Predictive Toxicology Approaches for Small Molecule Oncology Drugs

Cancer Statistics, 2009

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Synthetic Lethality — A New Direction in Cancer-Drug Development

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Physiochemical drug properties associated with in vivo toxicological outcomes

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A quantitative analysis of kinase inhibitor selectivity

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High-throughput kinase profiling as a platform for drug discovery

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Do molecularly targeted agents in oncology have reduced attrition rates?

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Drug Target Identification Using Side-Effect Similarity

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Nonclinical Safety Evaluation of Sunitinib: A Potent Inhibitor of VEGF, PDGF, KIT, FLT3, and RET Receptors

(2008) Shem Patyna et al.   TOXICOLOGIC PATHOLOGY

Mitochondrial off targets of drug therapy

(2008) Kendall B. Wallace   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular-targeted therapies: Lessons from years of clinical development

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Understanding mechanisms of toxicity: Insights from drug discovery research

(2007) Keith A. Houck et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY