Article
Fisheries
Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang Lu
Summary: Pesticides, such as haloxyfop-p-methyl, are harmful to the aquatic ecosystem as they leave residues in soil, water, and agricultural products. This study investigated the toxic effects of haloxyfop-p-methyl on zebrafish and found developmental, neurotoxic, and immunotoxic effects. Zebrafish larvae exhibited spinal deformities, decreased body length, slow heart rate, and enlarged yolk sac area. Behavior analysis showed reduced activity, accompanied by higher AChE activity. Exposure to haloxyfop-p-methyl also induced oxidative stress and affected immune cell populations in the thymus. Furthermore, haloxyfop-p-methyl caused neutrophil apoptosis and increased expression of proinflammatory cytokine genes. These findings provide insights into the toxicological mechanisms of haloxyfop-p-methyl in teleosts.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Toxicology
Lyle D. Burgoon, Claudio Fuentes, Christopher J. Borgert
Summary: This paper introduces a new method for calculating the kinetically derived maximal dose (KMD) based on Bayesian methods and the Kneedle algorithm. The new approach converts toxicokinetic data to the Michaelis-Menten curve using Bayesian methods and uses the Kneedle algorithm to find the point at which the curve begins to taper off. This reshapes the KMD methodology and places it within the Michaelis-Menten framework, leveraging existing biochemical and pharmacological concepts.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Environmental Sciences
Junchao Ma, Zeming Wang, Chao Qin, Tingting Wang, Xiaojie Hu, Wanting Ling
Summary: The widespread use of consumer products containing benzophenone-type ultraviolet filters has led to their presence in the human body and environment. Increasing evidence shows that these filters are endocrine disruptors, raising concerns about their carcinogenicity and effects on reproduction and development. Due to the varied types of benzophenone-type filters and limited toxicity studies, there is a need for a systematic review to expand knowledge on their health risks and identify safer alternatives.
Article
Fisheries
Fasheng Liu, Hongmei Hu, Guilan Chen, Yanqi Lin, Wei Li, Ziyi Liu, Chao Chen, Xue Li, Sujie Sun, Li Zhang, Dou Yang, Kangyu Liu, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Zigang Cao, Jianjun Chen
Summary: This study investigated the effects of pexidartinib on embryonic development and immunotoxicity in zebrafish, and found that pexidartinib caused developmental defects and reduced immune cell numbers, possibly through hyperactivation of the Wnt signaling pathway. These findings provide new insights into the mechanisms of pexidartinib.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Rayetta G. Henderson, Brian T. Welsh, John M. Rogers, Susan J. Borghoff, Kristen R. Trexler, Marcel O. Bonn-Miller, Timothy W. Lefever
Summary: A study was conducted on rats to determine the potential reproductive or developmental toxicity of cannabidiol (CBD). High doses of CBD caused mortality, moribundity, decreased body weight and food consumption in the adult rats, indicating severe maternal toxicity. No adverse effects were observed on reproductive performance or organs, but hypertrophy/hyperplasia in the thyroid gland, changes in thyroid hormone concentrations, litter loss, and dystocia were observed. Lower mean pup weights were also observed in high-dose group. Based on this study, the No Observed Adverse Effect Levels (NOAELs) for CBD were determined.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lingling Qian, Chen Chen, Liguo Guo, Junping Deng, Xiangling Zhang, Jiexiang Zheng, Genmei Wang, Xiaofei Zhang
Summary: In this study, the developmental and reproductive effects of BPA analogs (BPS, BPF, BPAF) on D. magna were evaluated. The results showed that BPF and BPAF exhibited similar or stronger toxicity compared to BPA. Additionally, exposure to BPs led to behavioral changes and activation of the antioxidant defense system in D. magna. These findings contribute to a better understanding of the toxicity of BPA analogs and provide empirical evidence for finding safe alternatives to BPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuanzhao Wu, Tianyi Chen, Yumei Xia, Jiawen Wang, Anli Wang, Binjie Wang, Jiye Wang, Weixuan Yao
Summary: This study revealed that exposure to methidathion caused developmental toxicity, cardiotoxicity, and immunotoxicity in embryogenetic zebrafish. It also impaired the locomotor activity of zebrafish and significantly affected the expression of related genes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Toxicology
Callie M. McDonough, Hannah Shibo Xu, Tai L. Guo
Summary: The review discusses the toxic effects of BPA analogues on various systems in different species, highlighting the mechanisms by which these compounds exert their toxicity. Further research is needed to compare the relative toxicity of lesser-known BPA analogues to BPA and to better understand the underlying mechanisms of action, especially regarding disruptions to microbiome and metabolism.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jong-Su Park, Palas Samanta, Sangwoo Lee, Jieon Lee, Jae-Woo Cho, Hang-Suk Chun, Seokjoo Yoon, Woo-Keun Kim
Summary: Acrylamide induces neurotoxicity and developmental toxicity in zebrafish, leading to various developmental abnormalities and impaired locomotor behavior. The zebrafish model offers a rapid and cost-efficient approach to studying acrylamide neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Cong M. Tran, Hyojin Lee, Byoungcheun Lee, Jin-Sung Ra, Ki-Tae Kim
Summary: This study compared the developmental toxicities of six major OPEs in chorionated and dechorionated zebrafish embryos using a fixed exposure scheme. Removal of the chorion increased sensitivity to OPEs, leading to higher incidence of mortality and malformation. Behaviorally, zebrafish larvae exhibited inhibited locomotive activity by OPEs regardless of chorion presence. At the molecular level, the presence of the chorion influenced the expression of certain genes in zebrafish embryos exposed to specific OPEs.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Hojun Lee, Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: This study demonstrates the toxic effects of molinate on zebrafish larvae, including reduced viability and successful hatching, and the induction of apoptosis, inflammation, and endoplasmic reticulum stress response. Additionally, molinate exposure leads to abnormal cardiovascular, neuronal, and liver development in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Marine & Freshwater Biology
Bangeppagari Manjunatha, B. Deekshitha, Eunseok Seo, Jeongju Kim, Sang Joon Lee
Summary: Research shows that exposure to PM2.5 leads to increased mortality, reduced hatching rates, lower heart rates, and various developmental abnormalities in zebrafish. It also causes damage in skin cell layers, abnormalities in neurons, heart, liver, gills, brain, and eyes, and increased organelle dissolution at cellular/subcellular levels. Further investigation is needed to understand the specific elements in diesel pollution that contribute to this toxicity.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoxia Wang, Weidong Hao
Summary: Plant growth regulators (PGRs) are widely used pesticides with relatively low toxicity compared to other pesticides. However, excessive use can lead to overexposure. Exposure to PGRs can have toxic effects on various organs in the body, such as the testes, ovaries, liver, kidneys, and brain. Some PGRs are also considered potential endocrine disruptors. Evidence suggests that prenatal and postnatal exposure to PGRs can result in developmental and reproductive toxicity in animals and humans. PGRs can interfere with sex hormone synthesis and secretion, disrupt the reproductive system's structure and function, and harm the growth and development of offspring. This review summarizes the available data on reproductive and developmental toxicity of PGRs in mammals. Comprehensive epidemiological studies are needed in the future to understand the underlying molecular mechanisms of reproductive and developmental toxicity caused by a mixture of PGRs.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Marine & Freshwater Biology
Samreen, Xiaona Zhang, Jun Wang, Yuejiao Li, Xuan Li, Yuqi Zheng, Muhammad Arif, Shaoguo Ru
Summary: This study found that prometryn, a widely detected triazine herbicide, has significant toxic effects on marine medaka embryos, including yolk sac shrinkage, heart malformations, delayed hatching time, increased heart rate, and hatching failure rate. It also caused obvious malformations and decreased body length in newly hatched larvae. Transcriptome analysis revealed that prometryn exposure affected the expression levels of several cardiac development-related genes in the larvae.
AQUATIC TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Koen Van Deun, H. Hatch, S. Jacobi, W. Kohl
Summary: The study investigated the reproductive and developmental toxicity of lithium carbonate in rats and found no toxic effects on reproductive and developmental organs at the doses administered. Results suggest that the use of lithium carbonate at appropriate dose levels may not raise immediate concerns for human reproductive or developmental toxicity effects.