Review
Food Science & Technology
Gary M. Bucciarelli, Maren Lechner, Audrey Fontes, Lee B. Kats, Heather L. Eisthen, H. Bradley Shaffer
Summary: TTX is a potent neurotoxin that can be therapeutic at levels below lethal doses, showing promise in treating cancer-related pain, neuropathic pain, and other ailments. Despite its lethal effects on humans, TTX has potential to treat various medical conditions.
Article
Neurosciences
Clement Verkest, Sylvie Diochot, Eric Lingueglia, Anne Baron
Summary: The study identifies JNK as a new post-translational positive regulator of ASICs in rodent sensory neurons, which can rapidly alter ASIC activity and contribute to peripheral sensitization and pain hypersensitivity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
Christopher Marra, Timothy V. Hartke, Matthias Ringkamp, Mitchell Goldfarb
Summary: Transient voltage-gated sodium currents are regulated by FHFs, and the ablation of Fhf genes affects neurological and cardiac functions. Fhf2(null) mice exhibit cardiac conduction block and lack of heat nociception due to FHF2 deficiency and elevated temperature affecting the inactivation gating of sodium channels. This study explains the deficits in neurological and cardiac function in Fhf2(null) mice by the combined effects of FHF deficiency and temperature on sodium channel gating kinetics.
Article
Pharmacology & Pharmacy
Yoshihiko Nakatani, Taku Amano
Summary: Citalopram and escitalopram decreased Nav1.5 VGSC current and altered the voltage-dependence of activation and inactivation, potentially contributing to the adverse cardiac effects. Escitalopram may have a stronger impact on these effects compared to R-citalopram.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Asfree Gwanyanya, Inga Andriule, Bogdan M. Istrate, Farjana Easmin, Kanigula Mubagwa, Regina Macianskiene
Summary: TRPM6 and TRPM7 proteins in the heart may be the molecular candidates for native cardiac Mg2+-sensitive channels, potentially influencing the duration of action potentials and having implications in arrhythmogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Houria Daimi, Estefania Lozano-Velasco, Amelia Aranega, Diego Franco
Summary: This review provides the latest information on the molecular events that regulate the Na(v)1.5 sodium channel and the cardiac channelopathies associated with defects in these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Dang Thuan Tran, Cam Van T. Do, Cuc T. Dinh, Mai T. Dang, Khanh Hy Le Ho, Truong Giang Le, Viet Ha Dao
Summary: In this study, Fe3O4@SiO2 and Fe3O4@SiO2-NH2 nanocomposites were synthesized for the adsorption and recovery of TTX derivatives from pufferfish viscera extract. The experimental data showed that Fe3O4@SiO2-NH2 exhibited a higher affinity towards TTX derivatives and achieved maximal adsorption yields of 97.9%, 99.6%, and 93.8% for 4epi-TTX, TTX, and Anh-TTX, respectively. Additionally, Fe3O4@SiO2-NH2 was capable of being regenerated up to three cycles with a 90% adsorptive performance, indicating its potential as an alternative material for purifying TTX derivatives.
Article
Food Science & Technology
Anna E. Vlasenko, Vasiliy G. Kuznetsov, Grigorii Malykin, Alexandra O. Pereverzeva, Peter V. Velansky, Konstantin Yakovlev, Timur Yu Magarlamov
Summary: The study investigated the accumulation and usage of toxins in nemertean worms. It found that TTX-positive cells released secretions actively in response to external stimuli, and revealed low probability of targeted TTX usage as a repellent. Additionally, mutations in Nav1 channels were identified, potentially contributing to nemertean channel resistance to TTX.
Article
Biochemistry & Molecular Biology
Anna N. Bukiya, Alex M. Dopico
Summary: The study shows that a high-CLR diet can protect cerebral arteries from alcohol-induced constriction by antagonizing the inhibition of BK channels and that this protection is dependent on cell integrity and a PKC-dependent mechanism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Cell Biology
Ratul Datta Chaudhuri, Ritwik Datta, Santanu Rana, Abhik Kar, Phuc Vinh Nguyen, Raja Mazumder, Sujata Mohanty, Sagartirtha Sarkar
Summary: This study reveals that nitrosative stress leads to S-Nitrosylation of IKK gamma, which improves cardiomyocyte apoptosis and promotes their cell cycle re-entry machinery. Mechanistically, the binding preference of p65 is shifted from p300 to HDAC1 via regulating the binding of IKK gamma with p300. This approach may serve as a novel strategy to restore cardiac function in diseased hearts.
CELLULAR SIGNALLING
(2022)
Article
Chemistry, Medicinal
Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin
Summary: Multiple animal species have developed resistance to the neurotoxin tetrodotoxin (TTX) by altering the amino acid substitutions in voltage-gated sodium ion channels (VGSCs). This study demonstrates that positionally convergent substitutions of amino acids do not generate similar patterns among TTX-resistant animal lineages, suggesting that flexibility and movement of the protein may play a greater role in causing changes in TTX block.
Article
Medicine, Research & Experimental
Jorge Lucas Teixeira-Fonseca, Artur Santos-Miranda, Joab Barbosa da Silva, Leisiane Pereira Marques, Julliane Vasconcelos Joviano-Santos, Paula Idma Chaves Nunes, Danilo Roman-Campos, Antonio Nei Santana Gondim
Summary: Eugenol, a natural compound found in aromatic plants, has been shown to have antiarrhythmic activity by reducing sodium current, shifting inactivation curve, delaying recovery from inactivation, and blocking the channel in the inactivated state. These findings suggest that eugenol interacts with Na(v)1.5 to exert its antiarrhythmic effects.
Review
Biochemistry & Molecular Biology
Friederike Cuello, Friedrich W. Herberg, Konstantina Stathopoulou, Philipp Henning, Simon Diering
Summary: Pathologies such as cancer, inflammatory and cardiac diseases are often associated with long-term oxidative stress, leading to protein dysfunction and failed trials of systemic antioxidant therapy. In cardiac myocytes, cardiac contractility is mainly driven by the beta-adrenoceptor-signaling cascade activating PKA-mediated phosphorylation for positive inotropic and lusitropic effects. Both kinase and phosphatase are redox-sensitive and play crucial roles in regulating cardiac contractile function.
Article
Cardiac & Cardiovascular Systems
Kinya Seo, Yuta Yamamoto, Anna Kirillova, Masataka Kawana, Sunil Yadav, Yong Huang, Qianru Wang, Kerry V. Lane, Beth L. Pruitt, Marco V. Perez, Daniel Bernstein, Joseph C. Wu, Matthew T. Wheeler, Victoria N. Parikh, Euan A. Ashley
Summary: R-enantiomer carvedilol attenuates hyperdynamic contraction, suppresses arrhythmia, and improves cardiac output without lowering heart rate by dual blockade of alpha 1-adrenergic receptor and RyR2 in mouse and human models of HCM. This combination of therapeutic effects is unique among current therapeutic options for HCM and may particularly benefit patients without LV outflow tract obstruction.
Article
Pharmacology & Pharmacy
Lorena Perez-Carrillo, Alana Aragon-Herrera, Isaac Gimenez-Escamilla, Marta Delgado-Arija, Maria Garcia-Manzanares, Laura Anido-Varela, Francisca Lago, Luis Martinez-Dolz, Manuel Portoles, Estefania Tarazon, Esther Rosello-Lleti
Summary: This study investigated the transcriptome alterations of genes involved in sodium transport in heart failure (HF) and found the overexpression of SLC9C2 and SCL9A1 sodium transport genes. The study also showed a correlation between NHE11 protein levels and left ventricular diameters, and reduced NHE11 mRNA levels after treatment with empagliflozin. These findings reveal alterations in sodium transport and highlight the importance of these channels in HF progression.
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.