Article
Biochemistry & Molecular Biology
Jiali Xiong, Haojie Zhang, Yuxuan Wang, Yunyun Cheng, Junyi Luo, Ting Chen, Qianyun Xi, Jiajie Sun, Yongliang Zhang
Summary: This study discovered the target relationship between rno_circRNA_0001004 and miR-709, and revealed the regulatory role of rno_circRNA_0001004 in pituitary GH synthesis and cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Bradley Reinfeld, Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, Allison S. Cohen, Ahmed Ali, Brian T. Do, Alexander Muir, Caroline A. Lewis, Rachel A. Hongo, Kirsten L. Young, Rachel E. Brown, Vera M. Todd, Tessa Huffstater, Abin Abraham, Richard T. O'Neil, Matthew H. Wilson, Fuxue Xin, M. Noor Tantawy, W. David Merryman, Rachelle W. Johnson, Christopher S. Williams, Emily F. Mason, Frank M. Mason, Katherine E. Beckermann, Matthew G. Vander Heiden, H. Charles Manning, Jeffrey C. Rathmell, W. Kimryn Rathmell
Summary: The study found that in the tumor microenvironment, different cell types have varying abilities to access and consume glucose and glutamine, with nutrient partitioning being programmed in a cell-intrinsic manner through mTORC1 signaling and the expression of genes related to glucose and glutamine metabolism.
Article
Cell Biology
Yiqing Cai, Liemei Lv, Tiange Lu, Mengfei Ding, Zhuoya Yu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang
Summary: Metabolic reprogramming, specifically dysregulation of glutamine metabolism, plays a crucial role in tumorigenesis, microenvironment remodeling, and therapeutic resistance in DLBCL. High levels of glutamine are associated with poor clinical outcomes, while the derivative of glutamine, a-KG, is negatively correlated with invasiveness features. Treatment with DM-aKG significantly inhibits tumor growth by inducing apoptosis and non-apoptotic cell death. The study highlights the potential use of a-KG as a novel therapeutic strategy for DHL patients.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Yuling Liu, Yuanzhou Zhang, Bowen Xiao, Ning Tang, Jingying Hu, Shunshun Liang, Yechun Pang, Huili Xu, Junping Ao, Juan Yang, Xiaofei Liang, Lin Wei, Yunfeng Wang, Xiaoying Luo
Summary: This study revealed that miR-103a may act as a key mediator in the progression of HCC, with its high expression associated with poor prognosis and promoting HCC cell growth and mobility by promoting glucose metabolism and inhibiting cell death. The findings suggest that miR-103a could be a potential therapeutic target for HCC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jingdian Liu, Junwen Wang, Weidong Tian, Yu Xu, Ran Li, Kai Zhao, Chao You, Yuan Zhu, Joerg Walter Bartsch, Hongquan Niu, Huaqiu Zhang, Kai Shu, Ting Lei
Summary: This study demonstrates for the first time that PDCD10 can induce aggressive behaviors of pituitary adenomas by promoting cellular proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) through the CXCR2-AKT/ERK signaling axis.
Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Qi Song, Matthew Ruffalo, Ziv Bar-Joseph
Summary: Inference of global gene regulatory networks from omics data is a long-term goal of systems biology. We developed a new computational method that combines neural networks and multi-task learning to predict RNA velocity rather than gene expression values. Application of our method to atlas scale single cell data from 6 HuBMAP tissues led to several validated and novel predictions and greatly improved on prior methods proposed for this task.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Gastroenterology & Hepatology
Liwen Wang, Yihao Liu, Yuting Dai, Xiaomei Tang, Tong Yin, Chaofu Wang, Ting Wang, Lei Dong, Minmin Shi, Jiejie Qin, Meilin Xue, Yizhi Cao, Jia Liu, Pengyi Liu, Jinyan Huang, Chenlei Wen, Jun Zhang, Zhiwei Xu, Fan Bai, Xiaxing Deng, Chenghong Peng, Hao Chen, Lingxi Jiang, Saijuan Chen, Baiyong Shen
Summary: This study explores the heterogeneity and pro-tumour mechanisms of neutrophils in pancreatic ductal adenocarcinoma (PDAC). The researchers discovered different subpopulations of tumour-associated neutrophils (TANs) associated with prognosis, as well as the glycolytic switch of TANs and the key regulatory factor in polarisation of neutrophils towards a pro-tumour phenotype. Importantly, immunohistochemistry analysis revealed the unfavorable prognostic value of BHLHE40(+) neutrophils in PDAC patients.
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Article
Cell Biology
Xingguang Liu, Tengda Zhao, Zhe Yuan, Shaohua Ge
Summary: This study found that lncRNA-MIR600HG plays a role in regulating glycometabolism and cisplatin resistance in oral squamous cell carcinoma cells by modulating the expression of miR-125a-5p and RNF44.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang
Summary: This study demonstrates that silencing of the CCNB2 gene can inhibit tumor formation and proliferation in nude mice. CCNB2 may accelerate the proliferation and metastasis of hepatocellular carcinoma cells by increasing JAG1 expression.
Article
Cell Biology
Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Goeber, Natalie Walterskirchen, Christine Brostjan, Catharina Mueller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig, Rudolf Oehler
Summary: Sporadic apoptosis of tumour cells in colorectal cancer is associated with poor patient prognosis. Apoptotic cancer cells release chemotactic factors that attract neutrophils, inducing changes in neutrophil phenotype and lifespan and promoting interaction with macrophages in the tumor microenvironment, potentially contributing to an immunologically unfavorable environment.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Andrew D. Weems, Erik S. Welf, Meghan K. Driscoll, Felix Y. Zhou, Hanieh Mazloom-Farsibaf, Bo-Jui Chang, Vasanth S. Murali, Gabriel M. Gihana, Byron G. Weiss, Joseph Chi, Divya Rajendran, Kevin M. Dean, Reto Fiolka, Gaudenz Danuser
Summary: Most human cells require anchorage for survival, and loss of cell-substrate adhesion can result in anoikis, a form of programmed cell death. Blebbing, the formation of small hemispherical plasma membrane protrusions, triggers the formation of signalling hubs that confer anoikis resistance by recruiting septin proteins as scaffolds for mutant NRAS and effectors. These signalling hubs activate pro-survival pathways, such as ERK and PI3K. Inhibition of blebs or septins in detached cells causes mislocalization of NRAS, reduced MAPK and PI3K activity, and cell death. Therefore, blebs play a crucial role in providing robust anoikis resistance.
Article
Plant Sciences
Chun Li, Xin-You Pan, Mingyun Ma, Jun Zhao, Fengda Zhao, Ya-Ping Lv
Summary: In hepatocellular carcinoma, APS inhibits tumor growth, migration, and invasion by suppressing M2 polarization of TAMs.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Monica I. Jimenez-Cordova, Carmen Gonzalez-Horta, Julio C. Ayllon-Vergara, Laura Arreola-Mendoza, Guadalupe Aguilar-Madrid, Efrain E. Villareal-Vega, Angel Barrera-Hernandez, Olivier C. Barbier, Luz M. Del Razo
ENVIRONMENTAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
N. Montes-Castro, I Alvarado-Cruz, L. Torres-Sanchez, I Garcia-Aguiar, A. Barrera-Hernandez, C. Escamilla-Nunez, L. M. Del Razo, B. Quintanilla-Vega
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Cesar G. Toriz, Angel Melo, Carmen Solano-Agama, Edgar Giovanhi Gomez-Dominguez, Ma de los Angeles Martinez-Munoz, Jorge Castaneda-Obeso, Eunice Vera-Aguilar, Elsa Liliana Aguirre-Benitez, Lucero Romero-Aguilar, Margarita Gonzalez-del Pliego, Ismael Jimenez-Estrada, Maricela Luna, Juan Pablo Pardo, Javier Camacho, Maria Eugenia Mendoza-Garrido
Article
Pharmacology & Pharmacy
Jose M. Torres-Arellano, Citlalli Osorio-Yanez, Luz C. Sanchez-Pena, Julio C. Ayllon-Vergara, Laura Arreola-Mendoza, Guadalupe Aguilar-Madrid, Luz M. Del Razo
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
G. A. Martinez-Nava, L. Mendoza-Soto, J. Fernandez-Torres, Y. Zamudio-Cuevas, D. Reyes-Hinojosa, R. Plata-Rodriguez, A. Olivos-Meza, E. A. Ruiz-Huerta, M. A. Armienta-Hernandez, E. Hernandez-Alvarez, B. Vargas-Sandoval, C. Landa-Solis, C. Suarez-Ahedo, O. C. Barbier, J. Narvaez-Morales, L. M. Del Razo, M. C. Camacho-Rea, K. Martinez-Flores
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
J. Fernandez-Torres, Y. Zamudio-Cuevas, G. A. Martinez-Nava, O. G. Aztatzi-Aguilar, M. P. Sierra-Vargas, C. A. Lozada-Perez, C. Suarez-Ahedo, C. Landa-Solis, A. Olivos-Meza, L. M. Del Razo, M. C. Camacho-Rea, K. Martinez-Flores
Summary: Evidence suggests a strong association between moderate to severe OA development and tobacco use, with higher blood Cd concentration triggering oxidative stress and inflammation, favoring cartilage loss. Inhaling Cd through tobacco smoke affects bone mineral density, resulting in OP through a decrease in antioxidant enzymes and promoting bone resorption. Smoking promotes the citrullination process in RA through Cd exposure, as well as increasing oxidative stress and inflammation. Understanding how tobacco use can increase joint damage at the articular level mediated by the toxic metal Cd is crucial for proposing prevention, control, and treatment strategies for diseases like OA, OP, and RA.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Correction
Biochemistry & Molecular Biology
J. Fernandez-Torres, Y. Zamudio-Cuevas, G. A. Martinez-Nava, O. G. Aztatzi-Aguilar, M. P. Sierra-Vargas, C. A. Lozada-Perez, C. Suarez-Ahedo, C. Landa-Solis, A. Olivos-Meza, L. M. Del Razo, M. C. Camacho-Rea, K. Martinez-Flores
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Soledad Solis-Angeles, Cuauhtemoc A. Juarez-Perez, Carmina Jimenez-Ramirez, Alejandro Cabello-Lopez, Guadalupe Aguilar-Madrid, Luz M. Del Razo
Summary: Studies suggest that exposure to lead is associated with inner ear damage and hearing loss. Participants with high blood lead levels showed an increase in hearing threshold, with prestin levels decreasing proportionally. This study is the first to evaluate prestin as a potential biomarker for hearing damage in individuals exposed to lead.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Environmental Sciences
J. Cervini-Silva, E. Palacios, A. Nieto-Camacho, L. C. S. Pena, L. M. del Razo
Summary: This study analyzed the interaction between arsenic and expandable clay minerals (hectorite and nontronite), and found that the higher content of iron in nontronite favored the retention of arsenic. The adsorbed arsenic formed irreversible bonding with the mineral surfaces. This work expanded the understanding of the interaction between arsenic and clay minerals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Jeannett A. Izquierdo-Vega, Manuel Sanchez-Gutierrez, Luz C. Sanchez Pena, Monica Martinez-Acuna, Luz M. Del Razo
Summary: This study aimed to investigate the risks of inorganic arsenic (iAs) and fluoride (iF) exposure among residents in Tula de Allende municipality, Hidalgo, Mexico. The findings indicate that high concentrations of iAs and iF in water pose a threat to the overall health and carcinogenic risk for both children and adults. Government intervention is necessary to mitigate these exposures.
WATER AIR AND SOIL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Marvin Paz-Sabillon, Luisa Torres-Sanchez, Maricela Pina-Pozas, Luz M. Del Razo, Betzabet Quintanilla-Vega
Summary: In recent years, the level of environmental pollutants, including metals, has increased. Early-life exposure to pollutants may lead to genetic or epigenetic changes that influence susceptibility to chronic diseases in adulthood. This review aimed to identify the association between prenatal and early postnatal exposure to potentially toxic metals (PTMs) and their adverse effects on offspring's genetic material. A systematic review was conducted, and 57 articles were included, with most focusing on prenatal exposure. The most commonly evaluated PTMs were As, Cd, and Pb. Adverse effects associated with PTM prenatal exposure included alterations in telomere length, gene or protein expression, mitochondrial DNA content, metabolomics, DNA damage, and epigenetic modifications.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Toxicology
Wendy L. Gonzalez-Alfonso, Petrosyan Pavel, Hernandez-Mercado Karina, Luz M. Del Razo, Luz C. Sanchez-Pena, Angelica Zepeda, Maria E. Gonsebatt
Summary: Exposure to toxic elements in drinking water, such as arsenic (As) and fluoride (F), can lead to memory and learning deficits in children. Rodent studies have shown that these neurotoxic effects are due to disruption of redox balance and synaptic transmission. Chronic exposure to As and F in drinking water resulted in reduced GSH levels, altered gene expression, and memory impairment in mice.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luz C. Sanchez Pena, Angel Barrera Hernandez, Luz M. Del Razo
Summary: The study aimed to determine the effect of fluoride exposure on the methylation patterns of inorganic arsenic in urine and tissues. Female C57BL/6 mice were divided into four groups and exposed to purified water (control), arsenite 1 mg/L, fluoride 50 mg/L, and arsenite & fluoride 1:50 mg/L through drinking water for 10 days. The results showed a significant decrease in arsenic species concentrations and altered proportions in tissues and urine in the coexposure group, indicating that fluoride exposure reduces arsenic disposition and alters methylation capacity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jonathan Guerrero-Arroyo, Monica I. Jimenez-Cordova, Octavio G. Aztatzi-Aguilar, Luz M. Del Razo
Summary: This study evaluated the impact of fluoride exposure on placental alterations in a rat model simulating conditions in endemic areas. The results showed that fluoride exposure led to morpho-structural changes in the placenta, with a non-linear relationship to exposure dose. Additionally, a significant increase in fluoride concentration in placental tissue was observed, as well as higher levels of MDA and VEGF-A in the lower dose group. The study also found an increase in placental zone thickness and a decrease in vascular density in the fluoride-exposed groups.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Urology & Nephrology
Manolo Ortega-Romero, Monica I. Jimenez-Cordova, Angel Barrera-Hernandez, Maria Eugenia Sepulveda-Gonzalez, Juana Narvaez-Morales, Guadalupe Aguilar-Madrid, Cuauhtemoc Arturo Juarez-Perez, Luz Maria Del Razo, Maria Del Carmen Cruz-Angulo, Pablo Mendez-Hernandez, Mara Medeiros, Olivier Christophe Barbier
Summary: The study aimed to evaluate the relationship between exposure to environmental pollutants and early kidney damage biomarkers. The results showed that urinary fluoride, vanadium, and total arsenic were significantly correlated with estimated glomerular filtration rate and albumin/creatinine ratio, suggesting a potential association between environmental factors and pediatric kidney damage.
JOURNAL OF NEPHROLOGY
(2023)