Article
Engineering, Environmental
Shuang Wang, Chenglong Ji, Fei Li, Junfei Zhan, Tao Sun, Jianhui Tang, Huifeng Wu
Summary: The study evaluated the reproductive endocrine-disrupting effects of TBBPA on mussels, showing that TBBPA treatment promotes gametogenesis and alters vertebrate sex hormone levels in mussels, while also affecting the transcription levels of SULT1E1 and STS. These findings provide new insights into assessing the impact of TBBPA and monitoring TBBPA in the marine environment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Anh Quoc Hoang, Daichi Aono, Isao Watanabe, Michinobu Kuwae, Tatsuya Kunisue, Shin Takahashi
Summary: The study investigated the contamination levels and temporal trends of PBDEs and alternative BFRs in a dated sediment core from Beppu Bay, Japan. Decabromodiphenyl ether (BDE-209) was found to be the most abundant congener, while decabromodiphenyl ethane (DBDPE) showed significant levels as a replacement of deca-BDE. The ratios of DBDPE to BDE-209 gradually increased during the time period, indicating opposite trends of these compounds.
Article
Environmental Sciences
Esther Smollich, Malte Bueter, Gerhard Schertzinger, Elke Dopp, Bernd Sures
Summary: The ecotoxicological effects of photolytic degradation mixtures of two brominated flame retardants, PolymericFR and TBBPA-BDBMPE, were studied in vitro and in vivo. The degradation of both substances under UV-exposure caused changes in their ecotoxicological potential. Short-term exposure to the degraded flame retardants resulted in physiological reactions of the annelid, while chronic exposure did not affect the growth, reproduction, fragmentation, and energy storage of the annelid.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Rui Wan, Xiaoxiao Li, Yunyi Zha, Xiong Zheng, Haining Huang, Minghui Li
Summary: This study revealed the influence of decabromodiphenyl ether (BDE-209) on denitrification process for the first time. BDE-209 caused a decrease in denitrification efficiency and the production of harmful substances, and these inhibitory effects were enhanced with increasing exposure duration and concentration. However, BDE-209 had insignificant effects on the global abundance of denitrifying bacteria, mainly due to microbial exchange with the overlying water.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Tian Chen, Xueting Wang, Jiaxin Jia, Dejun Wang, Yanxin Gao, Xin Yang, Shixuan Zhang, Piye Niu, Zhixiong Shi
Summary: This study investigated the changes in mtDNA copy number in populations exposed to decabrominated diphenyl ether (BDE-209) and its substitute decabromodiphenyl ethane (DBDPE), and found that these flame retardants may affect mitochondrial function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Anna Chen, Chengkang Chen, Shaoxuan Zhang, Li Li, Zhizhen Zhang, Jiazhe Chen, Qiaonan Jing, Jianguo Liu
Summary: This study estimated the temporal variance of DBDPE emissions and environmental concentrations in five regions of China from 2006 to 2026 using the PRODUCTION-To-EXPOSURE (PROTEX) mass balance model. The results showed that Guangdong Province and Shandong Province were the major hotspots of DBDPE pollution in China. The DBDPE concentrations in indoor and outdoor environments increased substantially in all regions during 2006-2021. These findings have significant implications for risk assessment and contamination mitigation actions.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Weilong Xing, Liangchen Zhong, Wen Gu, Mengyuan Liang, Lei Wang, Zhen Wang, Lili Shi, Shuai Sun
Summary: Surface soil and river sediment samples were collected from the downstream of Chuhe River basin in East China to investigate the occurrence and accumulation characteristics of legacy and novel brominated flame retardants (NBFRs). The concentrations of BDE-209 and nine NBFRs ranged from n.d. to 41.4 ng/g dw and from 0.29 to 19.73 ng/g dw in the collected samples. BTBPE was the predominant NBFR in both soil and sediment samples. The calculated concentration ratios of the total of the nine NBFRs to BDE-209 in most of the analyzed samples exceeded 1, indicating a clear shift from legacy brominated flame retardants to NBFRs in the downstream of Chuhe River basin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Wanlun Li, Shutao Wang, Yangyang Chen, Lu Liu, Shuying Hou, Hong You
Summary: This study investigated the toxicological molecular mechanisms of Pleurotus ostreatus during the biodegradation of Decabromodiphenyl ethane (DBDPE). Transcriptome and proteome analysis revealed differentially expressed genes and proteins involved in cellular processes, metabolic processes, oxidation-reduction processes, and membrane-related functions. Key enzymes associated with oxidative phosphorylation and the tricarboxylic acid cycle were down-regulated by DBDPE exposure. Cytochrome P450 enzymes and stress proteins were induced to participate in DBDPE degradation and resist its toxicity. These findings contribute to a better understanding of the effects of DBDPE on P. ostreatus and provide insights for improving DBDPE removal.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Rui Wang, Hongguang Cheng, Yiwei Gong, Tao Huang
Summary: As an alternative to PBDEs, DBDPE has become one of the most important NBFRs. Little is known about its environmental fate. Sediments are the main sink for DBDPE. Worldwide concentration data show that DBDPE concentrations in sediments have rapidly increased, especially in China's e-waste dismantling area. DBDPE is replacing BDE-209 as one of the most dominant NBFRs in the environment. It can enter the human body through contaminated seafood and the food chain, and can exhibit toxicity in organisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Joelma Leao-Buchir, Tugstenio Lima de Souza, Claudemir de Souza, Luis Fernando Favaro, Patricia Manuitt Brito, Milena Carvalho Carneiro, Bruna Hilzendeger Marcon, Luise Esquivel, Ciro Alberto de Oliveira Ribeiro, Maritana Mela Prodocimo
Summary: The study investigated the effects of BDE-99 on Oreochromis niloticus, and found that it caused histopathological changes in the liver and kidney, increased acetylcholinesterase activity in muscle, disrupted the antioxidant system in the liver and brain, and decreased plasmatic levels of vitellogenin in females.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Juan Manuel Perez-Iglesias, Patricia Gonzalez, Mirian Roxana Calderon, Guillermo Sebastian Natale, Cesar Americo Almeida
Summary: In recent years, there has been increasing concern about the adverse effects of polybrominated diphenyl ethers (PBDEs), especially BDE-209, on health and the environment. This study conducted a toxicological study on mosquitofish using BDE-209 and found that it had biochemical, cytotoxic, neurotoxic, and genotoxic potential on the species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Brigid Carr, Pere Masque, Carlos M. Alonso-Hernandez, David Huertas, Philippe Bersuder, Imma Tolosa
Summary: This study analyzed sediment from Cienfuegos Bay, Cuba to examine the occurrence of organic pollutants from 1990 to 2015. The results showed the presence of regulated contaminants such as PCBs, OCPs, and PBDEs, with a decline in PCB contamination since 2007. Emerging contaminants, including PAEs, OPEs, and aHFRs, showed sharp increases, possibly due to the growing global usage of flame retardants and plasticizer additives. Local sources, such as a plastic recycling plant and urban waste outfalls, may contribute to these trends. Further research is needed to understand the influx of these emerging contaminants.
Article
Chemistry, Analytical
Zijuan Peng, Mingwu Shao, Miao Yu, Boling Lu, Xingchen Zhao, Penghui Li, Shanjun Song, Qian Liu, Tao Zhou, Qinghe Zhang
Summary: A novel approach using solubility parameters as indicators for the extraction of additives in plastic products was developed and verified in various plastic materials. The results demonstrated the accuracy and feasibility of this method for field sample analysis.
ANALYTICAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Yi Wang, Xinpei Wang, Shaofeng Sui, Zhiyan Liu
Summary: BDE209, an industrial flame retardant, has been found to increase in human serum. Its structural similarity to thyroid hormones raises concerns about its toxic effects on the thyroid. Studies have shown that BDE209 may have toxic effects on thyroid function and tumorigenesis, but the exact pathway of thyroid toxicity remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Qing Wen, Xinni Xie, Qidong Ren, Yuguo Du
Summary: This study investigates the effects of PBDE 99 on adipocyte commitment and adipogenesis. PBDE 99 was found to enhance adipocyte commitment and promote adipogenesis in MSCs, possibly through inhibiting Hedgehog signaling.
Article
Engineering, Environmental
Chang He, Louise van Mourik, Shaoyu Tang, Phong Thai, Xianyu Wang, Sicco H. Brandsma, Pim E. G. Leonards, Kevin V. Thomas, Jochen F. Mueller
Summary: This study investigates the in vitro biotransformation of CPs by human liver fractions, which resulted in a decrease in CP concentrations. Ketones were identified as potential products of CP biotransformation, particularly for long-chain CPs. The ketone products may serve as biomarkers for CP exposure in biomonitoring studies.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Louise M. van Mourik, Elwin Janssen, Robin Breeuwer, Willem Jonker, Jacco Koekkoek, Arif Arrahman, Jeroen Kool, Pim E. G. Leonards
Summary: This study demonstrates the successful application of analyzing a whole gas chromatography (GC) chromatogram by nuclear magnetic resonance (NMR) spectroscopy using a continuous repeatable and stable high-resolution (HR) GC fractionation platform. The study shows the potential for separating, purifying, and enriching isomers in complex substances from a whole GC chromatogram, facilitating NMR analysis. Using a chlorinated paraffin (CP) mixture as a model substance, important information was obtained for unravelling their full structure from NMR spectra of all collected fractions.
ANALYTICAL CHEMISTRY
(2021)
Article
Reproductive Biology
Javier Esteban, Ismael Sanchez-Perez, Gerd Hamscher, Hanna M. Miettinen, Merja Korkalainen, Matti Viluksela, Raimo Pohjanvirta, Helen Hakansson
Summary: The study indicates that AHR and TCDD have significant effects on the retinoid system, with differences in impact based on sex among wild-type mice, and variations in concentrations of different retinoid forms in the liver, kidneys, and blood.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raimo Pohjanvirta, Ira Karppinen, Suylen Galban-Velazquez, Javier Esteban, Helen Hakansson, Satu Sankari, Jere Linden
Summary: Studies have shown that AHR is essential for the development of obesity and steatohepatitis, and AHRKO rats display different weight development and biochemical/genetic profiles compared to wildtype rats.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Reproductive Biology
A. Vieira Silva, I. Chu, M. Feeley, A. Bergman, H. Hakansson, M. Oberg
Summary: The toxicity of PCB-156 was investigated in rats and it was found to cause dose-dependent increases in liver, lung, and kidney weights, as well as enzyme activities and uroporphyrin concentration in the liver. Dose-dependent decreases were observed in body weight, thymus weight, and apolar retinoid concentrations. Histopathological examination showed dose-related changes in the liver, thyroid, and thymus. A LOAEL of 0.01 ppm was established based on reduced apolar liver retinoid concentration. These findings suggest that retinoid endpoints should be further studied for their causal relationship to PCB-induced liver toxicity.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Environmental Sciences
G. F. Whale, M. Hjort, C. Di Paolo, A. D. Redman, J. F. Postma, J. Legradi, P. E. G. Leonards
Summary: This study focused on the potential effects of effluent composition, particularly hydrocarbons, on aquatic toxicity in oil refineries. The research found that measured bioavailable hydrocarbons using BESPME correlated with responses in standard bioassays, confirming the relevance of bioassays and the importance of BE-SPME measurement in toxicity identification. Overall, the study suggests that oil refinery effluents treated in accordance with EU regulations have low to negligible toxicity to aquatic organisms.
Article
Reproductive Biology
Maria Herlin, Ismael Sanchez-Perez, Javier Esteban, Merja Korkalainen, Xavier Barber, Mikko A. J. Finnila, Gerd Hamscher, Bertrand Joseph, Matti Viluksela, Helen Hakansson
Summary: The study revealed that exposure to TCDD affects bone and retinoid systems, leading to increased retinol concentrations in the blood and altered bone mineral density in mice. TCDD disrupted gene expression related to osteoblast differentiation and retinoic acid metabolism, resulting in higher cellular retinoic acid levels.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Environmental Sciences
Mengmeng Xu, Jessica Legradi, Pim Leonards
Summary: This study provides detailed information on the impact of PFHxS exposure on lipid regulation in zebrafish embryos, showing dysregulation of lipid metabolism, oxidative stress, inflammation, and impaired fatty acid beta-oxidation. The significant changes in lipids suggest that PFHxS exposure leads to remodeling of glycerophospholipid composition with altered incorporation of omega-3 and omega-6 polyunsaturated fatty acids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Sicco H. Brandsma, Pim E. G. Leonards, Jacco C. Koekkoek, Jiri Samsonek, Franky Puype
Summary: This study evaluated the migration of brominated flame retardants (BFRs), phosphate flame retardants (PFRs), bisphenols (BPA, BPF), and phthalate ester-based plasticizers from recycled polymeric toy material, and calculated the daily intake values. The results showed that these chemicals migrated into saliva, but the intake levels did not exceed the tolerable daily intake.
Article
Engineering, Environmental
Ike van der Veen, Steffen Schellenberger, Anne-Charlotte Hanning, Ann Stare, Jacob de Boer, Jana M. Weiss, Pim E. G. Leonards
Summary: This study assessed the effects of aging, washing, and tumble drying on the concentration of PFASs in DWR coatings on outdoor clothing. The results showed that aging increased PFAS concentration and formation, while washing decreased PFAA concentrations and partly washed out volatile PFASs from the textiles. Tumble drying did not affect PFAS concentrations in textiles.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Johan Gustafsson, Jessica Legradi, Marja H. Lamoree, Lillemor Asplund, Pim E. G. Leonards
Summary: This study is the first to focus on the effects of OH-PBDEs at the metabolite level in vivo and uses metabolomics to investigate the metabolic effects of exposure to OH-PBDEs. The results suggest that OH-PBDEs may disrupt energy metabolism, neurotoxicity, and potential immunotoxicity, and different compounds have different metabolic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Maurice de Jonker, Pim E. G. Leonards, Marja H. Lamoree, Sicco H. Brandsma
Summary: A novel method using AP-MALDI coupled with qTOF-MS was developed for fast-screening analysis of additives in electronics and plastic consumer products. A GNP-doped target plate was developed to simplify sample preparation and increase sample throughput. The method showed high desorption/ionization capability for low molecular weight molecules and identified 56 additives in various products. The identification of certain additives in plastic toys suggests their recycling from electronic waste.
Article
Environmental Sciences
Mengmeng Xu, Jessica Legradi, Pim Leonards
Summary: This study provides detailed insights into the toxic mechanism of PFHxS, showing time and concentration-dependent bioaccumulation in zebrafish embryos and adverse effects on fatty acid oxidation, sugar metabolism, and other metabolic pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Roxana Suhring, Philipp Mayer, Pim Leonards, Matthew MacLeod
Summary: The environmental risk assessment of UVCBs is challenging due to their complexity, but an in silico fate-directed risk assessment framework can provide quantitative information on the impact of unknown constituents on the environmental risk of the entire UVCB. In the case of cedarwood oil, a risk assessment based on known constituents was found to be representative for the environmental risk of the entire UVCB, reducing the need for additional testing.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2022)
Article
Engineering, Environmental
Carolina N. Perez, Florence Carre, Amelie Hoarau-Belkhiri, Audrey H. Joris, Pim E. G. Leonards, Marja H. Lamoree
Summary: This review comprehensively summarizes the emerging techniques and state-of-the-art methods for extracting, analyzing, and characterizing microplastics (MPs) in soil. A wide range of concentrations of MPs in soil has been observed globally, mainly limited to China. The review also addresses the validation of analytical methods, quality assurance/quality control procedures, and recommendations for future research.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
