Journal
TOXICOLOGY LETTERS
Volume 213, Issue 2, Pages 260-265Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2012.06.012
Keywords
Styrene; Arene oxides; Mercapturic acids; Vinylphenylmercapturic acid; Biological monitoring
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic [2B08051]
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New metabolites of styrene, three isomeric vinylphenylmercapturic acids (2-, 3-, and 4-VPMA), were recently identified by LC-ESI-MS in the urine of mice. In this study, 4-VPMA together with traces of 2- and 3-VPMA were found also in the urine of hand-lamination workers, which were exposed to styrene vapours at concentrations ranging from 23 to 244 mg/m(3). Concentrations of 4-VPMA in these end-of-shift samples were 4.59 +/- 3.64 ng/mL (mean +/- S.D.; n = 10), those found next morning after the work-shift were 2.14 +/- 2.07 ng/mL (mean +/- S.D.; n =10). Strong correlation (R = 0.959) was found in the next-morning samples between concentrations of 4-VPMA and phenylglyoxylic acid, whereas correlations found between 4-VPMA and mandelic acid in both end-of-shift and next-morning samples were much weaker. The excretion of 4-VPMA accounted for only about 3.5 x 10(-4)% of the absorbed dose of styrene. Despite very low metabolic yield, formation of VPMAs clearly indicates occurrence and extent of styrene ring oxidation considered to be a toxicologically relevant metabolic pathway. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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