mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

Targeting of Rac GTPases blocks the spread of intact human breast cancer

(2015) Elad Katz et al.   Oncotarget

PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively

(2013) Wenting Zhu et al.   DEVELOPMENTAL BIOLOGY

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

(2013) Violeta Serra et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway

(2012) Alain Pauloin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer

(2012) Haiyan Li et al.   BREAST CANCER RESEARCH AND TREATMENT

PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials

(2012) F. Janku et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways

(2012) C.-C. Chen et al.   GENES & DEVELOPMENT

PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations

(2012) Filip Janku et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial–mesenchymal transition (EMT)

(2012) I Serrano et al.   ONCOGENE

Rictor regulates cell migration by suppressing RhoGDI2

(2012) N K Agarwal et al.   ONCOGENE

Extracellular matrix and cytoskeletal dynamics during branching morphogenesis

(2012) Hye Young Kim et al.   Organogenesis

Molecular regulators of pubertal mammary gland development

(2011) Sara McNally et al.   ANNALS OF MEDICINE

Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity

(2011) Senthil K. Muthuswamy et al.   Annual Review of Cell and Developmental Biology

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin

(2011) Hitomi Moriya et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors

(2011) D. S. Meyer et al.   CANCER RESEARCH

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer

(2011) Todd W. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors

(2011) F. Janku et al.   MOLECULAR CANCER THERAPEUTICS

Integrated morphodynamic signalling of the mammary gland

(2011) Nikolce Gjorevski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting the Phosphoinositide-3 (PI3) Kinase Pathway in Breast Cancer

(2011) J. Baselga   ONCOLOGIST

mTOR Complex Component Rictor Interacts with PKC  and Regulates Cancer Cell Metastasis

(2010) F. Zhang et al.   CANCER RESEARCH

Functions and regulation of the 70kDa ribosomal S6 kinases

(2010) Tim R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells

(2008) Ville Hietakangas et al.   BMC CANCER

Enhancing Mammalian Target of Rapamycin (mTOR)-Targeted Cancer Therapy by Preventing mTOR/Raptor Inhibition-Initiated, mTOR/Rictor-Independent Akt Activation

(2008) X. Wang et al.   CANCER RESEARCH

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

(2008) P. C. McDonald et al.   CANCER RESEARCH

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

(2008) Dana M. Brantley-Sieders et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming Growth Factor-  Signaling-Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion

(2008) N. Cheng et al.   MOLECULAR CANCER RESEARCH

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY