Article
Chemistry, Analytical
Zhou Xu, Qing-Xia Li, Lin-Wei Zhang, Mao-Long Chen, Jia Tu, Wei Chen, Ying-Yue Zhu, Yun-Hui Cheng
Summary: A FRET-labeled microenvironment-responsive immunosensor modulated by AChE was designed to enhance sensitivity to AFB1. By reducing the microenvironment pH around UCNPs and destroying UCNP-FITC for signal amplification, this system achieved quantitative determination of AFB1 with LODs as low as 0.003 nM, demonstrating a promising approach for future research in up-conversion fluorescence sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Editorial Material
Clinical Neurology
Saba Jafarpour, Mellad Khoshnood, Jonathan D. Santoro
Summary: This case reports a rare Acox1 gene variation and highlights the importance of reanalysis of previously undiagnosed genetic sequencing data. The patient's clinical stability for over 1 year on immunotherapy raises the possibility of disease modification in an otherwise universally fatal condition.
Article
Immunology
Tiziana Latronico, Marilena Larocca, Serafina Milella, Anna Fasano, Rocco Rossano, Grazia Maria Liuzzi
Summary: The study showed that SFN and PEITC could counteract H2O2-induced ROS production, and were effective inhibitors of MMP-9, with SFN significantly inhibiting MMP-2 activity as well. Additionally, all the ITCs used significantly inhibited the expression of both MMP-2 and MMP-9.
INFLAMMOPHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yaowen Liu, Pengfei Li, Yanwei Wang, Youai Qiu
Summary: Electrochemistry employs electrons as an efficient and sustainable alternative to chemical oxidants or reductants, and has gained popularity for selective organic synthesis. The combination of electrochemistry with readily available electrophiles has emerged as a viable method for constructing challenging C-C and C-heteroatom bonds. This mini-review provides a systematic summary of the recent advances in electroreductive cross-electrophile coupling (eXEC) reactions, focusing on aryl and alkyl organic (pseudo)halides, as well as small molecules such as CO2, SO2, and D2O.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Noha Shaker, Ezz Mohamed Kandil, Yasmen Osama, Tamer Kamal Khatab, Mohamed E. Khalifa
Summary: This study aimed to establish a novel catalytic eco-friendly one-pot reaction for the synthesis of thiosemicarbazone and N-thiocarbamoyl pyrazole derivatives, utilizing a silica-supported zinc chloride catalyst. The synthesized compounds exhibited potential antioxidant activity and were predicted to target bacterial cell walls as an undecaprenyl pyrophosphate synthase (UppS) inhibitor through molecular docking. Compared to other reported catalysts, the silica-zinc chloride catalyst was considered to be a more environmentally friendly and recyclable option.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Andrew C. Jones, William I. Nicholson, Jamie A. Leitch, Duncan L. Browne
Summary: The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is efficient and green, achieving reductive C-C bond formation under a mechanochemical manifold. The mechanical action provided by ball milling allows for the use of a variety of zinc sources to turnover the nickel catalytic cycle, resulting in the synthesis of 28 cross-electrophile coupled products.
Article
Plant Sciences
Chunying Wang, Ziqiang Gao, Yang Shi, Xiaoting Qi
Summary: Molecular, biochemical, and genetic experiments demonstrate that metal-responsive elements (MREs), initially identified in animals, confer the cadmium transcriptional response in Arabidopsis, thus providing deep functional insights of MREs in plants.
Article
Environmental Sciences
Juan Wang, Yuan He, Xianjin Peng, Bo Lv, Zhi Wang, Qisheng Song
Summary: Transcription factors play a crucial role in the molecular response of Pardosa pseudoannulata to cadmium stress, with candidate Cd-responsive TFs potentially linked to growth and antioxidant defense mechanisms. The study also identified hub genes and conserved sequences, shedding light on the adaptation mechanisms of spiders to heavy metal stress.
Article
Multidisciplinary Sciences
Wen Zhang, Lingxiang Lu, Wendy Zhang, Yi Wang, Skyler D. Ware, Jose Mondragon, Jonas Rein, Neil Strotman, Dan Lehnherr, Kimberly A. See, Song Lin
Summary: Recent research in medicinal chemistry has found a correlation between an increase in sp(3) carbons in drug candidates and their improved success rate in clinical trials. This study focuses on the development of robust and selective methods for constructing carbon(sp(3))-carbon(sp(3)) bonds. By using electrochemistry, the researchers achieve the selective activation of alkyl halides based on their electronic and steric properties, allowing for high selectivity in carbon(sp(3))-carbon(sp(3)) cross-electrophile coupling. This new protocol shows improved chemoselectivity and does not require a transition metal catalyst.
Article
Chemistry, Applied
Lars Andernach, Katja Witzel, Franziska S. Hanschen
Summary: Glucosinolates are precursors of isothiocyanates (ITCs). Amines were found to be enzymatic hydrolysis products of glucosinolates in Brassica vegetables. An endogenous ITC hydrolase (ITCase) in the plants is responsible for the conversion of ITCs to amines. The presence of amines from glucosinolates in the human diet was confirmed.
Article
Chemistry, Multidisciplinary
Linlin Ding, Yue Zhao, Hongjian Lu, Zhuangzhi Shi, Minyan Wang
Summary: For the first time, a catalytic enantioselective propargyl-aryl cross-coupling between two electrophiles was achieved in a stereoconvergent manner. The potential utility of this conversion is demonstrated in the facile construction of stereoenriched bioactive molecule derivatives and medicinal compounds based on the diversity of acetylenic chemistry. Detailed experimental studies have revealed the key mechanistic features of this transformation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Meng Wang, Huihua Huang, Chaokang Huang, Shujun Liu, Xiaohong Peng
Summary: The novel nanocapsule-embedded hydrogel dressing (MCNG-H), formed by crosslinking magnolol-grafted-chitosan hydrochloride (CSCl-MAG) with genipin, shows sustained antibacterial and antioxidant properties. MCNG-H exhibits good swelling properties and biocompatibility, with the combination of CSM-H and MCNGs effectively inhibiting bacteria and eliminating reactive oxygen species (ROS). The pH-responsive release of loaded MAG in MCNG-H ensures sustained release and long-term antibacterial and anti-oxidant activities. In a splinted excisional dermal wound model, MCNG-H significantly accelerates wound healing, making it a promising dressing for infected wounds.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
Anna Grygier
Summary: Mustard seeds are a valuable source of bioactive ingredients, such as polyunsaturated fatty acids and antioxidants, making them suitable for developing food and health-promoting products. The use of mustard varieties with reduced levels of erucic acid and glucosinolates has led to improved properties in mustard-infused foods, including microbiological safety, shelf life, lipid oxidation, protein content, and overall acceptability.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J. Charnock, Samuel Garfinkle, Todd K. Hyster
Summary: This study reports a highly chemoselective and enantioselective Csp(3)-Csp(3) XEC reaction catalyzed by flavin-dependent 'ene'-reductases (EREDs). The photoexcitation of the enzyme-templated charge-transfer complex enables the chemoselective reduction of alkyl halides and high enantioselectivity.
Editorial Material
Chemistry, Multidisciplinary
Sandy Schmidt
Summary: Enzymes have several advantages over conventional catalysts in organic synthesis. Efforts have been made to expand the range of biocatalytic reactions for synthetic chemists, particularly by diversifying enzymes for non-natural transformations. Exciting developments in photobiocatalysis have enabled the introduction of non-natural reactivity in enzymes to solve long-standing synthetic challenges, as demonstrated by the recent example from the Hyster group.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Toxicology
Jochem Louisse, Sieto Bosgra, Bas J. Blaauboer, Ivonne M. C. M. Rietjens, Miriam Verwei
ARCHIVES OF TOXICOLOGY
(2015)
Article
Pharmacology & Pharmacy
Rungnapa Boonpawa, Albertus Spenkelink, Ivonne M. C. M. Rietjens, Ans Punt
BIOCHEMICAL PHARMACOLOGY
(2014)
Article
Engineering, Chemical
A. J. Martijn, M. G. Boersma, J. M. Vervoort, I. M. C. M. Rietjens, J. C. Kruithof
DESALINATION AND WATER TREATMENT
(2014)
Article
Food Science & Technology
Wasma Alhusainy, Gary M. Williams, Alan M. Jeffrey, Michael J. Iatropoulos, Sean Taylor, Timothy B. Adams, Ivonne M. C. M. Rietjens
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Food Science & Technology
Erryana Martati, Rungnapa Boonpawa, Johannes H. J. van den Berg, Alicia Paini, Albertus Spenkelink, Ans Punt, Jacques Vervoort, Peter J. van Bladeren, Ivonne M. C. M. Rietjens
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Food Science & Technology
Suzanne J. P. L. van den Berg, Wasma Alhusainy, Patrizia Restani, Ivonne M. C. M. Rietjens
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Genetics & Heredity
E. F. Hoek-van den Hil, E. M. van Schothorst, I. van der Stelt, H. J. M. Swarts, D. Venema, M. Sailer, J. J. M. Vervoort, P. C. H. Hollman, I. M. C. M. Rietjens, J. Keijer
GENES AND NUTRITION
(2014)
Article
Toxicology
Si Wang, Jac M. M. J. G. Aarts, Laura H. J. de Haan, Dimitrios Argyriou, Ad A. C. M. Peijnenburg, Ivonne M. C. M. Rietjens, Toine F. H. Bovee
JOURNAL OF APPLIED TOXICOLOGY
(2014)
Article
Food Science & Technology
Lawrence J. Marnett, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, Ivonne M. C. M. Rietjens, Robert L. Smith, Timothy B. Adams, Maria Bastaki, Christie L. Harman, Margaret M. McGowen, Sean V. Taylor
JOURNAL OF FOOD SCIENCE
(2014)
Article
Pharmacology & Pharmacy
Niek C. A. van de Pas, Johan A. C. Rullmann, Ruud A. Woutersen, Ben van Ommen, Ivonne M. C. M. Rietjens, Albert A. de Graaf
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2014)
Article
Biochemistry & Molecular Biology
Nynke M. Evers, Johannes H. J. van den Berg, Si Wang, Diana Melchers, Rene Houtman, Laura H. J. de Haan, Antwan G. H. Ederveen, John P. Groten, Ivonne M. C. M. Rietjens
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2014)
Article
Endocrinology & Metabolism
Henriette D. L. M. van Eekelen, Linda Gijsbers, Chris A. Maliepaard, Robert A. M. Vreeburg, Richard Finkers, Yury M. Tikunov, Victoria M. Gomez Roldan, Laura H. J. de Haan, Ric C. H. de Vos, Jac M. M. J. G. Aarts, Ivonne M. C. M. Rietjens, Arnaud G. Bovy
Review
Food Science & Technology
Jonathan Nicolas, Peter J. M. Hendriksen, Arjen Gerssen, Toine F. H. Bovee, Ivonne M. C. M. Rietjens
MOLECULAR NUTRITION & FOOD RESEARCH
(2014)
Article
Medicine, Research & Experimental
Barae Jomaa, Sanne A. B. Hermsen, Maurijn Y. Kessels, Johannes H. J. van den Berg, Ad A. C. M. Peijnenburg, Jac M. M. J. G. Aarts, Aldert H. Piersma, Ivonne M. C. M. Rietjens
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2014)
Article
Chemistry, Multidisciplinary
Sourav Bhattacharjee, Dmitry Ershov, Mohammed A. Islam, Angela M. Kampfer, Katarzyna A. Maslowska, Jasper van der Gucht, Gerrit M. Alink, Antonius T. M. Marcelis, Han Zuilhof, Ivonne M. C. M. Rietjens
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
