Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains

Comparative structural analysis of the caspase family with other clan CD cysteine peptidases

(2015) Karen McLuskey et al.   BIOCHEMICAL JOURNAL

Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme

(2014) Malini Mukherjee et al.   JOURNAL OF NEURO-ONCOLOGY

The InterPro protein families database: the classification resource after 15 years

(2014) Alex Mitchell et al.   NUCLEIC ACIDS RESEARCH

The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces

(2013) Tengchuan Jin et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Critical Differences between Isoforms of Securin Reveal Mechanisms of Separase Regulation

(2013) Xianxian Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Specificity of a protein-protein interface: Local dynamics direct substrate recognition of effector caspases

(2013) Julian E. Fuchs et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1

(2013) Tengchuan Jin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mechanism and specificity of the human paracaspase MALT1

(2012) Janna Hachmann et al.   BIOCHEMICAL JOURNAL

Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis

(2012) Kwanwoo Lee et al.   CELL CYCLE

Kendrin Is a Novel Substrate for Separase Involved in the Licensing of Centriole Duplication

(2012) Kazuhiko Matsuo et al.   CURRENT BIOLOGY

Structural Determinants of MALT1 Protease Activity

(2012) Christian Wiesmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Oncogenic activity of separase

(2011) Debananda Pati   CELL CYCLE

Cleavage of cohesin rings coordinates the separation of centrioles and chromatids

(2011) Laura Schöckel et al.   NATURE CELL BIOLOGY

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

(2011) Michael Remmert et al.   NATURE METHODS

Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

(2011) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rec8 Phosphorylation by Casein Kinase 1 and Cdc7-Dbf4 Kinase Regulates Cohesin Cleavage by Separase during Meiosis

(2010) Vittorio L. Katis et al.   DEVELOPMENTAL CELL

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Separase Is Recruited to Mitotic Chromosomes to Dissolve Sister Chromatid Cohesion in a DNA-Dependent Manner

(2009) Yuxiao Sun et al.   CELL

Overexpression and Mislocalization of the Chromosomal Segregation Protein Separase in Multiple Human Cancers

(2009) R. Meyer et al.   CLINICAL CANCER RESEARCH

Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement

(2009) Akito Nakamura et al.   JOURNAL OF CELL BIOLOGY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Highly Sensitive Detection of Individual HEAT and ARM Repeats with HHpred and COACH

(2009) Fred Kippert et al.   PLoS One

Structural basis for executioner caspase recognition of P5 position in substrates

(2008) Guoxing Fu et al.   APOPTOSIS

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Separase induces aneuploidy and mammary tumorigenesis

(2008) N. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA