Journal
TOXICOLOGY
Volume 263, Issue 1, Pages 20-25Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2008.06.002
Keywords
Sulfur mustard; PARP; DNA repair; Cell death; NAD(+); 3-Aminobenzamide
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Funding
- Bundeswehr [U2.3 E/MG/4G121/5A805]
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Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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