated galactofucan (SJ-I) and sulfated heteropolysaccharide (SJ-GX-3), exhibited strong binding abilities and inhibited tau-cell interaction and tau cellular uptake.
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Priscila Apolinario Barboza, Mariana Nascimento Machado, Dayene de Assis Ferenandes Caldeira, Milena Simoes Peixoto, Luis Felipe Cruz, Christina Maeda Takiya, Alysson Roncally Carvalho, Mariana Boechat de Abreu, Rodrigo Soares Fortunato, Walter Araujo Zin
Summary: The study evaluated the pulmonary outcomes of acute CYN intoxication and found that dexamethasone could partially mitigate the toxic effects of CYN, improving some characteristics of the lungs and liver.
Review
Chemistry, Analytical
Yein Kwon, Yejin Yoon, Moonbong Jang, Sunggu Kang, Chulhwan Park, Taek Lee
Summary: Cylindrospermopsin (CYN) is a freshwater algal toxin that is produced during the proliferation of harmful cyanobacterial algal blooms. The effects of global warming have contributed to the worldwide occurrence of cyano-HABs, leading to increased damage to aquatic ecosystems. CYN exhibits cell toxicity, as well as toxicity to the skin, genes, liver, and other organs. Current methods for CYN detection have limitations, and recent studies have focused on biosensor-based technologies for improved detection.
Article
Cell Biology
Malgorzata Kucala, Michal Saladyga, Ariel Kaminski
Summary: Lemna trisulca showed potential as a phytoremediation agent for reducing cyanotoxin concentrations in water through co-cultivation with different species of cyanobacteria, affecting their growth and development, and stabilizing water conductivity and pH values.
Article
Chemistry, Organic
Si-Qing Wang, Wei-Yi Qi, Xue-Song Yin, Bing-Feng Shi
Summary: This paper presents a concise formal total synthesis of (+/-)-7-deoxycylindrospermopsin in 14 steps from commercially available 4-methoxypyridine, with key steps including the elaboration of densely functionalized piperidine, Sonogashira coupling to attach the pyrimidine moiety, and intramolecular conjugate addition of guanidine with alkyne to form the C ring. The synthesis of its 8-epi isomer was also achieved following the same synthetic strategy.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.