Article
Pharmacology & Pharmacy
Maria Herminia Hazelhoff, Romina Paula Bulacio, Adriana Monica Torres
Summary: In this study, it was found that treatment with TMZ can protect against kidney damage induced by mercuric chloride (HgCl2) by reducing urea and creatinine levels, decreasing urinary flow, glucosuria, and water excretion, and increasing Cr clearance. Additionally, TMZ can decrease lipid peroxidation levels caused by oxidative stress.
Article
Toxicology
M. H. Hazelhoff, A. M. Torres
Summary: The study found that pretreatment with recombinant human erythropoietin (Epo) can ameliorate mercuric chloride-induced renal tubular injury and regulate the expression of mercury transporters in the kidneys, thereby reducing the mercury content in the kidneys.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Franccesco P. P. Boeno, Jay Patel, Ryan N. N. Montalvo, Stephanie S. S. Lapierre-Nguyen, Claire M. M. Schreiber, Ashley J. J. Smuder
Summary: Doxorubicin (DOX) is an effective chemotherapy drug for cancer treatment, but its clinical use is limited due to off-target toxicity. DOX accumulation in the liver and kidneys causes inflammation and oxidative stress, leading to cytotoxicity. Endurance exercise preconditioning may help prevent liver and kidney damage caused by DOX treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyoung-Yun Han, Mi-Sun Choi, Seokjoo Yoon, Je-Won Ko, Sang-Kyum Kim, Tae-Won Kim
Summary: This study confirmed kidney-biased organ toxicity of ifosfamide in rats, with identically altered genes in both the liver and kidney. Interferon regulatory factor 7 was identified as the main upstream regulator that changed in both organs. Further toxicogenomic studies are needed to fully understand the relationship between ifosfamide-induced genes and organ toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Gurleen Kour, Syed Assim Haq, Bijender Kumar Bajaj, Prem N. Gupta, Zabeer Ahmed
Summary: Phytochemicals have long been known for their therapeutic potential in autoimmune disorders such as rheumatoid arthritis, but their combination with DMARDs can increase the efficacy of treatment while reducing toxic side effects. Studies have shown promising results in experimental and clinical settings when combining phytochemicals with DMARDs, highlighting the importance of this approach in future RA therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Nermeen N. Welson, Remon R. Rofaeil, Sabreen Mahmoud Ahmed, Shereen S. Gaber, Gaber El-Saber Batiha, Mary Girgis Shahataa
Summary: The study demonstrates that vitamin E exhibits significant protection against gabapentin-induced liver and kidney injury, improving biochemical markers and partially inhibiting apoptosis, with notable reparative effects on liver and kidney tissue.
Article
Environmental Sciences
Bilal Hussain, Muhammad Sajad, Hassan Usman, Khalid A. Al-Ghanim, Mian Nadeem Riaz, Aydin Berenjian, Shahid Mahboob, Pau Loke Show
Summary: Cytotoxicity induced by industrial effluents and dyes is a global issue for freshwater fishes. This study aims to determine the sub-lethal effects of trypan blue dye in fish. The results showed that exposure to trypan blue dye can cause liver and kidney tissue damage in freshwater fish.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Sefa Kucukler, Fatih Mehmet Kandemir, Selcuk Ozdemir, Selim Comakli, Cuneyt Caglayan
Summary: The study evaluated the protective effects of rutin against deltamethrin-induced liver and kidney toxicities in rats. Rutin significantly improved liver and kidney function damage, oxidative stress, inflammation, and apoptosis in the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Fatih Mehmet Kandemir, Cuneyt Caglayan, Ekrem Darendelioglu, Sefa Kucukler, Ebubekir Izol, Ozge Kandemir
Summary: Carvacrol (CRV) has been shown to modulate cadmium (Cd)-induced toxic effects on liver and kidney tissues by enhancing antioxidant enzymes' activities and reversing changes in inflammatory biomarkers and apoptotic genes. Additionally, CRV treatment reduced Cd content and increased levels of essential minerals in tissues, suggesting it as a promising strategy to protect against Cd-induced oxidative damage, inflammation, and apoptosis.
Article
Medicine, Research & Experimental
Danilo B. M. Lucchi, Gisela R. S. Sasso, Leticia S. Sena, Diego D. Santos, Paulo C. Franco, Izabella Lice, Fernanda T. Borges, Sonia M. Oliani, Cristiane D. Gil
Summary: In this study, the pharmacological treatment with AnxA1-derived peptide Ac2-26 was evaluated in an experimental model of cisplatin-induced toxicity. The results showed that Ac2-26 treatment could alleviate the inflammatory response induced by cisplatin and protect the liver and kidneys from cisplatin-induced damage. However, the peptide treatment had no significant effect on kidney morphology injury.
Article
Environmental Sciences
Mustafa Ileriturk, Fatih Mehmet Kandemir
Summary: The protective effect of carvacrol on lambda-Cyhalothrin-induced hepatotoxicity and nephrotoxicity was investigated. Carvacrol reduced oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy caused by lambda-Cyhalothrin, protecting liver and kidney tissues from damage.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lan-Xin Li, Jia-Hong Chu, Xue-Wei Chen, Pei-Chao Gao, Zhen-Yong Wang, Ci Liu, Rui-Feng Fan
Summary: Sodium selenite alleviated HgCl2-induced brain damage by activating the BDNF/TrKB/PI3K/AKT signaling pathway and suppressing NF-kappa B pathway, reducing oxidative stress and neuronal dysfunction.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yuheng Ge, Xudong Liu, Fangru Nan, Qi Liu, Junping Lv, Jia Feng, Shulian Xie
Summary: This study examined the toxic effects of mercuric chloride (HgCl2) on the green alga Scenedesmus quadricauda. High concentrations of HgCl2 completely inhibited algal cell growth and caused structural damage and disruption of photosynthesis, while low concentrations affected enzyme activity and cell content. These findings contribute to our understanding of the mechanisms by which HgCl2 pollution affects aquatic ecosystems and may inform future pollution management strategies.
Article
Toxicology
Ege Arzuk, Mehmet Tokdemir, Hilmi Orhan
Summary: Mitochondria are the major target of paracetamol-induced hepatotoxicity. This study found that mitochondrial CYPs can catalyze the formation of toxic metabolite NAPQI from paracetamol, leading to the transmission of death signals. However, in the kidneys, there is no correlation between the formation of NAPQI and kidney CYP2E1 activity, suggesting a different toxicity mechanism compared to the liver.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Khaksari, Samira Esmaili, Reyhane Abedloo, Hossein Khastar
Summary: Palmatine can alleviate hepatotoxicity and nephrotoxicity induced by gentamicin mainly through inhibiting oxidative stress and apoptosis.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Physiology
Evangelina Cecilia Nosetto, Romina Valeria Campagno, Adriana Monica Torres, Anabel Brandoni
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Food Science & Technology
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Furst, Rainer Gurtler, Trine Husoy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens-Berendsen, Detlef Wolfle, Matthew Wright, Birgit Dusemund, Alicja Mortensen, Dominique Turck, Stefania Barmaz, Camilla Smeraldi, Alexandra Tard, Giorgia Vianello, Ana Maria Rincon, Ursula Gundert-Remy
Article
Food Science & Technology
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Furst, Ursula Gundert-Remy, Rainer Gurtler, Trine Husoy, Melania Manco, Peter Moldeus, Agneta Oskarsson, Sabina Passamonti, Romina Shah, Ine Waalkens-Berendsen, Detlef Wolffle, Matthew Wright, Romualdo Benigni, Claudia Bolognesi, Kevin Chipman, Eugenia Cordelli, Gisela Degen, Daniel Marzin, Camilla Svendsen, Giorgia Vianello, Wim Mennes
Article
Food Science & Technology
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Furst, Rainer Gurtler, Ursula Gundert-Remy, Trine Husoy, Melania Manco, Wim Mennes, Sabina Passamonti, Romina Shah, Dina Hendrika Waalkens-Berendsen, Detlef Wolfle, Matthew C. Wright, Polly Boon, Paul Tobback, Ana Maria Rincon, Alexandra Tard, Peter Moldeus
Article
Food Science & Technology
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Furst, Rainer Gurtler, Ursula Gundert-Remy, Trine Husoy, Melania Manco, Wim Mennes, Sabina Passamonti, Romina Shah, Dina Hendrika Waalkens-Berendsen, Detlef Wolfle, Matthew Wright, Polly Boon, Paul Tobback, Alessandra Giarola, Ana Maria Rincon, Alexandra Tard, Peter Moldeus
Article
Toxicology
M. H. Hazelhoff, A. M. Torres
Summary: The study found that pretreatment with recombinant human erythropoietin (Epo) can ameliorate mercuric chloride-induced renal tubular injury and regulate the expression of mercury transporters in the kidneys, thereby reducing the mercury content in the kidneys.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Sanja Vlaisavljevic, Milena Raseta, Sanja Berezni, Sabina Passamonti, Federica Tramer
Summary: The study found that Arame algae extract has the highest scavenging activity, and the antioxidant potential of all extracts is correlated with total phenol content, rather than total carotenoids content. Although biomolecules in the algae extracts showed in vitro antioxidant activity, they did not exhibit a significant effect on PC3 cells.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Food Science & Technology
Maged Younes, Gabriele Aquilina, Laurence Castle, Karl-Heinz Engel, Paul Fowler, Peter Furst, Rainer Gurtler, Ursula Gundert-Remy, Trine Husoy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Dina Hendrika Waalkens-Berendsen, Detlef Wolfle, Matthew Wright, Polly Boon, Riccardo Crebelli, Alessandro Di Domenico, Metka Filipic, Alicja Mortensen, Ruud Woutersen, Henk Van Loveren, Alessandra Giarola, Federica Lodi, Ana Maria Rincon, Alexandra Tard, Maria Jose Frutos Fernandez
Summary: The Panel concluded that polydextrose (E 1200) is safe as a food additive, with no identified toxicological issues, and recommended the European Commission to introduce restrictions in EU specifications for polydextrose (E 1200).
Article
Pharmacology & Pharmacy
Romina V. Campagno, Evangelina C. Nosetto, Anabel Brandoni, Adriana M. Torres
Summary: Obstructive renal diseases can impair liver and kidney function, with Oatp1(u) potentially serving as a new, early, and specific biomarker for obstructive nephropathy.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Adriana M. Torres, Ankur V. Dnyanmote, Jeffry C. Granados, Sanjay K. Nigam
Summary: In chronic kidney disease, the dysfunctional kidney can affect the function of various transporters and drug metabolizing enzymes in renal and non-renal tissues, leading to aberrant inter-organ communication. This has implications for the pharmacotherapy of CKD.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paola Sist, Antonella Bandiera, Ranieri Urbani, Sabina Passamonti
Summary: The recombinant fusion protein HUG exhibits human elastin-like polypeptide-specific thermal behavior and UnaG-specific bilirubin-dependent fluorescence emission. The UnaG domain has a measurable but limited effect on the thermal properties of HELP, while the HELP domain decreases the affinity of UnaG for bilirubin. However, HUG remains one of the strongest bilirubin-binding proteins known.
Article
Pharmacology & Pharmacy
Romina P. Bulacio, Adriana M. Torres
Summary: This study evaluated the presence of endogenous Epo in male Wistar rat urine and analyzed changes in urinary Epo levels in response to cisplatin-induced acute kidney injury (AKI). The results showed that urinary Epo levels significantly increased after cisplatin treatment, indicating its potential as an early biomarker for cisplatin-induced AKI.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonella Bandiera, Laura Colomina-Alfaro, Paola Sist, Giovanna Gomez d'Ayala, Federica Zuppardi, Pierfrancesco Cerruti, Ovidio Catanzano, Sabina Passamonti, Ranieri Urbani
Summary: Genetic engineering allows for precise control and manipulation of protein properties, enabling the development of novel materials and systems with enhanced interactive capabilities with biological systems. Elastin-like polypeptides are customizable recombinant biopolymers that have been shown to effectively interact with biological systems. The biomimetic approach for designing elastin-based recombinant polypeptides offers a versatile and valuable tool for creating protein-based materials with improved properties and advanced functionality.
Article
Biochemistry & Molecular Biology
Paola Sist, Federica Tramer, Antonella Bandiera, Ranieri Urbani, Sara Redensek Trampuz, Vita Dolzan, Sabina Passamonti
Summary: A versatile fluorometric method for nanoscale analysis of bilirubin was developed, allowing sensitive and accurate measurement in small animals and human plasma. The method is highly specific and robust, and can detect differences in bilirubin levels related to sex and genetic polymorphisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonella Bandiera, Laura Colomina-Alfaro, Paola Sist, Giovanna Gomez d'Ayala, Federica Zuppardi, Pierfrancesco Cerruti, Ovidio Catanzano, Sabina Passamonti, Ranieri Urbani
Summary: Genetic engineering allows the creation of new materials and systems with improved capacity to interact with biological systems by manipulating protein properties. Elastin-like polypeptides are tunable recombinant biopolymers that can interact with biological systems due to their thermoresponsive behavior. The biomimetic strategy adopted in the design of new elastin-based recombinant polypeptides is a versatile and valuable tool for developing protein-based materials with improved properties and advanced functionality.
