Article
Cell & Tissue Engineering
Behnoosh Tayebi, Mahnaz Babaahmadi, Mohammad Pakzad, Mostafa Hajinasrollah, Farhad Mostafaei, Shahrbanoo Jahangiri, Amir Kamali, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Seyedeh-Nafiseh Hassani, Ensiyeh Hajizadeh-Saffar
Summary: Mesenchymal stromal cells (MSCs) have shown potential in treating inflammatory and non-inflammatory diseases, but their clinical applications require strict evaluations and monitoring to ensure compliance with safety standards. This study aimed to assess the potential toxicity effects of cryopreserved human bone marrow-derived clonal MSCs in animal models during different time periods.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Fei Xiao, Jianping Peng, Yang Li, Xing Zhou, Ding Ma, Liming Dai, Jie Yuan, Xiaodong Chen, Chuandong Wang
Summary: This study investigated the cellular senescence mechanism of BMSCs and identified the expression changes of small noncoding RNAs during the senescence process, providing potential clues for developing new targeting senescence strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andrea Sorrentino, Emil Malucelli, Francesca Rossi, Concettina Cappadone, Giovanna Farruggia, Claudia Moscheni, Ana J. Perez-Berna, Jose Javier Conesa, Chiara Colletti, Norberto Roveri, Eva Pereiro, Stefano Iotti
Summary: Biomineralization is the process by which living organisms generate organized mineral crystals, especially in human cells the mechanism and propagation of the mineral remain largely unexplained and controversial. This study provides insight into the calcium depositions in human bone mesenchymal stem cells, suggesting a potentially redefined model for biomineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Min Wang, Tianming Dai, Qingqi Meng, Wen Wang, Siming Li
Summary: This study aimed to investigate the regulatory effects of miR-28 on osteogenic differentiation of hBMMSCs. It was found that miR-28 could inhibit STAT1 expression, upregulate AKP and RUNX2 expression, and promote osteogenic differentiation.
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Maria Diniz-da-Costa, Chow-Seng Kong, Katherine J. Fishwick, Thomas Rawlings, Paul J. Brighton, Amelia Hawkes, Joshua Odendaal, Siobhan Quenby, Sascha Ott, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens
Summary: The study identifies a highly proliferative population of mesenchymal cells (hPMC) in midluteal human endometrium, potentially serving as novel decidual precursors; hPMC differ from endometrial stromal cells in the expression of genes for prolactin and other decidual transcription factors, and show signs of differentiation into a decidual subpopulation discovered in early pregnancy; recurrent pregnancy loss is associated with depletion of hPMC.
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Bianca Nowlan, Elizabeth D. Williams, Michael Robert Doran
Summary: The study evaluated the impact of partially humanizing mouse bone marrow with human bone marrow-derived stromal cells on human prostate cancer cell behavior. Results showed that PC-3-DsRed cells preferentially populated bones in mice that had received human BMSC, and there were more bone lesions in these mice.
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Feifei Ni, Tao Zhang, Wanan Xiao, Hong Dong, Jian Gao, YaFeng Liu, Jianjun Li
Summary: The study revealed that IL-18 promotes osteogenic differentiation of hBMSCs through the SLC7A5/c-MYC pathway, suggesting a potential role in fracture healing and providing new treatment strategies for delayed fracture healing after splenectomy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Otorhinolaryngology
Philipp Schendzielorz, Lukas Ilgen, Franz-Tassilo Mueller-Graff, Laurent Noyalet, Johannes Voelker, Johannes Taeger, Rudolf Hagen, Tilmann Neun, Simon Zabler, Daniel Althoff, Kristen Rak
Summary: The study aimed to improve the accuracy of cochlear measurements postoperatively using fpVCT(SECO) technique. Results showed no significant difference in 2TL measurements, while there was a slight underestimation in CDL postoperatively. These findings can provide guidance for electrode selection and frequency mapping.
COCHLEAR IMPLANTS INTERNATIONAL
(2022)
Review
Cell Biology
Linda Bieniussa, Ipsa Jain, Montserrat Bosch Grau, Lukas Juergens, Rudolf Hagen, Carsten Janke, Kristen Rak
Summary: The organ of Corti in the inner ear is responsible for converting auditory signals into neuronal action potentials for processing by the brain. While the role of actin in hearing has been well-studied, this article highlights the importance of microtubules and their regulating mechanisms in the cochlea's function and their implications for hearing research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Surgery
Laurent Noyalet, Lukas Ilgen, Miriam Buerklein, Wafaa Shehata-Dieler, Johannes Taeger, Rudolf Hagen, Tilmann Neun, Simon Zabler, Daniel Althoff, Kristen Rak
Summary: Improved radiological examinations with newly developed 3D models can increase understanding of Meniere's disease (MD). By measuring the angle and length of the vestibular aqueduct (VA) in the temporal bone, and constructing a 3D model to develop the vestibular aqueduct score (VAS), it can be effectively used for diagnostic investigation.
FRONTIERS IN SURGERY
(2022)
Article
Otorhinolaryngology
Fraryz-Tassilo Mueller-Graff, Kristen Rak
Summary: Personalized care is crucial in cochlear implantation. Choosing the right electrode length is important for improved speech understanding. Measurements of cochlear length, especially using radiological imaging, play a significant role in pre- and post-operative evaluation, electrode fitting, and positioning.
LARYNGO-RHINO-OTOLOGIE
(2022)
Article
Audiology & Speech-Language Pathology
Mario Cebulla, David P. Herrmann, Rudolf Hagen, Kristen Rak
Summary: This study compared two methods of stimulus presentation during auditory brainstem response (ABR) measurements with the Vibrant Soundbridge (VSB) implant. Results showed that using the AcoustiAP for stimulus transmission provided minimal signal distortions and had similar performance to the wireless method. Additionally, the new system allowed for a more stable connection to the implant.
AMERICAN JOURNAL OF AUDIOLOGY
(2022)
Article
Clinical Neurology
Linda Bieniussa, Baran Kahraman, Johannes Skornicka, Annemarie Schulte, Johannes Voelker, Sibylle Jablonka, Rudolf Hagen, Kristen Rak
Summary: This study investigated the effect of peg-IGF-1 treatment on the auditory system in the PMN mouse model. The results showed positive effects on OHC synapses and MOC fibers, but no restoration of hearing could be achieved. It suggests that the synaptic pathology of efferent MOC fibers in PMN mice represents a unique form of auditory neuropathy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
David P. Herrmann, Franz-Tassilo Mueller-Graff, Stefan Kaulitz, Mario Cebulla, Anja Kurz, Rudolf Hagen, Tilmann Neun, Kristen Rak
Summary: This study demonstrates the feasibility of using evoked electromyographic (EMG) activation of the facial nerve to monitor the electrode insertion during cochlear implantation (CI). The results show that the EMG response evoked by electrical stimulation from the CI increases as the stimulating contact gets closer to the facial nerve during insertion. After full insertion, the contacts on the apical half of the CI array stimulate higher EMG responses compared to those on the basal half.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Rudolf Hagen, Kristen Rak, Anja Kurz, Wolf-Dieter Baumgartner, Javier Gavilan, Paul van de Heyning
Summary: A platform named HEARRING Counselling 1.0 was developed to help clinicians provide comprehensive information to hearing device candidates regarding their treatment options and establish realistic expectations. The platform has received positive feedback and will be expanded to cover more treatment options.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Otorhinolaryngology
Franz-Tassilo Muller-Graff, Johannes Voelker, Anja Kurz, Rudolf Hagen, Tilmann Neun, Kristen Rak
Summary: The preoperative prediction of electrode position in cochlear implantation can be accurately done using otological planning software and different clinical imaging modalities. High-resolution imaging, such as fpVCT(SECO), is recommended for more accurate predictions.
COCHLEAR IMPLANTS INTERNATIONAL
(2023)
Article
Clinical Neurology
Kristen Rak, Carolina Koestler, Ute Geiger, Stefan Kaulitz, David Herrmann, Wafaa Shehata-Dieler, Rudolf Hagen, Mario Cebulla
Summary: The objective of this study was to investigate the benefit of intraoperative auditory brainstem response (ABR) measurements in revision active middle ear implant surgery. Results showed that the application of ABR measurement improved sound field thresholds and enhanced speech understanding. Analysis revealed a significant correlation between intraoperative gain in ABR threshold and postoperative gain in sound field thresholds. Therefore, ABR monitoring can be a useful tool to improve postoperative hearing success, especially in revision surgeries.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Health Care Sciences & Services
Georg Mathias Sprinzl, Astrid Magele, Philipp Schoerg, Rudolf Hagen, Kristen Rak, Anja Kurz, Paul Van de Heyning, Miryam Calvino, Luis Lassaletta, Javier Gavilan
Summary: This study aims to evaluate the overall benefits of hearing rehabilitation by presenting both audiological and subjective outcomes in one graph using data from an existing study. The graph allows tracking the user's performance over time and visualizing the correlation between different measures.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
Jonas Engert, Bjoern Spahn, Linda Bieniussa, Rudolf Hagen, Kristen Rak, Johannes Voelker
Summary: This study aimed to investigate the neural stem cell potential of the medial geniculate body (MGB). The findings showed that MGB cells exhibited the cardinal features of neural stem cells, including self-renewal, formation of progenitor cells, and differentiation into all neuronal lineage cells. These findings contribute to a better understanding of the development of the auditory pathway.
Article
Clinical Neurology
Cordula Matthies, Laura Zeller, Anja Kurz, Kristen Rak, Rudolf Hagen, Wafaa Shehata-Dieler
Summary: This study provides a new EABR Classification Scheme for ABI surgery based on the analysis of EABR data. The findings show that all 23 subjects had EABR at the final ABI position and experienced auditory sensations at first activation. The most common EABR morphology consisted of two peaks, Classes B and C.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Anja Kurz, David Herrmann, Rudolf Hagen, Kristen Rak
Summary: Anatomy-based fitting (ABF) maps are potentially more effective than conventional clinically based fitting (CBF) methods for cochlear implant (CI) users. ABF maps were created using information from exact electrode contact positions determined by high-resolution computer tomography and clinical fitting software. In a study involving 10 bilateral CI users, the ABF map provided better speech understanding in quiet and noisy environments compared to the CBF map. Participants were more likely to accept the ABF map if their electrode array stimulated the apical region of their cochlea. The self-perceived sound quality with the ABF map was similar to the CBF map. ABF mapping may be an effective tool to compensate for frequency-to-place mismatch in experienced bilateral CI users.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
Jonas Engert, Julia Doll, Barbara Vona, Totta Ehret Kasemo, Bjoern Spahn, Rudolf Hagen, Kristen Rak, Johannes Voelker
Summary: This study investigated the changes in mRNA abundance of genes influencing neural stem cell development and neurogenesis in the rat cochlear nucleus over time. Age- and hearing-specific patterns of changes in mRNA abundance of neurogenically relevant genes were detected. Crucial neurogenic factors with significant and relevant influence on neurogenesis were identified. These findings contribute to a better understanding of the molecular mechanisms underlying the neurogenesis of the auditory pathway.
