Intra-Tumour Signalling Entropy Determines Clinical Outcome in Breast and Lung Cancer

High concordance of protein (by IHC), gene (by FISH; HER2 only), and microarray readout (by TargetPrint) of ER, PgR, and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial

(2014) G. Viale et al.   ANNALS OF ONCOLOGY

Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non-Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway

(2014) C. Shao et al.   CLINICAL CANCER RESEARCH

EZH2 expands breast stem cells through activation of NOTCH1 signaling

(2014) M. E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Breast cancer stem cells and epithelial mesenchymal plasticity – Implications for chemoresistance

(2013) Cletus A. Pinto et al.   CANCER LETTERS

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Comparison of PAM50 Risk of Recurrence Score With Oncotype DX and IHC4 for Predicting Risk of Distant Recurrence After Endocrine Therapy

(2013) Mitch Dowsett et al.   JOURNAL OF CLINICAL ONCOLOGY

Validation of a Histology-Independent Prognostic Gene Signature for Early-Stage, Non–Small-Cell Lung Cancer Including Stage IA Patients

(2013) Sandy D. Der et al.   Journal of Thoracic Oncology

Human Lung Epithelial Cells Progressed to Malignancy through Specific Oncogenic Manipulations

(2013) Mitsuo Sato et al.   MOLECULAR CANCER RESEARCH

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling

(2013) Erhan Bilal et al.   PLoS Computational Biology

Biomarker Discovery in Non-Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation

(2012) J. Botling et al.   CLINICAL CANCER RESEARCH

Cell Plasticity and Heterogeneity in Cancer

(2012) N. D. Marjanovic et al.   CLINICAL CHEMISTRY

Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types

(2012) Francisco Ferro de Beça et al.   JOURNAL OF CLINICAL PATHOLOGY

A lung cancer molecular prognostic test ready for prime time

(2012) Yang Xie et al.   LANCET

A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies

(2012) Johannes R Kratz et al.   LANCET

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic Genes of Stage I Lung Adenocarcinoma

(2012) Mai Yamauchi et al.   PLoS One

TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer

(2012) Alejandra Bruna et al.   Nature Communications

Differential network entropy reveals cancer system hallmarks

(2012) James West et al.   Scientific Reports

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

(2011) Kuo-Jang Kao et al.   BMC CANCER

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

(2011) Masashi Takawa et al.   CANCER SCIENCE

Prognostic Value of a Combined Estrogen Receptor, Progesterone Receptor, Ki-67, and Human Epidermal Growth Factor Receptor 2 Immunohistochemical Score and Comparison With the Genomic Health Recurrence Score in Early Breast Cancer

(2011) Jack Cuzick et al.   JOURNAL OF CLINICAL ONCOLOGY

The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation

(2011) J T Buijs et al.   ONCOGENE

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Statistical analysis of the cancer cell's molecular entropy using high-throughput data

(2010) Wessel N. van Wieringen et al.   BIOINFORMATICS

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Gene Expression-Based Prognostic Signatures in Lung Cancer: Ready for Clinical Use?

(2010) J. Subramanian et al.   JNCI-Journal of the National Cancer Institute

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

An Embryonic Stem Cell-Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma

(2009) K. A. Hassan et al.   CLINICAL CANCER RESEARCH

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

First-generation genomic tests for breast cancer treatment

(2009) Fabrice Andre et al.   LANCET ONCOLOGY

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

(2008) M. Schmidt et al.   CANCER RESEARCH

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

(2008) Kerby Shedden et al.   NATURE MEDICINE