Article
Microbiology
Yang Hong, Qinghong Guo, Xue Zhou, Liying Tang, Cheng Chen, Zheng Shang, Kerou Zhou, Zhizhong Zhang, Jinming Liu, Jiaojiao Lin, Bin Xu, Jun-Hu Chen, Zhiqiang Fu, Wei Hu
Summary: The prevalence and infectious intensity of schistosomiasis japonica has significantly decreased in China. However, more accurate and sensitive diagnostic methods are urgently required for the further control and elimination of the disease.
Article
Parasitology
Vicente Y. Belizario, John Paul Caesar R. delos Trinos, Olivia T. Sison, Raul V. Destura, John Robert Medina, April Joy E. Gigataras, Joy Ann G. Petronio-Santos, Adrian B. Abarientos
Summary: This study aimed to describe the prevalence and seroprevalence of schistosomiasis in Siargao Island, Surigao del Norte and to compare the performance of ELISA Ab and LAMP for diagnosis of schistosomiasis. The results show that schistosomiasis remains a public health concern in Siargao Island.
Article
Immunology
Ian Kim B. Tabios, Marcello Otake Sato, Ourlad Alzeus G. Tantengco, Raffy Jay C. Fornillos, Masashi Kirinoki, Megumi Sato, Raniv D. Rojo, Ian Kendrich C. Fontanilla, Yuichi Chigusa, Paul Mark B. Medina, Mihoko Kikuchi, Lydia R. Leonardo
Summary: Schistosomiasis still has a significant impact on public health in the Philippines. The commonly used Kato-Katz (K-K) technique has low sensitivity, especially in low endemic areas and patients with light infection. This study compared the diagnostic performance of immunological, molecular, parasitological, and ultrasonographic tests, and found that SjcDNA detection assay and POC-CCA urine test were more sensitive than stool microscopy in detecting schistosomiasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Parasitology
Cheng Chen, Qinghong Guo, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Kai Xiao, Pengxiang Sun, Xiaonan Cong, Runxia Liu, Yang Hong
Summary: Despite a significant decrease in the prevalence and intensity of Schistosoma japonicum infection in China, this disease remains a serious public health concern in certain endemic areas in the Philippines and Indonesia. Therefore, more accurate and sensitive diagnostic methods are crucial for further control of this disease. This review explores the research progress in techniques for diagnosing S. japonicum infection.
Article
Parasitology
Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou, Yingzi Ming
Summary: The study compared the composition of gut microbiota in patients with chronic and advanced Schistosoma japonicum infection, revealing differences between the two groups. Patients with advanced infection had lower diversity and abundance of intestinal flora compared to those with chronic infection, with certain bacteria potentially serving as biomarkers for diagnosis. Analysis also showed that microbiota function shifted towards metabolism-related functions in the advanced infection group.
PARASITES & VECTORS
(2022)
Article
Immunology
Bikash R. R. Giri, Shun Li, Chuantao Fang, Lin Qiu, Shi Yan, Maria Y. Y. Pakharukova, Guofeng Cheng
Summary: This study characterized the miRNA profiles of T cells in the liver and blood of S. japonicum infected mice, and found distinct miRNA landscapes between these two systems. The differential expression of miRNAs was associated with T cell immune responses. These findings contribute to a better understanding of the regulation of T cells during S. japonicum infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou, Meng Xia, Yingzi Ming
Summary: The study revealed alterations in gut microbiota and metabolites in patients with different stages of Schistosoma japonicum infection, which were correlated with disease progression. This inter-omics analysis may provide insights into the mechanisms of S. japonicum infection progression and aid in identifying new potential targets for diagnosis and prognosis, although further validation with a larger sample size and investigation into underlying mechanisms are needed.
PARASITES & VECTORS
(2023)
Article
Immunology
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang
Summary: The study showed that USP21 plays a crucial role in regulating immune interactions between Schistosoma and its host, with potential implications for treating hepatic fibrosis in patients with schistosomiasis. This was evidenced by changes in Th1 and Th17 responses amplified by Tregs and reduced levels of liver immunopathology in USP21 knockout mice.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Infectious Diseases
Oliver Barenbold, Amadou Garba, Daniel G. Colley, Fiona M. Fleming, Rufin K. Assare, Edridah M. Tukahebwa, Biruck Kebede, Jean T. Coulibaly, Eliezer K. N'Goran, Louis-Albert Tchuem Tchuente, Pauline Mwinzi, Jurg Utzinger, Penelope Vounatsou
Summary: Taking into account the geometric or arithmetic mean infection intensity in a population improves the estimation of 'true' S. mansoni prevalence. Parametric models, including different sampling schemes such as triplicate slides per day over three days, can provide more accurate estimates of sensitivity. The relation between observed and 'true' prevalence is linear, with triplicate slides per day on three consecutive days ensuring close to perfect sensitivity.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Infectious Diseases
Md. Obaidur Rahman, Miho Sassa, Natasha Parvin, Md. Rashedul Islam, Aya Yajima, Erika Ota
Summary: IHA exhibited the highest detection accuracy for S. japonicum, followed closely by ELISA. Meta-analysis for S. mekongi was not possible due to insufficient studies. Further research is needed to identify suitable diagnostic methods for verifying the absence of S. mekongi transmission and compare detection accuracy against more sensitive reference standards such as PCR.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Da-Bing Lu, Qiu-Fu Yu, Jie-Ying Zhang, Meng-Tao Sun, Man-Man Gu, Joanne P. Webster, You-Sheng Liang
Summary: Research shows that unpaired female and male schistosomes can survive within their definitive host for at least 1 year and produce viable eggs after subsequent pairing, posing an additional biological challenge in achieving elimination of schistosomiasis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Infectious Diseases
Man-Man Gu, Meng-Tao Sun, Jie-Ying Zhang, Qiu-Fu Yu, Da-Bing Lu
Summary: Schistosomiasis-associated liver abnormalities are still a significant burden in China, with nearly one-fifth of examined individuals diagnosed with this condition. The prevalence varies across regions and age groups, providing valuable information for accurately calculating disease burden and guiding public health prioritization.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Wangping Deng, Shenglin Wang, Liping Wang, Chao Lv, Yinlong Li, Ting Feng, Zhiqiang Qin, Jing Xu
Summary: This study evaluated the performance of a basic RPA assay for the early detection of Schistosoma japonicum infection within its hosts. The results showed that the RPA assay had high sensitivity and specificity, making it a promising tool for early detection of S. japonicum infection.
Article
Multidisciplinary Sciences
Jingyi Liu, Xiaoxu Wang, Fei Sheng, Bikash R. Giri, Shun Li, Tianqi Xia, Xuxin Li, Guofeng Cheng
Summary: Timely diagnosis of Schistosoma infection, particularly in the early stage, is crucial for effective control strategies. This study used metagenomic next-generation sequencing to identify specific circulating DNAs in infected rabbits and developed diagnostic methods for murine and human schistosomiasis. The results showed the potential of using specific cDNAs as biomarkers for detecting Schistosoma infection in the early stages.
Review
Infectious Diseases
Hong-Mei Li, Zhi-Qiang Qin, Robert Bergquist, Men-Bao Qian, Shang Xia, Shan Lv, Ning Xiao, Jurg Utzingerg, Xiao-Nong Zhou
Summary: This review assessed the nucleic acid amplification techniques for diagnosing S. mansoni infections in humans, intermediate host snails, and rodent reservoirs. The results showed high sensitivity and specificity in human samples, with different performance in snail and rodent samples. Overall, nucleic acid amplification techniques had high diagnostic potential for identifying S. mansoni infections in humans.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Chun-Xue Zhou, Kang Ai, Cui-Qin Huang, Jing-Jing Guo, Hua Cong, Shen-Yi He, Xing-Quan Zhu
Article
Environmental Sciences
Wei Cong, Nian-Zhang Zhang, Rui-Si Hu, Feng-Cai Zou, Yang Zou, Wen-Yan Zhong, Jing-Jing Wu, Christopher J. Fallaize, Xing-Quan Zhu, Hany M. Elsheikha
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Parasitology
Ting-Cui Li, Zhao Li, Yu-Lin Zhan, Wen-Jie Chen, Xian-Lan Dong, Jian-Fa Yan, Hong-Xia Li, Feng-Cai Zou
PARASITOLOGY RESEARCH
(2020)
Article
Parasitology
Ye-Ting Ma, Qing Liu, Shi-Chen Xie, Xiao-Dong Li, Yuan-Yuan Ma, Tao-Shan Li, Wen-Wei Gao, Xing-Quan Zhu
KOREAN JOURNAL OF PARASITOLOGY
(2020)
Article
Parasitology
Li-Xiu Sun, Qin-Li Liang, Lan-Bi Nie, Xiao-Hui Hu, Zhao Li, Jim-Fa Yang, Feng-Cai Zou, Xing-Quan Zhu
PARASITOLOGY INTERNATIONAL
(2020)
Article
Parasitology
Jian Qiang Han, Zhao Li, Yang Zou, Li Hua Pu, Xin Quan Zhu, Feng Cai Zou, Cui-Qin Huang
ACTA PARASITOLOGICA
(2020)
Article
Computer Science, Information Systems
Shuliang Wang, Qi Li, Chuanfeng Zhao, Xingquan Zhu, Hanning Yuan, Tianru Dai
Summary: Peak clustering, a density based clustering method, has shortcomings in finding cluster centers in low density clusters and detecting normal points as noises. Extreme clustering, which identifies density extreme points and introduces a noise detection module, overcomes these drawbacks and improves performance significantly.
INFORMATION SCIENCES
(2021)
Article
Immunology
Yang Zou, Wen-Bin Yang, Feng-Cai Zou, Rui-Qing Lin, Xing-Quan Zhu, Jun-Ling Hou
Summary: This study investigated the prevalence and subtypes of Blastocystis infections in farmed pigs in southern China, with ST5 being the predominant subtype. Factors such as gender, age, and region were considered as risk factors associated with Blastocystis infection in farmed pigs. This study provided valuable data for the control of Blastocystis infections in pigs, other animals, and humans in China.
MICROBIAL PATHOGENESIS
(2021)
Article
Computer Science, Theory & Methods
Zhabiz Gharibshah, Xingquan Zhu
Summary: This survey provides a comprehensive review of user response prediction in online advertising and related recommender applications. It covers the ecosystem, stakeholders, data availability, and prediction methods in online advertising platforms. A taxonomy is proposed to categorize machine learning methods used in different online platforms, and applications and resources in the field are also reviewed.
ACM COMPUTING SURVEYS
(2022)
Article
Immunology
Xia-Xia Liang, Yang Zou, Tao-Shan Li, Hong Chen, Sha-Sha Wang, Fu-Qiong Cao, Jian-Fa Yang, Xiao-Lin Sun, Xing-Quan Zhu, Feng-Cai Zou
Summary: This study investigated the prevalence and characterization of Giardia duodenalis and Cryptosporidium spp. in Yunling cattle in Yunnan province, China. The overall prevalence of G. duodenalis was 10.49% and Cryptosporidium spp. was 0.77%. Age was identified as a risk factor for G. duodenalis infection in Yunling cattle. Two assemblages of G. duodenalis and two species of Cryptosporidium were identified using nested PCR methods. This study provides baseline data for further research on the prevalence, genetic identity, and public health implications of these parasites in Yunling cattle.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Yu-Gui Wang, Yang Zou, Ze-Zhong Yu, Dan Chen, Bin-Ze Gui, Jian-Fa Yang, Xing-Quan Zhu, Guo-Hua Liu, Feng-Cai Zou
Summary: This study investigated the prevalence and genotypes of Giardia duodenalis, Enterocytozoon bieneusi, and Cryptosporidium spp. in pet dogs and cats in Yunnan province, southwestern China. The results showed a higher prevalence and genetic diversity in dogs compared to cats, with potential zoonotic threats posed by both pet dogs and cats.
Article
Mathematical & Computational Biology
Magdalyn E. Elkin, Xingquan Zhu
Summary: Clinical trials are essential for medical advancement, but there is limited analysis of the valuable data from ClinicalTrials.gov. This study uses network analysis to understand infectious disease clinical trials, focusing on summarizing research areas and recommending clinical trials to sponsors.
NETWORK MODELING AND ANALYSIS IN HEALTH INFORMATICS AND BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Meilin Hao, Juncai Jiang, Yongyun Zhang, Shaoqing Wang, Guowen Fu, Fengcai Zou, Yuxiao Xie, Sumei Zhao, Weizhen Li
Summary: This study utilized RNA-seq to analyze the mammary tissue transcriptomics of water buffalo with different milk fat phenotypes, revealing differentially expressed genes (DEGs). The results indicated similar gene expression patterns between high and medium fat buffalo, with the identified DEGs involved in milk protein and fat synthesis as well as immune response.
Article
Computer Science, Artificial Intelligence
Youxi Wu, Meng Geng, Yan Li, Lei Guo, Zhao Li, Philippe Fournier-Viger, Xingquan Zhu, Xindong Wu
Summary: Nonoverlapping sequential pattern mining aims at identifying repetitive patterns in a set of discrete sequences. Compared with overlapping patterns, nonoverlapping patterns have stricter constraints on occurrences and meet the Apriori property. This paper proposes an efficient algorithm for mining high average utility nonoverlapping sequential patterns, demonstrating its efficiency and superiority through experiments.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Agriculture, Dairy & Animal Science
Hai-Yang Song, Kai-Sheng Wang, Jian-Fa Yang, Hua-Ming Mao, Li-Hua Pu, Yang Zou, Jun Ma, Xing-Quan Zhu, Feng-Cai Zou, Jun-Jun He
Summary: This study reported the prevalence and genotype distribution of Enterocytozoon bieneusi in dairy cattle in Yunnan province, China, identifying two novel zoonotic potential genotypes. Despite the low prevalence in dairy cattle, they may still pose a risk for transmitting E. bieneusi to humans. These findings are crucial for the development of effective prevention strategies for microsporidiosis.