Article
Chemistry, Medicinal
Pablo Rayff da Silva, Nadjaele de Melo Apolinario, Simone Angela Soares da Silva, Maria Elaine Cristina Araruna, Thassia Borges Costa, Yvnni M. S. de Medeiros e Silva, Teresinha Goncalves da Silva, Ricardo Olimpio de Moura, Vanda Lucia dos Santos
Summary: This study evaluated the anti-inflammatory potential of the compound JR19 and found that it can exert its anti-inflammatory effects through the nitric oxide pathway and cytokine signaling.
Article
Biochemistry & Molecular Biology
Malgorzata Klosek, Agnieszka Krawczyk-Lebek, Edyta Kostrzewa-Suslow, Ewelina Szliszka, Joanna Bronikowska, Dagmara Jaworska, Grazyna Pietsz, Zenon P. Czuba
Summary: Inflammation plays a crucial role in immune defense, but chronic inflammation may lead to neurodegenerative diseases, atherosclerosis, inflammatory bowel diseases, or cancer. Flavanones found in citrus fruits possess anti-oxidative and anti-inflammatory properties. This study demonstrates that methyl derivatives of flavanone can inhibit inflammation and modulate the production of inflammatory cytokines.
Review
Biochemistry & Molecular Biology
Philipp von Hundelshausen, Kanin Wichapong, Hans-Joachim Gabius, Kevin H. Mayo
Summary: The trafficking and local activity of leukocytes are essential for various physiological processes. Microenvironments are complex due to the multiple mediators from diverse cell types playing regulated roles. Chemokines and galectins represent important effector molecules involved in inflammatory processes and have the capacity to form various molecular interactions in response to inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Microbiology
Lu Cui, Yong Ma, Yumeng Liang, Yanhui Zhang, Zhijie Chen, Zhitao Wang, Hanguang Wu, Xuefeng Li, Li Xu, Shengwang Liu, Hai Li
Summary: Avian Tembusu virus (TMUV) infection mainly polarized host macrophages into the classically activated (M1) type, while the increased nitric oxide (NO) upon infection did not exhibit antiviral effects. Infected polarized macrophages showed increased migration but reduced phagocytosis.
VETERINARY MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wan-Jiao Gao, Jian-Xin Liu, Yie Xie, Pei Luo, Zhong-Qiu Liu, Liang Liu, Hua Zhou
Summary: A large number of macrophages in inflamed sites can exacerbate inflammatory responses, while Sinomenine can exert its anti-inflammatory effects by inhibiting macrophage migration. Sinomenine can also alleviate inflammation and prevent macrophage infiltration.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biology
Chun-Yu Lin, Shih-Han Kao, Ling-Chien Hung, Hsin-Ju Chien, Wen-Hung Wang, Yu-Wei Chang, Yen-Hsu Chen
Summary: The study indicates that TGII effectively reduces LPS-induced NO production and its upstream regulatory factors, suggesting its potential as a therapeutic agent for sepsis and other inflammatory diseases. TGII pre- or post-treatment significantly decreases the expression of pro-inflammatory proteins induced by LPS, and inhibits the production of NO and PGE2.
Article
Cell Biology
Nathalia Santos Carvalho, Julia Borges Paes Lemes, Marco Pagliusi Jr, Ana Carolina dos Santos Machado, Kaue Franco Malange, Lais Passariello Pral, Jose Luis Fachi, Catarine Massucato Nishijima, Gilson Goncalves dos Santos, Claudia Herrera Tambeli, Cesar Renato Sartori, Marco Aurelio Ramirez Vinolo, Carlos Amilcar Parada
Summary: This study demonstrates the key role of neutrophil-derived COX-2 in peripheral inflammatory hyperalgesia, as shown in knockout mice experiments where the absence of COX-2 in neutrophils led to higher pain sensitivity and prolonged allergic reactions. These findings suggest that neutrophil COX-2 plays an important regulatory role in inflammatory hyperalgesia.
Article
Food Science & Technology
Gabriel Silva Xavier, Amanda Mara Teles, Carla Junqueira Moragas-Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Wendel Fragoso de Freitas Moreira, Ana Lucia Abreu-Silva, Katia da Silva Calabrese, Maria do Desterro Soares Brandao Nascimento, Fernando Almeida-Souza
Summary: This study evaluated the effects of catechin-rich acai extract on inflammation control, showing inhibitory effects on macrophages and paw edema. The findings provide evidence for further research on E. oleracea seeds for inflammation treatment.
Article
Immunology
Holly J. Hulsebus, Kevin M. Najarro, Rachel H. McMahan, Devin M. Boe, David J. Orlicky, Elizabeth J. Kovacs
Summary: Alcohol consumption increases the risk of infections, particularly pneumococcal pneumonia. Pneumonia patients with alcohol use require more intensive treatment and longer hospital stays. Alcohol consumption affects the immune response in the respiratory tract.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shevanuja Theivendran, Zhengying Gu, Jie Tang, Yannan Yang, Hao Song, Yang Yang, Min Zhang, Dan Cheng, Chengzhong Yu
Summary: This study reports the synthesis of a nanoparticle-based NO delivery platform that utilizes tetrasulfide-modified organosilica nanoparticles for effective NO delivery and macrophage activation. The enhanced intracellular delivery of NO resulted in macrophage activation and delayed tumor growth in a breast cancer model.
Article
Toxicology
Zahraa Haidar, Hussein Traboulsi, David H. Eidelman, Carolyn J. Baglole
Summary: Cannabis contains cannabinoids such as THC and CBD, which have psychoactive and anti-inflammatory effects. Inhalation of cannabis smoke may damage the lungs, but the relationship with respiratory health is not well understood. This study developed a mouse model of cannabis smoke exposure and found that acute inhalation of cannabis smoke modulates the pulmonary immune response, with different effects depending on the THC:CBD ratio.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huiyuan Zhu, Shaochun Yan, Jingshuo Wu, Zhong Zhang, Xiaolin Li, Zheng Liu, Xing Ma, Lina Zhou, Lin Zhang, Mingming Feng, Yiwei Geng, Aixin Zhang, Sabina Janciauskiene, Aiguo Xu
Summary: Serum MIF levels were found to be associated with the pathophysiology of allergic asthma in patients, and may serve as a potential biomarker for evaluating therapeutic response.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Rheumatology
Ming Liu, Zikun Xie, Guang Sun, Liujun Chen, Dake Qi, Hongwei Zhang, Jieying Xiong, Andrew Furey, Proton Rahman, Guanghua Lei, Guangju Zhai
Summary: The study found that MIF expression is lower in osteoarthritis patients, suggesting a potential protective role, serving as a biomarker to differentiate osteoarthritis from other joint disorders.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Integrative & Complementary Medicine
Frederick Ayertey, Ebenezer Ofori-Attah, Stephen Antwi, Michael Amoa-Bosompem, Georgina Djameh, Nathaniel Lartey Lartey, Mistuko Ohashi, Kwadwo Asamoah Kusi, Alfred Ampomah Appiah, Regina Appiah-Opong, Laud Kenneth Okine
Summary: The hydroethanolic extract of Morinda lucida leaves demonstrated significant anti-inflammatory activity by reducing nitric oxide and prostaglandin E-2 levels, and influencing the production of inflammation mediators. This study also showed that HEML has antioxidant activity and can regulate cytokine levels, indicating its potential therapeutic value for inflammation.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Wan-Jiao Gao, Jian-Xin Liu, Meng-Nan Liu, Yun-Da Yao, Zhong-Qiu Liu, Liang Liu, Huan-Huan He, Hua Zhou
Summary: Macrophages are heterogeneous cells with various physiological functions, including migration which plays a crucial role in the progression of inflammatory diseases, autoimmune diseases, and cancers. Research indicates that macrophage migration in three-dimensional environments is associated with disease pathology, suggesting it as a potential therapeutic target.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Benildo Sousa Cavada, Vanir Reis Pinto-Junior, Vinicius Jose Silva Osterne, Messias Vital Oliveira, Ivanice Bezerra Silva, Eva Pollyanna Peixe Laranjeira, Alana Freitas Pires, Jorge Luiz Coelho Domingos, Wandemberg Paiva Ferreira, Jeanlex Soares Sousa, Ana Maria Sampaio Assreuy, Kyria Santiago Nascimento
Summary: Lectins are proteins capable of recognizing and interacting with carbohydrates, leading to biological effects. This study investigated the interaction of DlyL with various carbohydrates using molecular dynamics, and its in vitro vasorelaxation effects.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Fernandes Oliveira Marques, Alana Freitas Pires, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Ivanice Bezerra Silva, Maria Gleiciane Queiroz Martins, Messias Vital Oliveira, Angelica Maciel Gomes, Luiz Augusto Gomes de Souza, Mauro Sergio Goncalves Pavao, Benildo Sousa Cavada, Ana Maria Sampaio Assreuy, Kyria Santiago Nascimento
Summary: In a rat model of peritonitis, the lectin isolated from Vatairea guianensis seeds induces an inflammatory effect through interactions with toll-like receptor 4 (TLR4) and tumor necrosis factor receptor 1 (TNFR1). VGL stimulates gene expression and release of TNF-alpha in peritoneal macrophages, while also inducing peritonitis in female Wistar rats in vivo. The study suggests that VGL induces an acute inflammatory response by interacting with TLR and TNFR receptor pathways, leading to the activation of peritoneal macrophages and TNF-alpha release.
JOURNAL OF MOLECULAR RECOGNITION
(2021)
Article
Hematology
Lucas C. M. Arruda, Arwen Stikvoort, Melanie Lambert, Liqing Jin, Laura Sanchez Rivera, Renato M. P. Alves, Tales Rocha de Moura, Carsten Mim, Soren Lehmann, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Bjorn Onfelt, Mattias Carlsten, Michael Uhlin
Summary: A CD34-specific bi-specific T-cell engager (BTE) has been designed and tested in this study, demonstrating its ability to activate T cells and kill leukemia cells with the CD34(+) phenotype. In vivo experiments showed that the CD34-specific BTE had robust anti-tumor effects.
Article
Biochemistry & Molecular Biology
Messias Oliveira, Vinicius J. S. Osterne, Claudia F. Lossio, Sonia Serna, Niels C. Reichardt, Kyria S. Nascimento, Els J. M. Van Damme, Benildo S. Cavada
Summary: CsL is a novel lectin from Collaea speciosa that shows specificity for GlcNAc/glucose, being stable at pH 7-8 and non-toxic to Artemia. Its binding properties to N-glycans with terminal GlcNAc residues suggest it may represent a new group within the Diocleinae lectins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Francisco S. B. Mota, Kyria S. Nascimento, Messias Oliveira, Vinicius J. S. Osterne, Joana C. M. Clemente, Cornevile Correia-Neto, Abelardo B. Lima-Neto, Mauricio F. van Tilburg, Jose H. Leal-Cardoso, Maria I. F. Guedes, Benildo S. Cavada
Summary: This study collected saliva samples from children with different degrees of ASD and healthy children, and used proteomics to analyze differentially expressed proteins in saliva to identify potential biomarkers for ASD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Pedro Henrique Chaves Isaias, Thamara Manoela Marinho Bezerra, Filipe Nobre Chaves, Ana Paula Negreiros Nunes Alves, Karuza Maria Alves Pereira, Mario Rogerio Lima Mota
Summary: This study presents a rare case of desmoplastic fibroblastoma (DF) in an unusual oral site, accompanied by painful symptoms. The histopathological examination and immunohistochemical results supported the diagnosis of DF, and no recurrence was observed during one year of follow-up.
REVISTA PORTUGUESA DE ESTOMATOLOGIA MEDICINA DENTARIA E CIRURGIA MAXILOFACIAL
(2022)
Article
Microbiology
Maria Imaculada de Queiroz Rodrigues, Camila Carvalho de Oliveira Coelho, Fabricio Bitu Sousa, Lidiany Karla Azevedo Rodrigues Gerage, Mario Rogerio Lima Mota, Ana Paula Negreiros Nunes Alves
Summary: This study describes a new protocol for polymicrobial oral conventionalization in mice. By inoculating specific pathogen free animals with wild mouse microbiota, the researchers were able to achieve colonization of a microbiota similar to that of wild animals for up to 80 days. This technique proves to be effective, low-cost, and easily reproducible.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Review
Anatomy & Morphology
Paola de Lima, Renata Souza e Silva, Denis Guilherme Guedert, Ana Carolina Figueiredo Costa, Delane Viana Gondim, Mariana Lima Vale
Summary: This article systematically reviews the teaching of human anatomy for the visually impaired and finds that manually produced tactile materials, Braille, and cadaveric pieces are effective tools for teaching human anatomy to this population. The study highlights the need for adaptations of teaching methods to enhance accessibility and inclusivity.
Article
Biochemistry & Molecular Biology
Samara Rodrigues Bonfim Damasceno Oliveira, Alvaro Xavier Franco, Marielle Pires Quaresma, Cecilia Mendes Morais de Carvalho, Fabricia da Cunha Jacome Marques, Patricia da Silva Pantoja, Vanessa Azevedo Mendonca, Vinicius Jose da Silva Osterne, Jorge Luis Almeida Correia, Ana Maria Sampaio Assreuy, Marcellus Henrique Loiola Pontes de Souza, Kyria Santiago do Nascimento, Benildo Sousa Cavada, David Neil Criddle, Pedro Marcos Gomes Soares
Summary: This study investigated the effects of lectins isolated from Canavalia ensiformis and Canavalia brasiliensis on acute pancreatitis. The results showed that these lectins can decrease bile acid-induced pancreatic acinar cell death, inflammation, and necrosis.
GLYCOCONJUGATE JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Isabelly Vidal do Nascimento, Maria Imaculada de Queiroz Rodrigues, Pedro Henrique Chaves Isaias, Paulo Goberlanio Barros-Silva, Fabricio Bitu Sousa, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota
Summary: The study aimed to evaluate the inflammatory response and development of apical periodontitis in rats chronically treated with glucocorticoids. The results showed that glucocorticoid treatment caused an early increase in bone resorption and pulp necrosis, accompanied by alterations in cytokine levels, inflammatory response, and collagen deposition.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Vinicius J. S. Osterne, Joost Verduijn, Claudia F. Lossio, Bogdan Parakhonskiy, Messias Oliveira, Vanir R. Pinto-Junior, Kyria S. Nascimento, Andre G. Skirtach, Els J. M. Van Damme, Benildo S. Cavada
Summary: This study created a controlled-release system using CaCO3 particles adsorbed with Dioclea violacea lectin (DVL) to enhance its anticancer potential against cervical cancer cells. The bioconjugates showed a stronger cytotoxic effect compared to free lectin, suggesting the potential of lectin-particle bioconjugates as agents in cancer research.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joana Maria dos Santos Alves, Khalil Fernandes Viana, Anamaria Falcao Pereira, Roberto Cesar Pereira Lima Junior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim
Summary: The objective of this study was to identify changes in the trigeminal pathway in oral cancer and establish an effective approach to pain control. The results showed that 4-NQO induced macroscopic lesions consistent with neoplastic tumors, and histopathological analysis confirmed the presence of oral squamous cell carcinoma. Changes in nociceptive behavior, as indicated by nociceptive expression scores and increased grooming and exploratory activity, were observed. Alterations in c-Fos expression further supported the findings.
Article
Oncology
Thinali Sousa Dantas, Aline Samara Araujo de Sousa, Thiago Oliveira Pinheiro Sales, Osias Vieira deOliveira Filho, Paulo Goberlanio de Barros Silva, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota, Fabricio Bitu Sousa
Summary: This study investigated the impact of healthcare coverage on the prognosis of OOSCC patients. It found that patients covered by the publicly funded healthcare system had lower education levels, advanced T stage, and delayed treatment initiation. The study also identified T stage as a predictor of poor prognosis in oral squamous cell carcinoma, and age as a predictor in oropharyngeal squamous cell carcinoma. Surgical treatment and marital status were considered predictors of better prognosis in OOSCC. The exclusive dependence on the publicly funded healthcare system can be considered an indirect prognostic factor for OOSCC.
CANCER INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Maria Elisa Quezado Lima-Verde, Maria Imaculada de Queiroz Rodrigues, Basilio Rodrigues Vieira, Francisco Tarcisio Guedes Lima-Verde Neto, Enzo Victorino Hernandez Agressott, Frederico Barbosa de Sousa, Alexandre Rocha Paschoal, Paulo Goberlanio de Barros Silva, Fabricio Bitu Sousa, Mario Rogerio Lima Mota, Ana Paula Negreiros Nunes Alves
Summary: This study investigated the effects of sex and treatment on the establishment of ONJ and bone biomechanical alterations in a ZA-related osteonecrosis mouse model. The results showed that ZA-treated groups had lower bone density and females had lower bone density compared to males. The ZA treatment decreased flexural modulus and yield stress but increased stiffness due to higher bone volume. Additionally, ZA increased crystallinity in bone and dental structure. In conclusion, ZA modifies the mineral matrix in bone and dental structure, improving bone mechanical properties despite the occurrence of osteonecrosis.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Eugene F. Baulin, Sunandan Mukherjee, S. Naeim Moafinejad, Tomasz K. Wirecki, Nagendar Goud Badepally, Farhang Jaryani, Filip Stefaniak, Masoud Amiri Farsani, Angana Ray, Tales Rocha de Moura, Janusz M. Bujnicki
Summary: We presented a workflow for computational modeling of RNA 3D structures and interactions using various methods developed in our laboratory. The results showed that our workflow and its individual components are robust in predicting RNA 3D structures of acceptable quality, although there is still room for improvement. The study highlights the need for better prediction of stacking interactions and non-canonical base pairs.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2023)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
