Article
Food Science & Technology
Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang
Summary: The metabolites of plasticizers did not show direct effects on the glucocorticoid receptor, but they could synergistically activate the receptor in combination with dexamethasone. The study found that monobutyl phthalate (MBP) in combination with dexamethasone enhanced the expression of specific genes and proteins regulated by the glucocorticoid receptor. The interactions between MBP and the glucocorticoid receptor were influenced by the chemical properties of MBP, with hydrophobic and hydrogen bonding interactions playing crucial roles in stabilizing the complex.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Annick N. Enangue Njembele, Zoheir B. Demmouche, Janice L. Bailey, Jacques J. Tremblay
Summary: This study found that an environmentally relevant mixture of organochlorine chemicals (OCs) disrupts steroidogenesis in Leydig cells by decreasing the levels of the STAR protein, which is involved in cholesterol transportation for steroid hormone synthesis. Additionally, the OC mixture affects other proteins involved in mitochondrial transport, lipid metabolism, and steroidogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Vicente Mustieles, Juan-Pedro Arrebola, Miquel Porta
Summary: Citizens should have access to regulatory changes and policies that prioritize the needs of humans, the climate, and nature. We draw on past experiences of preventable human suffering and economic losses caused by delayed regulation of both old and new pollutants. It is crucial for health professionals, the media, and citizens' organizations to increase awareness of environmental health issues. Improving the translation of research into clinical practices and policies is necessary to reduce the burden of diseases caused by exposure to environmental chemicals. There are valuable lessons to be learned from previous science-to-policy processes and current trends in regulating pollutants.
PREVENTIVE MEDICINE
(2023)
Editorial Material
Immunology
Amy S. Weinmann
Summary: Signaling via T cell antigen receptors is reduced in aging. Surprisingly, CD4(+) T cells from older adults exhibit a preference for differentiating into effector-like cells rather than memory cells. This decision is influenced by an altered balance between HELIOS, IL-2R alpha, and STAT5 activities.
Article
Biochemistry & Molecular Biology
Reinaldo Sousa Dos Santos, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Summary: Metabolism-disrupting chemicals (MDCs), including bisphenol-A (BPA) and tributyltin (TBT), can decrease the viability of alpha cells and negatively affect glucagon secretion. These effects are mediated through the activation of estrogen receptors and PPAR gamma. Other MDCs, such as perfluorooctanoic acid (PFOA), triphenylphosphate (TPP), triclosan (TCS), and dichlorodiphenyldichloroethylene (DDE), do not affect cell viability but still impair glucagon secretion. The study suggests that the alpha TC1-9 cell line can be used as a model to test metabolism-disrupting chemicals, and the proposed test methods could be incorporated into protocols for screening diabetogenic MDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Massimo Venditti, Mariem Ben Rhouma, Maria Zelinda Romano, Imed Messaoudi, Russel J. Reiter, Sergio Minucci
Summary: This study found that melatonin can alleviate the damage of cadmium on the adult rat testis, including decreased testosterone concentrations, altered sperm parameters, and disruption of the blood-testis barrier and germ cell structure. Melatonin can reduce oxidative damage caused by cadmium, reverse observed changes, and improve sperm quality.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Lidia Caporossi, Paola Vigano, Enrico Paci, Silvia Capanna, Alessandra Alteri, Giovanni Campo, Daniela Pigini, Mariangela De Rosa, Giovanna Tranfo, Bruno Papaleo
Summary: The study revealed significantly higher concentrations of certain phthalates, particularly in women with recurrent pregnancy loss (RPL) and idiopathic infertility. Work environment may have a differential impact on the exposure to these compounds, which warrants further investigation.
Article
Environmental Sciences
Sujin Lee, Bareum Kwon, Junhyeok Jeong, Younglim Kho, Kyunghee Ji
Summary: In this study, the adverse effects of benzisothiazolinone (BIT) on the thyroid neuroendocrine system of zebrafish embryos/larvae were investigated. BIT exposure resulted in coagulation and hatching delay, decreased hatchability and larval survival, and altered gene expression related to thyroid hormones and thyrotropin-releasing hormone secretion. The underlying mechanisms involve central regulation, receptor binding, and deiodination.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Toxicology
Ambra Maddalon, Luigi Cari, Martina Iulini, Mahdieh Naghavi Alhosseini, Valentina Galbiati, Marina Marinovich, Giuseppe Nocentini, Emanuela Corsini
Summary: This study investigated the potential effects of endocrine disruptors (EDs) on immune cells, with a focus on gender differences. The results showed that exposure to different EDs resulted in alterations in RACK1 expression, pro-inflammatory activity, natural killer lytic ability, and lymphocyte differentiation, with gender-specific effects and magnitudes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Rong Zhong, Heng He, Meng Jin, Zequn Lu, Yao Deng, Chong Liu, Na Shen, Jiaoyuan Li, Haoxue Wang, Pingting Ying, Bin Li, Qiang Zeng, Qing Lu, Liming Cheng, Ying Zhu, Xiaoping Miao, Jianbo Tian
Summary: This study in a Chinese population found a positive association between bisphenols, triclosan and oxidative stress markers. Significant interactions between genetic variants and endocrine disruptors were identified, indicating that endocrine disruptors may modify the effect of genetic variants on oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Massimo Venditti, Maria Zelinda Romano, Francesco Aniello, Sergio Minucci
Summary: Quality sperm production is essential for proper fertility, but environmental pollutants can disrupt the spermatogenetic process. D-Aspartic acid (D-Asp) has been shown to prevent harmful effects, potentially by reducing oxidative stress. This compound could be a promising candidate for alleviating the toxic effects of environmental pollutants and preserving reproductive function.
Article
Food Science & Technology
Jingchao Guo, Xiaochun Ye, Yongxia Zhao, Deyu Huang, Qinghua Wu, Awais Ihsan, Xu Wang
Summary: This study uncovered the mechanism by which T-2 toxin enhances mitochondrial function and biogenesis through the regulation of NRF-2 alpha and its target genes. It was also demonstrated that T-2 toxin induces autophagy and mitophagy, and that mitophagy plays a protective role in maintaining mitochondrial function and cell survival in the presence of T-2 toxin.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Karen Julie la Cour Karottki, Hooman Hefzi, Songyuan Li, Lasse Ebdrup Pedersen, Philipp N. Spahn, Chintan Joshi, David Ruckerbauer, Juan A. Hernandez Bort, Alex Thomas, Jae Seong Lee, Nicole Borth, Gyun Min Lee, Helene Faustrup Kildegaard, Nathan E. Lewis
Summary: Media and feed optimization have improved mammalian biopharmaceutical production, but genome editing offers a new avenue for enhancing cell metabolism. A comprehensive pooled CRISPR screen identified a glutamine response network in CHO cells, and knockout of a poorly characterized lipase gene significantly increased cell growth in glutamine-free media. The screen provides a targeted platform to study genes involved in metabolic traits and elucidate novel regulators of metabolism.
METABOLIC ENGINEERING
(2021)
Correction
Environmental Sciences
Markus Hecker, Henner Hollert, Ralph Cooper, Anne-Marie Vinggaard, Yumi Akahori, Margaret Murphy, Christine Nellemann, Eric Higley, John Newsted, John Laskey, Angela Buckalew, Stefanie Grund, Sibylle Maletz, John Giesy, Gary Timm
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Meeting Abstract
Toxicology
C. Taxvig, M. Scholze, A. Kortenkamp, J. Boberg, T. Svingen, S. Ermler, S. S. Hermann, A. K. Lykkeberg, M. Pedersen, U. Hass, S. Bonomo, A. M. Vinggaard
TOXICOLOGY LETTERS
(2018)
Article
Environmental Sciences
Monica Kam Draskau, Julie Boberg, Camilla Taxvig, Mikael Pedersen, Henrik Lauritz Frandsen, Sofie Christiansen, Terje Svingen
ENVIRONMENTAL POLLUTION
(2019)
Article
Environmental Sciences
Cecilie N. Ramskov Tetzlaff, Terje Svingen, Anne M. Vinggaard, Anna K. Rosenmai, Camilla Taxvig
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Toxicology
Karin Lauschke, Anna Kjerstine Rosenmai, Ina Meiser, Julia Christiane Neubauer, Katharina Schmidt, Mikkel Aabech Rasmussen, Bjorn Holst, Camilla Taxvig, Jenny Katarina Emneus, Anne Marie Vinggaard
ARCHIVES OF TOXICOLOGY
(2020)
Review
Environmental Sciences
Anne Marie Vinggaard, Eva Cecilie Bonefeld-Jorgensen, Tina Kold Jensen, Mariana F. Fernandez, Anna Kjerstine Rosenmai, Camilla Taxvig, Andrea Rodriguez-Carrillo, Maria Wielsoe, Manhai Long, Nicolas Olea, Jean-Philippe Antignac, Timo Hamers, Marja Lamoree
Summary: Human exposure to chemical mixtures from various sources may pose risks to health, especially during critical periods of development. Traditional one-chemical-at-a-time approaches have limited understanding of the combined effects of mixtures. Researchers are now using in vitro assays to assess exposure and health impacts of chemical mixtures, providing a more comprehensive understanding of their effects on human health.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Toxicology
Karin Lauschke, Andreas Frederik Treschow, Mikkel Aabech Rasmussen, Nichlas Davidsen, Bjorn Holst, Jenny Emneus, Camilla Taxvig, Anne Marie Vinggaard
Summary: A novel in vitro assay called the PluriLum assay was developed, which uses luminescence intensity as a readout instead of traditional cell counting methods, showing higher efficiency and standardized results for toxicity screening.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Cecilie Nethe Ramskov Tetzlaff, Louise Ramhoj, Aurelie Lardenois, Marta Axelstad, Bertrand Evrard, Frederic Chalmel, Camilla Taxvig, Terje Svingen
Summary: The study indicates that early life exposure to endocrine disrupting chemicals may influence offspring body weight later in life, but this effect may not necessarily be reflected in altered gene expression in fat tissue.
TOXICOLOGY LETTERS
(2021)
Article
Toxicology
Hanna Katarina Lilith Johansson, Camilla Taxvig, Gustav Peder Mohr Olsen, Terje Svingen
Summary: The study examined the impact of exposure to HH-disrupting chemicals on ovary development, indicating that HH signal disruptors may affect ovary development with potential long-term consequences for female reproductive health. Potent HH inhibitors could cause severe teratogenic effects, raising concerns about reproductive disorders when present at low concentrations in combination with other ovary or endocrine disrupting compounds.
TOXICOLOGICAL SCIENCES
(2021)
Review
Environmental Sciences
Vicente Mustieles, Ria K. Balogh, Marta Axelstad, Parisa Montazeri, Sandra Marquez, Martine Vrijheid, Monica K. Draskau, Camilla Taxvig, Francisco M. Peinado, Tamar Berman, Hanne Frederiksen, Mariana F. Fernandez, Anne Marie Vinggaard, Anna-Maria Andersson
Summary: This study comprehensively evaluated the safety issues of BP-3 and BP-1 in the human body and found that they have endocrine disrupting properties. HBM studies showed that North Americans have potential exposure levels 10 to 20 times higher than Europeans and Asians. Therefore, it is recommended to use commercially available sunscreens with inorganic UV filters for susceptible populations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Yanying Ma, Camilla Taxvig, Andrea Rodriguez-Carrillo, Vicente Mustieles, Lena Reiber, Anja Kiesow, Nathalie Michelle Lobl, Mariana F. Fernandez, Tina Vicky Alstrup Hansen, Maria Joao Valente, Marike Kolossa-Gehring, Madlen David, Anne Marie Vinggaard
Summary: As part of the European Joint programme 'Human Biomonitoring for Europe', a new methodology for mixture risk assessment of chemicals affecting male reproductive function was explored. The study identified 231 chemicals that can interfere with human androgen receptor activity, and 61 of them were finally identified to have reliable data. The major drivers of the mixture effect were PCB 118, BBP, PFOS, DBP, and benzophenone-3, contributing to 75% of the total mixture effect.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Food Science & Technology
Brajesh K. Singh, Evan D. G. Fraser, Tom Arnold, Patricia Biermayr-Jenzano, Jacqueline E. W. Broerse, Gianluca Brunori, Patrick Caron, Olivier De Schutter, Karen Fabbri, Shenggen Fan, Jessica Fanzo, Magdalena Gajdzinska, Mirjana Gurinovic, Marta Hugas, Jacqueline McGlade, Christine Nellemann, Jemimah Njuki, Hanna L. Tuomisto, Seta Tutundjian, Justus Wesseler, Roberta Sonnino, Patrick Webb
Summary: This paper summarizes the findings of the European Commission's High Level Expert Group on Food Systems Science, which identified barriers that prevent food systems policy from achieving society-wide impacts. Three potential pathways for food system transformation were identified: adapting the current science-policy interface landscape, enhancing the current policy landscape with multisectoral task-forces, and establishing a network of networks. These pathways aim to engage stakeholders, translate evidence into outcomes, ensure access to data, explore future scenarios, produce assessment reports and policy publications, and establish diplomatic fora to set standards and targets.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Letter
Food Science & Technology
Brajesh K. Singh, Evan D. G. Fraser, Tom Arnold, Patricia Biermayr-Jenzano, Jacqueline E. W. Broerse, Gianluca Brunori, Patrick Caron, Olivier De Schutter, Karen Fabbri, Shenggen Fan, Jessica Fanzo, Magdalena Gajdzinska, Mirjana Gurinovic, Marta Hugas, Jacqueline McGlade, Christine Nellemann, Jemimah Njuki, Hanna L. Tuomisto, Seta Tutundjian, Justus Wesseler, Roberta Sonnino, Patrick Webb
Article
Environmental Sciences
Martin Scholze, Camilla Taxvig, Andreas Kortenkamp, Julie Boberg, Sofie Christiansen, Terje Svingen, Karin Lauschke, Henrik Frandsen, Sibylle Ermler, Susan Strange Hermann, Mikael Pedersen, Anne Kruse Lykkeberg, Marta Axelstad, Anne Marie Vinggaard
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Meeting Abstract
Toxicology
C. Taxvig, M. Scholze, A. Kortenkamp, J. Boberg, T. Svingen, K. Lauschke, S. Christiansen, S. Ermler, S. Strange Hermann, M. Pedersen, H. Frandsen, A. Kruse Lykkeberg, A. M. Vinggard
TOXICOLOGY LETTERS
(2019)