Article
Biochemistry & Molecular Biology
Shuai Zhao, Yichi Zhang, Xiuqin Lu, Han Ding, Bing Han, Xiaoling Song, Huijie Miao, Xuya Cui, Shiyin Wei, Wangrui Liu, Shuxian Chen, Jian Wang
Summary: This study found that CDC20 is highly expressed in HCC and is involved in radio resistance of HCC cells by affecting P53 mutation Bcl-2/Bax signaling pathway, enhancing the sensitivity of HCC to radiation therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Robert T. Flemmer, Sarah P. Connolly, Brittany A. Geizer, Joseph T. Opferman, Jacqueline L. Vanderluit
Summary: Mcl-1 plays a crucial role in promoting neural precursor cell survival by inhibiting the activation of Bax during development, although there are other pro-apoptotic targets. Co-deletion of Bax and Mcl-1 can rescue most NPC apoptosis but may lead to embryonic lethality.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Honglin Yan, Wenxian Huang, Jie Rao, Jingping Yuan
Summary: miR-21 exhibits anti-apoptotic and pro-survival effects in ischemia by regulating the p53/Bcl-2/Bax signaling pathway, suggesting it as an attractive therapeutic molecule for ischemic stroke treatment.
Article
Biochemistry & Molecular Biology
Mohammad Z. Ahmed, Fahd A. Nasr, Wajhul Qamar, Omar M. Noman, Javed Masood Khan, Abdullah A. Al-Mishari, Ali S. Alqahtani
Summary: The study showed that janerin inhibits THP-1 cell proliferation in a dose-dependent manner by causing cell cycle arrest at the G2/M phase. Additionally, janerin promotes THP-1 cell death through apoptosis induction, which involves upregulation of pro-apoptotic markers and downregulation of anti-apoptotic marker. Furthermore, janerin treatment leads to the activation of P38-MAPK and ERK1/2 signaling pathways, suggesting its potential as a therapeutic agent for leukemia.
Article
Oncology
Ayat Moradipour, Hassan Dariushnejad, Changiz Ahmadizadeh, Hamed Esmaiil Lashgarian
Summary: The study demonstrated that carvacrol induces apoptosis in MCF-7 cells by increasing the expression of P53 and Bax, and decreasing the expression of Bcl-2. Experimental results showed the inhibitory effect of carvacrol on the growth of breast cancer cells.
Article
Chemistry, Multidisciplinary
Anna Poma, Massimo Aloisi, Antonella Bonfigli, Sabrina Colafarina, Osvaldo Zarivi, Pierpaolo Aimola, Giulia Vecchiotti, Lorenzo Arrizza, Alessandra Di Cola, Patrizia Cesare
Summary: Air pollution in urban areas is a major concern, with tire microparticles and nanoparticles being a significant component of particulate matter. These particles are generated from the friction of wheels with asphalt, especially in slow-moving areas with frequent braking actions. A study was conducted to investigate the effect of microparticles from passenger tires on murine macrophage cells. The results showed an initial induction of the apoptotic process, which was later reversed by Bcl2. No genotoxic damage was observed, but mild cellular abnormalities were detected in the treated cells.
Article
Biochemistry & Molecular Biology
Sudjit Luanpitpong, Montira Janan, Juthamas Yosudjai, Jirarat Poohadsuan, Pithi Chanvorachote, Surapol Issaragrisil
Summary: Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with poor prognosis due to drug resistance. Overexpression of antiapoptotic Bcl-xL and depletion of proapoptotic Bax contribute to acquired resistance to bortezomib (BTZ) in MCL cells. High Bcl-xL and low Bax levels are associated with poor prognosis in MCL patients. Targeting these proteins using BH3 mimetics and Bax activators may be a promising strategy to overcome drug resistance in MCL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nesrine A. Helaly, Noha E. Esheba, Desouky E. Abou Ammo, Nahed M. Elwan, Rasha A. Elkholy
Summary: The study found that a lower Bax/Bcl-2 ratio was associated with worse prognosis in CLL patients, with good sensitivity and specificity in predicting survival, making it an important indicator for predicting treatment outcomes and progression in patients.
Article
Multidisciplinary Sciences
Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner, Evripidis Gavathiotis
Summary: The BCL-2 family protein BAX plays a crucial role in regulating mitochondria-driven cell death, with the potential for aberrant cell death in diseases when dysregulated. The FDA-approved drug Eltrombopag is shown to directly inhibit BAX by preventing its conformational transformation and stabilizing its inactive structure, thereby inhibiting BAX-mediated apoptosis induced by cytotoxic stimuli.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Gehan Safwat, Esraa S. M. Soliman, Hanan R. H. Mohamed
Summary: This study evaluated the therapeutic potential of erbium oxide nanoparticles (Er2O3-NPs) on human hepatocellular carcinoma (Hep-G2) cells. Exposure to Er2O3-NPs inhibited the growth of Hep-G2 cells and induced cell death in a concentration dependent manner. Er2O3-NPs also caused high levels of DNA damage and intracellular reactive oxygen species (ROS) production in Hep-G2 cells. Flow cytometry analysis revealed that Er2O3-NPs arrested the cell cycle of Hep-G2 cells at the G0/G1 phase and increased the number of cells in the apoptotic and necrotic phases. Furthermore, Er2O3-NPs upregulated the expression levels of apoptotic genes (p53 and Bax) and downregulated the expression level of the anti-apoptotic gene Bcl2 in Hep-G2 cells. In conclusion, Er2O3-NPs inhibit the proliferation of Hep-G2 cells and induce apoptosis through ROS generation, DNA damage, and alteration of apoptotic genes. Further in vitro and in vivo studies are recommended to explore the potential of using Er2O3-NPs in cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Simin Sharifi, Elaheh Dalir Abdolahinia, Mohammad Ali Ghavimi, Solmaz Maleki Dizaj, Michael Aschner, Luciano Saso, Haroon Khan
Summary: The study prepared curcumin-loaded mesoporous silica nanoparticles (Cur-MSN) to enhance its anti-cancer effect, revealing higher cytotoxicity and increased intracellular reactive oxygen species production in HN5 head and neck cancer cells treated with Cur-MSNs.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chun-Sheng Kuo, Shih-Yun Chen, Jen-Chieh Tsai
Summary: This study demonstrates that the supercritical fluid extract of Magnolia figo can induce apoptosis in A549 lung cancer cells through specific pathways, highlighting the potential of this plant as a source for developing novel drugs for lung cancer treatment.
Article
Multidisciplinary Sciences
Abir A. Alamro, Manal M. Al-Malky, Mohammed G. A. Ansari, Osama E. Amer, Abdullah M. Alnaami, Syed D. Hussain, Tlili A. Barhoumi, Amani A. Alghamdi, Samina H. Haq, Shaun Sabico, Nasser M. Al-Daghri
Summary: The study showed that treatment with melatonin and vitamin D3 can inhibit proliferation and induce apoptosis in breast cancer cells by upregulating Bax and downregulating BCL-2 at both the DNA and protein level.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Cell Biology
Zonghong Li, Ruiming Zhang, Xuewei Yin, Nana Li, Siyuan Cui, Teng Wang, Xing Tan, Mingyue Shen, Yun Guo, Jinxin Wang, Dadong Guo, Ruirong Xu
Summary: Realgar, a Chinese medicine containing arsenic, has been used to treat acute promyelocytic leukemia (APL) for over a thousand years. This study found that realgar can inhibit APL cell proliferation and induce cell death in a time- and dose-dependent manner. Realgar decreases ATP levels and induces cell cycle arrest. The Bcl-2/Bax/Cyt-C/AIF signaling pathway is involved in realgar-induced APL cell death.
Article
Biochemistry & Molecular Biology
Atefeh Maddah, Nasrin Ziamajidi, Hossein Khosravi, Hiva Danesh, Roghayeh Abbasalipourkabir
Summary: This study investigated the apoptotic and anti-cancer effect of gold nanoparticles on HCT-116 colon cancer cells. The results showed that treatment with nanoparticles led to an increase in the expression of Bax and P53 genes, a decrease in the expression of Bcl-2 and CCNB1 genes, and an increase in the level of apoptosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
