Article
Chemistry, Applied
Juanjuan Qin, Min Yang, Yucheng Wang, Wenqiang Wa, Jie Zheng
Summary: The study found that caffeic acid and caffeic acid phenethyl ester form complexes with micellar casein through hydrophobic interactions, with higher thermal stability and DPPH radical scavenging capacity compared to free micellar casein or caffeic acid/caffeic acid phenethyl ester. These complexes do not induce the dissociation of casein micelles.
Review
Food Science & Technology
Sajjad Ehtiati, Mehdi Alizadeh, Faeghe Farhadi, Kimia Khalatbari, Basiru O. Ajiboye, Vafa Baradaran Rahimi, Vahid Reza Askari
Summary: Caffeic acid and caffeic acid phenethyl ester (CAPE) are natural compounds that have shown promising effects against natural and chemical toxins. Their antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to their protective effects. They can protect against a wide range of toxins, including mycotoxins, heavy metals, environmental toxins, pesticides, industrial chemicals, and pharmaceuticals. Their potential makes them candidates for developing novel therapies and functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Andrology
Zubeyir Huyut, Hamit Hakan Alp, Turan Yaman, Omer Faruk Keles, Zabit Yener, Fikret Turkan, Kemal Ayengin
Summary: This study found that curcumin and CAPE can reduce DOX-induced testicular injury by inhibiting matrix metalloproteinases, lowering oxidative stress and apoptosis, and suppressing proinflammatory cytokines. Curcumin exhibited more pronounced effects than CAPE in all studied parameters.
Article
Anatomy & Morphology
Paulo Henrique Neves Santos, Hebert Lacerda Silva, Elizabeth Ferreira Martinez, Julio Cesar Joly, Ana Paula Dias Demasi, Larissa Moreira Spinola de Castro Raucci, Lucas Novaes Teixeira
Summary: The study demonstrated that low concentrations of CAPE can positively modulate osteogenesis in vitro, as evidenced by enhanced cell viability, increased alkaline phosphatase activity, promoted matrix mineralization, and elevated expression of bone-related genes.
Review
Biochemistry & Molecular Biology
Batoryna Olgierd, Zyla Kamila, Banys Anna, Morawiec Emilia
Summary: Caffeic acid phenethyl ester (CAPE) is a potent antioxidant derived from honey bee-hive propolis, known for its anti-inflammatory, antiviral, antibacterial, anticancer, immunomodulatory, and wound-healing properties. This review highlights the biological properties and potential therapeutic applications of CAPE in various diseases.
Article
Agronomy
Ivair Valmorbida, Brad S. Coates, Erin W. Hodgson, Molly Ryan, Matthew E. O'Neal
Summary: This study analyzed the relationship between vgsc gene mutations and fitness costs in soybean aphids. The results showed that there was no negative pleotropic effect associated with pyrethroid resistance in the tested clones, and discussed the potential impact on insecticide resistance management and integrated pest management plans.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anna Kleczka, Radoslaw Dzik, Agata Kabala-Dzik
Summary: This study investigated the effects of the combined use of caffeic acid phenethyl ester (CAPE) and paclitaxel (PTX) on ovarian cancer cells. The results showed that low doses of PTX exerted cytotoxic effects against all tested cell lines, and the combined use of CAPE and PTX enhanced the cytotoxicity and anti-migration activity.
Article
Agriculture, Multidisciplinary
Min Ling, Yanfei Xu, Xuan Huang, Changwei He, Zheng Zhou
Summary: In this study, stable nanocomplexes between phosphorylated walnut protein and chitosan were successfully fabricated under acidic pH conditions, which showed promising encapsulation capacity for caffeic acid phenethyl ester (CAPE). The nanocomplexes exhibited stability, high viscosity, good suspensibility, and controlled release of CAPE.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Rili Hao, Junlin Ge, Yongfeng Ren, Xinyu Song, Yang Jiang, Dongxiao Sun-Waterhouse, Feng Li, Dapeng Li
Summary: Cadmium-induced liver damage was significantly reduced by caffeic acid phenethyl ester (CAPE) through multiple pathways, including alleviation of oxidative stress, inhibition of apoptosis, and suppression of inflammation. This study provides novel insights into the treatment of cadmium-related diseases through targeting miR-182-5p/TLR4 axis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
Summary: This study demonstrates that caffeic acid phenethyl ester (CAPE) can reduce hyperuricemia by inhibiting xanthine oxidase (XOD) activity and up-regulating organic anion transporter 3 (OAT3), suggesting its potential as a treatment for gout.
Article
Medicine, Research & Experimental
Qian Wu, Junya Li, Shengyu Hao, Yuyang Guo, Zongze Li, Zhengxin Liu, Hongzhuan Xuan
Summary: Glycolysis and lipid metabolism play crucial roles in the growth and metastasis of tumor cells. In this study, caffeic acid phenethyl ester (CAPE) was found to inhibit proliferation, migration, invasion, and angiogenesis of breast cancer cells by modulating inflammatory mediators and inhibiting key proteins and enzymes in glycolysis and lipid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Katya Kamenova, Georgy Grancharov, Vasilena Kortenova, Petar D. Petrov
Summary: We report the preparation of redox-responsive functional micellar nanocarriers for triggered release of CAPE in cancer therapy. The three-layered micelles, composed of PCL core, PAA/PEO middle layer, and PEO outer corona, were assembled by two amphiphilic triblock copolymers. The loaded micelles were crosslinked to enhance structural stability and prevent premature release of CAPE. However, under weak acidic conditions and in the presence of reducing agent, the payload was rapidly released due to the breakup of disulfide linkages. The developed CPMs showed potential for controlled drug release in the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Rebeca Perez, Viviana Burgos, Victor Marin, Antoni Camins, Jordi Olloquequi, Ivan Gonzalez-Chavarria, Henning Ulrich, Ursula Wyneke, Alejandro Luarte, Leandro Ortiz, Cristian Paz
Summary: Neurodegenerative disorders involve the progressive degeneration and death of neurons, and oxidative stress and neuroinflammation play crucial roles in their progression. Two major pathways, Nrf2 and NF-kappa B, have been identified as potential therapeutic targets due to their involvement in oxidative protection and the promotion of cytokine expression, respectively. Caffeic acid phenethyl ester (CAPE), a compound found in propolis, has shown neuroprotective activity by modulating these pathways. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives and discusses their neuroprotective activity in both in vitro and in vivo studies conducted from 2010 to 2023.
Article
Chemistry, Multidisciplinary
Rasha AlSheikh, Hamad N. Albagieh, Ismail Abdouh, Hattan Zaki, Amal M. Alzahrani, Hassan S. Halawany, Khalifa S. Al-Khalifa
Summary: This in vitro study evaluated the antimicrobial effect of propolis extract caffeic acid phenethyl ester (CAPE) on four different oral microorganisms. The results showed that CAPE had the strongest inhibitory effect on Staphylococcus aureus and the weakest effect on Streptococcus mutans. S. salivarius and S. aureus were the most resistant bacteria to CAPE. These findings suggest that CAPE could be used as an adjunct dental hygiene substance and have potential therapeutic effects in oral health care.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Km Anjaly, Ashu Bhan Tiku
Summary: In this study, the radiomodulatory potential of caffeic acid phenethyl ester (CAPE) in prostate cancer cells was evaluated. CAPE was found to enhance the sensitivity of prostate cancer cells to radiation and induce apoptosis, while inhibiting cell migration. The combination treatment of CAPE and radiation increased DNA damage and cell death by inhibiting DNA repair proteins. Therefore, CAPE may be a potential adjuvant for the treatment of hormone-refractory radioresistant prostate cancer.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Mayssa Abdelwahed, Ines Maaloul, Valerie Benoit, Pascale Hilbert, Mongia Hachicha, Hassen Kamoun, Leila Keskes-Ammar, Neila Belguith
Summary: Juvenile nephronophthisis (NPHP) is a common genetic cause of chronic renal failure in children. Analysis of NPHP1 deletion using diagnostic methods like MLPA and multiplex PCR is important, especially in patients from consanguineous families. This study provides insights into genotype-phenotype correlations in juvenile nephronophthisis for genetic counseling.
ACTA CLINICA BELGICA
(2021)
Article
Biochemistry & Molecular Biology
Olfa Alila-Fersi, Hajer Aloulou, Ines Werteni, Nadia Mahfoudh, Imen Chabchoub, Hassen Kammoun, Leila Keskes, Mongia Hachicha, Neila Belguith, Faiza Fakhfakh
JOURNAL OF MOLECULAR NEUROSCIENCE
(2020)
Article
Obstetrics & Gynecology
Imen Belguith, Dhoha Dhieb, Mouna Turki, Sourour Yaich, Kais Chaabene, Mouna Mnif, Fatma Ayadi, Leila Ammar Keskes
Summary: This study explored the expression pattern of circulating miR-199a-3p, miR-21-5p, and miR-let7i-3p in infertile women with dysregulated AMH levels. The results showed significant overexpression of miR-199a-3p and underexpression of miR-21-5p in the plasma samples of infertile women, suggesting their potential as non-invasive biomarkers for distinguishing infertile from fertile women.
Article
Genetics & Heredity
Mouna Tabebi, Wajdi Safi, Rahma Felhi, Olfa Alila Fersi, Leila Keskes, Mohamed Abid, Mouna Mnif, Faiza Fakhfakh
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Oncology
Rim Frikha, Maha Ben Jemaa, Fakher Frikha, Ines Turki, Moez Elloumi, Leila Keskes, Hassen Kamoun, Tarek Rebai
Summary: This study found that the C677T variant of MTHFR is associated with HDMTX-related toxicity in Tunisian ALL patients, while the A1289C variant is not significantly correlated.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2021)
Article
Genetics & Heredity
Ikhlas Ben Ayed, Wael Ouarda, Fakher Frikha, Fatma Kammoun, Amal Souissi, Mariem Ben Said, Amal Bouzid, Ines Elloumi, Tarak M. Hamdani, Nourhene Gharbi, Nesrine Baklouti, Manel Guirat, Fatma Mejdoub, Najla Kharrat, Imene Boujelbene, Fatma Abdelhedi, Neila Belguith, Leila Keskes, Abdullah Ahmed Gibriel, Hassen Kamoun, Chahnez Triki, Adel M. Alimi, Saber Masmoudi
Summary: Pathogenic variants in SRD5A3 cause a rare inherited disorder known as SRD5A3-CDG, with common clinical features including arched eyebrows, wide eyes, shallow nasal bridge, short nose, and large mouth. A novel missense pathogenic variant was reported, alongside the successful development of a computer-based dysmorphic facial analysis tool for accurate diagnosis.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Obstetrics & Gynecology
Rihab Derbel, Hanen Sellami, Rim Sakka, Ahlem Ben Slima, Ilyess Mkaddem, Radhouane Gdoura, Elreavy Mcelreavey, Leila Ammar-Keskes
Summary: The association of leukocytospermia with male fertility remains under debate. This study aimed to evaluate the association of leukocytospermia with sperm parameters, mitochondrial DNA variations, and oxidative stress and inflammatory cytokines in Tunisian infertile men. The results showed a significant increase in DNA fragmentation, mitochondrial DNA substitutions, and oxidative stress levels in the leukocytospermic group compared to the non-leukocytospermic group.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2021)
Article
Andrology
Rihab Derbel, Hanen Sellami, Ahmed Rebai, Radhouane Gdoura, Elreavy Mcelreavey, Leila Ammar-Keskes
Summary: Leukocytospermia was found to impact sperm nuclear DNA integrity and mitochondrial DNA structure, possibly through oxidative stress leading to compromised sperm function. Patients with leukocytospermia exhibited higher MDA levels and more severe sperm DNA fragmentation, along with a greater number of substitutions in mitochondrial DNA sequencing, particularly in COXI. These findings suggest a potential link between leukocytospermia, prostate cancer, and mitochondrial DNA modifications influenced by oxidative stress.
Article
Genetics & Heredity
Mayssa Abdelwahed, Pascale Hilbert, Asma Ahmed, Mouna Dey, Salem Bouomrani, Hassen Kamoun, Leila Ammar-Keskes, Neila Belguith
Summary: A high prevalence of genetic kidney disease has been detected in Tunisia, and this study provides important clinical and genetic information. Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of kidney-related morbidity and mortality in Tunisia. The study analyzes the clinical and genetic characteristics of a cohort of Tunisian patients with ADPKD, providing insights for early diagnosis and management.
Article
Genetics & Heredity
Rim Sakka, Fatma Abdelhedi, Hanen Sellami, Bruno Pichon, Yosra Lajmi, Mouna Mnif, Sahbi Kebaili, Rihab Derbel, Hassen Kamoun, Radhouane Gdoura, Anne Delbaere, Julie Desir, Marc Abramowicz, Francois Vialard, Jean -Michel Dupont, Leila Ammar-Keskes
Summary: We report on a study of POI in a Tunisian family, which identified a duplication in the Xp22.12 region and a new heterozygous variant in the SPIDR gene associated with POI. Our findings suggest that EIF1AX and SPIDR genes may be involved in ovarian function.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Obstetrics & Gynecology
Myriam Ghorbel, Siwar Baklouti-Gargouri, Rim Keskes, Afifa Sellami, Ken McElreavy, Leila Ammar-Keskes
Summary: The present study aimed to investigate the implication of Y chromosome genetic variations and haplogroups in Tunisian infertile men. The results showed a significantly higher frequency of the J1J* haplogroup in azoo/oligospermic patients compared to normospermic men, suggesting it may be a risk factor for infertility in the Tunisian population. Additionally, the R1 haplogroup was found to provide stability to the Y chromosome in Tunisian men.
Article
Microbiology
Nour El Houda Mathlouthi, Aicha Kriaa, Leila Ammar Keskes, Moez Rhimi, Radhouane Gdoura
Summary: Colorectal cancer is a complex disease, and gut microbiota plays a significant role in its development and progression. The study found that the microbiota in colorectal cancer patients is enriched with virulence factors related to cell adhesion, isochorismatase, and microbial siderophores. Furthermore, advanced stages of colorectal cancer showed increased abundances of proteins associated with antibiotic resistance and biofilm development.
Article
Biochemistry & Molecular Biology
Bochra Ben Rhouma, Manuel Kley, Fakhri Kallabi, Faten Hadj Kacem, Thouraya Kammoun, Wajdi Safi, Leila Keskes, Mouna Mnif, Alex Odermatt, Neila Belguith
Summary: 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) plays a crucial role in male sexual development by converting androstenedione to testosterone. Mutations in the HSD17B3 gene that cause 17 beta-HSD3 deficiency have been found in individuals with 46,XY Disorders of Sex Development (46,XY DSD). This study reports three new cases of Tunisian patients with HSD17B3 mutations, including a previously reported mutation and two novel mutations with different effects on enzyme activity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Oncology
Salma Abbes, Simone Baldi, Hayet Sellami, Amedeo Amedei, Leila Keskes
Summary: Colorectal cancer (CRC) is the third most common malignancy and second most deadly cancer worldwide, with a higher incidence in developed countries. It is a heterogeneous genomic disease with various alterations contributing to its development. Previous screening efforts for CRC have been limited by performance issues and low penetrance of standard screening tools, but the advent of next-generation sequencing (NGS) has revolutionized the identification of novel genomic CRC characteristics and understanding of its carcinogenesis. This review focuses on the diagnostic tools used for CRC screening, with an emphasis on recent NGS approaches and their role in identifying clinically actionable targets for personalized medicine.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nour El Houda Mathlouthi, Hamadou Oumarou Hama, Imen Belguith, Slim Charfi, Tahya Boudawara, Jean-Christophe Lagier, Leila Ammar Keskes, Ghiles Grine, Radhouane Gdoura
Summary: In this study, the researchers performed a metagenomic analysis of colorectal cancer (CRC) patients in Tunisia to investigate the link between archaea and CRC. They found a significant association between Halobacteria, particularly Natrialba magadii, and tumor tissues in CRC patients. This study demonstrates the feasibility of archaeome analysis from formalin-fixed paraffin-embedded tissues using simple protocols and provides insight into the potential role of archaea in CRC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
