Article
Public, Environmental & Occupational Health
Sachiko Yamaguchi-Sekino, Masao Taki, Miwa Ikuyo, Kaoru Esaki, Atsuko Aimoto, Kanako Wake, Noriko Kojimahara
Summary: This study assessed the exposure levels to electromagnetic fields among library workers in Japan. It found that the exposure levels were generally low, but there were some cases where the levels exceeded the median by 10 times. These findings provide useful information for future epidemiological studies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Han Luo, Xuyang Xia, Li-Bin Huang, Hyunsu An, Minyuan Cao, Gyeong Dae Kim, Hai-Ning Chen, Wei-Han Zhang, Yang Shu, Xiangyu Kong, Zhixiang Ren, Pei-Heng Li, Yang Liu, Huairong Tang, Ronghao Sun, Chao Li, Bing Bai, Weiguo Jia, Yi Liu, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Yiguo Hu, Jingqiang Zhu, Hong Jiang, Zhihui Li, Carlos Caulin, Jihwan Park, Heng Xu
Summary: This study conducts pan-cancer analysis on 226 samples across 10 solid cancer types, illustrating the commonalities and plasticity of heterogeneous CAFs. It reveals that the activation trajectory of major CAF types is divided into three states, showing distinct interactions with other cell components and correlation with immunotherapy prognosis. Additionally, minor CAF components may originate from other TME components such as endothelial cells and macrophages.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Chien-Ting Wu, Peter Lidsky, Yinghong Xiao, Ivan T. Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, Janos Demeter, Romina J. Bevacqua, Charles A. Chang, Robert L. Whitener, Anna K. Stalder, Bokai Zhu, Han Chen, Yury Goltsev, Alexandar Tzankov, Jayakar Nayak, Garry P. Nolan, Matthias S. Matter, Raul Andino, Peter K. Jackson
Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.
Article
Oncology
Kevin Bi, Meng Xiao He, Ziad Bakouny, Abhay Kanodia, Sara Napolitano, Jingyi Wu, Grace Grimaldi, David A. Braun, Michael S. Cuoco, Angie Mayorga, Laura DelloStritto, Gabrielle Bouchard, John Steinharter, Alok K. Tewari, Natalie Vokes, Erin Shannon, Maxine Sun, Jihye Park, Steven L. Chang, Bradley A. McGregor, Rizwan Haq, Thomas Denize, Sabina Signoretti, Jennifer L. Guerriero, Sebastien Vigneau, Orit Rozenblatt-Rosen, Asaf Rotem, Aviv Regev, Toni K. Choueiri, Eliezer M. Van Allen
Summary: The study shows that immune checkpoint blockade (ICB) remodels the RCC microenvironment and modifies the interplay between cancer and immune cell populations, critical for understanding response and resistance to ICB.
Article
Multidisciplinary Sciences
Huy Q. Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E. Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Haro, Li-Yan Li, Guo-Wei Huang, Joshua J. Breunig, H. Phillip Koeffler, Catherine C. Hedrick, Li-Yan Xu, De-Chen Lin, En-Min Li
Summary: This study utilized single-cell RNA sequencing to characterize the heterogeneous microenvironment of ESCC, identifying a tumor-specific subset of CST1(+) myofibroblasts with prognostic values and immunosuppressive features. The analysis of stromal cell types in the ESCC microenvironment provides a rich resource for further understanding of ESCC biology.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Fang Li, Tiantian Xu, Jiale Li, Xuxu Hao, Wei Ge, Xin Wang
Summary: This study utilized single-cell ATAC sequencing to investigate the chromatin accessibility during mouse hair follicle development, providing insights into the transcriptional regulation mechanism of different cell types.
Article
Cell & Tissue Engineering
Kenneth H. Hu, Nicholas F. Kuhn, Tristan Courau, Jessica Tsui, Bushra Samad, Patrick Ha, Johannes R. Kratz, Alexis J. Combes, Matthew F. Krummel
Summary: This study characterized the coordinated gene expression profiles of single cells during skin wound closure, revealing multicellular movements spanning multiple cell types. It also demonstrated the predictive value of this analysis in identifying gene programs in macrophages and fibroblasts, and found conserved wound healing movements in tumor models and human tumor samples.
Article
Cell Biology
Peter Deak, Bradley Studnitzer, Trevor Ung, Rachel Steinhardt, Melody Swartz, Aaron Esser-Kahn
Summary: In this study, a distinctive subpopulation of dendritic cells (DCs) that respond to pathogen-associated molecular patterns (PAMPs) was isolated and characterized. These cells, known as first responders (FRs), show increased responses to PAMPs and play a role in facilitating adaptive immune responses. Furthermore, they can be selectively targeted by vaccines to modulate antibody and T cell responses in vivo.
Article
Biology
Michael C. Kiritsy, Laurisa M. Ankley, Justin Trombley, Gabrielle P. Huizinga, Audrey E. Lord, Pontus Orning, Roland Elling, Katherine A. Fitzgerald, Andrew J. Olive
Summary: Two parallel pathways, involving GSK3β and MED16, control the expression of MHCII induced by IFNγ, and are essential for CD4(+) T cell activation.
Article
Multidisciplinary Sciences
Juraj Adamik, Paul V. Munson, Deena M. Maurer, Felix J. Hartmann, Sean C. Bendall, Rafael J. Arguello, Lisa H. Butterfield
Summary: This study analyzed the transcriptomic and immune-metabolic profiles of dendritic cells (DCs) from patients with late-stage melanoma. The results suggest that the metabolic profile of DCs is associated with the immunostimulatory potential of cancer vaccines.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Takahiro Nagatake, Yuki Shibata, Sakiko Morimoto, Eri Node, Kento Sawane, So-ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Azusa Saika, Koji Hosomi, Takeshi Tomonaga, Jun Kunisawa
Summary: This study investigated the impact of dietary intake of omega-3 fatty acids on atherosclerosis development and found that supplementing high-fat diet with alpha-linolenic acid-rich linseed oil improved atherosclerosis while inhibiting foam cell formation. The study also revealed a significant increase in the anti-inflammatory metabolite 12-hydroxyeicosapentaenoic acid (12-HEPE) in mice fed with linseed oil, which improved pulsatility and resistive indexes and inhibited macrophage foam cell transformation in a PPARγ-dependent manner.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Valeria Dall'Asta
Summary: This study investigated the effect of the SARS-CoV-2 spike S1 protein on human lung microvascular endothelial cells (HLMVEC), revealing that activation of macrophages by the spike protein can enhance the activation of endothelial cells, potentially contributing to vascular integrity impairment and pro-coagulative endothelium development.
Article
Multidisciplinary Sciences
Mina Baek, Eunyoung Yoo, Hae In Choi, Ga Yeong An, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Summary: The study demonstrates that the BET inhibitor JQ1 can modulate the inflammatory response and migration in LPS-activated human microglia by reducing IRF1 and its target genes, thereby inhibiting microglial migration.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Madoka Koyanagi, Satoshi Imai, Mayuna Matsumoto, Yoko Iguma, Nobuko Kawaguchi-Sakita, Takeshi Kotake, Yuki Iwamitsu, Mpumelelo Ntogwa, Ren Hiraiwa, Kazuki Nagayasu, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara
Summary: The elevated plasma galectin-3 level is a common pathologic change in both humans and mice with CIPN, and targeting galectin-3 is a proposed therapeutic option to delay CIPN progression. Schwann cell-derived galectin-3 plays a pronociceptive role via macrophage infiltration in the pathogenesis of taxane-induced peripheral neuropathy.
Article
Environmental Sciences
Piotr Piszczek, Karolina Wojcik-Piotrowicz, Krzysztof Gil, Jolanta Kaszuba-Zwoinska
Summary: The positive or negative impact of electromagnetic fields (EMF) on living organisms is still a debated topic as results remain inconsistent. The immune system, consisting of various cell types, plays a crucial role in defending the organism against external stressors. Factors that affect immunomodulatory effects can influence the immune response.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Myrtill Simko, Sonja Tischler, Mats-Olof Mattsson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Review
Environmental Sciences
Myrtill Simko, Daniel Remondini, Olga Zeni, Maria Rosaria Scarfi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2016)
Editorial Material
Medicine, Legal
Mats-Olof Mattsson, Myrtill Simko
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2017)
Meeting Abstract
Toxicology
Myrtill Simko
TOXICOLOGY LETTERS
(2017)
Article
Engineering, Electrical & Electronic
Mats-Olof Mattsson, Olga Zeni, Myrtill Simko
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
(2018)
Article
Medicine, Research & Experimental
Myrtill Simko, Mats-Olof Mattsson
MEDICAL HYPOTHESES
(2019)
Editorial Material
Biology
Kenneth R. Foster, Myrtill Simko, Luc Verschaeve
RADIATION RESEARCH
(2019)
Review
Environmental Sciences
Myrtill Simko, Mats-Olof Mattsson
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Editorial Material
Environmental Sciences
Maria Rosaria Scarfi, Mats-Olof Mattsson, Myrtill Simko, Olga Zeni
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Editorial Material
Public, Environmental & Occupational Health
Mats-Olof Mattsson, Myrtill Simko, Maria Rosaria Scarfi, Olga Zeni
FRONTIERS IN PUBLIC HEALTH
(2022)
Proceedings Paper
Computer Science, Hardware & Architecture
Nikolaos Petroulakis, Panos Chatziadam, Mats-Olof Mattsson, Myrtil Simko, Vasileios Theodorou, Andrianos M. Yiorkas, Andreas Gavrielides, Andreas Miaoudakis, Maria Rosaria Scarfi, Olga Zeni
Summary: While Europe faces dramatic changes and challenges, emerging technologies in telecommunications that emit RF electromagnetic field exposure have raised concerns about their effects on human health. The NextGEM Project aims to address these concerns by providing a safe living environment through the NextGEM Knowledge and Innovation Hub, which offers a standardized way for European citizens, regulatory authorities, and the scientific community to access data on EMF and Health.
2022 IEEE CONFERENCE ON STANDARDS FOR COMMUNICATIONS AND NETWORKING, CSCN
(2022)
Review
Engineering, Biomedical
Mats-Olof Mattsson, Myrtill Simko
MEDICAL DEVICES-EVIDENCE AND RESEARCH
(2019)
Review
Public, Environmental & Occupational Health
Maria Manuela Rosado, Myrtill Simko, Mats-Olof Mattsson, Claudio Pioli
FRONTIERS IN PUBLIC HEALTH
(2018)
Review
Public, Environmental & Occupational Health
Olga Zeni, Myrtill Simko, Maria Rosaria Scarfi, Mats-Olof Mattsson
FRONTIERS IN PUBLIC HEALTH
(2017)
Article
Public, Environmental & Occupational Health
Mats-Olof Mattsson, Myrtill Simko
FRONTIERS IN PUBLIC HEALTH
(2014)