Article
Chemistry, Multidisciplinary
Ania S. Sergeenko, Damir Paripovic, Nicolas Belanger-Desmarais, Christian Reber, Daniel B. Leznoff
Summary: This is a study on coordination polymers, which are found to have a 1-D zig-zag chain structure that interacts via hydrogen bonding to form a highly aligned 2-D array. These materials represent the first transition-metal coordination polymers that incorporate the [Pd(i-mnt)(2)](2-) building block.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Ashot H. Gevorgyan, Sergey S. Golik, Nikolay A. Vanyushkin, Ilya M. Efimov, Mushegh S. Rafayelyan, Hermine Gharagulyan, Tatevik M. Sarukhanyan, Meruzhan Z. Hautyunyan, Gvidon K. Matinyan
Summary: The research focuses on the magneto-optical properties of a dichroic cholesteric liquid crystal layer with large values of magneto-optical parameter g and low values of dielectric permittivity. The study delves into the solutions of the dispersion equation and their peculiarities, as well as investigating the specific properties of various spectra and the existence of a tunable linear and nonreciprocal transmission band.
Article
Environmental Sciences
Mersad Bagherpour Kalo, Mohsen Rezaei
Summary: The study found that low concentrations of pyruvate have a protective effect on mitochondria, while high concentrations in combination with arsenic trioxide lead to decreased complex II activity, increased mitochondrial ROS production, lipid peroxidation, GSH depletion, mitochondrial membrane damage, and swelling. These results suggest that pre-diabetics exposed to low concentrations of arsenic through food and water may develop mitochondrial dysfunction that accelerates their progression to diabetes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Bin Li, Yuhui Wei, Qian Li, Nan Chen, Jiang Li, Lin Liu, Jinjin Zhang, Ying Wang, Yanhong Sun, Jiye Shi, Lihua Wang, Zhifeng Shao, Jun Hu, Chunhai Fan
Summary: The authors used an integrated atomic force microscope and brightfield/epifluorescent microscope platform to simulate living single cells under physiological conditions, measuring the autophagic response and its transmission to neighboring cells. The study showed the dynamics of autophagosome formation, degradation, and induction in neighboring cells, as well as the enhancement of autophagic responses in neighboring cells via a gap junction-dependent mechanism. The AFM-based nanoacupuncture platform can be a valuable tool for understanding the primary mechanism of mechanical stimulation in living systems and other biomechanical therapeutics.
Article
Chemistry, Multidisciplinary
Olivier Noel, Pierre-Emmanuel Mazeran, Igor Stankovic
Summary: This paper investigates the physics of dynamic friction on water molecule contaminated surfaces, focusing on friction mechanisms in hydrophobic contact. Experimental investigations and molecular dynamic simulations reveal that water molecules form droplets within the sliding nanocontact instead of being squeezed out, leading to a full slip regime on the hydrophobic substrate. This research is of great significance for understanding the dynamic friction behavior of water molecules on surfaces.
Article
Multidisciplinary Sciences
Tomas Raila, Tadas Penkauskas, Filipas Ambrulevicius, Marija Jankunec, Tadas Meskauskas, Gintaras Valincius
Summary: Atomic force microscopy (AFM) image analysis can reveal the membrane damage and predict the electrochemical impedance spectroscopy (EIS) response of bilayers. Automated detection of defects in AFM images using a convolutional neural network (CNN) was found to be sufficient to predict EIS spectra, but systematic errors need to be taken into account. Comparison with experimental curves allowed the estimation of important physical parameters.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Marcel Hanke, Daniel Dornbusch, Christoph Hadlich, Andre Rossberg, Niklas Hansen, Guido Grundmeier, Satoru Tsushima, Adrian Keller, Karim Fahmy
Summary: This study investigates the correlation between atomistic, molecular, nanoscopic, and thermodynamic properties of DNA origami triangles. The results show that sulfate and chloride ions have stabilizing and destabilizing effects on DNA origami stability, respectively. The study also reveals that heat capacity changes delta C-p determine the temperature sensitivity of structural damage in DNA origami.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Materials Science, Paper & Wood
Kenta Morita, Musashi Takenaka, Kohei Tomita, Jun Ishii, Hideo Kawaguchi, Daisuke Murakami, Hikaru Amo, Miku Fujii, Tatsuo Maruyama, Takuya Matsumoto, Takashi Nishino, Chiaki Ogino
Summary: Cellulose has been developed as a sustainable alternative to petrochemical materials. Lignocellulose nanofibers (LCNFs) show promise as they are produced from biomass with mild pretreatment. This study developed two methods to detect and visualize lignin in LCNFs, revealing its microscopic location and providing a strong tool for analyzing lignin-containing materials.
Article
Microscopy
Shengli Zhang, Ying Wang, Bowei Wang, Yi Zeng, Jiani Li, Xingyue Wang, Cuihua Hu, Zhankun Weng, Zuobin Wang
Summary: Curcumin was found to have effects on the activity, migration, and mitochondrial membrane potential of malignant hepatocytes and their mitochondria. The findings from both optical microscopy and atomic force microscopy studies confirm these effects on cell morphology and biomechanics.
Review
Microbiology
Valentina B. Pavez, Nicolas Pacheco, Juan Castro-Severyn, Coral Pardo-Este, Javiera Alvarez, Phillippi Zepeda, Gabriel Kruger, Karem Gallardo, Francisco Melo, Rolando Vernal, Carlos Aranda, Francisco Remonsellez, Claudia P. Saavedra
Summary: In this study, the capacity of Exiguobacterium strains isolated from the Salar de Huasco in Chile to form biofilms in the presence of arsenic was assessed to understand their resistance mechanisms to this heavy metal. The results showed that these strains exhibit a significant ability to form biofilms when exposed to arsenic, shedding light on the underlying mechanisms. These findings enhance our understanding of biofilm formation, its role in arsenic resistance, and the adaptive strategies employed by bacteria in extreme environments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Materials Science, Coatings & Films
D. Gutnik, A. Kleinbichler, P. J. Imrich, M. J. Cordill, A. Lassnig
Summary: Quantification of adhesion between thin films and their substrates is crucial for reliable multi-material components. Metal-polymer interfaces are challenging to quantify due to their unique properties. In this study, the adhesion of a 150 nm WTi film to polyimide was determined experimentally, and two models were compared for quantification.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Kevin Pachuta, Halyna Volkova, Benjamin Hirt, Marie-Helene Berger, Emily Pentzer, Alp Sehirlioglu
Summary: Two-dimensional materials have attracted attention for their unique properties, and research into their processing and scalability is crucial for next-generation technologies. A liquid-phase exfoliation method has been developed to produce multilayer cobalt oxide nanosheets in pH-neutral aqueous solutions, with their size, thickness, and morphology confirmed using microscopy techniques.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Nan Liu, Yi Cao, Yin-Lian Zhu, Yu-Jia Wang, Yun-Long Tang, Bo Wu, Min-Jie Zou, Yan-Peng Feng, Xiu-Liang Ma
Summary: The study presents a self-assembled uniform biphasic system as a potential stable and enduring RRAM medium, demonstrating advantages in stability, uniformity, and durability for further application in RRAM devices.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Construction & Building Technology
Yuhong Wang, Kecheng Zhao, Fangjin Li, Qi Gao, King Wai Chiu Lai
Summary: This study investigated the presence of asphaltenes in different types of asphalt and their impacts on the asphalt properties. It was found that the dispersion and formation of asphaltene particles vary depending on the asphalt source, with asphaltene content playing a predominant role in determining viscosity and asphaltene morphology likely affecting the derived ductility of asphalt.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Food Science & Technology
Gilda Aiello, Raffaele Pugliese, Lukas Rueller, Carlotta Bollati, Martina Bartolomei, Yuchen Li, Josef Robert, Anna Arnoldi, Carmen Lammi
Summary: This study focused on valorizing the residual proteins in okara by using ultrasound extraction at different temperatures, resulting in improved solubility and antioxidant properties. The physicochemical and conformational changes of the extracted proteins were investigated, leading to a significant morphological transition and enhancement in peptides generation and amino acid exposure. The integrated strategy allows for the okara protein to be utilized as valuable materials for new applications.
Article
Environmental Sciences
Santu Kumar Saha, Sourav Sikdar, Avinaba Mukherjee, Kakali Bhadra, Naoual Boujedaini, Anisur Rahman Khuda-Bukhsh
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2013)
Article
Chemistry, Inorganic & Nuclear
Ayan Patra, Santu Kumar Saha, Tamal K. Sen, Luca Carrella, Ghezai T. Musie, Anisur Rahman Khuda-Bukhsh, Manindranath Bera
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2014)
Review
Pharmacology & Pharmacy
Santu Kumar Saha, Anisur Rahman Khuda-Bukhsh
EUROPEAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Santu Kumar Saha, Anisur Rahman Khuda-Bukhsh
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Oncology
Anisur Rahman Khuda-Bukhsh, Sreemanti Das, Santu Kumar Saha
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2014)
Article
Oncology
Praveen D. Sudhindar, Daniel Wainwright, Santu Saha, Rachel Howarth, Misti McCain, Yvonne Bury, Sweta S. Saha, Stuart McPherson, Helen Reeves, Arvind H. Patel, Geoffrey J. Faulkner, John Lunec, Ruchi Shukla
Summary: Chronic hepatitis C virus infection can activate L1 retrotransposons, potentially contributing to hepatocellular carcinoma development in patients with active or cleared viral infection. The study suggests a novel pathway for liver cancer development in chronic HCV patients.
Article
Oncology
Santu Saha, Stuart Rundle, Ioannis C. Kotsopoulos, Jacob Begbie, Rachel Howarth, Isabel Y. Pappworth, Asima Mukhopadhyay, Ali Kucukmetin, Kevin J. Marchbank, Nicola Curtin
Summary: This study demonstrates that DDR inhibitors targeting PARP, ATR, CHK1, and WEE1 can kill cervical cancer cells and enhance the cytotoxicity of cisplatin and radiotherapy. Additionally, the study shows that cisplatin-induced kidney injury is due to over-activation of PARP and can be reduced by co-administration of a PARP inhibitor. DDR inhibition is a promising strategy to improve the efficacy of current treatment and protect kidneys from cisplatin-induced toxicity.
Article
Biology
Santu Saha, Rachel Howarth, Sweta Sharma-Saha, Charles Kelly
Summary: A tumor-stroma based in vitro three-dimensional co-culture model of HPC has been developed, which mimics the complex tumor microenvironment. This model can assist researchers in understanding and developing new treatment approaches, such as combination therapy of radiotherapy and immunotherapy, in HPC and beyond.
Meeting Abstract
Oncology
S. Saha, R. Howarth, I. Pappworth, K. Marchbank, N. Curtin
EUROPEAN JOURNAL OF CANCER
(2020)
Review
Cell Biology
Santu Kumar Saha, Guru Prasad Maiti, Susanta Roychoudhury, Chinmay Kumar Panda