Article
Chemistry, Applied
Juanjuan Qin, Min Yang, Yucheng Wang, Wenqiang Wa, Jie Zheng
Summary: The study found that caffeic acid and caffeic acid phenethyl ester form complexes with micellar casein through hydrophobic interactions, with higher thermal stability and DPPH radical scavenging capacity compared to free micellar casein or caffeic acid/caffeic acid phenethyl ester. These complexes do not induce the dissociation of casein micelles.
Review
Food Science & Technology
Sajjad Ehtiati, Mehdi Alizadeh, Faeghe Farhadi, Kimia Khalatbari, Basiru O. Ajiboye, Vafa Baradaran Rahimi, Vahid Reza Askari
Summary: Caffeic acid and caffeic acid phenethyl ester (CAPE) are natural compounds that have shown promising effects against natural and chemical toxins. Their antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to their protective effects. They can protect against a wide range of toxins, including mycotoxins, heavy metals, environmental toxins, pesticides, industrial chemicals, and pharmaceuticals. Their potential makes them candidates for developing novel therapies and functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Anatomy & Morphology
Paulo Henrique Neves Santos, Hebert Lacerda Silva, Elizabeth Ferreira Martinez, Julio Cesar Joly, Ana Paula Dias Demasi, Larissa Moreira Spinola de Castro Raucci, Lucas Novaes Teixeira
Summary: The study demonstrated that low concentrations of CAPE can positively modulate osteogenesis in vitro, as evidenced by enhanced cell viability, increased alkaline phosphatase activity, promoted matrix mineralization, and elevated expression of bone-related genes.
Article
Biochemistry & Molecular Biology
Riichi Hashimoto, Hiyori Iai, Rie Fujita, Kengo Hanaya, Shuhei Higashibayashi, Hiroyoshi Inoue, Takeshi Sugai
Summary: Caffeic acid beta-phenethyl ester (CAPE), an antioxidative bioactive catechol isolated from propolis, was semisynthesized from chlorogenic acid and related compounds in unroasted Robusta coffee beans, with a total yield of 31% in 5 steps. The oxidative degradation of intermediates and target molecule was prevented by alkaline hydrolysis of chlorogenic acids and deprotection of the catecholic diacetate precursor using Candida antarctica lipase B-mediated transesterification.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Gokhan Nur, Emrah Caylak, Haci Ahmet Deveci, Pinar Aksu Kilicle, Ayla Deveci
Summary: This study assessed the subacute effects of alpha cypermethrin on rat renal tissues. The severity of damage was dose-dependent. Treatment with alpha cypermethrin and CAPE showed some therapeutic effects but were not robust.
Review
Biochemistry & Molecular Biology
Batoryna Olgierd, Zyla Kamila, Banys Anna, Morawiec Emilia
Summary: Caffeic acid phenethyl ester (CAPE) is a potent antioxidant derived from honey bee-hive propolis, known for its anti-inflammatory, antiviral, antibacterial, anticancer, immunomodulatory, and wound-healing properties. This review highlights the biological properties and potential therapeutic applications of CAPE in various diseases.
Article
Biochemistry & Molecular Biology
Anna Kleczka, Radoslaw Dzik, Agata Kabala-Dzik
Summary: This study investigated the effects of the combined use of caffeic acid phenethyl ester (CAPE) and paclitaxel (PTX) on ovarian cancer cells. The results showed that low doses of PTX exerted cytotoxic effects against all tested cell lines, and the combined use of CAPE and PTX enhanced the cytotoxicity and anti-migration activity.
Article
Agriculture, Multidisciplinary
Min Ling, Yanfei Xu, Xuan Huang, Changwei He, Zheng Zhou
Summary: In this study, stable nanocomplexes between phosphorylated walnut protein and chitosan were successfully fabricated under acidic pH conditions, which showed promising encapsulation capacity for caffeic acid phenethyl ester (CAPE). The nanocomplexes exhibited stability, high viscosity, good suspensibility, and controlled release of CAPE.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Rili Hao, Junlin Ge, Yongfeng Ren, Xinyu Song, Yang Jiang, Dongxiao Sun-Waterhouse, Feng Li, Dapeng Li
Summary: Cadmium-induced liver damage was significantly reduced by caffeic acid phenethyl ester (CAPE) through multiple pathways, including alleviation of oxidative stress, inhibition of apoptosis, and suppression of inflammation. This study provides novel insights into the treatment of cadmium-related diseases through targeting miR-182-5p/TLR4 axis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Applied
Yongqi Liu, Keke Liu, Xiaolong Wang, Yiwen Shao, Xue Li, Limin Hao, Xuemei Zhang, Juanjuan Yi, Jike Lu
Summary: Asiatic acid-caffeic acid phenethyl ester nanoparticles (ASA-CAPE NPs) were prepared to overcome the limitations of poor solubility, bioavailability, and stability of caffeic acid phenethyl ester (CAPE). The encapsulation and loading efficiencies of ASA-CAPE NPs reached 47.72% and 11.62%, respectively. The nanoparticles exhibited regular spherical morphology, improved water solubility, stability, and bioactivities compared to free CAPE.
Article
Plant Sciences
Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
Summary: This study demonstrates that caffeic acid phenethyl ester (CAPE) can reduce hyperuricemia by inhibiting xanthine oxidase (XOD) activity and up-regulating organic anion transporter 3 (OAT3), suggesting its potential as a treatment for gout.
Article
Medicine, Research & Experimental
Qian Wu, Junya Li, Shengyu Hao, Yuyang Guo, Zongze Li, Zhengxin Liu, Hongzhuan Xuan
Summary: Glycolysis and lipid metabolism play crucial roles in the growth and metastasis of tumor cells. In this study, caffeic acid phenethyl ester (CAPE) was found to inhibit proliferation, migration, invasion, and angiogenesis of breast cancer cells by modulating inflammatory mediators and inhibiting key proteins and enzymes in glycolysis and lipid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Seon-Hee Choi, Dong-Yeon Lee, Sohi Kang, Min-Kyung Lee, Jae-Heun Lee, Sang-Heon Lee, Hye-Lim Lee, Hyo-Young Lee, Young-IL Jeong
Summary: In this study, CAPE-incorporated HAsPBPE nanoparticles were successfully synthesized and shown to have radiosensitivity. These nanoparticles effectively prevented radiation-induced cell death and apoptotic cell death, making them promising candidates for the radio-sensitive delivery of CAPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Km Anjaly, Ashu Bhan Tiku
Summary: In this study, the radiomodulatory potential of caffeic acid phenethyl ester (CAPE) in prostate cancer cells was evaluated. CAPE was found to enhance the sensitivity of prostate cancer cells to radiation and induce apoptosis, while inhibiting cell migration. The combination treatment of CAPE and radiation increased DNA damage and cell death by inhibiting DNA repair proteins. Therefore, CAPE may be a potential adjuvant for the treatment of hormone-refractory radioresistant prostate cancer.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Katya Kamenova, Georgy Grancharov, Vasilena Kortenova, Petar D. Petrov
Summary: We report the preparation of redox-responsive functional micellar nanocarriers for triggered release of CAPE in cancer therapy. The three-layered micelles, composed of PCL core, PAA/PEO middle layer, and PEO outer corona, were assembled by two amphiphilic triblock copolymers. The loaded micelles were crosslinked to enhance structural stability and prevent premature release of CAPE. However, under weak acidic conditions and in the presence of reducing agent, the payload was rapidly released due to the breakup of disulfide linkages. The developed CPMs showed potential for controlled drug release in the tumor microenvironment.