Article
Pharmacology & Pharmacy
Prasada Rao S. Kodavanti, Matthew Valdez, Judy E. Richards, Datonye I. Agina-Obu, Pamela M. Phillips, Kimberly A. Jarema, Urmila P. Kodavanti
Summary: The study found that exposure to ozone in elderly rats leads to an increase in oxidative stress in certain brain regions and has a negative impact on horizontal motor activity. Rats of different age groups respond differently to ozone, with younger rats showing more pronounced effects, especially in terms of horizontal motor activity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Physiology
Terence Al L. Abaquita, Milena Damulewicz, Grzegorz Tylko, Elzbieta Pyza
Summary: This study investigates the neuroprotective and neurotoxic effects of heme oxygenase (HO) in Drosophila melanogaster neurons through chronic overexpression or silencing of the ho gene. The results show that pan-neuronal ho overexpression leads to early deaths and behavioral defects, while pan-neuronal ho silencing has similar effects to the parental controls. Furthermore, the study reveals that HO can have both pro-apoptotic and anti-apoptotic effects depending on different conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Pediatrics
Constanza P. Soto Conti
Summary: Hyperbilirubinemia is a common reason for consultation and hospitalization in neonates, requiring timely treatment to prevent neurotoxicity and oxidative stress. Bilirubin itself acts as a potent antioxidant, and understanding the mechanisms of its cell damage can facilitate more accurate phototherapy treatment.
ARCHIVOS ARGENTINOS DE PEDIATRIA
(2021)
Article
Cell Biology
Hussein Kadhem Al-Hakeim, Mazin Fadhil Altufaili, Abbas F. Almulla, Shatha Rouf Moustafa, Michael Maes
Summary: MA dependence and acute intoxication are associated with increased oxidative stress and lowered antioxidant defenses, increasing the risk of MIP during acute intoxication.
Article
Nanoscience & Nanotechnology
Heba Ghamry, Mustafa Shukry, Mohamed A. Kassab, Foad A. Farrag, Nagi M. El-Shafai, Enas Elgendy, Amany N. Ibrahim, Salwa A. Elgendy, Ali Behairy, Samah F. Ibrahim, Florin Imbrea, Florin Crista, Mohamed Abdo, Inas A. Ahmed, Marwa H. Muhammad, Hala Anwer, Ahmed Abdeen
Summary: The study found that Arthrospira platensis nanoparticles (NSP) can protect rats from aging injuries and alleviate oxidative changes caused by D-galactose (D-gal). This suggests that NSP may be a promising natural protective compound that can prevent aging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Annu Phogat, Jagjeet Singh, Vinay Malik, Vijay Kumar
Summary: This study aimed to evaluate the ameliorative potential of berberine (BBR) on acetamiprid (ACMP)-induced neurotoxicity. BBR significantly reduced oxidative stress and increased endogenous antioxidants in rat brain regions. It also protected against mitochondrial dysfunction caused by ACMP and modulated the expression of mitochondrial complexes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hiva Sharebiani, Shayan Keramat, Abdolali Chavoshan, Bahar Fazeli, Agata Stanek
Summary: Obesity is a global trend with a fast-growing incidence rate. The dysfunction of adipose tissue caused by obesity is associated with oxidative stress. Oxidative stress and inflammation caused by obesity play a crucial role in the development of vascular diseases, specifically vascular aging. This study aims to review the impact of antioxidants on obesity-induced vascular aging resulting from oxidative stress.
Review
Environmental Sciences
Velid Unsal, Mustafa Cicek, Ilhan Sabancilar
Summary: This study discusses the damage-causing mechanism of free radicals produced by CCl4 on tissues/cells and the role of antioxidants in preventing tissue/cell damage. By maintaining a balance between free radicals and antioxidants, the negative effects induced by CCl4 can be reduced.
REVIEWS ON ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Carmine Merola, Jacopo Fabrello, Valerio Matozzo, Caterina Faggio, Annamaria Iannetta, Antonella Tinelli, Giuseppe Crescenzo, Michele Amorena, Monia Perugini
Summary: This study evaluated the potential effects of PND on the development of zebrafish early-life stages. The results showed that PND exposure caused mortality and sublethal alterations in the fish, including impaired fin development, delayed ossification of the vertebral column, disrupted muscle morphology, and increased neurotoxicity. In addition, biochemical changes in antioxidant enzymes were observed. These findings confirm the developmental toxicity of PND in zebrafish and suggest the role of oxidative stress in the sublethal alterations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Hazem K. Ghneim, Mohammad A. Alfhili, Sami O. Alharbi, Shady M. Alhusayni, Manal Abudawood, Feda S. Aljaser, Yazeed A. Al-Sheikh
Summary: This study reveals that senescence decreases the mitochondrial antioxidant capacity and disrupts the redox state of human cells, leading to metabolic dysfunction and oxidative stress. The findings suggest a potential protective role of antioxidants in aging-associated diseases.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Ece Yalcin, Izzet Yavuz, Neslisah Rakicioglu
Summary: Younger adults showed greater dietary diversity compared to older adults, while older adults exhibited lower dietary total antioxidant capacity and diversity. The serum total oxidant status and oxidative stress index were significantly higher in older adults than in younger adults.
TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
(2021)
Article
Sport Sciences
Hakan Celikhisar, Fidel Demir
Summary: This study aimed to investigate the relationship between physical activity and oxidative stress biomarkers in adults over 65 years of age. The results showed that increased duration of physical activity in everyday life is associated with higher antioxidant capacity, lower oxidative stress, glycemic level, and BMI.
PHYSICAL ACTIVITY REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Ashafaq, Sohail Hussain, Saeed Alshahrani, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S. Alqahtani, Abdulmajeed M. Jali, Hashim M. Aljohani
Summary: Cypermethrin (CPM), a toxic synthetic pyrethroid, causes neurotoxicity by inducing oxidative stress and neurochemical agitation in rats. Curcumin nanoparticles (NC), with potent antioxidant and anti-inflammatory properties, can attenuate CPM-induced neurotoxicity in rat brains. This study supports the use of NC as an effective treatment option for CPM-induced neurotoxicity.
Review
Biochemistry & Molecular Biology
Gregory A. Shilovsky, Vasily V. Ashapkin
Summary: The transcription factor Nrf2 and mitochondria play important roles in regulating cellular antioxidant systems and the aging rate. Nrf2 affects mitochondrial quality control and dynamics through mechanisms such as regulation of mitochondrial proteins and ROS balance. Multiple regulatory proteins associated with mitochondria also influence Nrf2 activity and form regulatory loops. Additionally, mtDNA-encoded signal peptides have been found to interact with nuclear regulatory systems, including Nrf2, and may be involved in regulating the aging rate.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Chemistry, Multidisciplinary
Lazhar Mhadhbi, Tahani El Ayari, Meriam Tir, Dorra Kadri
Summary: This study assessed the acute and chronic effects of azithromycin on European sea bass early life stages, finding that short-term exposure to high concentrations of azithromycin caused larval mortality and morphological abnormalities. The antibiotic also induced oxidative stress, peroxidative damage, and neurotoxicity in juveniles, impacting enzyme activities in gill and liver tissues.
DRUG AND CHEMICAL TOXICOLOGY
(2022)