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Multidisciplinary Sciences
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Summary: Fibroblasts play a significant role in autoimmune skin diseases by producing and secreting cytokines under inflammatory conditions, particularly by inducing the expression of the chemokine IL-8 through IL-1β. Understanding the signaling pathways involved, such as MAPK signaling mediated by Tpl2, is crucial for the pathogenesis of autoimmune diseases like atopic dermatitis.
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Pharmacology & Pharmacy
Wen Cheng, Jingjing Lu, Bixu Wang, Ling Sun, Bingqi Zhu, Fangmei Zhou, Zhishan Ding
Summary: Studies suggest that compounds like coelonin and militarine found in orchids can inhibit the damage caused by PM2.5 pollutants by reducing inflammation factors. These compounds work by suppressing PM2.5-induced IKK phosphorylation, leading to inhibition of inflammation and migration.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
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Biochemistry & Molecular Biology
Florentine Dylong, Jan Riedel, Gaurang M. Amonkar, Nicole Peukert, Paula Lieckfeldt, Katinka Sturm, Benedikt Hoexter, Wai Hei Tse, Yuichiro Miyake, Maria Moormann, Lena Marie Bode, Steffi Mayer, Richard Keijzer, Martin Lacher, Xingbin Ai, Jan-Hendrik Gosemann, Richard Wagner
Summary: NF-κB is highly active in the development of CDH lungs, and blocking its signaling pathway may be a potential therapeutic approach for improving lung development in CDH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Immunology
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma
Summary: The intestinal epithelial tight junction (TJ) barrier plays a crucial role in intestinal diseases, especially inflammatory bowel diseases. The IL-1 beta-induced increase in intestinal TJ permeability is a key factor in the inflammatory process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luis Fernando Mendez-Lopez
Summary: The paper presents a hypothesis on the origin of carcinomas, suggesting that cellular aging and inflammation enable the recovery of cellular plasticity, potentially resulting in cancer. The author critically reviews molecular, cellular, and histopathological evidence to propose possible mechanisms for the origin and progression of carcinomas. The hypothesis also discusses its implications for cancer treatment strategies and proposes a potential mechanism for restraining dedifferentiation and malignant behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Summary: Recent research has revealed the non-random distribution of 8-oxoguanine induced by reactive oxygen species, suggesting its epigenetic effects. 8-oxoguanine DNA glycosylase 1 (OGG1), the repair protein for 8-oxoGua, has been found to participate in transcriptional initiation and transmit acute inflammatory signals in airway epithelial cells. The interactions between epithelial-mesenchymal and epithelial-immune contribute to the development of chronic pulmonary diseases through inflammatory remodeling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhukai Cong, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao, Xi Zhu
Summary: In this study, it was found that alpha 1-AR activation could alleviate lung injuries and inflammation and improve alveolar capillary barrier integrity in the lipopolysaccharide-induced ARDS mouse model without influencing cardiovascular hemodynamics.
FRONTIERS IN IMMUNOLOGY
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Article
Critical Care Medicine
Erika Wong, Fengyun Xu, Jeremie Joffre, Nina Nguyen, Kevin Wilhelmsen, Judith Hellman
Summary: ERK1/2 plays a complex role in LPS-induced inflammatory activation and permeability of human lung microvascular endothelial cells, with inhibition of ERK1/2 enhancing IL-6 and VCAM-1 production while promoting IL-6 production in monocytes. ERK1/2 activation limits IL-6 production by HMVEC but promotes HMVEC permeability, suggesting its important role in regulating endothelial cell inflammation and vascular permeability in sepsis and injury.
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Oncology
Hiromichi Kawasaki, Hirotaka Amano
Summary: The study revealed the biological function of miR-429 in gingival cells, showing its regulation of various interleukins and NF-kappa B activation to modulate the inflammatory response. Furthermore, miR-429 was found to inhibit IKK beta expression by binding to its mRNA, thus affecting NF-kB activity and IL-8 production.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Sugyeong Ha, Yejin Yang, Jeong Won Kim, Minjung Son, Doyeon Kim, Mi-Jeong Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: Aging kidneys exhibit increased vulnerability to folic acid-induced renal fibrosis. The diminished expression of farnesoid X receptor (FXR) in the epithelial cells of renal tubules exacerbates the fibrotic response and inflammation. FXR activation reduces NF-kappa B activation and chemokine production, while FXR knockdown enhances inflammation and fibrosis.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Jiyu Chen, Yanli Huang, Xiaohong Bian, Yan He
Summary: The study demonstrates that berberine has a suppressive effect on the inflammatory response caused by lipopolysaccharides (LPS) through regulating the NF-kappa B/Nlrp3 signaling pathway, providing a potential therapeutic strategy for acute lung injury (ALI).
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Yiping Mu, Yang Zhang, Jie Wu, Qi Li
Summary: NLRC5 is a critical mediator of inflammatory response and its overexpression in chondrocytes suppressed IL-1β-induced inflammation. Knockdown of NLRC5 had the opposite effect. NLRC5 attenuated IL-1β-induced inflammatory injury through regulating the NF-κB signaling pathway in chondrocytes.
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Biochemistry & Molecular Biology
Hairong Xiong, Jiaxin Ye, Kairu Xie, Wenjun Hu, Ning Xu, Hongmei Yang
Summary: This study found that EVs secreted by LLC and C26 tumor cells induce adipocyte wasting through the extracellular IL-8-mediated NF-kappa B signaling pathway. This finding highlights the importance of exosomal IL-8 in CC lipolysis.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Multidisciplinary Sciences
Meenakshi Chawla, Tapas Mukherjee, Alvina Deka, Budhaditya Chatterjee, Uday Aditya Sarkar, Amit K. Singh, Saurabh Kedia, Josephine Lum, Manprit Kaur Dhillon, Balaji Banoth, Subhra K. Biswas, Vineet Ahuja, Soumen Basak
Summary: Research suggests that in inflammatory bowel disease (IBD), the noncanonical NF-kappa B signaling pathway is frequently involved and plays a critical role, activating the proinflammatory gene response driven by RelA and aggravating intestinal inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Hayam Hussein, Prosper Boyaka, Jennifer Dulin, Alicia Bertone
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2016)
Review
Immunology
Prosper N. Boyaka
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
D. F. Comiskey, A. G. Jacob, B. L. Sanford, M. Montes, A. K. Goodwin, H. Steiner, E. Matsa, A. S. Tapia-Santos, T. W. Bebee, J. Grieves, K. La Perle, P. Boyaka, D. S. Chandler
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Biochemistry & Molecular Biology
Sheng-Wei Chang, Jack Wellmerling, Xiaoli Zhang, Rachael E. Rayner, Wissam Osman, Sara Mertz, Amal O. Amer, Mark E. Peeples, Prosper N. Boyaka, Estelle Cormet-Boyaka
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2018)
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Cell Biology
Sankar Renu, Santosh Dhakal, Eunsoo Kim, Jonathan Goodman, Yashavanth S. Lakshmanappa, Michael J. Wannemuehler, Balaji Narasimhan, Prosper N. Boyaka, Gourapura J. Renukaradhya
CELLULAR IMMUNOLOGY
(2018)
Article
Immunology
Zayed Attia, John C. Rowe, Eunsoo Kim, Sanjay Varikuti, Haley E. Steiner, Ahmad Zaghawa, Hany Hassan, Estelle Cormet-Boyaka, Abhay R. Satoskar, Prosper N. Boyaka
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Jikang Wu, Anice Sabag-Daigle, Mikayla A. Borton, Linnea F. M. Kop, Blake E. Szkoda, Brooke L. Deatherage Kaiser, Stephen R. Lindemann, Ryan S. Renslow, Siwei Wei, Carrie D. Nicora, Karl K. Weitz, Young-Mo Kim, Joshua N. Adkins, Thomas O. Metz, Prosper Boyaka, Venkat Gopalan, Kelly C. Wrighton, Vicki H. Wysocki, Brian M. M. Ahmer
INFECTION AND IMMUNITY
(2018)
Article
Veterinary Sciences
Maria C. Jugan, Adam J. Rudinsky, Alexander Gordon, Denise L. Kramer, Joshua B. Daniels, Oleg Paliy, Prosper Boyaka, Chen Gilor
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2018)
Article
Immunology
Eunsoo Kim, Melanie Lembert, Ghaith M. Fallata, John C. Rowe, Tara L. Martin, Abhay R. Satoskar, Nicholas V. Reo, Oleg Paliy, Estelle Cormet-Boyaka, Prosper N. Boyaka
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
John C. Rowe, Zayed Attia, Eunsoo Kim, Estelle Cormet-Boyaka, Prosper N. Boyaka
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Amy R. Mackos, Jacob M. Allen, Eunsoo Kim, Chris A. Ladaika, Raad Z. Gharaibeh, Cathy Moore, Nicola M. A. Parry, Prosper N. Boyaka, Michael T. Bailey
FRONTIERS IN IMMUNOLOGY
(2019)
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Pathology
Lisa G. Lanigan, Blake E. Hildreth, Wessel P. Dirksen, Jessica K. Simmons, Chelsea K. Martin, Jillian L. Werbeck, Nandu K. Thudi, Tracey L. Papenfuss, Prosper N. Boyaka, Ramiro E. Toribio, Jerrold M. Ward, Katherine N. Weilbaecher, Thomas J. Rosol
Summary: The study found that the expression of the HTLV-1 oncogene Tax in mice leads to osteolytic tumors. Mechanisms of bone-invasive malignancies were identified, and related cell lines were established for further research.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Letter
Respiratory System
Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers, Estelle Cormet-Boyaka
RESPIRATORY RESEARCH
(2019)
Article
Cell & Tissue Engineering
H. Hussein, P. Boyaka, J. Dulin, D. Russell, L. Smanik, M. Azab, A. L. Bertone
JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE
(2017)
Article
Neurosciences
Jessica K. Lerch, Jessica K. Alexander, Kathryn M. Madalena, Dario Motti, Tam Quach, Akhil Dhamija, Alicia Zha, John C. Gensel, Jeanette Webster Marketon, Vance P. Lemmon, John L. Bixby, Phillip G. Popovich