Article
Agriculture, Dairy & Animal Science
Hongmei Zhu, Qianqian Jia, Yanyan Zhang, Dongming Liu, Diqi Yang, Li Han, Jianguo Chen, Yi Ding
Summary: It is still unclear how ovarian hormones affect goat lactation by regulating cell-cell junctions. This study reveals that ovarian hormones can elevate the expression of cell-cell junction proteins, which may affect intercellular space and molecule transportation between goat mammary epithelial cells. The results suggest that ovarian hormones may play a role in regulating milk production by influencing the expression of cell-cell junction proteins between mammary epithelial cells.
Article
Multidisciplinary Sciences
Shi Hao Lee, Yeannie H. Y. Yap, Chew Leng Lim, Amanda Rui En Woo, Valerie C. L. Lin
Summary: This study reveals the crucial role of the activation function AF1 of progesterone receptor (PGR) in mammary development. Gain of function mutant AF1_QQQ shows hyperactivity while loss of function mutant AF1_FFF exhibits hypoactivity on mammary development. AF1_FFF mutation significantly impairs mammary development in response to estrogen and progesterone and during pregnancy, but has no effect on mammary development in nulliparous mice. Furthermore, Rankl is identified as a major target gene of AF1.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Eun Pyo Kim, Giup Jang, Jin-Wook Kim, Sang Wha Kim, Heaji Chung, Yun Jung Yang, Wan Hee Kim, Geon A. Kim
Summary: Canine mammary gland tumor is commonly diagnosed in intact female dogs. Early and accurate diagnosis is crucial for prognosis. This study analyzed differentially expressed microRNAs and mRNA levels to investigate the malignancy and biopsy locations of the tumors. The miRNA cfa-miR-503 showed altered expression in response to malignancy and could potentially be used as a diagnostic biomarker and anti-tumor drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Yu Zhou, Zi Ye, Wei Wei, Mengna Zhang, Fujing Huang, Jinpeng Li, Cheguo Cai
Summary: The adult stem cell niche consists of various stromal cells and signals that regulate tissue development and homeostasis. In this study, we demonstrate that mammary resident macrophages play a role in regulating mammary epithelium cell division and mammary development through the TNF-alpha-Cdk1/Cyclin B1 axis. Depletion of macrophages in vivo reduces the number of mammary basal cells and mammary stem cells (MaSCs), while increasing mammary luminal cells. In vitro, co-culturing mammary basal cells with macrophages promotes the formation of functional mammary organoids.
NPJ REGENERATIVE MEDICINE
(2023)
Review
Cell Biology
Nikita Thakkar, Ye Bin Shin, Hoon-Ki Sung
Summary: The mammary gland is a complex organ that can be regulated by nutritional stimuli, affecting glandular function and disease development. Obesity increases the risk of breast cancer, while fasting or calorie restriction may have a negative impact on mammary tumor progression. However, the specific effects of fasting on the mammary microenvironment are still not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Veterinary Sciences
Mami Araki, Syunya Noguchi, Yoshiaki Kubo, Akiko Yasuda, Miki Koh, Hirotada Otsuka, Makoto Yokosuka, Satoshi Soeta
Summary: This study explored the expression of COL6a3 in canine mammary gland carcinomas (CMGCs) and its correlation with tumor histological features, grades, and differentiation status. The results showed that low expression of COL6a3 was associated with high malignancy and mitotic indices in CMGCs. Furthermore, COL6a3 was more frequently expressed in simple carcinomas compared to solid carcinomas. Additionally, COL6a3 expression was observed in tumors containing luminal progenitor-like and mature luminal cells, suggesting its involvement in the differentiation of these cells and suppression of malignant phenotypes in CMGCs.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Edmund Charles Jenkins, Mrittika Chattopadhyay, Maria Gomez, Denis Torre, Avi Ma'ayan, Miguel Torres-Martin, Daniela Sia, Doris Germain
Summary: A major limitation in breast cancer research using mouse models is that most mice develop estrogen receptor-alpha (ER alpha)-negative mammary tumors, while in humans, the majority of breast cancers are ER alpha-positive. However, a new study using an inducible mouse model revealed that mammary tumors in young mice are ER alpha-negative, while they are ER alpha-positive in aged mice. The study also identified genes involved in the activation of ER alpha axis and the regulation of UPR stress responses in aged female-derived mammary tumors. These findings suggest that aging alters the oncogenic trajectory towards ER alpha-positive breast cancer subtype.
Article
Cell Biology
Nguyen Xuan Thang, Dong Wook Han, Chanhyeok Park, Hyeonji Lee, Hyeonwoo La, Seonho Yoo, Heeji Lee, Sang Jun Uhm, Hyuk Song, Jeong Tae Do, Kyoung Sik Park, Youngsok Choi, Kwonho Hong
Summary: This study investigated the relationship between INO80 expression and breast cancer sub-classification and progression using weighted gene co-expression network analysis (WCGNA). The findings suggest that INO80 repression is associated with increased risk of breast carcinogenesis and differential responsiveness of estrogen receptors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Summary: The study presents an integrated mammary cell gene expression atlas derived from mouse and human single-cell RNA-sequence data, characterizing key life stages of mammary gland remodeling and inferring cells of origin for various breast cancer subtypes using breast cancer expression data.
COMMUNICATIONS BIOLOGY
(2021)
Article
Veterinary Sciences
Soo-Bin Cheon, Wan Hee Kim
Summary: This study evaluated the expression of the SLUG gene in canine mammary gland tumors (MGTs) and found that its upregulation is associated with poor prognosis. These results suggest that SLUG protein may serve as a novel biomarker and therapeutic target for canine patients with MGT.
BMC VETERINARY RESEARCH
(2023)
Article
Cell & Tissue Engineering
Junichi Matsuo, Naing Naing Mon, Daisuke Douchi, Akihiro Yamamura, Madhura Kulkarni, Dede Liana Heng, Sabirah Chen, Napat Nuttonmanit, Ying Li, Henry Yang, May Yin Lee, Wai Leong Tam, Motomi Osato, Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: Researchers have identified an active element called eR1 that can mark mammary stem cells and found its activity in a small population of luminal epithelial cells in the mammary glands. They demonstrated that eR1+ luminal cells can generate the entire luminal lineage and milk-secreting alveoli, indicating that eR1 specifically marks lineage-restricted luminal stem cells.
Review
Oncology
Lokman Varisli, Garrett M. Dancik, Veysel Tolan, Spiros Vlahopoulos
Summary: Breast cancer is one of the most commonly diagnosed malignancies in women, and estrogen signaling plays a critical role in its development and progression. SRC-3 is an important factor in breast cancer and has versatile effects in promoting malignant behavior of tumor cells and creating an immunosuppressive tumor microenvironment.
Article
Chemistry, Multidisciplinary
Yusaku Tsugami, Haruka Wakasa, Takanori Nishimura, Ken Kobayashi
Summary: Genistein is able to directly inhibit the phosphorylation of STAT5 in lactating MECs, independent of the phosphorylation of EGFR.
Article
Multidisciplinary Sciences
Christelle Golebiewski, Cecile Gastaldi, Diane-Lore Vieu, Bernard Mari, Roger Rezzonico, Francoise Bernerd, Claire Marionnet
Summary: The epidermis, composed mainly of keratinocytes, forms a protective barrier against external aggression and dehydration. The regulation of keratinocyte proliferation and differentiation is crucial for epidermal homeostasis, and miR-203 plays an important role in promoting differentiation by targeting genes involved in proliferation. Transcriptome analysis of miR-203 overexpressed keratinocytes revealed the inhibition of proliferation-related functions and upregulation of differentiation-related functions. Furthermore, SRC and RAPGEF1 were identified as direct targets of miR-203, contributing to keratinocyte proliferation and differentiation.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Vivian W. Gu, Edward Cho, Dakota T. Thompson, Victoria C. Cassady, Nicholas Borcherding, Kelsey E. Koch, Vincent T. Wu, Allison W. Lorenzen, Dana M. van der Heide, Jeffrey R. White, Mikhail V. Kulak, Trevor Williams, Weizhou Zhang, Ronald J. Weigel
Summary: The AP-2 gamma transcription factor plays a crucial role in the maintenance and differentiation of mammary stem cells, with loss of AP-2 gamma leading to altered mammary gland structures and inhibited regenerative capacity.
Article
Pharmacology & Pharmacy
Ana Clara de Tomaso Portaz, Giselle Romero Caimi, Marcela Sanchez, Florencia Chiappini, Andrea S. Randi, Diana L. Kleiman de Pisarev, Laura Alvarez
Article
Toxicology
Carolina Pontillo, Alejandro Espanol, Florencia Chiappini, Noelia Miret, Claudia Cocca, Laura Alvarez, Diana Kleiman de Pisarev, Maria Elena Sales, Andrea Silvana Randi
TOXICOLOGY LETTERS
(2015)
Article
Pharmacology & Pharmacy
Florencia Chiappini, Juan Ignacio Baston, Agustina Vaccarezza, Jose Javier Singla, Carolina Pontillo, Noelia Miret, Mariana Farina, Gabriela Meresman, Andrea Randi
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Noelia Miret, Carolina Pontillo, Clara Ventura, Alejandro Carozzo, Florencia Chiappini, Diana Kleiman de Pisarev, Natalia Fernandez, Claudia Cocca, Andrea Randi
Article
Toxicology
Florencia Chiappini, Laura Alvarez, Victoria Lux-Lantos, Andrea S. Randi, Diana L. Kleiman de Pisarev
TOXICOLOGICAL SCIENCES
(2009)
Article
Toxicology
Carolina A. Pontillo, Maria A. Garcia, Delfina Pena, Claudia Cocca, Florencia Chiappini, Laura Alvarez, Diana Kleiman de Pisarev, Andrea S. Randi
TOXICOLOGICAL SCIENCES
(2011)
Article
Toxicology
Florencia Chiappini, Carolina Pontillo, Andrea S. Randi, Laura Alvarez, Diana L. Kleiman de Pisarev
TOXICOLOGICAL SCIENCES
(2013)
Article
Pharmacology & Pharmacy
Laura Giribaldi, Florencia Chiappini, Carolina Pontillo, Andrea S. Randi, Diana L. Kleiman de Pisarev, Laura Alvarez
Article
Pharmacology & Pharmacy
Carolina Andrea Pontillo, Paola Rojas, Florencia Chiappini, Gonzalo Sequeira, Claudia Cocca, Maximo Crocci, Lucas Colombo, Claudia Lanari, Diana Kleiman de Pisarev, Andrea Randi
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2013)
Article
Toxicology
Florencia Chiappini, Carolina Pontillo, Andrea Randi, Laura Alvarez, Diana L. Kleiman de Pisarev
TOXICOLOGY LETTERS
(2014)
Article
Food Science & Technology
Florencia Chiappini, Marcela Sanchez, Noelia Miret, Claudia Cocca, Elsa Zotta, Leandro Ceballos, Carolina Pontillo, Mariela Bilotas, Andrea Randi
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Lorena Zarate, Carolina A. Pontillo, Alejandro Espanol, Noelia Miret, Florencia Chiappini, Claudia Cocca, Laura Alvarez, Diana Kleiman de Pisarev, Maria E. Sales, Andrea S. Randi
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Food Science & Technology
Florencia Chiappini, Leandro Ceballos, Carla Olivares, Juan Ignacio Baston, Noelia Miret, Carolina Pontillo, Lorena Zarate, Jose Javier Singla, Mariana Farina, Gabriela Meresman, Andrea Randi
Summary: This study found that hexachlorobenzene (HCB) exposure can induce changes associated with endometriosis, including increased levels of estrogen receptor α and aromatase protein, decreased progesterone receptor content, and promoted cell migration and invasion. These results reveal the mechanisms by which pesticide exposure may contribute to the development of endometriosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Noelia Miret, Lorena Zarate, Fernando Erra Diaz, M. Agustina Leguizamon, Carolina A. Pontillo, Florencia A. Chiappini, Leandro Ceballos, Jorge Geffner, Andrea S. Randi
Summary: A reduction in extracellular pH promotes breast cancer progression by activating the AhR/c-Src axis, which increases cell migration and MMP-9 activity.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)