Journal
TOXICOLOGIC PATHOLOGY
Volume 38, Issue 1, Pages 180-181Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623309356450
Keywords
NTP; animal models; B6C3F1/N mouse; F344/N rat; Wistar Han rat; Sprague Dawley rat
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES021219] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
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Based on recommendations of participants at the National Toxicology Program (NTP) workshop Animal Models for the NTP Cancer Bioassay: Strains and Stocks-Should We Switch? some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model Used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP. the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies.
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