Article
Biochemistry & Molecular Biology
Ivan V. Chernikov, Yaroslav Yu. Staroseletz, Irina S. Tatarnikova, Aleksandra V. Sen'kova, Innokenty A. Savin, Andrey V. Markov, Evgeniya B. Logashenko, Elena L. Chernolovskaya, Marina A. Zenkova, Valentin V. Vlassov
Summary: We reanalyzed transcriptome data from mice and humans with acute lung injury and identified a set of genes that could be targeted to suppress inflammation in lung tissue. We evaluated the expression of these genes in cells from different origins during LPS-induced inflammation and identified tissue inhibitor of metalloproteinase Timp1 as a promising target. We designed an effective chemically modified anti-TIMP1 siRNA and demonstrated that silencing Timp1 reduced IL6 secretion in macrophage cells and alleviated LPS-induced acute lung injury in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Erica L. Littlejohn, Anthony J. DeSana, Hannah C. Williams, Rudy T. Chapman, Binoy Joseph, Jelena A. Juras, Kathryn E. Saatman
Summary: Adult hippocampal neurogenesis is acutely stimulated after traumatic brain injury (TBI), with factors like IGF1 and mTOR playing key regulatory roles in neuronal differentiation and development. Controlled activation of mTOR activity could potentially reduce aberrant plasticity post-TBI, affecting therapeutic strategies for TBI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
L. E. Carter, S. Bugiel, A. Nunnikhoven, A. J. Verster, G. S. Bondy, I. H. A. Curran
Summary: This study investigates the toxicity of low doses of OTA in rats exposed in utero and throughout development using transcriptomics and previous data. The findings suggest that male rats show activation of innate and adaptive immune responses to OTA exposure, while this response is not observed in female rats. Differentially expressed genes related to karyomegaly, MAPK activity, and immune activation are found in both male and female rats, indicating the developmental effects of OTA exposure. The study confirms that OTA causes renal toxicity and alters liver and reproductive pathways in rats.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Meng Wang, Haoyu Liu, Xu Zhang, Wenbo Zhao, Danyang Li, Chengpeng Xu, Zhen Wu, Fei Xie, Xiangzhi Li
Summary: The study revealed that MOF is significantly overexpressed during ALI and can impact liver cell proliferation, fibrosis, and activation of certain signaling pathways. Knockdown of Mof attenuated ALI and promoted liver regeneration by activating the Insulin-like growth factor 1 signaling pathway. These findings suggest a potential therapeutic target for ALI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Merrie Mosedale, Yanwei Cai, J. Scott Eaddy, Patrick J. Kirby, Francis S. Wolenski, Yvonne Dragan, William Valdar
Summary: The development of TAK-875 was halted due to cases of drug-induced liver injury observed in Phase 3 clinical trials. Further studies identified oxidative stress, mitochondrial dysfunction, altered bile acid homeostasis, and immune response as mechanisms of TAK-875 DILI, with genetic risk factors playing a role in toxicity susceptibility. A novel preclinical approach using Collaborative Cross mice was used to identify human-relevant mechanisms of toxicity and genetic risk factors at the hepatocyte level, potentially aiding in understanding, predicting, and preventing clinical DILI for other drugs.
Article
Biochemistry & Molecular Biology
Yi Liu, Cong Zhang, Jiayong Zhu, Hui Qu, Siqi Zhou, Ming Chen, Dan Xu, Liaobin Chen, Hui Wang
Summary: Clinical and animal studies suggest that paternal exposure to adverse environments has profound impacts on offspring development. This study found that paternal exposure to nicotine, ethanol, or caffeine is a high-risk factor for adverse pregnancy outcomes. Furthermore, the study reveals the impact of paternal chronic stress on sperm quality, pregnancy outcomes, and fetal development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
David M. Crizer, Sreenivasa C. Ramaiahgari, Stephen S. Ferguson, Julie R. Rice, Paul E. Dunlap, Nisha S. Sipes, Scott S. Auerbach, Bruce Alex Merrick, Michael J. DeVito
Summary: Interpretation of untargeted metabolomics data from in vitro and in vivo models poses a challenge in toxicology research, but potency-based modeling can help translate testing data effectively. This study utilized benchmark concentration (BMC) analysis to interpret metabolomics data from HepaRG cells exposed to different compounds, revealing concentration-related increases in metabolomic response for liver injury compounds. The findings demonstrate the utility of BMC modeling in providing a sensitive indicator of human liver injury potential.
TOXICOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Hitomi Takemura, Kohsuke Kushimoto, Yasuhiko Horii, Daisuke Fujita, Megumi Matsuda, Teiji Sawa, Fumimasa Amaya
Summary: Regulation of GRK2 expression plays a key role in resolving acute pain after tissue injury, with tissue-derived IGF1 inducing GRK2 expression to alleviate hyperalgesia. Dysregulation of IGF1-GRK2 signaling may lead to chronic pain development after surgery.
BRAIN RESEARCH BULLETIN
(2021)
Article
Plant Sciences
Somayya Tariq, Brice Landry Koloko, Ayesha Malik, Sidra Rehman, Bushra Ijaz, Ahmad Ali Shahid
Summary: Tectona grandis leaves have the potential to ameliorate liver fibrosis induced by CCl4 in mice by modulating the TGF-beta 1/Smad pathway and upregulating the MMP3/TIMP1 ratio. The study shows promising results for the use of Tectona grandis leaves in treating liver fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agronomy
Jowita Grzedzicka, Izabela Dabrowska, Paula Kielbik, Maciej Perzyna, Olga Witkowska-Pilaszewicz
Summary: By evaluating the changes in IGF1, MMP-2, and IL-13 after exercise at different fitness levels and intensities, this study suggests that the basal values of certain cytokines can better predict the fitness levels of horses.
Article
Cell & Tissue Engineering
Dong Wang, Weihang Li, Ziyi Ding, Quan Shi, Shilei Zhang, Zhuoru Zhang, Zhibin Liu, Xiaocheng Wang, Ming Yan
Summary: This study aimed to identify the differential expression profiles of mRNA in weightlessness osteoporosis and investigate the molecular mechanisms, especially in bone marrow mesenchymal stem cells (BMSCs). The results revealed 10 hub genes that are significant in the development of weightlessness osteoporosis, providing a theoretical basis and new ideas for future research and clinical treatment of this condition.
STEM CELLS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Sarah E. Minnis-Lyons, Sofia Ferreira-Gonzalez, Niya Aleksieva, Tak Yung Man, Victoria L. Gadd, Michael J. Williams, Rachel Guest, Wei-Yu Lu, Benjamin J. Dwyer, Tam Jamieson, Colin Nixon, Noemi Van Hul, Frederic P. Lemaigre, John McCafferty, Isabelle A. Leclercq, Owen J. Sansom, Luke Boulter, Stuart J. Forbes
Summary: The study demonstrates that Notch signaling is crucial for the expansion of biliary epithelial cells and subsequent hepatocyte regeneration. Different signaling mechanisms regulate the proliferation of BECs and the differentiation into hepatocytes.
Article
Toxicology
Andrew J. Newell, Dereje Jima, Benjamin Reading, Heather B. Patisaul
Summary: Toxicogenomics is an important field for hazard identification and understanding the mechanisms and markers of exposure to toxic compounds. Machine learning provides an effective alternative analytical approach to handle the challenges of analyzing highly dimensional data. In this study, an ensemble machine learning approach was used to predict developmental exposure to a mixture of organophosphate esters in the brain and placenta of rats, and specific genes and pathways affected by exposure were identified.
TOXICOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Christina Vohlen, Jasmine Mohr, Alexey Fomenko, Celien Kuiper-Makris, Tiffany Grzembke, Rabia Aydogmus, Rebecca Wilke, Dharmesh Hirani, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: Prematurely born infants often require supplemental oxygen which can impair lung growth, resulting in arrest of alveolarization and bronchopulmonary dysplasia (BPD). Research findings show that both short-term and prolonged exposure to hyperoxia can impact GH and IGF1 signaling, affecting alveolar epithelial cell differentiation and inflammatory activation of fibroblasts.
Article
Multidisciplinary Sciences
Saad Mohamed Asseri, Nehal M. Elsherbiny, Mohamed El-Sherbiny, Iman O. Sherif, Alsamman M. Alsamman, Nadia M. Maysarah, Amira M. Elsherbini
Summary: The study aimed to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced submandibular gland (SMG) damage. It was found that GA could alleviate SMG damage by regulating oxidative stress, autophagy, and angiogenesis in diabetes.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Applied
Hiroyuki Okamura, Hajime Abe, Yasuko Hasegawa-Baba, Kenji Saito, Fumiko Sekiya, Shim-Mo Hayashi, Yoshiharu Mirokuji, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima, Masakuni Degawa, Shogo Ozawa, Makoto Shibutani, Tamio Maitani
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2015)
Letter
Medicine, Legal
Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose, Makoto Hayashi
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2015)
Article
Toxicology
Mutsuko Hirata-Koizumi, Ryota Ise, Hirohito Kato, Takashi Matsuyama, Tomoko Nishimaki-Mogami, Mika Takahashi, Atsushi Ono, Makoto Ema, Akihiko Hirose
JOURNAL OF TOXICOLOGICAL SCIENCES
(2016)
Article
Medicine, Legal
Mariko Matsumoto, Hiroaki Todo, Takumi Akiyama, Mutsuko Hirata-Koizumi, Kenji Sugibayashi, Yoshiaki Ikarashi, Atsushi Ono, Akihiko Hirose, Kazuhito Yokoyama
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Chemistry, Applied
Kenji Saito, Yasuko Hasegawa-Baba, Fumiko Sekiya, Shim-mo Hayashi, Yoshiharu Mirokuji, Hiroyuki Okamura, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima, Masakuni Degawa, Shogo Ozawa, Makoto Shibutani, Tamio Maitani
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2017)
Article
Medicine, Legal
Toshime Igarashi, Hideki Serizawa, Katsumi Kobayashi, Hiroshi Suzuki, Mariko Matsumoto, Takako Iso, Tomoko Kawamura, Kaoru Inoue, Atsushi Ono, Takashi Yamada, Akihiko Hirose
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Environmental Sciences
Hina Kato, Sakiko Fujii, Mika Takahashi, Mariko Matsumoto, Mutsuko Hirata-Koizumi, Atsushi Ono, Akihiko Hirose
ENVIRONMENTAL TOXICOLOGY
(2015)
Article
Toxicology
Masaharu Fujita, Yusuke Yamamoto, Shinichi Watanabe, Tsunetsugu Sugawara, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kei Kusakari, Yoshihiko Kurokawa, Tsuyoshi Kawakami, Kohichi Kojima, Hajime Kojima, Atsushi Ono, Yasuhiro Katsuoka, Hideto Tanabe, Hiroshi Yokoyama, Toshihiko Kasahara
JOURNAL OF APPLIED TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yoshinobu Igarashi, Noriyuki Nakatsu, Tomoya Yamashita, Atsushi Ono, Yasuo Ohno, Tetsuro Urushidani, Hiroshi Yamada
NUCLEIC ACIDS RESEARCH
(2015)
Article
Medicine, Legal
Toshime Igarashi, Hiromasa Takashima, Michihito Takabe, Hiroshi Suzuki, Kazuo Ushida, Tomoko Kawamura, Mariko Matsumoto, Takako Iso, Shihori Tanabe, Kaoru Inoue, Atsushi Ono, Takashi Yamada, Akihiko Hirose
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Yusuke Yamamoto, Masaru Fujita, Sayaka Wanibuchi, Yasuhiro Katsuoka, Atsushi Ono, Toshihiko Kasahara
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Article
Medicine, Legal
Yoko Yokoyama, Atsushi Ono, Midori Yoshida, Kiyoshi Matsumoto, Mikako Saito
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yasunari Kanda
Summary: Current research suggests that FTY720 is effective in inhibiting breast cancer stem cells in vitro, potentially reducing the expression of stem cell markers through upregulation of protein phosphatase 2A (PP2A).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Shota Yanagida, Ayano Satsuka, Sayo Hayashi, Atsushi Ono, Yasunari Kanda
Summary: This study focused on assessing the cardiotoxicity risk of COVID-19 treatments using hiPSC-CMs, finding that hydroxychloroquine poses a proarrhythmic risk while other drugs have low risks. Therefore, hiPSC-CMs may be a useful tool for evaluating the comprehensive cardiotoxicity caused by COVID-19 treatments in nonclinical settings.
TOXICOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda
Summary: This study identified the highly expressed LPA receptor 3 in ALDH-positive TNBC cells and elucidated the regulatory role of the LPA-TRPC3 signaling axis in BCSCs. The findings provide important insights into potential therapeutic targets for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
