Article
Multidisciplinary Sciences
Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A. Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C. Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J. Robson, Randy D. Blakely, Adam J. Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W. Jacobsen
Summary: In this study, the researchers uncover a feedback mechanism in which IL-1 secreted by activated platelets signals through niche Lepr+ cells to activate HSCs and restore platelet homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Yan Shi, Shang Wang, Weiwei Zhang, Yihan Zhu, Zhiqiang Fan, Yuesheng Huang, Furong Li, Ronghua Yang
Summary: This study reveals that hypoxic BMSCs can regulate the autophagy of epidermal cells through the HIF-1 alpha/TGF-beta 1/SMAD pathway, promoting the repair and healing of diabetic wounds.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Hematology
Lucine Fahy, Julien Calvo, Sara Chabi, Laurent Renou, Charly Le Maout, Sandrine Poglio, Thierry Leblanc, Arnaud Petit, Andre Baruchel, Paola Ballerini, Irina Naguibneva, Rima Haddad, Marie-Laure Arcangeli, Frederic Mazurier, Francoise Pflumio, Benjamin Uzan
Summary: Leukemic cells grow slowly in hypoxic environments and become less sensitive to antileukemic drugs, indicating that hypoxic niches can protect T-ALL from the effects of chemotherapy. Inhibiting HIF-1α and activating the mTORC1 pathway may help alleviate the drug resistance of T-ALL in hypoxic niches.
Article
Biochemistry & Molecular Biology
Xiaoyan Zhi, Shu Shi, Yang Li, Mingxia Ma, Yaolin Long, Chen Li, Haihu Hao, Huirong Liu, Xiaohui Wang, Li Wang
Summary: The study found that β(1)-AAs induce the expression of S100a9, leading to cardiomyocyte death and cardiac dysfunction. S100a9 interacts with HIF-1α, inhibiting the transcription of Atg9a and further suppressing autophagy.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Jian Wang, Xin Lv, A-Shan-Jiang A-Ni-Wan, Sha-Sha Tian, Jun-Mei Wang, Hong-Yan Liu, Xiao-Guang Fan, Sai-Jun Zhou, Pei Yu
Summary: This study investigated the protective mechanisms of Canagliflozin in patients on peritoneal dialysis. It was found that Canagliflozin could improve peritoneal hypoxia, inhibit fibrotic protein production, prevent peritoneal fibrosis, and enhance peritoneal function.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pramod Mallikarjuna, Yang Zhou, Marene Landstrom
Summary: Transforming growth factor beta (TGF-beta) regulates homeostasis and immune responses in adult animals and humans. Abnormal TGF-beta signaling promotes cancer and fibrosis, while suppressing immune responses in cancer patients. Understanding the synergistic cooperation between TGF-beta and hypoxia in development, fibrosis, and cancer can guide the development of novel anti-cancer therapeutic strategies.
Article
Medicine, Research & Experimental
Sanghyuk Choi, Jinyeong Yu, Wootak Kim, Ki-Sook Park
Summary: In this study, N-cadherin was identified as a key molecule in mediating the migration of BM-MSCs towards breast tumors. The expression of N-cadherin increased on the intercellular borders of BM-MSCs through TGF-beta canonical signaling, leading to their collective migration in response to breast tumor cells via N-cadherin-dependent cell-cell adhesion. This introduces a novel and promising strategy for controlling and re-engineering the breast tumor microenvironment.
Article
Medicine, Research & Experimental
Jing Yang, Xinli Ouyang, Hong Fu, Xinyu Hou, Yan Liu, Yongfang Xie, Haiqun Yu, Guohui Wang
Summary: Myopia has become a critical global health issue due to increasing time spent indoors and genetic susceptibility. Pathological myopia can lead to complications such as retinal detachment and blindness. Signaling pathways such as dopamine and nitric oxide play crucial roles in the development of myopia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Tuling Li, Xiaomeng Li, Yixian Hao, Jinpeng Liu, Bo Bao, Zhaohui Yang, Mengxian Zhou, Huixia Wei, Ruixue Zhang, Jiawen Hao, Wenjun Jiang, Hongsheng Bi, Dadong Guo
Summary: This study aimed to investigate the effect of miR-138-5p on choroidal fibrosis in myopic guinea pigs via regulating the HIF-1 alpha signaling pathway. The results showed that miR-138-5p can efficiently decrease the refraction and ocular length, and ameliorate the choroidal fibrosis of the experimental myopic guinea pigs through inhibiting the HIF-1 alpha signaling pathway. These findings provide new insight into controlling myopic development using microRNAs in clinical practice.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Jiachang Xu, Xue Yu, Hangyu Ye, Songze Gao, Niuniu Deng, Yuyou Lu, Haoran Lin, Yong Zhang, Danqi Lu
Summary: This study explores the effects of hypoxia and infection on the liver function and signaling pathways of the host. By using Takifugu obscurus and Vibrio parahaemolyticus as models, the study shows consistent changes in differential metabolites and proteins under hypoxia, infection, or dual stressors. The findings suggest that the liver tends towards cell proliferation under these conditions, and that hypoxia and infection can cause tissue damage and fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinok Noh, Jinyeong Yu, Wootak Kim, Aran Park, Ki-Sook Park
Summary: The tumor microenvironment in prostate cancer plays vital roles in tumor cell metastasis and re-growth. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are crucial in forming this microenvironment. The study found that N-cadherin is a key mediator of BM-MSCs migration towards hormone-insensitive prostate tumor cells.
Article
Hematology
Mark J. Koury, Rajiv Agarwal, Glenn M. Chertow, Kai-Uwe Eckardt, Steven Fishbane, Tomas Ganz, Volker H. Haase, Mark R. Hanudel, Patrick S. Parfrey, Pablo E. Pergola, Prabir Roy-Chaudhury, James A. Tumlin, Robert Anders, Youssef M. K. Farag, Wenli Luo, Todd Minga, Christine Solinsky, Dennis L. Vargo, Wolfgang C. Winkelmayer
Summary: Vadadustat has beneficial effects on three aspects of erythropoiesis in patients with anemia associated with chronic kidney disease: increased endogenous EPO production, improved iron availability to erythroid cells, and increased reticulocytes in the circulation.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Hong Liu, Changjin Chen, Jinhao Zeng, Ziyi Zhao, Qiongying Hu
Summary: This study revealed that hypoxia-induced miR-210-3p activity promoted EMT and chemoresistance in glioma cells by upregulating TGF-β expression. The positive correlation between HIF-1α and TGF-β levels suggests a potential regulatory mechanism for the malignant behaviors and chemoresistance in glioma.
Article
Oncology
Wootak Kim, Aran Park, Hyun Hee Jang, Seung-Eun Kim, Ki-Sook Park
Summary: Breast tumor cells recruit bone marrow-derived mesenchymal stem cells (BM-MSCs) and alter their cellular characteristics to establish a tumor microenvironment. BM-MSCs enhance tumor angiogenesis through various mechanisms. Our study found that the increased expression of HIF-1 alpha in BM-MSCs under breast tumor conditions is mediated by ROS and JAK/Stat3. This increased expression promotes the angiogenic sprouting capacity of endothelial cells through a VEGF-dependent mechanism.
Article
Medicine, Research & Experimental
Yongquan Huang, Liu Liao, Haitao Su, Xinlin Chen, Tao Jiang, Jun Liu, Qiuke Hou
Summary: Psoralen from Psoralea corylifolia was found to enhance osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating the TGF-beta/Smad3 pathway, showing potential for future osteoporosis treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
