Article
Cell Biology
Dominika Szlezak, Patrycja Bronowicka-Adamska, Tomasz Hutsch, Marcin Ufnal, Maria Wrobel
Summary: Hypertension and age were found to affect hepatic sulfur metabolism and the production of H2S in rats, with SHRs showing higher capacity for H2S generation. Differences in gene expression and enzyme activity related to sulfur metabolism were observed between WKY and SHR, as well as between different age groups of rats.
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yan Huang, Gang Wang, Zhan Zhou, Zhengshan Tang, Ningning Zhang, Xiaoyan Zhu, Xin Ni
Summary: The gasotransmitter H2S plays a crucial role in maintaining normal oxygen saturation in the lungs and preventing lung injury, inflammation, and oxidative stress. GYY4137 treatment was effective in ameliorating these conditions in both genetic deficiency and hypoxia-induced mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qian Lin, Bin Geng
Summary: This article discusses the significant impact of atherosclerosis on cardiovascular events and global mortality, as well as the role of hydrogen sulfide in plaque stability and its regulation mechanism on different cell populations.
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang
Summary: This study identified differentially expressed proteins (DEPs) associated with hydrogen sulfide metabolism in Holstein cows with clinical mastitis (CM), indicating the important role of cystathionine-gamma-lyase (CTH)/H2S in CM. The findings provide insight into the function and regulatory mechanism of CTH/H2S in Holstein cows and can contribute to the prevention and treatment of CM.
Article
Plant Sciences
Huibiao Li, Xiaohong Chen, Jiayao Liu, Muyuan Chen, Ming Huang, Guoxin Huang, Xinlin Chen, Qin Du, Jiyan Su, Rongfeng Lin
Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Song Wang, Yanyu Ding, Wenjun Jiang
Summary: CSE/H2S protects mice from colitis by preserving EGCs function and inhibiting the RhoA/ROCK signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Summary: H2S plays a crucial role in glucose metabolism by affecting insulin secretion, apoptosis of islet β cells, insulin sensitivity, glucose uptake, adipogenesis, lipolysis, and modulation of circadian-clock genes. Further studies are needed to determine whether H2S could be a promising target for diabetes mellitus treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Immunology
Yizhuo Wang, Kunjian Liu, Zhiyong Qi, Tong Chen, Wei Yu, Yang Jiang, Guofeng Li, Huijie Xiao
Summary: Camptothecin (CPT) is a cytotoxic alkaloid derived from the bark and branches of the Chinese tree Camptotheca acuminata, with antitumor activities mainly used in colon, ovarian, liver, and bone cancers as well as leukemia treatment. CPT has been shown to protect against ulcerative colitis, reducing disease activity index and inflammatory cytokines, indicating its potential as a therapeutic agent for UC.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Sunil Jamuna Tripathi, Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul
Summary: The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective effects in the brain through post-translational modification of cysteine residues by sulfhydration. It cannot be stored in vesicles due to its gaseous nature and is either synthesized or released from endogenous stores. Sulfhydration has both specific and general neuroprotective effects and is diminished in neurodegenerative disorders, while excessive cellular H2S is linked to certain forms of neurodegenerative disease. This review explores the role of H2S in signaling across various neurodegenerative diseases and age-related neurodegeneration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Do Yeong Kweon, Hee Jin Song, Ji Eun Kim, You Jeong Jin, Yu Jeong Roh, Ayun Seol, Ju Min Park, Eun Suk Lee, Won Sik Choi, Dae Youn Hwang
Summary: This study found that Aloe saponaria can improve clinical symptoms and attenuate inflammatory response in UC mice without significant hepatotoxicity or nephrotoxicity.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Huiqin Wang, Jin Huang, Yanan Ding, Jianwu Zhou, Guanzhen Gao, Huan Han, Jingru Zhou, Lijing Ke, Pingfan Rao, Tianbao Chen, Longxin Zhang
Summary: Food incidental nanoparticles may affect human health by regulating gastrointestinal tissue inflammation and gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng
Summary: The study identified NW as a novel CSE agonist that enhances CSE generation of H2S, thereby alleviating kidney I/R injury and hypertension. NW shows potential therapeutic merit for cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Ryuichi Tsujita, Maho Tsubota, Yusuke Hayashi, Haruka Saeki, Fumiko Sekiguchi, Atsufumi Kawabata
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Review
Pharmacology & Pharmacy
Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Neurosciences
Fumiko Sekiguchi, Risa Domoto, Kana Nakashima, Daichi Yamasoba, Hiroki Yamanishi, Maho Tsubota, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
Article
Health Care Sciences & Services
Tomoyoshi Miyamoto, Masanori Fujitani, Hiroki Fukuyama, Shigekatsu Hatanaka, Yuichi Koizumi, Atsufumi Kawabata
JOURNAL OF PALLIATIVE MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Shiori Tomita, Fumiko Sekiguchi, Tomoyo Deguchi, Takaya Miyazaki, Yuya Ikeda, Maho Tsubota, Shigeru Yoshida, Huy Du Nguyen, Takuya Okada, Naoki Toyooka, Atsufumi Kawabata
Article
Biochemistry & Molecular Biology
Maho Tsubota, Kenta Uebo, Koki Miki, Fumiko Sekiguchi, Akihiko Ishigami, Atsufumi Kawabata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Pharmacology & Pharmacy
Kazuki Matsui, Maho Tsubota, Saaya Fukushi, Nene Koike, Hiroshi Masuda, Yoshihito Kasanami, Takaya Miyazaki, Fumiko Sekiguchi, Tsuyako Ohkubo, Shigeru Yoshida, Yutaro Mukai, Akira Oita, Mitsutaka Takada, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Immunology
Maho Tsubota, Ryotaro Fukuda, Yusuke Hayashi, Takaya Miyazaki, Shin Ueda, Rika Yamashita, Nene Koike, Fumiko Sekiguchi, Hidenori Wake, Shuji Wakatsuki, Yuka Ujiie, Toshiyuki Araki, Masahiro Nishibori, Atsufumi Kawabata
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Pharmacology & Pharmacy
Kazuki Matsui, Yuka Terada, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Yuhei Irie, Maho Tsubota, Mariko Maeda, Shiori Hiramoto, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Fumiko Sekiguchi, Atsufumi Kawabata
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is resistant to most existing medicines and is one of the major dose-limiting side effects of chemotherapeutic agents. HMGB1 plays a key role in the development of CIPN, while TMα is effective in preventing CIPN in both animal models and patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
Summary: Neuroimmune crosstalk plays a crucial role in both somatic and visceral pathological pain, with macrophages interacting with neurons to regulate pain signals in peripheral tissues; recent studies have uncovered different characteristics and mediators of macrophages from various sources, highlighting their multitasking abilities in homeostatic conditions.
Article
Cell Biology
Maho Tsubota, Takaya Miyazaki, Yuya Ikeda, Yusuke Hayashi, Yui Aokiba, Shiori Tomita, Fumiko Sekiguchi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Summary: Bortezomib-induced chemotherapy-induced peripheral neuropathy (CIPN) involves caspase-dependent release of HMGB1 from macrophages, leading to the activation of RAGE and CXCR4 receptors. Preventative measures for CIPN include the use of anti-HMGB1-neutralizing antibodies, thrombomodulin alfa, RAGE and CXCR4 antagonists, or macrophage depletion.
Article
Pharmacology & Pharmacy
Tomoka Ozaki, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2018)