Article
Agriculture, Multidisciplinary
Yu-Lei Chen, Ming-Hui Zhang, Le-Le Su, Le-Chang Sun, Xu-Jian Qiu, Duanquan Lin, Ling-Jing Zhang, Tengchuan Jin, Min-Jie Cao
Summary: This study reveals that collagenases are involved in the postmortem tissue self-degradation of Haliotis discus hannai by degrading type I collagen. The study also highlights the crucial role of tissue inhibitors of metalloproteinases (TIMPs) in regulating the activity of collagenases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Developmental Biology
Junjie Bao, Xiaodi Wang, Lina Chen, Bolun Wen, Qiu Gao, Xiuyu Pan, Yunshan Chen, Kaiyuan Ji, Huishu Liu
Summary: The upregulation of TIMP1 during labor facilitates and coordinates myometrial contraction by decreasing collagen and cell adhesive capacity.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Oncology
Shih-Chi Su, Chung-Han Hsin, Yen-Ting Lu, Chun-Yi Chuang, Yu-Ting Ho, Fang-Ling Yeh, Shun-Fa Yang, Chiao-Wen Lin
Summary: EF-24, an analog of curcumin, has demonstrated enhanced bioavailability and various anti-cancer properties. It inhibits the invasion of nasopharyngeal carcinoma (NPC) by interfering with the nuclear translocation of NF-kappa B and the activation of JNK, leading to the transcriptional suppression of MMP-9 gene. These findings suggest the potential use of curcumin analogs with increased bioavailability in controlling the spread of NPC.
Article
Multidisciplinary Sciences
Akira Takakuma, Mototsugu Nishii, Alan Valaperti, Haruto Hiraga, Ryo Saji, Kazuya Sakai, Reo Matsumura, Yasuo Miyata, Nozomu Oba, Fumiya Nunose, Fumihiro Ogawa, Kouichi Tamura, Ichiro Takeuchi
Summary: The study demonstrated that EP4 stimulation improved impaired cardiac function in autoimmune myocarditis, potentially preventing adverse ventricular remodeling post-myocarditis by regulating the TIMP-3/MMP-2 axis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Article
Multidisciplinary Sciences
Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Ryoki Hara, Ayako Murase, Asami Ohara, Ai Ohnishi, Takashi Ohya, Shuichi Ito
Summary: Arthritis is a common complication of Kawasaki disease, with 20% of patients developing arthritis and 14% experiencing persistent arthritis. Persistent arthritis mainly presents as oligoarthritis in large joints, accompanied by joint pain and fever. Adequate diagnosis and treatment are necessary for patients with Kawasaki disease.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Jagoda Kruszewska, Agnieszka Cudnoch-Jedrzejewska, Katarzyna Czarzasta
Summary: Obesity is a growing problem, affecting two-thirds of adults and increasing the risk of cardiovascular diseases. Chronic obesity can also lead to heart failure with preserved ejection fraction. Excessive collagen deposition in the extracellular matrix during obesity can stiffen the myocardium and impair heart function. This review discusses the rationale and potential factors behind this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Ana C. Palei, Juliana de O. Cruz, Joao Leandro Chaguri, Jose Carlos Peracoli, Mariana Romao-Veiga, Vanessa R. Ribeiro-Vasques, Ricardo C. Cavalli, Priscila R. Nunes, Marcelo R. Luizon, Valeria C. Sandrim
Summary: This study found that circulating tissue inhibitor of metalloproteinase 3 (TIMP-3) concentrations were increased in women with pre-eclampsia compared to healthy pregnant women, and that it was positively correlated with plasma matrix metalloproteinase 2 (MMP-2) and TIMP-1 concentrations in pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Biochemistry & Molecular Biology
Anna Skurska, Violetta Dymicka-Piekarska, Robert Milewski, Malgorzata Pietruska
Summary: The study investigated the levels of MMP-1 and MMP-8 in GCF during different healing stages after root coverage procedures using MCAT with SCTG or CM. Results showed significant changes in MMP-1, MMP-8, and SFFR values after both techniques. Correlations were found between MMP concentration differences and clinical outcomes, suggesting that the choice of augmentative material may impact MMP secretion dynamics.
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Article
Integrative & Complementary Medicine
Alemeh Taheri, Samira Ezzati Mobaser, Pegah Golpour, Mona Nourbakhsh, Masoumeh Tavakoli-Yaraki, Sahar Yarahmadi, Mitra Nourbakhsh
Summary: In this study, the anti-fibrotic effects of hesperetin were investigated by targeting ECM components and matrix metalloproteinase enzymes. The results showed that hesperetin significantly reduced the production of markers of adipose tissue fibrosis and may be considered a potential compound for the treatment of obesity-associated fibrosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Medicine, Research & Experimental
Kumaravel Mohankumar, Subhashree Sridharan, Sankar Pajaniradje, Vivek Kumar Singh, Larance Ronsard, Akhil C. Banerjea, Dinesh Babu Somasundaram, Mohane Selvaraj Coumar, Latha Periyasamy, Rukkumani Rajagopalan
BIOMEDICINE & PHARMACOTHERAPY
(2015)
Article
Chemistry, Medicinal
Garima Shakya, Sangeetha Balasubramanian, Rukkumani Rajagopalan
PHARMACOGNOSY MAGAZINE
(2015)
Article
Chemistry, Medicinal
A. Parthiban, M. Kumaravel, J. Muthukumaran, R. Rukkumani, R. Krishna, H. Surya Prakash Rao
MEDICINAL CHEMISTRY RESEARCH
(2016)
Article
Nanoscience & Nanotechnology
Muddasarul Hoda, Sankar Pajaniradje, Garima Shakya, Kumaravel Mohankumar, Rukkumani Rajagopalan
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2016)
Article
Toxicology
Garima Shakya, Sangeetha Balasubramanian, Muddasarul Hoda, Rukkumani Rajagopalan
TOXICOLOGY MECHANISMS AND METHODS
(2018)
Review
Public, Environmental & Occupational Health
R. Sarangarajan, S. Meera, R. Rukkumani, P. Sankar, G. Anuradha
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2017)
Article
Toxicology
Garima Shakya, Sangeetha Balasubramanian, Muddasarul Hoda, Rukkumani Rajagopalan
TOXICOLOGY MECHANISMS AND METHODS
(2018)
Review
Biochemistry & Molecular Biology
Shamim Akhtar Sufi, Sankar Pajaniradje, Victor Mukherjee, Rukkumani Rajagopalan
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Public, Environmental & Occupational Health
Garima Shakya, Praveen Kumar Randhi, Sankar Pajaniradje, Kumaravel Mohankumar, Rukkumani Rajagopalan
TOXICOLOGY AND INDUSTRIAL HEALTH
(2016)
Article
Biochemistry & Molecular Biology
Kumaravel Mohankumar, Arul Prakash Francis, Sankar Pajaniradje, Rukkumani Rajagopalan
Summary: The study found that BDMC-A more effectively inhibited the transcription factors and markers of invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells compared to curcumin. The results suggest that BDMC-A may have potential as a novel chemotherapeutic agent for treating laryngeal carcinoma.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Pharmacology & Pharmacy
Amrutha Arjunan, Sankar Pajaniradje, Arul Prakash Francis, Srividya Subramanian, Sathyapriya Chandramohan, D. Parthasarathi, Ayyiliath M. Sajith, M. Syed Ali Padusha, P. P. Mathur, Rukkumani Rajagopalan
Summary: The novel compound TBUEIB demonstrated potential anti-cancer activities in lung cancer cell line A549, primarily by targeting the expression of DNMT1 enzyme, leading to apoptosis of cancer cells. The compound may be a potential multi-target compound in the epigenetic pathway.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Polymer Science
Neena Yadav, Arul Prakash Francis, Veeraraghavan Vishnu Priya, Shankargouda Patil, Shazia Mustaq, Sameer Saeed Khan, Khalid J. Alzahrani, Hamsa Jameel Banjer, Surapaneni Krishna Mohan, Ullas Mony, Rukkumani Rajagopalan
Summary: Polysaccharide-based drug carriers have been widely studied for anticancer therapy due to their biocompatibility, high drug loading capacity, and ability to target cancer cells specifically.
Review
Materials Science, Multidisciplinary
Arul Prakash Francis, Akshaya Rani Augustus, Sathyapriya Chandramohan, Suhail Ahmad Bhat, Veeraraghavan Vishnu Priya, Rukkumani Rajagopalan
Summary: Bone regeneration is an important field in orthopaedics and tissue engineering. The use of scaffolds as carriers for cells and growth factors has shown promising results in overcoming the issues caused by conventional bone repair methods. The versatility of biomaterials in terms of their physicochemical properties has led to better outcomes in bone regeneration. This review focuses on the fabrication of scaffolds and the various properties and applications of biomaterials, along with discussing the role of stem cells, growth factors, and signalling molecules in bone tissue regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Muddasarul Hoda, Bindu Madhuri Cavuturu, Saleem Iqbal, Garima Shakya, Rukkumani Rajagopalan
EUROPEAN JOURNAL OF NANOMEDICINE
(2017)
Article
Medicine, Research & Experimental
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S. Coumar, H. Surya Prakash Rao, Rukkumani Rajagopalan
BIOMEDICINE & PHARMACOTHERAPY
(2017)
