Article
Biochemistry & Molecular Biology
Yating Yang, Ruining Cheng, Jingyun Liu, Jing Fang, Xiaojing Wang, Yingxue Cui, Pan Zhang, Bin Du
Summary: This study found that linarin can effectively prevent bone deformities in mice exposed to cadmium, and reduce oxidative stress and inflammation by modulating the RANK/RANKL/OPG pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Plant Sciences
Xiangmin Ni, Bin Wu, Shuo Li, Wenyi Zhu, Zhe Xu, Guiming Zhang, Hanqiang Cui, Qian Bai, Jian Wang
Summary: Eq, as a metabolite of soy isoflavones, has a therapeutic effect on PMOP by promoting osteoblast proliferation, inhibiting apoptosis, and upregulating the OPG/RANKL pathway.
Article
Medicine, Research & Experimental
El-Shaimaa A. Arafa, Noran O. Elgendy, Mai A. Elhemely, Eglal A. Abdelaleem, Wafaa R. Mohamed
Summary: This study aimed to investigate the protective effects of diosmin against glucocorticoid-induced osteoporosis. The results showed that diosmin could alleviate bone impairment, enhance bone development, and inhibit bone resorption caused by glucocorticoids. Therefore, diosmin supplementation may be recommended for patients chronically using glucocorticoids.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai
Summary: Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits bone resorption by competitively binding with RANKL and blocking the activation of the RANK/RANKL/OPG signaling pathway. It is used to treat metabolic bone diseases and has potential in the treatment of osteoarthritis, bone tumors, and other autoimmune diseases. However, more research is needed to understand its mechanism of action and optimize its clinical use for bone metastasis of malignant tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Rui-Zhu Lin, Jian-Feng Xu, Shi-Qiang Zhu, Xiao-Yan Hei, Zhi-Jun Li, Wei-Xia Su, Sha Wen, Jin-Chen Zhang
Summary: In this study, the OPG/RANKL/RANK signaling pathway in KOA subchondral bone reconstruction was investigated, with HMm treatment showing effectiveness in improving subchondral bone microstructure in KOA. The results suggest that HMm treatment may regulate the OPG/RANK/RANKL system and may provide a basis for KOA treatment.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Physiology
Mingming Zhang, Ming Chen, Yi Li, Man Rao, Duanyang Wang, Zhongqi Wang, Licheng Zhang, Pengbin Yin, Peifu Tang
Summary: Recent evidence has revealed the important role of OPG/RANKL/RANK signaling axis in both bone and muscle tissue, but its effects on muscle atrophy are not well understood. This study found that denervated Opg knockout mice showed improved functional recovery and delayed muscle atrophy. OPG deficiency also led to milder activation of the ubiquitin-proteasome pathway in denervated muscle. Transcriptome sequencing revealed changes in gene expression in denervated muscle from Opg knockout mice, and in vitro experiments showed enhanced differentiation ability of satellite cells from Opg knockout mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska
Summary: This study investigated the protective effect of zinc supplementation against the adverse effects of cadmium on the vascular tissue of the abdominal aorta. The results showed that zinc supplementation prevented oxidative stress and inflammation caused by cadmium exposure, and reduced the concentrations of cholesterol and triglycerides in the vascular tissue, thus exerting a beneficial influence on the cardiovascular system.
Review
Endocrinology & Metabolism
Yan Zhang, Jingqi Liang, Peilong Liu, Qiong Wang, Liang Liu, Hongmou Zhao
Summary: With the increasing incidence of cancer, tumor bone metastasis has become more common among patients. The RANK/RANKL/OPG system and osteoclasts play important roles in bone homeostasis and tumor bone metastasis formation, and inhibiting this system can prevent metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Laetitia Marcadet, Zineb Bouredji, Anteneh Argaw, Jerome Frenette
Summary: Although bones, skeletal and smooth muscles, as well as the heart have different functions, they share the same embryonic origin and common signaling pathways, such as the RANK/RANKL/OPG pathway. This pathway is not only essential for bone homeostasis but also implicated in various physiological processes including muscle function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shaymaa J. Abdulrahman, Mohanad Ali Abdulhadi, Abduladheem Turki Jalil, Dumooa Falah, Muna S. Merza, Abbas F. Almulla, Ahmed Ali, Ronak Taher Ali
Summary: The skeletal system undergoes constant changes and is affected by various diseases. Several methods are used to protect bone health, but some drugs can cause bone loss. New studies are exploring the potential effects of CLA and glucosamine on bone turnover, but comprehensive research is still lacking.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska, Malgorzata Galazyn-Sidorczuk, Alicja Roszczenko, Nazar M. Smereczanski
Summary: This research showed that increasing zinc intake can alleviate oxidative stress and damage caused by cadmium in the brain. The interaction between zinc and cadmium can effectively prevent the imbalance in oxidative/antioxidative status and protect against injury to cellular macromolecules in the nervous system.
Article
Pediatrics
Suzan Omar Mousa, Asmaa Hosni Abd El-Hafez, Mostafa Ahmed Abu El-Ela, Mohamed Aboul-Fotouh Mourad, Rasha Nady Saleh, Samira Zain Sayed
Summary: The study found that the RANK/RANKL/OPG pathway affects cognition in children with transfusion-dependent thalassemia (TDT), with certain gene polymorphisms and alleles significantly impacting the intelligence quotient (IQ) levels of these children.
Review
Endocrinology & Metabolism
Jing-Yi Xue, Shiro Ikegawa, Long Guo
Summary: The RANKL/OPG/RANK signaling pathway plays a crucial role in bone metabolism and genetic mutations in associated genes can lead to various skeletal disorders. These disorders can be categorized into two types based on their effects on osteoclast formation and bone density.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Review
Medicine, General & Internal
Diego De Leon-Oliva, Silvestra Barrena-Blazquez, Laura Jimenez-Alvarez, Oscar Fraile-Martinez, Cielo Garcia-Montero, Laura Lopez-Gonzalez, Diego Torres-Carranza, Luis M. Garcia-Puente, Sara T. Carranza, Miguel Angel Alvarez-Mon, Melchor Alvarez-Mon, Raul Diaz, Miguel A. Ortega
Summary: The RANK-RANKL-OPG system is a crucial signaling pathway in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL binds to RANK on osteoclasts, dendritic cells, T cells, and other cells, promoting osteoclast differentiation and activation, resulting in bone resorption. OPG acts as a decoy receptor to inhibit RANKL signaling. Increased RANKL expression in cancer cells can lead to enhanced bone resorption and bone metastases. RANKL-neutralizing antibodies, like denosumab, have shown efficacy in treating skeletal-related events and cancer.
MEDICINA-LITHUANIA
(2023)
Article
Orthopedics
Chenyang Meng, Boyong Jiang, Wanlin Liu, Lianjuan Wang, Zhenqun Zhao, Rui Bai, Yan Zhao
Summary: Upregulation of miR-217 inhibits the proliferation and tumorigenesis of GCT cells by blocking autophagy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska, Malgorzata Galazyn-Sidorczuk, Alicja Roszczenko, Nazar M. Smereczanski
Summary: This research showed that increasing zinc intake can alleviate oxidative stress and damage caused by cadmium in the brain. The interaction between zinc and cadmium can effectively prevent the imbalance in oxidative/antioxidative status and protect against injury to cellular macromolecules in the nervous system.
Article
Medicine, General & Internal
Ewa Olszewska, Joanna Rogalska, Malgorzata M. Brzoska
Summary: Individuals with obstructive sleep apnea syndrome (OSAS) exhibit oxidative stress in the uvular mucosa that correlates with the occurrence of OSAS. This study found an oxidative/reductive imbalance in the uvula mucosa of OSAS individuals, with a negative correlation between total antioxidative status (TAS) in the mucosa and the severity of the syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Michal Biernacki, Malgorzata Michalina Brzoska, Agnieszka Markowska, Malgorzata Galazyn-Sidorczuk, Bogdan Cylwik, Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: The study concludes that CBD has a protective effect against oxidative stress caused by UVB radiation, enhancing antioxidant capacity and reducing lipid peroxidation and protein modifications. CBD showed to counteract the down-regulation of 2-arachidonylglycerol induced by UV, promoting antioxidant and anti-inflammatory effects.
Article
Cell Biology
Barbara M. Onopiuk, Zofia N. Dabrowska, Joanna Rogalska, Malgorzata M. Brzoska, Adam Dabrowski, Kamil Bijowski, Pawel Onopiuk, Barbara Mroczko, Karolina Orywal, Ewa Dabrowska
Summary: The study found that consuming black chokeberry products during cadmium intoxication can prevent oxidative stress and its consequences, thus counteracting the unfavorable impact of this xenobiotic on the oral cavity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Toxicology
Agnieszka Ruczaj, Malgorzata M. Brzoska
Summary: Nowadays, there is increasing attention on the risk of neurotoxicity from environmental exposure to cadmium (Cd). Studies have shown that concentrations of Cd >0.8μg Cd/L in urine and >0.6μg Cd/L in blood may have adverse effects on the human nervous system. The neurotoxic mechanism of Cd may involve oxidative stress, disruption of enzyme activity, and disturbance of bioelement homeostasis in the brain.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska
Summary: This study investigated the protective effect of zinc supplementation against the adverse effects of cadmium on the vascular tissue of the abdominal aorta. The results showed that zinc supplementation prevented oxidative stress and inflammation caused by cadmium exposure, and reduced the concentrations of cholesterol and triglycerides in the vascular tissue, thus exerting a beneficial influence on the cardiovascular system.
Article
Biochemistry & Molecular Biology
Piotr Fiedorczuk, Ewa Olszewska, Joanna Rogalska, Malgorzata M. Brzoska
Summary: Obstructive sleep apnea (OSA) is a prevalent and underdiagnosed disease associated with cardiovascular diseases, depression, accidents, and stroke. This study evaluated the concentrations of Osteoprotegerin (OPG), Chitinase 3-like protein 1 (YKL-40), and Cardiotrophin-1 (CT-1) in the serum and plasma to determine their correlation with OSA severity. It was found that the concentrations of YKL-40 and CT-1 were higher in OSA patients, while the concentrations of OPG were lower compared to non-OSA controls. The diagnostic capabilities for moderate and severe OSA were better for YKL-40 and CT-1 in the serum and OPG in the plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Malgorzata Galazyn-Sidorczuk, Magdalena Kozlowska, Nazar M. Smereczanski
Summary: The study found that the extract from Aronia melanocarpa L. berries can protect the body's manganese status and improve the antioxidant capacity of cells under exposure to cadmium. These findings confirm the protective impact of aronia berries against cadmium toxicity.
Review
Biochemistry & Molecular Biology
Nazar M. Smereczanski, Malgorzata M. Brzoska
Summary: The increasing number of reports suggests that exposure to cadmium in the environment has negative effects on human health, particularly on the kidney. This article critically reviews the available literature on the impact of current levels of environmental cadmium exposure in industrialized countries on kidney function, and evaluates the associated risk of organ damage, including chronic kidney disease (CKD). Based on comprehensive data review, it is recognized that the observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) of cadmium concentrations in the blood and urine are within the lower range of concentrations noted in residents of industrialized countries. This indicates that the current levels of environmental cadmium exposure may increase the risk of clinically relevant kidney damage and contribute to the development of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nazar M. M. Smereczanski, Malgorzata M. Brzoska, Joanna Rogalska, Tomasz Hutsch
Summary: This study investigated the impact of low and moderate levels of cadmium exposure on the kidney function and structure in rats. It was found that such exposure led to damage in the kidney tubules and glomeruli. However, the administration of Aronia melanocarpa berry extract significantly protected against this injurious effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
