Article
Multidisciplinary Sciences
Thilini M. Wijerathna, Nicholas A. Buckley, Indika B. Gawarammana, Jacques Raubenheimer, Seyed Shahmy, Umesh Chathuranga, Chathura Palangasinghe, Fathima Shihana, Fahim Mohamed
Summary: This study investigates the epidemiology and clinical outcomes of MCPA poisoning in Sri Lanka between 2002 and 2019, and analyzes the acute kidney injury in a subset of patients. The results show that MCPA poisoning can cause renal injury, but severe injury is uncommon. Patient age and ingested dose are associated with the severity of the condition, and most patients with renal dysfunction have no pre-existing kidney diseases.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
David Lozano-Paniagua, Tesifon Parron, Raquel Alarcon, Mar Requena, Marina Lacasana, Antonio F. Hernandez
Summary: Growing evidence suggests that chronic exposure to pesticides may cause kidney damage. This study found that levels of osteopontin and trefoil factor 3 in the urine were significantly higher in farmers exposed to pesticides, indicating the presence of subclinical tubular damage linked to pesticide exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Infectious Diseases
Dilip Roy, Amol Kulkarni, Manu Chaudhary, Saransh Chaudhary, Anurag Payasi, Anmol Aggarwal
Summary: The novel formulation of polymyxin-B showed a significant reduction in the risk of polymyxin-induced kidney injury in rats compared to standard polymyxin-B, as indicated by kidney injury biomarkers and histopathological evaluation.
Article
Oncology
Marie Lambert, Melanie White-Koning, Mathieu Alonso, Arnaud Garnier, Gwennaelle Alphonsa, Chloe Puiseux, Caroline Munzer, Joseph Berthier, Laurence Malard, Marlene Pasquet, Etienne Chatelut
Summary: Plasma cystatin C was found to be a better marker for GFR changes during chemotherapy compared to other markers. An equation incorporating plasma cystatin C, serum creatinine, and body weight accurately described the evolution of GFR during chemotherapy. Although the urinary cystatin C/creatinine ratio was increased in children with tubular toxicity, it did not provide additional information beyond existing markers of tubulopathy.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Environmental Sciences
Tao Wei, Na Cao, Tiantian Han, Yi Chen, Xingtao Zhou, Liyang Niu, Wenting Liu, Chang Li
Summary: The present study investigated the nephrotoxicity and lipidomic mechanisms of 3-monochloropropane-1,2-diol (3-MCPD) in Sprague Dawley rats. The results showed that the ingestion of 3-MCPD caused dose-dependent renal impairment and altered oxidative stress indicators. Lipidomic analysis revealed that 3-MCPD interfered with glycerophospholipid metabolism and sphingolipid metabolism, leading to kidney injury. Additionally, 38 lipids were identified as potential biomarkers. This study provides new insights into the mechanism of 3-MCPD renal toxicity and offers a novel approach to its study using lipidomics.
Article
Medicine, General & Internal
Yating Hou, Yujun Deng, Linhui Hu, Linling He, Fen Yao, Yifan Wang, Jia Deng, Jing Xu, Yirong Wang, Feng Xu, Chunbo Chen
Summary: The study in the ICU patients found that serum cystatin C (CysC) had the best performance in predicting AKI and severe AKI. Combinations of CysC with N-acetyl-beta-d-glucosaminidase-to-creatinine ratio (NAG/Cr) or lactic acid (LAC) were effective for predicting AKI and severe AKI respectively. Additionally, CysC combined with clinical markers such as Acute Physiology and Chronic Health Evaluation (APACHE) II score or Multiple Organ Dysfunction Score (MODS) showed good predictive abilities for AKI and severe AKI.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sang-Mi Kim, Hyun-Seung Lee, Min-Ji Kim, Hyung-Doo Park, Soo-Youn Lee
Summary: The study evaluated the diagnostic value of nine serum biomarkers for vancomycin-induced kidney injury (VIKI) and found that TFF3, cystatin C, TNF-R1, and osteopontin had excellent diagnostic value for VIKI and showed a strong negative correlation with estimated glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Parasitology
Patricia Ruiz, Angela Duran, Francisco Javier Duque, Mario Alberto Gonzalez, Jose Ignacio Cristobal, Paloma Nicolas, Eva Maria Perez-Merino, Beatriz Macias-Garcia, Rafael Barrera
Summary: Canine leishmaniasis (CanL) is a disease caused by Leishmania infantum that can range from mild to severe. Dogs with CanL often have renal dysfunction, but traditional biomarkers are not accurate enough. This study aimed to investigate the performance of urinary cystatin C (CysC) and N-acetyl-beta-D-glucosaminidase (NAG) as biomarkers for renal damage in different stages of CanL. The results showed that both uCysCc and uNAGc increased significantly from the LI stage, and a cutoff value was determined for early detection of renal damage.
VETERINARY PARASITOLOGY
(2023)
Article
Critical Care Medicine
Todd A. Miano, Sean Hennessy, Wei Yang, Thomas G. Dunn, Ariel R. Weisman, Oluwatosin Oniyide, Roseline S. Agyekum, Alexandra P. Turner, Caroline A. G. Ittner, Brian J. Anderson, F. Perry Wilson, Raymond Townsend, John P. Reilly, Heather M. Giannini, Christopher Cosgriff, Tiffanie K. Jones, Nuala J. Meyer, Michael G. S. Shashaty
Summary: The study suggests that the combination of vancomycin and piperacillin-tazobactam may increase the risk of acute kidney injury, but does not significantly affect alternative kidney biomarkers, dialysis, or mortality. This supports the hypothesis that the effects of vancomycin and piperacillin-tazobactam on creatinine represent pseudotoxicity.
INTENSIVE CARE MEDICINE
(2022)
Article
Transplantation
Euan N. Paterson, Alexander P. Maxwell, Frank Kee, Sharon Cruise, Ian S. Young, Bernadette McGuinness, Gareth J. McKay
Summary: This study found a significant association between decreased eGFR and increased risk of cognitive impairment, especially when calculated using Cys-C. In addition, CKD Stages 3-5 were also associated with an increased risk of cognitive impairment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Lara Staechele, Daniel J. Stekhoven, Jan A. Birzele, Martin Risch, Raeto T. Strebel
Summary: The purpose of this preliminary study was to assess the changes in concentration of biomarkers indicating renal injury after RIRS. The results showed a significant increase in certain biomarkers after RIRS, but this increase was temporary and normalized within 14 days. Further studies are needed to determine the clinical value of these markers in assessing the long-term impact of intrarenal pressure elevation during RIRS.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Ruth E. Campbell, Chang Huei Chen, Charles L. Edelstein
Summary: Drug-induced nephrotoxicity is a common cause of acute kidney injury in hospitalized patients, leading to increased morbidity and mortality. Antibiotics are a major culprit, causing various forms of kidney damage. Novel biomarkers can aid in early detection, optimization of treatment, and prevention of nephrotoxicity.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Chemistry, Medicinal
V. A. Evteev, I. S. Semenova, N. D. Bunyatyan, A. B. Prokof'ev
Summary: This study investigates the potential use of contemporary biomarkers - cystatin C and clusterin - for assessing drug-induced kidney damage in the RPTEC/TERT1 cell line model. Enzyme immunoassay was used to measure the biomarker protein concentrations. The results show that clusterin concentration increased sharply during the first 4 hours of incubation with vancomycin and then returned to normal, while cystatin C concentration gradually increased throughout the entire incubation period with both cisplatin and vancomycin.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Malene Laurberg, Claude Saegerman, Stine Jacobsen, Lise Berg, Sigrid Hyldahl Laursen, Emma Hoeberg, Elaine Alexandra Sange, Gaby van Galen
Summary: This study evaluated the biomarker NGAL in neonatal foals with sepsis and assessed its relation to outcome. The results showed that NGAL concentrations were significantly higher in septic foals and lower in survivors. NGAL concentrations can be used to diagnose sepsis and predict outcome.
Article
Multidisciplinary Sciences
Eva Jablonska, Zdenek Michal, Bara Krizkovska, Ondrej Strnad, Van Nguyen Tran, Tereza Zalmanova, Jaroslav Petr, Jan Lipov, Jitka Viktorova
Summary: In this study, Lilial and its metabolites were tested in various in vitro assays, and no negative effects were observed on cell viability, endocrine system function, and other aspects within a certain concentration range.
SCIENTIFIC REPORTS
(2023)
