Article
Chemistry, Organic
Rui Chen, Rongchen Wang, Jie Sun, Xuemei Dong, Chengjun Dong, Lixin Sun, Xianfeng Gu, Chunchang Zhao
Summary: An H2O2-activated, endoplasmic reticulum-targeted theranostic probe was developed, which can be activated by H2O2, leading to increased NIR fluorescence and photothermal signals for specific recognition of H2O2 and further photothermal therapy in H2O2-overexpressing cancer cells in the endoplasmic reticulum.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Plant Sciences
Nadiyah M. Alabdallah, Md. Mahadi Hasan, Ines Hammami, Azzah Ibrahim Alghamdi, Dikhnah Alshehri, Hanan Ali Alatawi
Summary: Metal oxide nanoparticles are critical tools for overcoming crop productivity challenges, boosting crop production and resistance to abiotic stresses such as drought. They enhance osmotic adaptation and crop water balance by mitigating drought-induced reactive oxygen species. The impacts of different forms, features, and dosages of MONPs on plant growth and development under drought stress are summarized and discussed in this review.
Article
Biochemistry & Molecular Biology
Olivia Koufos, Ryan J. Mailloux
Summary: Dihydroorotate dehydrogenase (DHODH) is involved in pyrimidine biosynthesis and can be inhibited by S-glutathionylation, which is a negative feedback loop for hydrogen peroxide (H2O2) production. This redox modification can be influenced by sex differences in liver mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Fanai Lalsangpuii, Samuel Lalthazuala Rokhum, Fanai Nghakliana, Lal Fakawmi, Joseph V. L. Ruatpuia, Esther Laltlanmawii, Ralte Lalfakzuala, Zothan Siama
Summary: This study describes the green synthesis of silver nanoparticles using Spilanthes acmella leaf extract and its potential usage in mitigating the toxicity caused by doxorubicin. The synthesized silver nanoparticles showed spherical shape, confirmed by scanning electron microscope analysis, and possessed higher free-radical scavenging activities compared to the leaf extract. Additionally, the silver nanoparticles exhibited inhibitory effects against erythrocyte hemolysis and lipid peroxidation.
Article
Biochemistry & Molecular Biology
Andras Ballo, Peter Czetany, Kinga Szekvari Busznyakne, Laszlo Mark, Nora Mike, Attila Torok, Arpad Szanto, Gabor Mate
Summary: The incidence of infertility varies between regions, affecting an average of 15% of couples and 10-12% of men worldwide. Oxidative stress is closely associated with infertility, especially poor semen quality. However, there is currently no accepted protocol for diagnosing and treating oxidative stress in andrology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Xia Zhang, Li Zhang, Xinyan Cheng, Shudi Liu, Shujing Fang, Liangwei Zhang, Xiaoyan Wang, Lingxin Chen
Summary: Mercury is a toxic heavy metal pollutant that induces oxidative stress and hypoxia stress. Excessive H2O2 can trigger oxidative stress. There is a need for powerful tools to study H2O2 fluctuations under mercury stress.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Cell Biology
Steffi Goffart, Petra Tikkanen, Craig Michell, Trevor Wilson, Jaakko L. O. Pohjoismaki
Summary: This study found that different oxidants elicit different responses in HEK293T cells, and acute oxidative stress does not universally induce DNA repair or antioxidant defense mechanisms. Additionally, cells previously exposed to oxidative stress show adaptive changes in their responses when stress is renewed.
Article
Chemistry, Analytical
Mingxiu Wang, Feng Zhang, Cai-Qi Wang, Nan Yin, Yuting Wang, Guixin Qin, Qingling Xu, Jianhua Gong, Huizhen Liu, Xinrui Duan
Summary: Abnormal production of H2O2 is associated with cancer. It is crucial to develop fluorescent probes that can selectively image basal H2O2 in tumor cells. We have successfully developed a fluorescent probe, BBHP, which contains benzil as a recognition site for H2O2 and biotin as a target binding motif. BBHP enables a selective fluorescence turn-on response to H2O2 and can sufficiently image basal H2O2 in biotin receptor-positive cancer cells and tumor tissues.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaoxiao Li, Xiaoyan Duan, Peng Yang, Lu Li, Bo Tang
Summary: In this study, robust surface-enhanced Raman spectroscopy (SERS) nanoprobes based on Au nanoparticles were developed for monitoring mitochondrial H2O2 in living cells, showing superior performance compared to traditional nanoprobes.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Yuting Wang, Huming Yan, Yongkang Yue, Yongbin Zhang, Fangjun Huo, Fangqin Cheng, Caixia Yin
Summary: Ferroptosis, a type of cell death caused by lipid peroxidation, is closely related to the development of tumors, ischemia-reperfusion injury, and other diseases. It involves the accumulation of reactive oxygen species and thiols, which promote or inhibit ferroptosis. Understanding the dynamic correlation between reactive oxygen species and active sulfur in these pathways is crucial for revealing the regulation mechanism of ferroptosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yunfeng Yan, Xiaofei Huang, Yao Zhou, Jingyi Li, Feiyun Liu, Xueying Li, Xiaotao Hu, Jing Wang, Lingyan Guo, Renning Liu, Naoki Takaya, Shengmin Zhou
Summary: In Aspergillus nidulans, the peroxiredoxin (PrxA) plays a crucial role in protecting dormant conidia against high levels of H2O2, while catalase (CatB) becomes the main antioxidant during the mature hyphae stage. CatB needs to be secreted to function, and this process is limited to the mature hyphae stage.
Article
Environmental Sciences
Leila Lemos, Laura Gantiva, Catherine Kaylor, Alessandra Sanchez, Natalia Quinete
Summary: This study assessed the exposure of per- and polyfluoroalkyl substances (PFAS) and phthalate esters (PAEs) in American oysters collected from three study sites in Florida. The results showed that all tested PFAS and PAEs compounds were detected in at least one oyster at each site. The oysters from Biscayne Bay exhibited the highest concentrations of PFAS and PAEs, while the oysters from Marco Island displayed the highest levels of lipid peroxidation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Rongrong Zhou, Qiyao Peng, Dan Wan, Chao Yu, Yuan Zhang, Yi Hou, Quan Luo, Xiong Li, Shuihan Zhang, Lin Xie, Pinghua Ou, Yongbo Peng
Summary: A new lysosome-targeting fluorescent probe NPT-H2O2 was developed for ratiometric detection and imaging of H2O2, especially in lysosomes and inflammation models. The probe exhibited rapid response, high selectivity and sensitivity towards H2O2, along with low cytotoxicity. The results suggest that this probe can serve as a powerful tool to investigate the physiological and pathological relationship between inflammation and lysosomal H2O2.
Article
Chemistry, Multidisciplinary
Rakesh Ruchel Khanikar, Monalisa Kalita, Parismita Kalita, Bhaswati Kashyap, Santanu Das, Mojibur R. Khan, Heremba Bailung, Kamatchi Sankaranarayanan
Summary: This study demonstrates that cold atmospheric pressure plasma treatment can deactivate the SARS-CoV-2 spike protein and degrade the RNA of the virus. The deactivation of spike protein binding is correlated with the higher concentration of hydrogen peroxide formation due to the interaction with reactive oxygen species in the plasma. This green process, using noble gases to generate reactive oxygen species, shows potential for designing disinfection systems and biomedical applications.
Article
Biotechnology & Applied Microbiology
Feng Liu, Rui Min, Jie Hong, Guangqin Cheng, Yongqian Zhang, Yulin Deng
Summary: The study investigated the impact of endogenous oxidative stress caused by submicromolar hydrogen peroxide in a mutant strain of E. coli. Through label-free quantitative proteomic analysis, 265 differentially expressed proteins were identified, activating DNA repair and cellular antioxidant signaling pathways. These findings highlight the role of oxidative signaling and the potential of mutant E. coli as a cell model for studying oxidative stress effects.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
