Article
Pharmacology & Pharmacy
Adria Farras, Montserrat Mitjans, Filippo Maggi, Giovanni Caprioli, Maria Pilar Vinardell, Victor Lopez
Summary: P. vulgare, a common fern in Europe, contains polyphenolic compounds in its fronds which show cytoprotective and cellular repair activity in vitro. The extract is not cytotoxic at physiological concentrations and could be a potential candidate for pharmaceutical applications and as food ingredients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Mercedes Garcia-Gil, Benedetta Turri, Morena Gabriele, Laura Pucci, Alessandro Agnarelli, Michele Lai, Giulia Freer, Mauro Pistello, Robert Vignali, Renata Batistoni, Silvia Marracci
Summary: The study showed that specific combinations of PRO/GEM can induce cytotoxic effects in pancreatic tumor cells but have cytoprotective or no effects in non-tumor human dermal fibroblasts.
Article
Food Science & Technology
Pamela Gallegos-Alcala, Mariela Jimenez, Daniel Cervantes-Garcia, Laura Elena Cordova-Davalos, Irma Gonzalez-Curiel, Eva Salinas
Summary: In this study, it was found that glycomacropeptide (GMP) has anti-inflammatory and antioxidative properties on HaCaT keratinocytes in an in vitro model of atopic dermatitis. Furthermore, GMP stimulated cell proliferation and migration, suggesting its potential therapeutic use in wound healing.
Article
Horticulture
Adria Farras, Victor Lopez, Filippo Maggi, Giovanni Caprioli, Maria Pilar Vinardell, Montserrat Mitjans
Summary: This study screened polyphenolic compounds from Asplenium adiantum-nigrum L. fronds and evaluated their in vitro activities. The results showed that the extract had strong antioxidant and cytoprotective effects without cytotoxicity, and it did not cause phototoxicity under specific conditions.
Article
Environmental Sciences
Martin McLaughlin, Manuela A. Gilea, Martyn J. Earle, Kenneth R. Seddon, Brendan F. Gilmore, Stephen A. Kelly
Summary: The study found that ILs with longer alkyl chains exhibited greater biocidal activity at relevant concentrations, comparable to commonly used biocides. The primary cytotoxic mechanism was determined to be necrosis, with apoptosis observed at lower concentrations. The modification of anion significantly affected cytotoxicity, indicating that cytotoxicity may be a tuneable property when using ILs as biocides.
Article
Chemistry, Multidisciplinary
Fariba Saadati, Walison Augusto da Silva Brito, Steffen Emmert, Sander Bekeschus
Summary: Research suggests that nano- and micro-plastic particles (NMPPs) may pose a potential threat to human health. In this study, non-malignant HaCaT keratinocytes were exposed to different types, concentrations, and sizes of polystyrene (PS) and poly methyl methacrylate (PMMA) particles to determine their ability to induce micronuclei (MN) formation. The results showed that most non-charged polymer particles were neither toxic nor genotoxic, while aminated particles were toxic but not genotoxic.
Article
Food Science & Technology
Menglei Wang, Huanxin Zheng, Jiawen Chen, Yingmei Tang, Meixin Feng, Li Li
Summary: This study evaluated the toxicity risk of ZnO NPs in the treatment of inflammatory skin diseases. The results showed that ZnO NPs can activate protective cell autophagy and reduce the viability of inflammatory skin cells. The TRIM16-NRF2-p62 pathway plays a key role in the blockade of autophagy flux and the reduction of cell viability mediated by ZnO NPs.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Sulaiman A. Al Yousef
Summary: Asparaginase plays a crucial role in leukemia treatment as part of chemotherapy. It is isolated from Fusarium sp. and characterized as a metalloprotease with specific inhibitory and activating effects on different ions and substrates. The enzyme also exhibits antileukemic activity with a potential as a chemotherapeutic agent.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jiajia Zhong, Wenjie Yu, Yuzhao Tang, Xiaojie Zhou
Summary: This research utilized SR-FTIR microspectroscopy to investigate the biomolecular alterations in WRL68 cells induced by vincristine treatment. The results revealed changes in lipid structures, decreased protein alpha-helical content, and decreased nucleic acid content in vincristine-treated WRL68 cells.
Article
Oncology
Cristian Urla, Irene Corteletti, Ann-Sophie Raible, Rupert Handgretinger, Jorg Fuchs, Steven W. Warmann, Evi Schmid
Summary: This study found that combined treatment of D,L-methadone with doxorubicin, carboplatin, and vincristine had strong antitumor effects on pediatric rhabdomyosarcoma (RMS) cell lines. These effects were mediated by increased ROS production and up-regulation of caspase-3/7 activity. The combination of D,L-methadone with doxorubicin significantly reduced cell migration in both cell lines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Beatriz Salesa, Angel Serrano-Aroca
Summary: The study revealed that multi-layer graphene oxide shows time-concentration dependence and has potential biomedical applications in human keratinocyte cells. Compared to few-layer graphene oxide, multi-layer graphene oxide at non-cytotoxic concentrations had positive effects on gene expression in HaCaT cells.
Article
Dentistry, Oral Surgery & Medicine
Heitor Ceolin Araujo, Juliano Pelim Pessan, Anne Caroline Morais Caldeira, Caio Sampaio, Marcelo Jose dos Santos Oliveira, Douglas Henrique Sales, Silvio Rainho Teixeira, Carlos Jose Leopoldo Constantino, Alberto Carlos Botazzo Delbem, Sandra Helena Penha Oliveira, Gordon Ramage, Douglas Roberto Monteiro
Summary: This study developed and characterized a dual nanocarrier of chlorhexidine and fluconazole, and evaluated its antibiofilm and cytotoxic effects. The results showed that the dual nanocarrier had superior antibiofilm effects compared to the combination of chlorhexidine and fluconazole, without increasing cytotoxicity.
JOURNAL OF DENTISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kirilka Mladenova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Svetla Petrova, Jordan Doumanov, Irini Doytchinova
Summary: Compound 4b, similar to GAL, exhibits cytoprotective effects against Aβ cytotoxicity, while compound 8 and CU enhance the toxic effects of Aβ. Allosteric stimulation of alpha 7 nAChRs is suggested as a possible mechanism for the cytoprotectivity of 4b.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Marijana Vicic, Vlatka Sotosek, Ines Brajac, Marija Kastelan, Larisa Prpic-Massari
Summary: Lichen planus is a chronic mucocutanous disorder where cytotoxic lymphocytes attack basal keratinocytes leading to apoptosis. The article hypothesizes that granulysin molecule may play a crucial role in keratinocytes killing in lichen planus.
MEDICAL HYPOTHESES
(2021)
Article
Chemistry, Physical
Walter de Souza Tavares, Manuel Martin Pastor, Lourdes Perez, Maria del Carmen Moran, Francisco Fabio Oliveira de Sousa
Summary: In this study, zein nanoparticles loaded with ellagic acid (EA) were prepared using a nanoprecipitation method. The nanoparticles were spherical, homogeneous, and monodisperse with a size of 370 nm and encapsulation efficiency of over 82%. The results demonstrated that the EA-loaded zein nanoparticles exhibited excellent skin protection and repairing abilities, inhibitory effects on multiple skin enzymes, no hemolytic activity, limited cytotoxicity on HaCaT cells, and an SPF value of 29.88. Therefore, the nanoparticles show great potential in skin protection and repairing processes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Business
Daniel D. Prior, Lakshi Karunarathne Hitihami Mudiyanselage, Omar Khadeer Hussain
Summary: This study aims to evaluate which information processing approach is more suitable for procurement complexity in knowledge-intensive procurement and finds that formalization has a significant positive impact on procurement performance, while centralization has negligible effects.
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING
(2022)
Article
Computer Science, Theory & Methods
Hamed Aboutorab, Omar K. Hussain, Morteza Saberi, Farookh Khadeer Hussain
Summary: Risk management is crucial for ensuring the smooth operation of supply chain activities, with risk identification being the first step in managing risks effectively. Timely identification of risk events is essential for proactive risk management in supply chain operations.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2022)
Review
Computer Science, Artificial Intelligence
Sonia Farhana Nimmy, Omar K. Hussain, Ripon K. Chakrabortty, Farookh Khadeer Hussain, Morteza Saberi
Summary: This paper emphasizes the importance of managing operational disruptions for the success of supply chain operations and the necessity of using explainable AI methods to manage operational risks. The research also highlights the shortcomings of current techniques and provides inspiration for future research directions.
KNOWLEDGE-BASED SYSTEMS
(2022)
Review
Computer Science, Theory & Methods
Aisha Muhammad A. Hamdi, Farookh Khadeer Hussain, Omar K. Hussain
Summary: Vehicular fog computing (VFC) is a promising solution to overcome the limitations of edge computing by utilizing idle resources of moving and parked vehicles. This paper argues that the selection of target fog node should follow the steps of forming a service level agreement (SLA) and identifies the requirements that need to be addressed in forming such an SLA.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Hang Thanh Bui, Omar Khadeer Hussain, Daniel Prior, Farookh K. Hussain, Morteza Saberi
Summary: This paper proposes the Proof by Earnestness (PoE) consensus mechanism to address the issue of subjective information authenticity in blockchain, with supply chain risk management as the application area.
KNOWLEDGE-BASED SYSTEMS
(2022)
Editorial Material
Computer Science, Interdisciplinary Applications
Omar Khadeer Hussain
SERVICE ORIENTED COMPUTING AND APPLICATIONS
(2022)
Review
Computer Science, Theory & Methods
Afnan Bukhari, Farookh Khadeer Hussain, Omar K. Hussain
Summary: This study aims to provide a detailed overview of the state of the art in the area of fog node discovery and selection. Based on the analysis of existing literature, gaps and open issues related to optimal fog node discovery and selection are identified.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2022)
Article
Cell Biology
Khalidah Ibraheem, Albashir M. A. Yhmed, Mohamed M. Nasef, Nikolaos T. Georgopoulos
Summary: CD40 accelerates the death of colorectal carcinoma cells by simultaneously activating both intrinsic and extrinsic pathways, highlighting its multifaceted properties.
Article
Automation & Control Systems
Sonia Farhana Nimmy, Omar K. Hussain, Ripon K. Chakrabortty, Farookh Khadeer Hussain, Morteza Saberi
Summary: Decision support systems (DSS) assist in various decision-making tasks but lack explainability behind their recommendations. To address this, we propose an interpretable artificial intelligence framework that models feature dependencies and evolution over time to interpret the contributing features leading to recommended output.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Computer Science, Artificial Intelligence
Mahmoud M. Bassiouni, Ripon K. Chakrabortty, Omar K. Hussain, Humyun Fuad Rahman
Summary: The ongoing COVID-19 pandemic has posed significant challenges to global supply chains. This study proposes several deep learning approaches to predict and mitigate shipment risks under COVID-19 restrictions, increasing the resiliency of supply chains. The results show that one of the proposed models achieves an accuracy of 100%.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Review
Computer Science, Artificial Intelligence
Hada A. Alsobhi, Rayed A. Alakhtar, Ayesha Ubaid, Omar K. Hussain, Farookh Khadeer Hussain
Summary: A micro-credential is a proof of a student's knowledge, skills, and experience that can be used to advance in a particular field of study in a short amount of time. It has gained popularity in higher education, especially during the Covid-19 pandemic, and many universities are offering courses based on micro-credentials. However, validating these micro-credentials is a complex process, and blockchain technology can provide an efficient solution. This study provides an overview of managing micro-credentials using blockchain technology, comparing existing research and identifying research gaps.
KNOWLEDGE-BASED SYSTEMS
(2023)
Article
Oncology
Robin E. Heibloem, Manon M. C. Komen, Onaedo U. C. Ilozumba, Corina J. G. van den Hurk
Summary: This observational study investigated the effects of wetting hair before scalp cooling on preventing chemotherapy-induced alopecia and on tolerance in cancer patients. The results suggested that wetting hair improves the use of head covers and tolerance during scalp cooling for patients receiving docetaxel, carboplatin-paclitaxel, or 5-fluorouracil-epirubicin-cyclophosphamide-docetaxel. However, the effects were not significant for patients receiving 5-fluorouracil-epirubicin-cyclophosphamide.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Computer Science, Information Systems
Afnan Abdulrahman Bukhari, Farookh Khadeer Hussain, Omar Khadeer Hussain
Summary: Fog computing is proposed as a mechanism to solve issues in cloud computing. This study presents an intelligent and distributed fog node discovery mechanism to help fog consumers discover suitable fog nodes based on context-aware criteria. By comparing performance metrics and execution time, the experiment results indicate that the K-d tree algorithm is the optimal choice for discovering the nearest fog nodes efficiently and quickly.
INTERNET OF THINGS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Amir Hossein Ordibazar, Omar Hussain, Morteza Saberi
Summary: In this study, an optimization problem is proposed to design a transportation schedule for the supply chain network, and a counter-factual explanation (CE) model is integrated into the system to increase resiliency and transparency. The results show that the CE-added constraints significantly enhance system resilience with minimal financial cost increase.
SERVICE-ORIENTED COMPUTING, ICSOC 2021 WORKSHOPS
(2022)
Article
Transportation
Pegah Norouzian-Maleki, Hamidreza Izadbakhsh, Morteza Saberi, Omar Hussain, Mustafa Jahangoshai Rezaee, Nasim Ghanbar Tehrani
Summary: This paper proposes a new framework for managing urban traffic congestion by combining a system dynamics approach with a data envelopment analysis technique. Compared to previous studies, this approach shows improvement in forecasting travel demand and managing traffic congestion through effective policies.
TRANSPORTATION LETTERS-THE INTERNATIONAL JOURNAL OF TRANSPORTATION RESEARCH
(2022)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)